Cystic fibrosis patients with mycobacterium abscessus complex. Medical search. Frequent questions

M. least one positive sample for this microorganism (versus 6 abscessus has been reported to be acquired iatrogenically patients positive for M. avium complex), including 10 with in non-cystic fibrosis patients (9). (cdc.gov)
3 positive samples (versus 3 patients for M. avium com- fortuitum complex are saprophytic organisms living in soil plex). (cdc.gov)
Although over 150 different species of NTM have been described, pulmonary infections are most commonly due to Mycobacterium avium complex (MAC), Mycobacterium kansasii, and Mycobacterium abscessus (see image). (wikipedia.org)
Nonchromogens include a group of prevalent opportunistic pathogens called M. avium complex (MAC). (wikipedia.org)
Most NTM disease cases involve the species known as Mycobacterium avium complex or MAC for short, M. abscessus, M. fortuitum and M. kansasii. (wikipedia.org)
Non-tuberculosis mycobacteria (NTM) are a group of diverse, but related, organisms, including members of the Mycobacterium avium complex and the Mycobacterium abscessus group. (seattlechildrens.org)
[ 8 ] and that Mycobacterium avium and Mycobacterium intracellulare (known together as M avium complex [MAC]) infections are the main driver of this increase. (medscape.com)
See "Epidemiology of nontuberculous mycobacterial infections" and "Microbiology of nontuberculous mycobacteria" and "Pathogenesis of nontuberculous mycobacterial infections" and "Diagnosis of nontuberculous mycobacterial infections of the lungs" and "Treatment of Mycobacterium avium complex pulmonary infection in adults" and "Rapidly growing mycobacterial infections: Mycobacteria abscessus, chelonae, and fortuitum" and "Buruli ulcer (Mycobacterium ulcerans infection)" . (medilib.ir)
See "Mycobacterium avium complex (MAC) infections in persons with HIV" and "Overview of nontuberculous mycobacteria (excluding MAC) in patients with HIV" and "Nontuberculous mycobacterial infections in solid organ transplant candidates and recipients" . (medilib.ir)
Pulmonary disease, especially in older persons with or without underlying lung disease and patients with cystic fibrosis, caused primarily by Mycobacterium avium complex (MAC), Mycobacterium abscessus subsp abscessus , and Mycobacterium kansasii . (medilib.ir)
See "Mycobacterium avium complex (MAC) infections in persons with HIV" and "Rapidly growing mycobacterial infections: Mycobacteria abscessus, chelonae, and fortuitum" . (medilib.ir)
Among nontuberculous mycobacteria (NTM), MAC (specifically M. avium and M. intracellulare ) is the most common cause of pulmonary disease worldwide. (medilib.ir)
Mycobacterium avium complex (MAC)-the closely related species of M. avium and M. intracellulare -accounts for most NTM disease, but M. abscessus is increasingly becoming common. (msdmanuals.com)
A magnified view of a petri dish culture plate with cultivated colonies of the bacterium Mycobacterium avium . (the-microbiologist.com)
Two of the most common forms of NTM bacteria in the U.S. are Mycobacterium avium complex (MAC) and M. abscessus . (the-microbiologist.com)
Mycobacterium abscessus Complex (MABSC) and Mycobacterium avium Complex (MAC) are now recognized as insidious opportunists that can seriously affect morbidity and mortality in CF. Fundamental paradigms of NTM pulmonary disease concerning clinical impact, patient susceptibility, transmission, bacterial modes of growth and implications for lung transplantation are currently being revised. (springer.com)
Mycobacterium avium complex (MAC) accounts for more than 80% of all NTM lung disease cases in the United States. (ntmfacts.com)
Most pulmonary NTM disease involves Mycobacterium avium complex (MAC), but with enhanced identification multiple species have now been recognised as opportunistic pathogens. (ersjournals.com)
Mycobacterium avium subsp. (up.ac.za)
And probably many of them were non-tuberculous mycobacteria, as they were found in a lot of animals that we now know harbor some non-tuberculous mycobacteria, like birds that are known to carry mycobacterium avium and mycobacterium genavense. (hstalks.com)
Mycobacterium avium complex may represent colonization or a true pathogen. (hopkinsguides.com)

sex subspecies of M. chelonae , and used the designation M. ratio, 0.47) for nontuberculous mycobacteria in respiratory chelonae-M. abscessus , M. chelonae group, or even M. samples from January 1, 1996, to December 31, 1999. (cdc.gov)
Mycobacterium abscessus (formerly M. chelonae patients attending our center, the degree of transmissibility subsp. (cdc.gov)
The most common species were M. marinum, accounting for 45% of cases and M. chelonae and M. abscessus, together accounting for 32% of patients. (wikipedia.org)
The majority of isolates (82%) were M. abscessus (formerly M. chelonae subsp. (nih.gov)
Disseminated disease in severely immunocompromised patients (most commonly caused by MAC and less commonly by the rapidly growing mycobacteria [RGM], eg, M. abscessus , M. fortuitum , and Mycobacterium chelonae ). (medilib.ir)
See "Rapidly growing mycobacterial infections: Mycobacteria abscessus, chelonae, and fortuitum" . (medilib.ir)
Other causative species are M. kansasii , M. xenopi , M. marinum , M. ulcerans , M. fortuitum , and M. chelonae ( M. fortuitum and M. chelonae are related to M. abscessus ). (msdmanuals.com)
Mycobacterium chelonae belongs to the family of nontuberculous mycobacteria (NTM) classified in the rapidly growing mycobacteria (RGM), Runyon group IV that are nonpigmented. (medscape.com)
1] M chelonae is further grouped in the M chelonae-abscessus group that encompasses Mycobacterium immunogenum, Mycobacterium massiliense, and Mycobacterium bolletii, in addition to M chelonae and M abscessus. (medscape.com)
2, 3] Hence, when researching and reviewing the literature prior to 1992, M abscessus and M chelonae were considered the same organism or subspecies within the M chelonae-abscessus group, which complicated its taxonomy. (medscape.com)
M chelonae, along with M abscessus, are considered the most drug resistant of the NTM group, which leads to difficulty when treating infections these organisms. (medscape.com)
M chelonae tends to respond better to treatment regimens since is lacks the erm gene that confers macrolide resistance in M abscessus strains. (medscape.com)
M chelonae causes disease sporadically, as well as in patients with identifiable risk factors, owing to its hardiness, resistance to chemical and antimicrobial degradation, and ubiquitous environmental presence. (medscape.com)
12] According to some series, as many as 75% of patients with disseminated disease are initially colonized with M chelonae, and skin trauma is thought to be the etiology for cutaneous invasion. (medscape.com)
20] M chelonae has caused peritonitis and dialysis catheter infections in peritoneal dialysis patients. (medscape.com)
Unique characteristics of Norwegian Mycobacterium abscessus/chelonae complex strains. (uu.se)
Growth pattern of Mycobacterium species are different such as M. chelonae and M. fortuitum form biofilm as vertical and entire surface growth, respectively [ 93 ]. (biomedcentral.com)
Or reptiles that are known to harbor mycobacterium chelonae and the fish that are known to harbor mycobacterium marinum. (hstalks.com)

Nontuberculous mycobacteria (NTM), also known as environmental mycobacteria, atypical mycobacteria and mycobacteria other than tuberculosis (MOTT), are mycobacteria which do not cause tuberculosis or leprosy (also known as Hansen's disease). (wikipedia.org)

M. abscessus subsp. (ersjournals.com)
[ 6 ] Person-to-person spread is extremely uncommon, although in 2012 the first known outbreak of respiratory Mycobacterium abscessus subsp massiliense disease occurring in a population of patients with cystic fibrosis (CF) was reported. (medscape.com)
M abscessus subspecies (subsp) abscessus, M abscessus subsp bolletii, and M abscessus subsp massiliense . (contagionlive.com)
Massive and Lengthy Clonal Nosocomial Expansion of Mycobacterium abscessus subsp. (cdc.gov)

Mycobacterium abscessus complex (MABC) is one of the major NTM lung pathogens that disproportionately colonize and infect the lungs of individuals with cystic fibrosis (CF). MABC infection can persist for years, and antimicrobial treatment is frequently ineffective. (cdc.gov)
The role of rapidly growing mycobacteria (RGM) as pulmonary pathogens has been unclear. (nih.gov)
Learn about the primary pathogens isolated in cystic fibrosis patients and consider these microorganisms' relative antimicrobial susceptibility. (beckmancoulter.com)
He explains that his lab has focused mainly on the mycobacterium group because it contains important human pathogens like Mycobacterium tuberculosis , which is responsible for the symptoms and spread of tuberculosis. (findinggeniuspodcast.com)
Studying the phages that infect this group of mycobacterium helps understand such pathogens as well as potential treatments. (findinggeniuspodcast.com)
Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis. (cam.ac.uk)
Rapid detection of emerging pathogens and the loss of microbial diversity associated with severe lung disease in cystic fibrosis. (cdc.gov)
Mycobacterium abscessus, which is from the same family as tuberculosis, is one of the predominant pathogens in a wide spectrum of infections, including 50 percent of those involving the lungs. (rnz.co.nz)
Mycobacterium abscessus is such a difficult micro-organism to treat, and I hope that this research will lay the foundation using this for many other respiratory pathogens. (rnz.co.nz)
Mycobacteria other than Mycobacterium tuberculosis can be human pathogens, and the incidence of infection appears to be increasing. (msdmanuals.com)
The Mycobacterium genus of bacteria contains more than 190 species, including the pathogens that cause leprosy and tuberculosis. (blogspot.com)
A number of non-tuberculous mycobacterium species are opportunistic pathogens and ubiquitously form biofilms. (microbialcell.com)
M. abscessus was isolated from the wounds of two patients, and various nosocomial pathogens, but not M. abscessus , were isolated from the surrounding environment. (kjccm.org)

We encountered one case of M. abscessus infection in a Since 1990, an increasing number of studies have patient with cystic fibrosis in 1995. (cdc.gov)
It is not uncommon for alpha 1-antitrypsin deficiency, Marfan syndrome, and primary ciliary dyskinesia patients to have pulmonary NTM colonization and/or infection. (wikipedia.org)
The diagnosis of M. abscessus pulmonary infection requires the presence of symptoms, radiologic abnormalities, and microbiologic cultures. (wikipedia.org)
In this study, we investigate whether immune defects explain the apparent susceptibility to this opportunistic infection in non-CF patients. (ersjournals.com)
Methods: We sequenced the genomes of 175 isolates longitudinally collected from 30 patients with MABC lung infection. (cdc.gov)
METHODS: We conducted a retrospective analysis of the medical records of all patients with laboratory-confirmed HFMD-related enterovirus infection at the West China Second University Hospital from January 2013 to December 2022. (bvsalud.org)
4,7 Alpha-1 antitrypsin phenotypes and abnormal cystic fibrosis genotypes increase the risk for NTM infection. (contagionlive.com)
4,7 MABC infection can cause complications (soft tissue and mediastinal abscess) in patients who undergo lung transplant, thereby requiring assessment for NTM pulmonary disease before lung transplant evaluation. (contagionlive.com)
This combination has been used as part of the treatment for a patient in America, who subsequently recovered from their infection. (indiaeducationdiary.in)
This means that the combined treatment was successful at eradicating the infection and enabling the patient to receive the lifesaving lung transplant. (indiaeducationdiary.in)
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. (cam.ac.uk)
An overview of NTM infection in HIV-negative patients, with emphasis on chronic lung infections that account for up to 90 percent of patient encounters due to NTM, will be reviewed here. (medilib.ir)
The epidemiology, microbiology, pathogenesis, diagnosis, and treatment of NTM infection, as well as infection due to rapidly growing mycobacteria and M. ulcerans , are discussed separately. (medilib.ir)
Skin and soft tissue infection usually as a consequence of direct inoculation, caused primarily by Mycobacterium marinum and Mycobacterium ulcerans , the RGM, and other NTM species including MAC. (medilib.ir)
Mycobacterium abscessus can also cause infections in the skin and soft tissue as well as in the lungs so that some people do get a disseminated infection, but it is most commonly associated with respiratory infections. (rnz.co.nz)
Nonetheless, the number of patients presenting with NTM infection that requires treatment appears to be increasing. (msdmanuals.com)
More than 35,000 people in the U.S. have cystic fibrosis, which causes the body to produce thick mucus, causing lung damage and trapping bacteria, increasing the likelihood of lung infection. (the-microbiologist.com)
This study measured whether the concentration of metals and minerals in the water had any influence on the probability of MAC and M. abscessus infection in people with cystic fibrosis. (the-microbiologist.com)
The observed increase in NTM disease, especially infection with multidrug-resistant Mycobacterium abscessus complex, is probably multifactorial. (ersjournals.com)
Minimal resection surgery, in a carefully selected subgroup of patients with focal disease or persistent symptoms can be considered as an adjuvant therapy in the treatment of pulmonary nontuberculous mycobacterium infection. (ersjournals.com)
Topics A-Z These atypical mycobacterial infections are a frequent complication in patients with human immunodeficiency virus (HIV) infection or AIDS. (vint.cz)
Mycobacterium abscessus Infection most common in Central and West Africa around areas of lush vegetation and swamps but may also occur in Australia. (vint.cz)
Repeated exposure to these atypical mycobacteria may cause subclinical infection in man that may. (vint.cz)
Atypical mycobacteria or nontuberculous mycobacteria are organisms that cause various diseases such as skin and soft tissue infection, lymphadenitis, pulmonary infection, disseminated infection, and a wide range of more rarely encountered infections. (statpearls.com)
A minority of patients with this infection may also develop "cepacia syndrome", which leads to an acute clinical decline which is frequently fatal. (up.ac.za)
On 2 March 2009, a patient (index case) who was referred from a local clinic in Ha-dong-gun province, was diagnosed with an NTM infection in hospital A and was reported to the Korea Centers for Disease Control and Prevention (KCDC). (kjccm.org)
Data from the Early Pseudomonas Infection Control (EPIC) trial, which followed 838 children before and after their initial isolation of Pseudomonas (mean 4.6 years), show that 51% patients eventually acquire Pseudomonas . (dkbmed.com)
Further, it has been reported that early NTM infection diagnosis and treatment can considerably improve patient prognosis. (degruyter.com)
Here, we report the case of a 22-year-old woman with renal and lymph node Mycobacterium xenopi infection. (degruyter.com)

responsible for disseminated infections in patients undergoing lung transplantation (7). (cdc.gov)
NTM cause lung and other infections in patients with underlying conditions, such as cystic fibrosis, HIV/AIDS and other immune deficiencies. (seattlechildrens.org)
The two-year grant funds a cross-institution collaborative pilot project that will measure the effectiveness of a panel of drug combinations targeting Mycobacterium abscessus (MABSC), a bacterium related to tuberculosis that causes difficult to treat infections in patients already suffering from other lung diseases. (seattlechildrens.org)
The prevalence of Mycobacterium abscessus infections in non-cystic fibrosis (CF) patients has increased in recent years. (ersjournals.com)
Mycobacterium abscessus is a nontuberculous mycobacterium notorious for causing difficult-to-treat pulmonary infections. (ersjournals.com)
In the last decade, an increasing prevalence of M. abscessus infections has been reported in many countries [ 2 ]. (ersjournals.com)
Background: Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and an increasingly frequent cause of opportunistic infections. (cdc.gov)
The patient, who has cystic fibrosis, received the Aston University combination of antibiotics as part of a complex treatment regime, including an experimental therapy known as phage therapy, which uses viruses to treat bacterial infections. (indiaeducationdiary.in)
Outbreak of Pandoraea commovens Infections among Non-Cystic Fibrosis Intensive Care Patients, Germany, 2019-2021. (cdc.gov)
Molecular Epidemiologic Investigation of Mycobacterium intracellulare subspecies chimaera Lung Infections at an Adult Cystic Fibrosis Program. (cdc.gov)
Cross-transmission is not the source of new Mycobacterium abscessus infections in a multi-centre cohort of cystic fibrosis patients. (cdc.gov)
Time between collection and storage significantly influences bacterial sequence composition in sputum samples from cystic fibrosis respiratory infections. (cdc.gov)
NTM infections in patients with HIV and lung transplant candidates and recipients are also reviewed separately. (medilib.ir)
Although person-to-person transmission of most NTM infections is generally not thought to occur, M. abscessus may be transmitted among patients with cystic fibrosis. (msdmanuals.com)
21] It causes intravascular catheter infections of all types and is particularly common in the immunocompromised patient. (medscape.com)
High levels of some minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria (NTM) pulmonary infections in people with cystic fibrosis, according to a new study from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. (the-microbiologist.com)
Both are linked to chronic lung infections in people with cystic fibrosis and other lung diseases. (the-microbiologist.com)
The work is particularly focused on Mycobacteria, such as M. tuberculosis the etiological agent of tuberculosis, and on M. abscessus a pathogen causing opportunistic infections patients with lung diseases, such as cystic fibrosis. (unipv.it)
Atypical mycobacteria infections cause little mortality. (vint.cz)
General Information: Associated with infections in cystic fibrosis patients. (up.ac.za)
This species is associated with infections in cystic fibrosis patients. (up.ac.za)
The aim of this report is to investigate Mycobacterium abscessus infections at a rural clinic and carry out a surveillance program to determine the extent and source of these infections. (kjccm.org)
Although M. abscessus is an uncommon causative pathogen of human disease, it can cause skin and soft tissue infections (SSTI) on damaged skin lesions following inoculation, minor trauma or surgery [ 5 , 6 ]. (kjccm.org)
This monograph was adapted from the live webinar Cystic Fibrosis Virtual Roundtable: Challenges in Treating Lung Infections . (dkbmed.com)

Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF). Viviani L, Harrison MJ, Zolin A, Haworth CS, Floto RA . (cam.ac.uk)
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. (cam.ac.uk)
Longitudinal sampling of the lung microbiota in individuals with cystic fibrosis. (cdc.gov)
Twenty-five-year outbreak of Pseudomonas aeruginosa infecting individuals with cystic fibrosis: identification of the prairie epidemic strain. (cdc.gov)

fortuitum complex. (cdc.gov)
abscessus ), a rapidly growing mycobacterium of of this organism, and its clonality, by using DNA-based the M. fortuitum complex, is of particular concern. (cdc.gov)
[ 2 ] Mycobacterium fortuitum has been reported as a commensal on human skin. (medscape.com)
Effective treatment for M. fortuitum long disease was accomplished with drug therapy, whereas surgical resection of localized disease was the only effective long-term therapy for M. abscessus. (nih.gov)

Mycobacteria are a unique group of bacteria, also referred to as "acid fast bacteria," including the causative organisms of diseases of global and pediatric significance. (seattlechildrens.org)
How do the interactions between mycobacteria and immune cells make the bacteria less susceptible to killing by antibiotics? (seattlechildrens.org)
Due to the extreme drug resistance intrinsic to these bacteria, M. abscessus has rightfully been dubbed an "antibiotic nightmare" [ 1 ]. (ersjournals.com)
Mycobacteria are a large group of aerobic bacteria that produce filamentous pellicles similar to molds when grown in liquid media. (medscape.com)
What interpretive category breakpoints can be used with these opportunistic, environmental pathogenic, non-fermenting, Gram-negative bacteria in cystic fibrosis patients? (beckmancoulter.com)
In this workshop, recorded at the 29th European Congress of Clinical Microbiology & Infectious Diseases, Dr. Samantha Sottotetti explains the importance of cystic fibrosis microbiology in Gram-negative, non-fermenting bacteria isolated from the respiratory tract of cystic fibrosis patients. (beckmancoulter.com)
She also studies the molecular characterization of multidrug-resistant bacteria, particularly those involved in cystic fibrosis microbiology. (beckmancoulter.com)
He also describes phage biology and coevolution with bacteria, which has led to a complex relationship. (findinggeniuspodcast.com)
Discrepancy in MALDI-TOF MS identification of uncommon Gram-negative bacteria from lower respiratory secretions in patients with cystic fibrosis. (cdc.gov)
That can be quite unpleasant and distressing, so one of the things that we hope to achieve with this as we move this forward is to look to see whether or not we get the improvement of the nebulisation treatment, not just from an anti-microbial perspective, not just about killing the bacteria, but also, making the treatment a little more pleasant for the patients. (rnz.co.nz)
The graph above from the CF Patient Registry demonstrates the prevalence of various bacteria within the airways. (dkbmed.com)

The M. abscessus isolates from 14 patients were and water that are ubiquitous in hospital environments and typed by pulsed-field gel electrophoresis: each of the 14 survive well in adverse conditions (10-13). (cdc.gov)
Genomic analyses of longitudinal Mycobacterium abscessus isolates in a multicenter cohort reveal parallel signatures of in-host adaptation. (cdc.gov)
Her main research interests include molecular identification of clinical isolates of Burkholderia cepacia complex, and Mycobacterium abscessus complex. (beckmancoulter.com)
Pulsed-field gel elctrophoresis (PFGE) was performed for comparing with M. abscessus isolates from the patients. (kjccm.org)

Pulmonary disease caused by NTM is most often seen in postmenopausal women and patients with underlying lung disease such as cystic fibrosis, bronchiectasis, and prior tuberculosis. (wikipedia.org)
Within the non-COPD patients, those with bronchiectasis showed defective interferon (IFN)-γ production in response to Candida albicans . (ersjournals.com)
Patients with COPD and bronchiectasis showed different cytokine defects. (ersjournals.com)
Cystic fibrosis (CF), non-CF bronchiectasis, COPD and low body mass index (BMI) are the best-known predisposing conditions for nontuberculous mycobacteria (NTM) pulmonary disease (NTM-PD) [ 2 , 5 ]. (ersjournals.com)
6 MABC is seen in patients with underlying structural lung disease such as cystic fibrosis, bronchiectasis, prior tuberculosis, pulmonary alveolar proteinosis, and esophageal motility disorders. (contagionlive.com)
When combined with antibiotics, natural mānuka honey can greatly reduce the suffering associated with Mycobacterium abscessus complex (MABC) - an environmental pathogen found in people with underlying respiratory conditions like cystic fibrosis and bronchiectasis. (rnz.co.nz)
So, people that have either cystic fibrosis or bronchiectasis, where they've got long-term inflammation of the bronchial walls - those are the two main [conditions that predispose someone] to mycobacterium abscessus colonisation in the lungs. (rnz.co.nz)
The index of suspicion for NTM in your differential diagnoses should be elevated in bronchiectasis patients. (ntmfacts.com)
However, in people with underlying structural lung disease such as bronchiectasis, poor sputum clearance as found in cystic fibrosis (CF), or underlying immunodeficiency they do have pathogenic potential. (ersjournals.com)
The present disclosure relates to methods for treating bronchiectasis, for example, non-cystic fibrosis bronchiectasis with compositions comprising an effective amount of certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds of Formula (I), including pharmaceutically acceptable salts thereof, that inhibit dipeptidyl peptidase 1 (DPP1) activity. (justia.com)
Bronchiectasis, along with chronic obstructive pulmonary disease (COPD), acute lung injury, acute respiratory distress syndrome, and cystic fibrosis (CF) are all conditions of severe pulmonary dysfunction resulting from a massive inflammatory response. (justia.com)
The present invention addresses the need for a therapy effective for the treatment of bronchiectasis, e.g., in non-cystic fibrosis patients. (justia.com)
In one aspect, a method for treating a bronchiectasis patient is provided. (justia.com)
The bronchiectasis patient in one embodiment, is present in a cystic fibrosis patient. (justia.com)

Although both corticosteroids and antifungal drugs have a role in the management of these problems, it is disappointing that after so many publications on the subject of Aspergillus and cystic fibrosis, a Cochrane review recently concluded "there are no randomised controlled trials to evaluate the use of antifungal therapies for the treatment of ABPA in people with cystic fibrosis. (cysticfibrosis.online)

massiliense among Patients Who Are Ventilator Dependent without Cystic Fibrosis. (cdc.gov)

This major mycobacterial pathogen in children and teenagers with cystic fibrosis patients attending the same department-care facilities does not appear to be acquired nosocomially. (cdc.gov)
This pathogen is the third most frequently isolated nontuberculous mycobacteria seen in the United States. (contagionlive.com)
M abscessus is the third most frequently isolated nontuberculous mycobacteria (NTM) pulmonary pathogen in the United States. (contagionlive.com)
Sputum DNA sequencing in cystic fibrosis: non-invasive access to the lung microbiome and to pathogen details. (cdc.gov)

usually also susceptible to only a few drugs (8), and some All patients with cystic fibrosis who attended the strains may exhibit multidrug resistance (7). (cdc.gov)
and recent evidence suggests that highly drug resistant strains may spread through susceptible populations, such as patients with cystic fibrosis. (seattlechildrens.org)
Two strains of M. abscessus from patients were identical as a result of PFGE. (kjccm.org)
And at that time, many of those strains were given names, referring to either a patient or the localization of where the patient reported to his physician. (hstalks.com)

The lungs are most commonly affected by NTM, with M abscessus being the most common cause of lung disease. (contagionlive.com)
And one of those antibiotics is called amikacin and we deliver it into the patients through nebulisation, where it's aerosolised into their lungs. (rnz.co.nz)
By integrating single-cell datasets of human lung tissues, we discovered immune-primed subsets enriched in lungs and organoids derived from patients with chronic respiratory disease. (stanford.edu)

Mycobacterial species other than Mycobacterium tuberculosis and Mycobacterium leprae are classified as atypical mycobacteria, nontuberculous mycobacteria (NTM), or environmental mycobacteria. (medscape.com)
INTRODUCTION - Nontuberculous mycobacteria (NTM) species are mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex (eg, M. tuberculosis , Mycobacterium bovis , Mycobacterium africanum , and Mycobacterium microti ) and Mycobacterium leprae . (medilib.ir)
and Mycobacterium leprae, the cause of leprosy. (vint.cz)
Nontuberculous mycobacteria (NTM) refer to all mycobacteria, excluding Mycobacterium tuberculosis complex and Mycobacterium leprae . (degruyter.com)

The type of disease depends on the species of mycobacteria, the route and degree of exposure, and the immune status of the host. (medscape.com)
Other species that cause lung disease include Mycobacterium xenopi , Mycobacterium malmoense , Mycobacterium szulgai , and Mycobacterium simiae ( table 1 ) [ 3 ]. (medilib.ir)
There are over 170 recognized species of mycobacteria, mostly environmental. (msdmanuals.com)
There are more than 180 recognized species of nontuberculous mycobacteria (NTM) and some of these cause disease in humans. (cdc.gov)
Atypical mycobacteria (MAC) diseases are caused by species of mycobacteria that do not cause tuberculosis or leprosy. (vint.cz)
A 2019 retrospective study in Taiwan concluded that surgical resection of nontuberculous mycobacteria (NTM) solitary pulmonary nodules is curative in asymptomatic patients without positive culture of the same NTM species from respiratory specimens and a history of NTM pulmonary disease. (vint.cz)
Some of the molecules elaborated from 24c (including 29a) inhibited growth of Mycobacteria species, though further improvements in affinity will be needed, and no DMPK properties are provided. (blogspot.com)
We have discussed the biofilms of several pathogenic non-tuberculous mycobacterium (NTM) species in context to the in vivo pathologies. (microbialcell.com)
This species is a member of the Burkholderia cepacia complex, although it does not appear to spread from patient to patient as do the other members of the group. (up.ac.za)
Nontuberculous mycobacteria (NTM) are found in the natural environment throughout the world and include at least 65 different species [ 1 ]. (kjccm.org)

We contextualized our cohort amidst the broader MABC phylogeny and investigated genes undergoing parallel adaptation across patients. (cdc.gov)
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study. (cam.ac.uk)
Whole-Genome Sequencing and Epidemiological Analysis Do Not Provide Evidence for Cross-transmission of Mycobacterium abscessus in a Cohort of Pediatric Cystic Fibrosis Patients. (cdc.gov)
The graph above is from a study that included a cohort from Sweden and looked at patients with and without pancreatic insufficiency. (dkbmed.com)

To critically review the literature describing the use of surgery in the treatment of pulmonary disease caused by nontuberculous mycobacteria (NTM). (ersjournals.com)
Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor. (vint.cz)

Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients. (cdc.gov)

In conclusion, susceptibility to M. abscessus is likely determined by a combination of immunological defects and predisposing pulmonary disease. (ersjournals.com)
Impact of rapid identification and antimicrobial susceptibility testing on antibiotic therapy and outcomes for patients with Gram-negative bacteraemia or candidaemia at an acute care hospital. (uu.se)

Nontuberculous mycobacteria (NTM) are aerobic, generally free-living organisms that do not form spores. (medscape.com)

This was the first description of allergic bronchopulmonary aspergillosis (ABPA) occurring in two children with cystic fibrosis. (cysticfibrosis.online)
Children with cystic fibrosis are infected with multiple subpopulations of Mycobacterium abscessus with different antimicrobial resistance profiles. (cdc.gov)
Suri R. High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis. (cysticfibrosis.online)

Mycobacterium tuberculosis , the causative agent of tuberculosis, kills over 1 million people per year. (seattlechildrens.org)
Despite recent progress in biomedical research, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is still the world's leading infectious disease killer worldwide. (researchportal.be)
In the end, we have described the biofilms of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. (microbialcell.com)

1980 Brueton MJ, Omerod LP, Shah KJ, Anderson CM. Allergic bronchopulmonary aspergillosis complicating cystic fibrosis in childhood. (cysticfibrosis.online)
Cystic fibrosis and allergic bronchopulmonary aspergillosis. (cysticfibrosis.online)
Aspergillus fumigatus can lead to allergic bronchopulmonary aspergillosis (ABPA) in patients with asthma and cystic fibrosis. (hopkinsguides.com)

The successful treatment of this patient with the combination of antibiotics and phage demonstrates the impact of this combined approach for tackling antibiotic resistant Mycobacterium abscessus. (indiaeducationdiary.in)
Despite optimised antibiotic treatment, sputum clearance is difficult to achieve and highly variable in patients with pulmonary NTM disease. (ersjournals.com)
Often in heavily antibiotic-experienced patients, MRSA or Gram negatives predominate. (hopkinsguides.com)

Besides pathogenic NTMs, Mycobacterium smegmatis is often used as a model organism for understanding mycobacterial physiology and has been studied extensively for understanding the mycobacterial biofilms. (microbialcell.com)
Glycopeptidolipids are indispensable for initial surface attachment during biofilm formation in Mycobacterium smegmatis [ 111 ]. (biomedcentral.com)

Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation. (ku.dk)
Formation of biofilms in mycobacteria can be defined as similar as other biofilms communities. (biomedcentral.com)

Patients were clinically well at the time of diagnosis (Shwachman scores 70-90, Chrispin-Norman chest x ray scores 2-15) and they responded rapidly to treatment with oral prednisolone. (cysticfibrosis.online)
Clinical features of pulmonary disease caused by rapidly growing mycobacteria. (nih.gov)
A group of mycobacteria that usually produce mature growth on media plates within 7 days are collectively called rapidly growing mycobacteria (RGM). (contagionlive.com)

Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis. (cdc.gov)

Patients were predominantly white (83%), female (65%) nonsmokers (66%), and they had prolonged periods from onset of symptoms to diagnosis of their disease. (nih.gov)

It is therefore crucial to interpret the immunological results within the clinical background of the patients tested. (ersjournals.com)
Clinical analysis was performed for 141 patients from 2013 to 2017 using Kaplan-Meier and Chi-square methods. (bvsalud.org)
In a clinical capacity, Professor Thomson is able to offer patients expert management of their disease at Pulmedica, Greenslopes Private Hospital, at public clinics at The Prince Charles Hospital and the MetroSouth Clinical TB service of the Princess Alexandra Hospital and via telehealth for patients across Australia. (edu.au)
Patients can also access novel treatments through clinical trials in both the private and public sector. (edu.au)
Identifying patients with NTM and clinical deterioration is difficult, but important, as these are the once most likely to benefit from antimycobacterial treatment. (springer.com)
Tsukamura M, Mizuno S, Tsukamura S. PMID: 5301575 For many years, the Runyon classification of Mycobacterium was utilized in clinical laboratories to provide a convenient way to differentiate among … What are the factors which induce heart failure? (vint.cz)
Clinical specimens were collected from the patients and an envirnmental investigation. (kjccm.org)
In conclusion, assessment of HRQoL can provide important information about the health status of patients with CD, and its use in clinical practice is warranted. (scielo.br)
In conclusion, these findings may aid in clinical management and should be considered in the aftercare of patients. (scielo.br)

Any talk about mycobacteria of course has to start by mentioning that in 1882, Robert Koch, a German microbiologist, found the causative agent of human tuberculosis, mycobacterium tuberculosis. (hstalks.com)

Dr. Sottotetti is part of the Laboratory of Cystic Fibrosis Microbiology at the IRCCS CA' Granda Foundation Opsedale Maggiore Policlinico, of Milan, Italy. (beckmancoulter.com)

Even with these new techniques, though, the Runyon classification is still sometimes used to organize the mycobacteria into categories. (wikipedia.org)

Mycobacterium abscessus complex (MABC) is one of the most commonly isolated RGM in respiratory specimens and also the most pathogenic organism in the group. (contagionlive.com)

Lung transplantation should be viewed as a potential treatment option for highly selected patients with very advanced chronic lung disease who continue to progress despite maximal medical therapy. (ersjournals.com)
It can also colonize the airways of patients with chronic lung diseases. (hopkinsguides.com)

Longer survival of patients with cystic fibrosis and patients with other predisposing lung diseases may be a factor. (msdmanuals.com)

Aerosols, patients harbored a unique strain, ruling out a common pulmonary function equipment, and bronchoscopes are environmental reservoir or person-to-person transmission. (cdc.gov)
Six specimens were obtained from the 6 patients respectively and 22 environmental samples were obtained. (kjccm.org)
And in the environmental samples, like basic water and soil samples, a variety of non-tuberculous mycobacteria were found at the time. (hstalks.com)

Many studies on least one sputum sample per year, which was processed for nontuberculous mycobacteria in such patients did not the culture of acid-fast bacilli (AFB). (cdc.gov)
The family Mycobacteriaceae consists of a single genus, Mycobacterium , which are thin, slightly curved-to-straight, non-spore-forming, nonmotile acid-fast bacilli. (medscape.com)
One defining feature of most atypical mycobacteria is that they are acid-fast bacilli. (statpearls.com)
And then many of those investigations did turn up acid fast bacilli that turned out to be mycobacteria. (hstalks.com)

Anatomy18

Organisms41

Diseases37

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes31

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Named Groups1

Health Care18

Geographicals2

Avium21

Chelonae18

Atypical mycobacteria1

Subsp4

Pathogens13

Infection29

Infections24

Individuals with cystic fibrosis4

Fortuitum4

Bacteria11

Isolates4

Bronchiectasis14

People with cystic fibrosis1

Massiliense1

Pathogen4

Strains4

Lungs3

Leprae4

Species10

Cohort4

Caused by nontuberculous mycobacteria2

Life of cystic fibrosis1

Susceptibility2

Organisms1

Children with cystic3

Agent of tuberculosis3

Allergic bronchopulmon3

Antibiotic3

Smegmatis2

Biofilms2

Rapidly3

Microbiome1

Diagnosis1

Clinical9

Microbiologist1

Microbiology1

Runyon1

MABC1

Chronic lung2

Lung diseases1

Environmental3

Acid-fast ba4