• Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene. (wikipedia.org)
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. (wikipedia.org)
  • The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (wikipedia.org)
  • This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. (wikipedia.org)
  • The human cytochrome P450 3A locus. (wikipedia.org)
  • Many clinically important drug interactions occur due to inhibition of human liver cytochrome P450 3A (CYP3A) metabolism. (nih.gov)
  • Identification and characterization of the pregnane X receptor (PXR) as a key regulator of cytochrome P450 3A ( CYP3A ) gene expression has led to an increased understanding of the molecular basis of many drug-drug interactions. (aspetjournals.org)
  • Previous in vitro studies suggested that the compound undergoes hepatic biotransformation by cytochrome P450 (CYP) 3A into a more cytotoxic metabolite(s). (unboundmedicine.com)
  • The interindividual variability of cyclosporin A (CsA) pharmacokinetics might be explained by heterogeneity in the cytochrome P450 3A (CYP3A) subfamily. (transhumanist.ru)
  • Altered CYP3A enzyme activity was associated with variant allele of P450 oxidoreductase gene ( POR *28). (transhumanist.ru)
  • The aim of the present study was to investigate the influence of the cytochrome P450 (CYP) 3A4/5 genotype in paediatric liver transplant recipients and donors, and the contribution of age and gender to tacrolimus disposition on the first day after transplantation. (transhumanist.ru)
  • Nevirapine is extensively metabolized by the cytochrome P450 system, mainly 3A4. (antimicrobe.org)
  • Nevirapine is an inducer of hepatic cytochrome P450 3A. (antimicrobe.org)
  • Advances in Medicine and Biology, Vol. 93 Yamazaki, H., Chowdhury, G. and Guengerich, F.P. Activation of Thalidomide to Reactive Metabolites by Autoinduced Human Cytochrome P450 3A Enzymes, with Substrate Cooperativity, and Implications for Development of Analogs. (shoyaku.ac.jp)
  • Fifty Years of Cytochrome P450 Research, ed. (shoyaku.ac.jp)
  • Effects of time culture and prototypical cytochrome P450 3A (CYP3A) inducers on CYP2B22, CYP2C, CYP3A and nuclear receptors (NRs) mRNAs in long-term cryopreserved pig hepatocytes (CPHs). (unipd.it)
  • Exonic polymorphisms of cytochrome P450 3As (CYP3As) in Piedmontese cattle breed. (unipd.it)
  • The influence of age and sex on the clearance of cytochrome P450 3A substrates. (bvsalud.org)
  • Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. (csnpharm.com)
  • Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. (csnpharm.com)
  • inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor. (csnpharm.com)
  • 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. (csnpharm.com)
  • In humans, bosentan is extensively metabolized by the cytochrome P450 isoforms 2C9 and 3A4 before excretion into bile, the latter process accounting for more than 90% of total drug elimination. (aspetjournals.org)
  • Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
  • Gender-dependent differences in cytochrome P450 activity, drug metabolism, drug elimination, and their clinical consequences are increasingly apparent. (asahq.org)
  • Cytochrome P450 3A4 is responsible for the biotransformation of myriad therapeutic drugs, toxins, and endogenous substrates, and it has the broadest substrate profile of any known P450 isoform. (asahq.org)
  • TAM ( a ) proceeds four steps leading to genotoxicity which are 1) α-hydroxylation by cytochrome p450, 2) sulfonation by sulfotransferase (SULT), and 3) formation of carbocation to react with DNA, particularly with 2′-deoxyguanosine (dG) [ 11 ]. (biomedcentral.com)
  • At therapeutic concentrations, cytochrome P4502B6 (CYP2B6) is the major P450 isoform catalyzing hepatic ketamine N -demethylation to norketamine in vitro . (silverchair.com)
  • Mice lacking PXR (PXR-KO) were used in the present study to delineate the role of PXR in regulating hepatomegaly and regulating the activity of CYP3A , organic anion transporting polypeptide-2 ( Oatp2 ), and Cyp7a1 (cholesterol 7α-hydroxylase) gene products in vivo. (aspetjournals.org)
  • Alternate splicing of this gene results in three transcript variants encoding different isoforms. (wikipedia.org)
  • Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. (wikipedia.org)
  • Cytochrome P450s (CYPs) are an important family of enzymes in the metabolism of many therapeutic agents and endogenous metabolic reactions. (bvsalud.org)
  • Effect of Age and Allele Variants of CYP3A5 , CYP3A4 , and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. (transhumanist.ru)
  • In patients having metastatic mela- noma, activating mutations were observed in the gene which encodes for protein kinase B-raf (BRAF) mutations. (nadph-oxidasesignaling.com)
  • The 775-kb-long mMdr gene cluster is located on mouse chromosome 5 [2], while the rMdr cluster is found in the rat chromosomal region 4q11-12 [3]. (solvobiotech.com)
  • Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. (her2signaling.com)
  • We used cell lines expressing human, mouse, and rat mdr1 genes. (nih.gov)
  • While humans have only one MDR1 gene to encode a single P-gp drug transporter, there are two genes in rodents, Mdr1a and Mdr1b, that encode P-gps with largely overlapping functions and extensive sequence identity to the single human gene [1]. (solvobiotech.com)
  • These distribution data suggest that the two murine Mdr1 genes jointly accomplish the same function as the single MDR1 in humans. (solvobiotech.com)
  • In addition, they also interfere with the expression of regulator genes, CHOP , ATF4 , and XBP , which further alters lipid metabolism and autophagy. (medscape.com)
  • Human CYP3A43 genome location and CYP3A43 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Resistance of NNRTIs occurs through mutations of the reverse transcriptase gene in the viral genome. (antimicrobe.org)
  • Most Committee members expressed concerns over the mutagenicity of molnupiravir on the viral genome, particularly in the spike gene. (icpcovid.com)
  • Cytochrome P4503A, P-glycoprotein, and UGT1A1 interactions are significant. (uspharmacist.com)
  • Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy. (dgidb.org)
  • La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Cyclic LIPopeptides from Bacillus subtilis ABS-S14 elicit defense-related gene expression in citrus fruit. (perflavory.com)
  • Moreover, the expression of FGF18 is correlated with the expression of profibrotic genes, such as COL1A1 and ACTA2, in human liver biopsy samples. (bvsalud.org)
  • Effects of illicit growth promoters upon steroidogenic enzyme gene expression profiles in cattle testis. (unipd.it)
  • Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. (csnpharm.com)
  • A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. (dgidb.org)
  • Both genes are expressed at similar levels in the mouse kidney. (solvobiotech.com)
  • The cytochrome superfamily consists of nearly 60 members in humans (Human Genome Project 2013), which may be expressed differently in individual cells when challenged by xenobiotics, leading to cellular heterogeneity that remains concealed in a bulk analysis. (biomedcentral.com)
  • 1. Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. (nih.gov)
  • solute carrier organic anion transporter family member 1B1 gene, SLCO1B1 ), simvastatin ( ABCB1 ), and atorvastatin ( CYP3A5 ). (medscape.com)
  • Wrighton SA, Vandenbranden M: Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. (drugbank.com)
  • Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. (childrensmercy.org)
  • Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. (childrensmercy.org)
  • CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. (childrensmercy.org)
  • Many other severe ADEs (e.g., hypersensitivity) are not related to the concentration of drug or metabolite, and the association of an ADE with a gene polymorphism in those cases may provide valuable insight into the prediction and prevention of ADEs. (medscape.com)
  • 8]Natalija M, Daria P, Branka G, et al.GenotypeFrequencies of UDP-Glucuronosyltransferase 1A1Promoter Gene Polymorphism in the Population ofHealthy Croatian Pre-Scholars[J].Coll Antropol, 2008, 32 (3) :725-729. (lcgdbzz.org)
  • Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations. (childrensmercy.org)
  • Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. (childrensmercy.org)
  • 16. Delineation of the insulin-responsive sequence in the rat cytosolic aspartate aminotransferase gene: binding sites for hepatocyte nuclear factor-3 and nuclear factor I. (nih.gov)
  • 18. Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors. (nih.gov)
  • We proposed a model that trans-acting factors, such as CTCF, induced the spatial organisation of parental genes to the same transcriptional factory so that parental genes were coordinatively transcribed to give birth to chimeric mRNAs. (biomedcentral.com)
  • the molecular mechanisms underlying the transcriptional regulation of this gene have yet to be elucidated. (aspetjournals.org)
  • Genetic Heterogeneity in the rRNA Gene Locus of Trichophyton tonsurans. (childrensmercy.org)
  • We comprehensively investigated the nucleotide diversity and haplotype structure and examined the possible role of natural selection in shaping the sequence variation throughout the gene cluster. (nih.gov)
  • 7. Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. (nih.gov)
  • 12. A natural sequence consisting of overlapping glucocorticoid-responsive elements mediates glucocorticoid, but not androgen, regulation of gene expression. (nih.gov)
  • Komori M, Nishio K, Ohi H, Kitada M, Kamataki T: Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (drugbank.com)
  • Furthermore, the genomic region of the 5 ′ partner gene shares a similar DNA sequence with that of the 3 ′ partner gene for 458 putative chimeric mRNAs. (biomedcentral.com)
  • 13. Role of glucocorticoid receptor binding sites in the human immunodeficiency virus type 1 long terminal repeat in steroid-mediated suppression of HIV gene expression. (nih.gov)
  • A previous study has identified 29 overlapping genes between the two diseases which demonstrated that genetic similarity existed [ 12 ]. (hindawi.com)
  • Gene polymorphisms are implicated in the development of diseases and corresponding disease-like ADEs. (medscape.com)
  • 2. Glucocorticoid activation of chromogranin A gene expression. (nih.gov)
  • 15. Transcription of the human thyrotropin-releasing hormone receptor gene-analysis of basal promoter elements and glucocorticoid response elements. (nih.gov)
  • 19. Glucocorticoid stimulates primate but inhibits rodent alpha-fetoprotein gene promoter. (nih.gov)
  • A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus. (cdc.gov)
  • These genes are involved in the pharmacokinetics of their respective drugs and are then logically related to dose- and/or concentration-related ADEs. (medscape.com)
  • In this sense, chimeric genes can be used as desirable therapeutic targets for cancers. (biomedcentral.com)
  • These four subgroups display differential gene expression profiles upon cocktail treatment and xenobiotic metabolism-related specialization. (biomedcentral.com)
  • The disease-associated genes provide candidate genes for exploring ADEs and may provide genomic biomarkers for assessing the risk for developing severe calcineurin inhibitor-related ADEs as well as for developing preventive strategies. (medscape.com)
  • Chimeric mRNAs fused by two previously separate genes located on different genomic loci may allow a limited number of genes to encode a substantially large number of mRNAs and proteins. (biomedcentral.com)
  • As a consequence, gene fusion can change the properties of precursor proteins and can even perturb normal regulatory pathways and initiate or stimulate neoplastic cell growth. (biomedcentral.com)
  • Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
  • Human CYP3A43 genome location and CYP3A43 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population. (cdc.gov)
  • 7]Eílsio C.Hematologically important mutations:BilirubinUDP-glucuronosyltransferase gene mutations in Gilbertand Crigler-Najjar syndromes[J].Blood Cells Mol Dis, 2006, 36 (1) :77-80. (lcgdbzz.org)
  • The development of PIs that select for distinct mutations in the HIV protease gene, in contrast to previously available PIs, would provide one useful path to successful treatment of patients who develop drug resistant HIV variants as a result of prior unsuccessful PI therapy. (webhealthsearch.com)
  • 10. Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids. (nih.gov)
  • demonstrated that these half-sites, organized as an ER-6 (everted repeat separated by six nucleotides), conferred rifampicin-responsiveness on heterologous reporter gene constructs when transfected into rabbit but not rat hepatocytes. (aspetjournals.org)
  • Alternate splicing of this gene results in three transcript variants encoding different isoforms. (wikipedia.org)