The effects of conjugated equine estrogens (CEE) 0.625 mg daily on cytochrome P450 (CYP) were quantified in 12 middle-aged and 13 elderly postmenopausal women at baseline and 6 months later. (nih.gov)
After AFB 1 is absorbed in the intestine, it is converted into various metabolites by many cytochrome oxidase P450 family members (CYP 450 s, CYPs) in the liver. (hindawi.com)
Purpose: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. (elsevierpure.com)
A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. (umassmed.edu)
Current in vitro studies were undertaken to probe the cytochrome P450 (P450)-mediated bioactivation of flutamide and identify the possible reactive species using reduced glutathione (GSH) as a trapping agent. (unboundmedicine.com)
The publication suggests that CBD+CBDA are each metabolized differently in dogs, with P450 enzymes, particularly CYP1A2 and CYP2C21, playing a major role with CYP1A2 being the likely primary metabolizer of CBD. (petfoodindustry.com)
One not often talked about is how it interacts with the cytochrome P450 system in the liver. (web.app)
8 Sep 2015 Cannabidiol is a safe, non-intoxicating, and non-addictive cannabis compound with significant therapeutic attributes, but CBD-drug interactions Aims: Cannabidiol (CBD), one of the major constituents in marijuana, has been to clarify cytochrome P450 (CYP) isoforms involved in the CBD oxidations. (web.app)
Via @Healthline, "Both CBD and grapefruit have an effect on cytochromes P450 (CYPs), a family of enzymes important to drug metabolism. (web.app)
The researcher who explained the CBD interaction with cytochrome P450 was Lester Bornheim to whom we owe discovering the potential of CBD in the treatment of refractory epilepsy. (web.app)
Similar to delta-9-THC, a majority of CBD is… CBD and other plant cannabinoids can potentially interact with many pharmaceuticals, decreasing their effectiveness by inhibiting the activity of cytochrome P450, a family of liver enzymes. (web.app)
The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. (web.app)
Warfarin is metabolized via the cytochrome P450 system by CYP 2C9, 1A2, and 3A4. (tag-challenge.com)
CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N-acetyltransferase 2 metabolism in postmenopausal women. (nih.gov)
Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. (web.app)
CYP3A44
Furthermore, of 13 human cytochrome P-450s (P-450s) examined, five (CYP1A1, CYP1A2, CYP2B6, CYP2E1, and CYP3A4) were active in the metabolic activation of coumarin, suggesting a potential risk of coumarin toxicity in humans. (aspetjournals.org)
Recombinant human CYPs predict that CYP2C9, CYP1A2, and CYP3A4 are the most important for total metabolism. (aspetjournals.org)
The conjugate formation was primarily catalyzed by heterologously expressed CYP2C19, CYP1A2, and, to a lesser extent, CYP3A4 and CYP3A5. (unboundmedicine.com)
CYP1A1, CYP1A2, and CYP3A4 metabolize the (R)-enantiomer and CYP2C9 metabolizes the more potent (S)-enantiomer. (tag-challenge.com)
CYP2C91
Inter-individual variation in imatinib disposition: any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in Nigerian CML patients? (tropmedres.ac)
Enzymes4
Many of these drugs are potent inhibitors of the cytochrome P- 450 enzymes (CYPs) of the liver. (elsevierpure.com)
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. (ox.ac.uk)
This process is largely carried out in the liver and is accomplished by a superfamily of heme-containing enzymes, termed the Cytochrome P450's. (uncg.edu)
COUMADIN is stereoselectively metabolized by hepatic microsomal enzymes (cytochrome P-450) to inactive hydroxylated metabolites (predominant route) and by reductases to reduced metabolites (warfarin alcohols). (tag-challenge.com)
Liver4
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (curehunter.com)
1988). Benzene is initially metabolized by cytochrome P-450-dependent mixed function oxidases primarily in the liver via several toxification and detoxification (via conjugation) pathways. (cdc.gov)
Diet, cardiac or liver disease, tobacco use, and medications (cimetidine, erythromycin, oral contraceptives) affecting the cytochrome P-450 system (CYP1A2) can affect the half-life. (medscape.com)
Biotransformation pathways and the potential for drug-drug interactions of the orally active antifungal terbinafine were characterized using human livermicrosomes and recombinant human cytochrome P-450s (CYPs). (aspetjournals.org)
Metabolism3
Several cytochrome P-450 isozymes are involved in the metabolism of benzene, although the predominant form is CYP2E1 (Gut et al. (cdc.gov)
CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. (ox.ac.uk)
In the first publication of its kind, a recently published study examines CBD and CBDA's metabolism and potential drug-drug interactions involving canine cytochrome P-450 metabolism, UDP-glucuronosyltransferase conjugation and P-glycoprotein drug efflux influences. (petfoodindustry.com)
Caffeine2
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. (ox.ac.uk)
Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. (ox.ac.uk)
CYP2B61
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2B6. (uchicago.edu)
CYPs2
This review highlights significant advances in our understanding of the AFB 1 metabolic activation, like cytochrome P450s (CYPs), and AFB 1 metabolic detoxification, like glutathione S-transferases (GSTs) in poultry. (hindawi.com)
The isoforms of the CYPs most relevant to the use of antidepressants are CYP1A2. (elsevierpure.com)
CYP1A1 and CYP1A22
The two SNPs rs2470893 and rs2472297 (P-values=1.6 × 10(-11) and 2.7 × 10(-11)), which were also in strong linkage disequilibrium (r(2)=0.7) with each other, lie in the 23-kb long commonly shared 5' flanking region between CYP1A1 and CYP1A2 genes. (ox.ac.uk)
Utilizing an activity guided fractionation scheme, acai berry extracts were assayed in CYP1A1 and CYP1A2 enzyme reactions to determine constituents responsible for enzyme inhibition. (uncg.edu)
CYP1B13
Cytochrome P-450 CYP1B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Cytochrome P-450 CYP1B1" by people in this website by year, and whether "Cytochrome P-450 CYP1B1" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Cytochrome P-450 CYP1B1" by people in Profiles. (umassmed.edu)
GSTT11
We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. (ox.ac.uk)
Genes1
We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P = 5 × 10 9) and PLCD3 (P = 1 × 10 8) genes. (uai.cl)
System1
Some of CBD oil's side effects can be dangerous if you do not understand the Cytochrome P-450 System. (web.app)
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (ox.ac.uk)
Consumption1
Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. (ox.ac.uk)
Activity1
Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. (ox.ac.uk)
Enzyme system1
The genotoxic impact of carcinogen exposure is heavily influenced by a complex array of metabolic pathways, which includes the cytochrome P 450 (CYP) enzyme system. (biomedcentral.com)
CYP1A14
We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. (nih.gov)
Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C to T) was carried out in 88, 76, 53, and 170 patients with gastric cancer (GC), functional dyspepsia (FD), peptic ulcer (PU), and healthy controls (HC), respectively. (nih.gov)
CYP1A1 polymorphism and CYP1A1-CYP1A2 haplotypes were comparable among different groups. (nih.gov)
In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. (ox.ac.uk)
Polymorphism1
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. (cdc.gov)
Catalyzes the hydroxylation1
A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. (jefferson.edu)
Polymorphisms1
Catechol-O-methyltransferase and cytochrome P-450 1B1 polymorphisms and endometrial cancer risk: a meta-analysis. (cdc.gov)
Substrates1
Whereas CYP1A2 can metabolize PAHs to a small extent, N -arylamines are the principle substrates for CYP1A2. (sciencewatch.com)
Phenotype1
The racial/ethnic distribution of selected CYP450 (CYP1A2, P2C8/9/19, 2D6 and 3A4/5) SNPs are reviewed with an emphasis on the agreement between genotype and phenotype. (nih.gov)
Induce3
Liver microsomes were isolated from uninduced rats and rats that were treated with cadmium and/or β-napthoflavone (BNF) to induce HO-1 and/or CYP1A2. (nih.gov)
These results suggested that VDL could induce the activity of CYP2C11, and inhibits the activity of CYP1A2, but had no significant effects on CYP2B, CYP2D1 and CYP3A. (bvsalud.org)
Induction4
Furthermore, HO-1 induction also was associated with slower rates of hydrogen peroxide and hydroxyl radical production by microsomes from rats induced for CYP1A2. (nih.gov)
The effects of HO-1 induction were less dramatic in the absence of substrate for CYP1A2, suggesting that the enzyme was more effective in inhibiting the CYP1A2-related activity than the CPR-related production of superoxide (that dismutates to form hydrogen peroxide). (nih.gov)
Essential role for induction of cytochrome P-448. (wakehealth.edu)
Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. (childrensmercy.org)
MeSH1
Cytochrome P-450 CYP2C8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Microsomes1
Anti-liver microsomes (anti-LM) autoantibodies in patients with dihydralazine-induced hepatitis were found to react specifically with cytochrome P4501A2 (P4501A2) but not with P4501A1 expressed in yeast and bacteria. (nih.gov)
Inhibits1
These results demonstrate that while one vegetable subgroup induces human CYP1A2 activity, another subgroup inhibits it. (nih.gov)
This graph shows the total number of publications written about "Cytochrome P-450 CYP2C8" by people in this website by year, and whether "Cytochrome P-450 CYP2C8" was a major or minor topic of these publications. (umassmed.edu)