• Inhibitors
  • Bestatin and amastatin are effective inhibitors, as are metal chelators such as EDTA and 1,10-phenanthroline , but these agents inhibit other metallo-aminopeptidases and indeed other metallopeptidases also. (ebi.ac.uk)
  • Kidney
  • Aminopeptidase N is important for the inactivation in the kidney of blood-borne polypeptidases such as enkephalins, substance P and interleukin 8, and contributes to proteolysis in the small intestine. (ebi.ac.uk)
  • role
  • Given that aminopeptidases (APs) play a major role in the metabolism of local peptides involved in blood pressure control, studying them helped us to understand cardiovascular control. (biomedsearch.com)
  • Animals
  • Bestatin (or ubenimex), an antibiotic of natural origin, is a specific, competitive inhibitor of many aminopeptidases, though it does not inhibit aminopeptidase A. Due to its low toxicity it has been administered to cultured cells, animals and humans. (bachem.com)