• Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. (wikipedia.org)
  • Cytarabine is mainly used in the treatment of acute myeloid leukaemia, acute lymphocytic leukaemia (ALL) and in lymphomas, where it is the backbone of induction chemotherapy. (wikipedia.org)
  • Cytarabine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
  • Cytarabine is used alone or with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML). (medlineplus.gov)
  • Cytarabine is also used alone or with other chemotherapy drugs to treat meningeal leukemia (cancer in the membrane that covers and protects the spinal cord and brain). (medlineplus.gov)
  • Standard chemotherapy was cytarabine 100 mg/m 2 and daunorubicin 60 mg/m 2 . (vyxeos.com)
  • Cytarabine, which is the generic form of the brands Cytosar-U and Tarabine PFS, is a member of the chemotherapy family of drugs. (booboone.com)
  • In June 2020, the European Commission granted marketing authorisation for Daurismo® (glasdegib), in combination with low-dose cytarabine, for the treatment of newly diagnosed de novo or secondary AML in adult patients who are not candidates for standard induction chemotherapy. (scuba-capsule.de)
  • four of nine being associated with toxicity of 5 days of etoposide and cytarabine. (nih.gov)
  • Lenalidomide monotherapy and in combination with cytarabine, daunorubicin and etoposide for high-risk myelodysplasia and acute myeloid leukaemia with chromosome 5 abnormalities. (ox.ac.uk)
  • Randomized phase-III study of low-dose cytarabine and etoposide? (cdc.gov)
  • tell your doctor and pharmacist if you are allergic to cytarabine or any of the ingredients in cytarabine injection. (medlineplus.gov)
  • You should not become pregnant while you are receiving cytarabine injection. (medlineplus.gov)
  • Liposomal cytarabine (DepoCyt®) is given by intrathecal injection. (schoolandyouth.org)
  • Although there are several ways to administer Cytarabine depending on the medical condition of the patient, the most common method is injection into a vein as directed by your doctor. (booboone.com)
  • CYTARABINE INJECTION Faulding Antileukemic Action And Clinical Pharmacology: Cytarabine is converted intracellularly to the nucleotide, cytarabine triphosphate. (rxmed.com)
  • DepoCyte ( cytarabine liposome injection) and DepoDur ( morphine sulfate extended-release liposome injection). (medscape.com)
  • For patients without CNS metastases, CNS prophylaxis (eg, with systemic and/or intrathecal methotrexate and/or cytarabine ) is essential. (msdmanuals.com)
  • This open-label, multicentre phase I/II study determined the maximum tolerated dose (MTD), safety and efficacy of clofarabine administered with cytarabine and idarubicin in newly diagnosed acute myeloid leukaemia (AML) patients lacking favourable genetic aberrations. (uni-luebeck.de)
  • We have previously established the activity of clofarabine plus cytarabine in AML relapse. (elsevierpure.com)
  • We have now conducted a phase 2 study of clofarabine plus cytarabine in patients aged 50 years or older with previously untreated AML. (elsevierpure.com)
  • Clofarabine was given at 40 mg/m 2 as a 1-hour intravenous infusion for 5 days (days 2 to 6) followed 4 hours later by cytarabine at 1 g/m 2 /d as a 2-hour intravenous infusion for 5 days (days 1 to 5). (elsevierpure.com)
  • Clofarabine plus cytarabine has activity in adult AML, achieving a good CR rate. (elsevierpure.com)
  • For more information see the Drug Information Summary for Daunorubicin Hydrochloride and Cytarabine Liposome . (cancer.gov)
  • Daunorubicin and cytarabine lipid complex is different than other products containing these medications and should not be substituted for one another. (safemedication.com)
  • Daunorubicin and cytarabine lipid complex slows or stops the growth of cancer cells in your body. (safemedication.com)
  • Daunorubicin and cytarabine lipid complex comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical facility. (safemedication.com)
  • You or your partner should not become pregnant while you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
  • You should use birth control to prevent pregnancy in yourself or your partner during your treatment with daunorubicin and cytarabine lipid complex and for 6 months after your final dose. (safemedication.com)
  • Daunorubicin and cytarabine lipid complex may harm the fetus. (safemedication.com)
  • You should not breastfeed during your treatment with daunorubicin and cytarabine lipid complex and for at least 2 weeks after your final dose. (safemedication.com)
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving daunorubicin and cytarabine lipid complex. (safemedication.com)
  • Daunorubicin and cytarabine lipid complex may cause side effects. (safemedication.com)
  • VYXEOS is a combination of 2 chemotherapies, daunorubicin and cytarabine, into tiny, bubble-like carriers called liposomes. (vyxeos.com)
  • This Joint Assessment aims to compare the clinical effectiveness and safety of glasdegib, in combination with low-dose cytarabine, in the target patient population with relevant comparators (azacitidine, decitabine, low-dose cytarabine, and best supportive care) according to the national requirements of EUnetHTA partners. (scuba-capsule.de)
  • Vallerand AHA, Sanoski CAC, Quiring CC. Daunorubicin/cytarabine liposomal. (drugguide.com)
  • Your doctor will tell you how often you will receive cytarabine. (medlineplus.gov)
  • Cytarabine is in the antimetabolite and nucleoside analog families of medication. (wikipedia.org)
  • The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein. (lu.se)
  • Presence of chromosome 7 abnormalities in patients with and without prior alkylating agent therapy suggests possible association with the antimetabolite cytarabine. (unm.edu)
  • Furthermore, SAMHD1 has been shown to limit the efficacy of cytarabine efficacy in patients. (wikipedia.org)
  • Find Clinical Trials for Cytarabine - Check for trials from NCI's list of cancer clinical trials now accepting patients. (cancer.gov)
  • Determine the clinical effectiveness of bevacizumab, cytarabine, and mitoxantrone in patients with poor-risk hematologic malignancies. (knowcancer.com)
  • Page 3 DEXAMETHASONE, CYTARABINE, AND CISPLATIN (DHAP) INTRAVENOUS CANCER TREATMENT EDUCATION Common Side Effects Common side effects that have been known to happen in patients receiving DHAP are listed in the left side of this table. (ivcanceredsheets.com)
  • Patients who have a history of serious hypersensitivity to daunorubicin, cytarabine or any component of the formulation should not use Vyxeos. (lls.org)
  • VYXEOS should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine, or any of its ingredients. (vyxeos.com)
  • In fact, most patients being treated with Cytarabine develop adverse effects. (booboone.com)
  • E2F1 rs3213150 polymorphism influences cytarabine sensitivity and prognosis in patients with acute myeloid leukemia. (cdc.gov)
  • When used in protocols designated as high dose, cytarabine can cause cerebral and cerebellar dysfunction, ocular toxicity, pulmonary toxicity, severe GI ulceration and peripheral neuropathy (rare). (wikipedia.org)
  • the fact that Cytarabine is administered in hospital, it is basically difficult for you to miss a dose if you respect your doctor appointment. (booboone.com)
  • How Effective is VENCLEXTA® + low-dose cytarabine Against AML? (venclexta.com)
  • Side effects may occur with VENCLEXTA + low-dose cytarabine. (venclexta.com)
  • The STORM regimen consisted of rituximab 375 mg/m(2) (day 2) and DHAP (dexamethasone 40 mg day 3-6, cisplatinum 100 mg/m(2) day 3, cytarabine 2 × 2 g/m(2) day 4) with temsirolimus added on day 1 and 8 of a 21-day cycle, with 2 to 4 cycles planned. (mdc-berlin.de)
  • 21 Cycle 2 Day 1 2 Dexamethasone Cytarabine Cisplatin Page 2 DEXAMETHASONE, CYTARABINE, AND CISPLATIN (DHAP) INTRAVENOUS CANCER TREATMENT EDUCATION Other medications Other medications may be ordered for you to prevent or treat certain side effects. (ivcanceredsheets.com)
  • The prescribing information for Vyxeos includes a boxed warning not to interchange Vyxeos with other daunorubicin- and/or cytarabine-containing products. (lls.org)
  • WARNING: VYXEOS has different dosage recommendations from other medications that contain daunorubicin and/or cytarabine. (vyxeos.com)
  • Do not substitute VYXEOS for other daunorubicin and/or cytarabine-containing products. (vyxeos.com)
  • All had been treated with cytarabine, topoisomerase 2 inhibitors and granulocyte or granulocyte-monocyte colony-stimulating factor and three with alkylating agents as part of autologous transplant regimens. (unm.edu)
  • Cytarabine comes as a powder to mixed with liquid to be injected intravenously (into a vein), subcutaneously (under the skin), or intrathecally (into the fluid-filled space of the spinal canal) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Cytarabine is FDA approved to prevent and treat leukemia that has spread to the meninges (the three membranes that cover the brain and spinal cord). (schoolandyouth.org)
  • Therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: possible role of cytarabine. (unm.edu)
  • SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. (bmj.com)
  • Cytarabine is in a class of medications called antimetabolites. (medlineplus.gov)
  • Other medications may also interact with cytarabine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • One of the challenges of effective AML treatment is resistance to cytarabine (or ara-C), a standard AML chemotherapeutic drug used in front-line treatment today. (bmj.com)
  • and cytarabine from 1.40 mg per 1000 population per day in 2010 to 0.96 in 2013. (who.int)
  • Cytarabine-5´-triphosphate is a substrate for SAMHD1. (wikipedia.org)
  • Cytarabine is an antimetabolic agent (Pyrimidine antagonist subgroup). (dr-adem.com)
  • Cytarabine is a pyrimidine analog and chemotherapeutic agent that kills rapidly dividing cells by causing DNA chain termination and inhibiting DNA polymerase during the S phase of the cell cycle. (pixorize.com)
  • Cytarabine has active ingredients of cytarabine . (ehealthme.com)
  • It is based on cytarabine (the active ingredients of Cytarabine) and Cytarabine (the brand name). (ehealthme.com)
  • It is then monophosphorylated by deoxycytidine kinase and eventually cytarabine-5´-triphosphate, which is the active metabolite being incorporated into DNA during DNA synthesis. (wikipedia.org)
  • When used as an antiviral, cytarabine-5´-triphosphate functions by inhibiting viral DNA synthesis. (wikipedia.org)
  • Cytarabine works by selectively inhibiting DNA synthesis. (booboone.com)
  • This page contains brief information about cytarabine and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. (cancer.gov)
  • The phase IV clinical study analyzes which people take Cytarabine and have Clostridium difficile colitis. (ehealthme.com)
  • If you become pregnant while receiving cytarabine, call your doctor. (medlineplus.gov)
  • Cytarabine is also used in the study of the nervous system to control the proliferation of glial cells in cultures, the amount of glial cells having an important impact on neurons. (wikipedia.org)
  • We study 53,624 people who have side effects when taking Cytarabine. (ehealthme.com)
  • citation needed] One of the unique toxicities of cytarabine is cerebellar toxicity when given in high doses, which may lead to ataxia. (wikipedia.org)
  • Cytarabine is rapidly deaminated by cytidine deaminase in the serum into the inactive uracil derivative. (wikipedia.org)
  • Unfortunately some rapidly dividing healthy cells are damaged by Cytarabine. (booboone.com)
  • The zinc finger protein ZNF224 can act as a transcriptional co-factor of WT1 and potentiate the cytotoxic response to the cytostatic drug cytarabine. (lu.se)
  • Treatment of leukemic K562 cells with cytarabine upregulated IRF8 protein and mRNA, which was correlated to increased expression of ZNF224. (lu.se)
  • In this Cytarabine fact sheet, you'll get to know about the precautions, usage, possible side effects, and the types of cancer that you can treat with this chemo drug. (dr-adem.com)
  • However, cytarabine is not very selective in this setting and causes bone marrow suppression and other severe side effects. (wikipedia.org)
  • 53,624 people reported to have side effects when taking Cytarabine. (ehealthme.com)
  • There are several important side effects of Cytarabine that are not listed in this document. (booboone.com)
  • Some drugs can alter the effects of Cytarabine and increased risk of developing side effects. (booboone.com)
  • Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/51188/all/cytarabine. (unboundmedicine.com)
  • www.drugguide.com/ddo/view/Davis-Drug-Guide/51188/all/cytarabine. (drugguide.com)