• similar
  • Given the high degree of amino acid homology between IL-17A and IL-17F and the conservation of the four cysteines that form the knot, it is likely that IL-17A and IL-17F adopt a similar structure. (jimmunol.org)
  • known
  • 10 Little is known about the motifs involved in the attachment of Slit2-N to the cell membrane or whether further enzymatic processing generates additional N-terminal fragments in vivo. (ahajournals.org)
  • human
  • Recently, we have shown that activated human CD4 + T cells not only express IL-17A and IL-17F homodimers, but also an IL-17F/IL-17A heterodimer, and that the conserved cysteines used in the knot formation of IL-17A and IL-17F homodimers are the cysteines involved in the disulfide linkage of the IL-17F/IL-17A heterodimer ( 20 ). (jimmunol.org)