Cytidine 5'-diphosphocholine, CDP-choline or citicoline, is an essential intermediate in the biosynthetic pathway of the structural phospholipids of cell membranes, especially in that of phosphatidylcholine. (nih.gov)
Healthy Origins® Cognizin is a trademark for Citicoline, (also known as CDP Choline and Cytidine-5 - diphosphate choline) a nutrient that supports memory function and healthy cognition. (vitacost.com)
Citicoline is cytidine diphosphatecholine, or CDP-choline, a nutrient that has been shown to support memory in patients with age-associated memory impairment, and brain cell recovery from injuries such as stroke or concussion. (buy-otc.com)
The main component of Citicoline is its cytidine group, which is what Citicoline delivers to the brain. (buy-otc.com)
AOR's Citicoline provides a source of choline along with added choline for enhanced acetylcholine production, while the cytidine end is converted into cytidine diphosphate which enhances the natural production of all the body's phospholipids in a balanced manner. (buy-otc.com)
CDP-diacylglycerol then reacts with glycerol-3-phosphate via phosphatidylglycerophosphate synthase to form 3-sn-phosphatidyl-1'-sn-glycerol 3'-phosphoric acid, with the release of cytidine monophosphate (CMP). (hmdb.ca)
2 C -methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2 C -methyl-D-erythritol-2-phosphate to 2 C -methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosphate in production of isoprenoid-precursors via the methylerythritol phosphate biosynthetic pathway. (biomedcentral.com)
Unexpectedly, one structure of Bc IspF revealed two molecules of cytidine monophosphate in the active site, and another identified citrate coordinating to the catalytic Zn 2+ . (biomedcentral.com)
The studies reveal new data on ligand binding, with citrate coordinating to the active site Zn 2+ and when present in high concentrations cytidine monophosphate displays two binding modes in the active site. (biomedcentral.com)
Fricke J, Neuhard J, Kelln RA, Pedersen S: The cmk gene encoding cytidine monophosphate kinase is located in the rpsA operon and is required for normal replication rate in Escherichia coli. (drugbank.com)
Diacylglycerol5
Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species. (mpg.de)
Phosphatidylglycerol is formed from phosphatidic acid by a sequence of enzymatic reactions that proceeds via the intermediate, cytidine diphosphate diacylglycerol (CDP-diacylglycerol). (hmdb.ca)
RBL1 encodes a cytidine diphosphate diacylglycerol synthase that is required for phospholipid biosynthesis2. (bvsalud.org)
It is a glycerophospholipid containing a diacylglycerol, with a cytidine diphosphate attached to the oxygen O1 or O2 of the glycerol part. (ymdb.ca)
In E. coli glycerophospholipid metabolism, The biosynthesis of CDP-diacylglycerol (CDP-DG) involves condensation of phosphatidic acid (PA) and cytidine triphosphate, with elimination of pyrophosphate, catalysed by the enzyme CDP-diacylglycerol synthase. (ymdb.ca)
Uridine3
2. Maxwell, E.S. and de Robichon-Szulmajster, H. Purification of uridine diphosphate galactose-4-epimerase from yeast and the identification of protein-bound diphosphopyridine nucleotide. (qmul.ac.uk)
Bioynthesis proceeds by condensation of phosphatidic acid and cytidine triphosphate with elimination of pyrophosphate via the action of phosphatidate cytidyltransferase (or CDP-synthase). (hmdb.ca)
Efficient recombinant protein production and crystallization protocols were developed, and high-resolution crystal structures of IspF from P. falciparum ( Pf IspF) and B. cenocepacia ( Bc IspF) in complex with cytidine nucleotides determined. (biomedcentral.com)
Active1
Comparisons with orthologues, indicate a high degree of order and conservation in parts of the active site where Zn 2+ is bound and where recognition of the cytidine moiety of substrate occurs. (biomedcentral.com)
Choline13
Choline can be synthesized from phosphatidylcholine via the cytidine-diphosphate (CDP) pathway. (nih.gov)
Citicoline is the generic name for synthetic cytidine diphosphatecholine (CDP-choline), an organic molecule produced endogenously and found in all living cells. (harristeeter.com)
One such supplement is our product Choline Complex which combines three choline derivatives: choline bitartrate, alpha-glycerophosphocholine, and cytidine-diphosphate-choline (also known as CDP-choline or citicoline), now available to buy at SuperSmart. (supersmart.com)
Each capsule contains an optimal 250 mg of alpha-glycerophosphocholine, 50 mg of cytidine-diphosphate-choline, and 35 mg of choline bitartrate, with a suggested dose of 2 capsules of Choline Complex a day, though this can be adapted to your needs and your therapist's advice. (supersmart.com)
CDP-Choline (cytidine-5'-diphosphate choline)Cognizin® is the brand name of CDP-Choline. (jomarlabs.com)
AOR Citicoline is cytidine 5'-diphosphate choline, a phospholipids booster that can help optimized your brain function. (wondersofnature.ca)
Citicoline, also known as CDP-choline or cytidine diphosphate-choline, is a naturally occurring compound in the body. (nooceptin.com)
Citicoline (CDP Choline, cytidine diphosphate-choline) is one of the most popular brain supplements available, known to both be highly effective and highly safe. (sarmscentral.org)
AOR - Citicoline - 60 Capsule(s) - NPN: 80033996 -- Citicoline is cytidine diphosphatecholine, or CDP-choline, a nutrient that has been shown to support memory in patients with age-associated memory impairment, and brain cell recovery from injuries such as stroke or concussion. (healthhut.ca)
Phospholipids are fundamental in the synthesis of neurotransmitters and the proper functioning of neural cell membranes both highly significant factors for healthy cognitive function.AOR AdvantageAORs Citicoline provides a source of choline along with added choline for enhanced acetylcholine production, while the cytidine end is converted into cytidine diphosphate which enhances the natural production of all the bodys phospholipids in a balanced manner. (healthhut.ca)
Citicoline Injection IP is a medicinal drug that is formulated by using an active pharmaceutical ingredient known as CDP-choline or cytidine diphosphatecholine which is highly effective against neurological disorders and cognitive impairments. (alvislabs.in)
Citicoline2
Additionally, it supports nerves in the eye, and studies administering Citicoline to patients with lazy-eye and other vision disorders have noted beneficial results.The main component of Citicoline is its cytidine group, which is what Citicoline delivers to the brain. (healthhut.ca)
The main component of citicoline is its cytidine group, which is what citicoline delivers to the brain. (healthservicecentre.ca)
Nucleoside diphosphates2
This enzyme catalyzes the phosphorylation of nucleoside diphosphates, including cytidine 5′-diphosphate (CDP), to generate the corresponding nucleoside triphosphates (CTP in this case). (musechem.com)
The discovery of Ochoa and coworkers (3, 4) that polyribonucleotides are formed from nucleoside diphosphates in a reaction catalyzed by an enzyme from Azotobacter vinelandii made it clear that ADP rather than ATP was the reactive component. (nih.gov)
Disodium2
Cytidine 5′-diphosphate disodium(CAT: I025443) is a compound that serves as a substrate for CDP (nucleoside diphosphate) kinase (EC 2.7.4.6). (musechem.com)
Cytidine 5′-diphosphate disodium plays a crucial role in supporting these biochemical processes by providing the necessary building blocks for nucleic acid synthesis. (musechem.com)
Phosphate1
CDP-DG is produced in metabolic pathways through the reaction of cytidine 5'-triphosphate and PA which releases a phosphate group. (avantilipids.com)
Moiety1
It is a glycerophospholipid in which a cytidine diphosphate moiety occupies a glycerol substitution site. (hmdb.ca)
Deoxycytidine1
dFdCDP inhibits RR, which converts cytidine diphosphate (CDP) to deoxycytidine diphosphate (dCDP), resulting in the depletion of dCTP necessary for DNA synthesis and repair. (medscape.com)
Pyrimidine1
The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. (mcw.edu)
Assay A: Incorporation of Labeled Nucleoside Diphosphate into Acid- Insoluble Precipitate-The incubation mixture (0.25 ml.) contained 0.05 ml. of glycylglycine buffer (1 m, pH 7.4), 0.02 ml. of ADP (0.04 m), 0.02 ml. of 8-C4-ADP (0.00227 m, 7.8 X 105 c.p.m. per umole), 0.01 ml. of 2 See Crawford, et al. (nih.gov)
Enzyme1
Instead, a previously unknown enzyme--which they called nucleoside diphosphokinase--uses ATP to phosphorylate the diphosphates of ribo- and deoxyribonucleosides to the respective tri phosphates (the building blocks of RNA and DNA, respectively). (nih.gov)
Activity1
Gemcitabine and dFdCMP are inactivated by CDA and AICDA is suggested to have cytidine deaminase activity. (medscape.com)