Cytochrome P450 omega hydroxylases, also termed cytochrome P450 ω-hydroxylases, CYP450 omega hydroxylases, CYP450 ω-hydroxylases, CYP omega hydroxylase, CYP ω-hydroxylases, fatty acid omega hydroxylases, cytochrome P450 monooxygenases, and fatty acid monooxygenases, are a set of cytochrome P450-containing enzymes that catalyze the addition of a hydroxyl residue to a fatty acid substrate. (wikipedia.org)
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. (nih.gov)
The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (nih.gov)
This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. (nih.gov)
A broad range of reactivities was observed when 13 purified rat cytochrome P450 isozymes were tested for epitope relatedness in a noncompetitive enzyme-linked immunosorbent assay or on immunoblots. (nih.gov)
Several antibodies were antigen-specific, others reacted with additional members of the 2C subfamily, and other monoclonal antibodies recognized cytochromes P450 from the 2E, 2B, 2A, and 1A subfamilies. (nih.gov)
In an effort to identify and characterize minor forms of human liver cytochrome P450, immunoblot analyses of microsome samples were developed with antibodies to various P450s that recognized multiple human P450s. (nih.gov)
Cytochrome P450 oxidoreductase deficiency is a disorder of hormone production. (medlineplus.gov)
The hormonal changes associated with cytochrome P450 oxidoreductase deficiency can affect the development of the reproductive system, skeleton, and other parts of the body. (medlineplus.gov)
The signs and symptoms of cytochrome P450 oxidoreductase deficiency vary from mild to severe. (medlineplus.gov)
People with moderate cytochrome P450 oxidoreductase deficiency usually do not have skeletal abnormalities. (medlineplus.gov)
The severe form of cytochrome P450 oxidoreductase deficiency is sometimes called Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis. (medlineplus.gov)
Some women who are pregnant with fetuses affected by cytochrome P450 oxidoreductase deficiency experience mild symptoms of the disorder even though they themselves do not have the disorder. (medlineplus.gov)
The prevalence of cytochrome P450 oxidoreductase deficiency is unknown. (medlineplus.gov)
Researchers suspect that cytochrome P450 oxidoreductase deficiency is underdiagnosed and that mild cases of this disorder may be relatively common. (medlineplus.gov)
Because the signs and symptoms can be difficult to detect, people with mild cytochrome P450 oxidoreductase deficiency may never come to medical attention. (medlineplus.gov)
Cytochrome P450 oxidoreductase deficiency is caused by mutations in the POR gene. (medlineplus.gov)
This gene provides instructions for making the enzyme cytochrome P450 oxidoreductase, which plays a critical role in the formation of steroid hormones . (medlineplus.gov)
Mutations in the POR gene reduce the activity of cytochrome P450 oxidoreductase, which disrupts the production of steroid hormones. (medlineplus.gov)
In a woman who is pregnant with an affected fetus, abnormal levels of sex hormones in the fetus may cause her to have mild, temporary signs and symptoms of cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
Cytochrome P450 oxidoreductase is also needed for the production of cholesterol. (medlineplus.gov)
Mutations in the POR gene can disrupt the production of cholesterol, which likely impairs normal bone formation in the severe form of cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. (adooq.com)
Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereo-specific hydroxylation of different sterols. (nist.gov)
Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. (nist.gov)
The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism. (wikigenes.org)
Cytochrome p450-dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids. (springer.com)
Blue genes are cytochrome P450 type hydroxylase (enzymes involved in detoxification in the liver) genes. (suntory.com)
The pharmacokinetics of perphenazine covary with the hydroxylation of debrisoquine which is mediated by cytochrome P450 2D6 (CYP 2D6) and thus is subject to genetic polymorphism - i.e., 7% to 10% of Caucasians and a low percentage of Asians have little or no activity and are called "poor metabolizers. (nih.gov)
A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. (umassmed.edu)
T cell responses to steroid cytochrome P450 21‑ hydroxylase in patients with autoimmune primary adrenal insufficiency. (prolekare.cz)
Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
The formation of both metabolites was inhibited by more than 90% by an antiserum directed against a pregnenolone 16 alpha-carbonitrile-inducible cytochrome P450 (P450PCN1) of rat liver. (aspetjournals.org)
The formation of both metabolites of midazolam was inhibited by triacetyloleandomycin, a known inhibitor of cytochromes P450 of the IIIA family. (aspetjournals.org)
Liver microsomes from four rats of each sex per group were assayed for protein and cytochrome P450 content, and the activities of UDP-glucuronyltransferase and several monooxygenases were determined (Vermeir, 1996). (inchem.org)
The classic pathway is the predominant pathway, with the first and rate-limiting reaction catalyzed by a cytochrome P450 enzyme, cholesterol 7 α -hydroxylase (CYP7A1). (aspetjournals.org)
Additionally, 193 cytochrome P450 (CYP450), 280 methyltransferase and 144 isomerase genes were identified, that are potential candidates for enzymes involved in RIN and IRN synthesis. (biomedcentral.com)
Tolbutamide is a sulfonylurea-type oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety catalyzed by cytochrome P-450 (CYP) enzymes of the human CYP2C subfamily. (aspetjournals.org)
Deficiency4
17-Hydroxylase (17-OH) deficiency syndrome is a rare genetic disorder of steroid biosynthesis that causes decreased production of glucocorticoids and sex steroids and increased synthesis of mineralocorticoid precursors. (medscape.com)
Although patients with 17-hydroxylase deficiency are cortisol deficient, they do not typically have adrenal insufficiency or experience adrenal crises. (medscape.com)
More than 90% of CAH is due to 21-hydroxylase deficiency and, in the newborn period, salt losing is present in 75% of patients. (health.am)
Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A , is the most common form of CAH, accounting for more than 90% of cases. (medscape.com)
Protein1
Thus, despite the high level of expression of cytochrome P450h in microsomes from adult male rats and the high catalytic activity of the purified protein for benzphetamine, this isozyme contributes only a small portion of the metabolism of this substrate in microsomes. (nih.gov)
Metabolism2
Conversion of cholesterol to 24S-OHC is mediated by cholesterol 24S-hydroxylase in the brain, which is the major pathway for oxysterol elimination, followed by oxidation through hepatic first-pass metabolism by CYP39A1. (mdpi.com)
We conclude that the metabolism of midazolam and triazolam in human liver is predominantly mediated by cytochrome P450IIIA4. (aspetjournals.org)
Hepatic1
A panel of 30 monoclonal antibodies against rat hepatic microsomal cytochrome P450h (2C11) has been produced, purified, and characterized. (nih.gov)
Sterol1
Subsequent enzymatic reactions catalyzed by sterol 12 α -hydroxylase (CYP8B1) and sterol 27-hyroxylase (CYP27A1), respectively, yield the primary BAs, cholic acid (CA) and chenodeoxycholic acid (CDCA). (aspetjournals.org)
Microsomes4
Immunoblot analysis of rat microsomes illustrated the male specificity of cytochrome P450h expression which extended to extrahepatic tissues including kidney and lung. (nih.gov)
Benzo(a)pyrene-hydroxylase and ethoxycoumarin-deethylase activities were also inhibited by Zn, Cd, and Pb in adrenal, liver and lung microsomes. (cdc.gov)
Moreover, midazolam hydroxylase activity was immunoprecipitated from solubilized human microsomes with polyclonal antibodies against rat P450PCN1 and the closely related human isozyme P450NF. (aspetjournals.org)
Alpha-hydroxylase3
Cholesterol 7-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Cholesterol 7-alpha-Hydroxylase" by people in UAMS Profiles by year, and whether "Cholesterol 7-alpha-Hydroxylase" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Cholesterol 7-alpha-Hydroxylase" by people in Profiles over the past ten years. (uams.edu)
Microsomal cytochrome1
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (curehunter.com)
Adrenal1
Cytochrome P450c17 is the single enzyme that mediates the 17α-hydroxylase and 17, 20 lyase activities during the biosynthesis of steroid hormones in the gonads and adrenal gland. (amrita.edu)
Aldosterone synthase1
Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively. (adooq.com)
Rate-limiti1
4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). (adooq.com)
Inhibitors1
All of the antibodies were screened as potential inhibitors of cytochrome P450h-mediated testosterone hydroxylation in a reconstituted system. (nih.gov)
Debrisoquin1
They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. (reference.md)
Arabidopsis1
CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. (wikigenes.org)
Benzphetamine2
The inhibitory antibodies were then used to assess the role of cytochrome P450h in microsomal benzphetamine N-demethylation, since this isozyme exhibits high catalytic activity for this substrate. (nih.gov)
Cd and Zn caused concentration dependent decreases in benzphetamine- demethylase and biphenyl-hydroxylase activities in liver, lung, and adrenals. (cdc.gov)
CYP4501
The CYP450 omega hydroxylases are accordingly better viewed as a subset of monooxygenases that have the ability to hydroxylate fatty acids. (wikipedia.org)
Substrate1
It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. (reference.md)
Liver1
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. (aspetjournals.org)
Inhibitor7
LX 1606 hippurate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. (adooq.com)
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. (adooq.com)
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. (adooq.com)
Epitope1
Autoantibody epitope mapping of the 21‑ hydroxylase antigen in autoimmune Addison's disease. (prolekare.cz)
Activity2
CYP4A, CYP4B, and CYP4F CYP2U1 also possesses ω hydroxylase activity. (wikipedia.org)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
MeSH1
Cytochrome P-450 CYP1B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Human1
Tolbutamide, an oral hypoglycemic agent, has been used extensively as a metabolic probe to study human cytochrome P-450 (CYP) 3 function. (aspetjournals.org)
Isomerase1
The enzymatic defects causing female virilization involve 3β-hydroxysteroid dehydrogenase Δ5-Δ4 isomerase (3β-HSD), P 450 C21 hydroxylase (21-OH), and P 450 C11 hydroxylase (11-OH). (health.am)
Adult1
Steroid 21‑ hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. (prolekare.cz)