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  • heme group
  • These data demonstrate the notable retention of the native secondary structure and tertiary fold despite the absence of covalent linkages between the heme group and the protein. (ox.ac.uk)
  • protein
  • Conversion of Hydrogenobacter thermophilus cytochrome c(552) into a b-type cytochrome by mutagenesis of both heme-binding cysteines to alanines significantly reduces the stability of the protein (Tomlinson, E. J., and Ferguson, S. J. (2000) Proc. (ox.ac.uk)
  • type
  • NMR analysis shows that a b-type variant of Hydrogenobacter thermophilus cytochrome c552 retains its native structure. (ox.ac.uk)
  • redox
  • Redox potentiometry, combined with UV-visible spectroscopy, showed that cytc-Ts4 is a diheme cytochrome with a redox potential of +282 +/- 10 mV, and both hemes are predicted to have His-Met ligation. (exeter.ac.uk)
  • gene
  • The same agents, except for macrophage colony-stimulating factor, induced the expression of the cytochrome b heavy chain gene 2- to 12-fold and light chain gene 2- to 6-fold in human granulocytes. (umassmed.edu)
  • heme
  • The shifted optical spectrum cannot be ascribed to an alteration in the strength of the hydrogen bond between the formyl group of the low-spin heme and its environment, as the Raman line assigned to this mode in aa3-600 has the same frequency and degree of resonance enhancement as the low-spin heme a formyl mode in most other aa3-type oxidases. (cut.ac.cy)
  • Binding of oxygen to a heme prosthetic group. (wikipedia.org)
  • Hemes are most commonly recognized as components of hemoglobin , the red pigment in blood , but are also found in a number of other biologically important hemoproteins such as myoglobin , cytochromes , catalases , heme peroxidase , and endothelial nitric oxide synthase . (wikipedia.org)
  • a histidine residue, located adjacent to the heme group, becomes positively charged under acidic conditions (which are caused by dissolved CO 2 in working muscles, etc.), releasing oxygen from the heme group. (wikipedia.org)
  • The addition of peroxide with the glutamyl -375 and aspartyl -225 of lactoperoxidase forms ester bonds between these amino acid residues and the heme 1- and 5-methyl groups, respectively. (wikipedia.org)
  • The enzyme comprises three subunits SerABC, where SerC is an unusual b-heme cytochrome. (exeter.ac.uk)
  • The 1H-NMR lines of heme c in reduced and oxidized cytochrome c-552 from E. gracilis were assigned and coordination geometry of the axial ligands was investigated. (eurekamag.com)
  • The electronic structure of the heme and chirality of the axially bound methionine were the same type as in mammalian cytochrome c, but different from cytochrome c-551 from Pseudomonas aeruginosa. (eurekamag.com)
  • mitochondria
  • The release of Cytochrome c from mitochondria is a pivotal event in the apoptotic process, but the precise mechanisms remain controversial. (nih.gov)
  • Purified mitochondria from Bid knockout mice, but not from Bax knockout mice, failed to release cytochrome c in response to autologous S-100 and GrB. (nih.gov)
  • Our findings suggest that the block in response of Bak-deficient Jurkat cells to GrB localizes to the cytochrome c release mechanism within the mitochondria of these cells. (nih.gov)
  • electron
  • The specific quinol-cytochrome c oxidoreductase (QCR) inhibitors myxothiazol and antimycin A partially inhibited selenate respiration, demonstrating that some electron flux is via the QCR. (exeter.ac.uk)
  • Electron transfer via a QCR and a diheme cytochrome c(4) is a novel route for a member of the DMSO reductase family of molybdoenzymes. (exeter.ac.uk)
  • suggests
  • This study demonstrates that GrB-cleaved Bid, which differs in size and site of cleavage from caspase-8-cleaved Bid, utilizes Bak for cytochrome c release, and therefore, suggests that deficiency in Bak may serve as a mechanism of immune evasion for tumor or viral infected cells. (nih.gov)
  • human
  • In vitro regulation of human phagocyte cytochrome b heavy and light ch" by Peter E. Newburger, Qun Dai et al. (umassmed.edu)
  • In vitro treatment with lipopolysaccharide, tumor necrosis factor alpha, or macrophage- or granulocyte-macrophage colony-stimulating factors increased the levels of transcripts for the cytochrome b heavy chain (gp91phox) 9- to 22-fold and transcripts for the light chain (p22phox) 2- to 5-fold in cultured human monocyte-derived macrophages. (umassmed.edu)
  • In addition to our research on human chaperones, our research group is interested in comparative studies of Hsp90 complex from other organisms. (ru.ac.za)
  • Biology
  • Our group is studying the biochemistry and cell biology of the molecular chaperone, Hsp90, in cancer and stem cell biology. (ru.ac.za)
  • residues
  • Especially important are the imidazole substituent in histidine residues, thiolate substituents in cysteine residues, and carboxylate groups provided by aspartate . (wikipedia.org)
  • Type
  • A previously proposed correlation between chirality of attachment of the axial methionine and electronic wave functions in oxidized cytochromes of the c type was supported. (eurekamag.com)
  • Research
  • Research projects in her group range from drug discovery to agricultural studies to databases. (ru.ac.za)