• In the liver of rats with SIUs, the expression of CYP2C11, CYP2E1, and CYP3A1 was significantly decreased, and loss of CYP3A protein was observed. (nih.gov)
  • The results suggest that repeated intake of GTE may aggravate cyclophosphamide-induced body weight loss and malformations of fetuses by modulating CYP2B and CYP3A. (biomedsearch.com)
  • The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3A, as in the case of clarithromycin. (elsevier.com)
  • However, concomitant treatment with RIF did not alter DEX-mediated induction of CYP3A mRNA expression and testosterone 6β-hydroxylase activity. (elsevier.com)
  • CYP3A inactivation by clarithromycin occurred at both sites.K I and k inact values for clarithromycin obtained from in vitro sources were unable to accurately predict the clinical effect of clarithromycin on CYP3A activity. (elsevier.com)
  • CYP3A has the highest affinity for oxidation of Acetaminophen (APAP) with a Km close to the concentration observed in human serum after administration of therapeutic doses of APAP. (dartmouth.edu)