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  • Hospital
  • Norihisa Shigemura, MD, PhD , has been appointed Surgical Director of Lung Failure, and Surgical Director of Lung Transplantation at Temple University Hospital (TUH), and Associate Professor of Surgery at the Lewis Katz School of Medicine at Temple University (LKSOM). (templehealth.org)
  • I am pleased to welcome Dr. Shigemura to the Temple team," says Yoshiya Toyoda, MD, PhD, William Maul Measey Professor of Surgery at LKSOM, and Chief of Cardiovascular Surgery and Surgical Director of Thoracic Transplantation at Temple University Hospital. (templehealth.org)
  • airway
  • Frizzell RA, Rechkemmer G, Shoemaker RL: Altered regulation of airway epithelial cell chloride channels in cystic fibrosis. (springer.com)
  • Li M, McCann JD, Liedtke CM: Cystic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. (springer.com)
  • My research interests have centered on the inflammatory responses that lead to airway disease in Cystic Fibrosis (CF) and the metabolic factors that contribute to CF lung disease progression. (stanford.edu)
  • Other signs include coughing up blood (hemoptysis), high blood pressure in the lung (pulmonary hypertension), heart failure, difficulties getting enough oxygen to the body (hypoxia), and respiratory failure requiring support with breathing masks, such as bilevel positive airway pressure machines or ventilators. (wikipedia.org)
  • organ
  • As of 2016, the most common procedure is to take a functioning heart from a recently deceased organ donor (cadaveric allograft) and implant it into the patient. (drsemitha.com)
  • Rather than cooling the heart, the living organ procedure keeps it at body temperature and connects it to a special machine called an Organ Care System that allows it to continue pumping warm, oxygenated blood. (drsemitha.com)
  • At any one time, there are about 250 people registered for heart-lung transplantation at the United Network for Organ Sharing (UNOS) in the USA, of which around forty will die before a suitable donor is found. (wikipedia.org)
  • Most surgeons endeavour to cut blood vessels as close as possible to the heart to leave room for trimming, especially if the donor heart is of a different size than the original organ. (wikipedia.org)
  • While the use of tissue grafts- which is much more common- is not transplantation, since an entire organ is not transferred, these two are closely related (skin, hair, and subdermal tissue, connective tissue, musculoskeletal tissue, and corneas are commonly grafted). (wikipedia.org)
  • Sometimes, the separation of conjoined individuals requires transplantation of an organ or organs, especially if complications develop. (wikipedia.org)
  • their prognosis (how stable they are now- whether they can survive major invasive surgery and the anesthesia and post-op period, and how they have been, and how they likely will fare with and/or without the organ, versus with other therapies that are not transplantation- such as continued dialysis or getting an artificial heart or left ventricular assist device). (wikipedia.org)
  • In 2008, the charity Kidney Wales Foundation established Opt for Life Cymru, with People Like us Cymru, the Welsh Kidney Patients Association, the British Heart Foundation, the British Lung Foundation, Diabetes Cymru, Cystic Fibrosis and the British Medical Association, to campaign to change the law in Wales to a 'soft opt-out' system of organ donation. (wikipedia.org)
  • Immunoglobulin therapy is also used in some treatment protocols for secondary immunodeficiencies such as human immunodeficiency virus (HIV), some autoimmune disorders (such as immune thrombocytopenia and Kawasaki disease), some neurological diseases (multifocal motor neuropathy, stiff person syndrome, multiple sclerosis and myasthenia gravis) some acute infections and some complications of organ transplantation. (wikipedia.org)
  • COPD
  • Risk factors include other lung diseases such as cystic fibrosis, COPD, and asthma, diabetes, heart failure, a history of smoking, a poor ability to cough such as following a stroke, or a weak immune system. (wikipedia.org)
  • genetic
  • Kerem B, Rommens JM, Buchanan JA, et al: Identification of the cystic fibrosis gene: genetic analysis. (springer.com)
  • Cystic fibrosis (CF) is an autosomal recessive genetic disease characterized by chronic pulmonary infection, exocrine pancreatic insufficiency, and high concentrations of sweat electrolytes. (scielo.br)
  • Substitution of whole genes or chromosomes, or large portions thereof, for the purpose of genetic therapy or engineering (which is not actually transplantation, since these are not whole organs, or even tissues) is generally not yet feasible. (wikipedia.org)
  • The fibrosis in IPF has been linked to cigarette smoking, environmental factors (e.g. occupational exposure to gases, smoke, chemicals or dusts), other medical conditions including gastroesophageal reflux disease (GERD), or to genetic predisposition (familial IPF). (wikipedia.org)
  • cardiology
  • cardiology, including coronary angiography and coronary angioplasty, plus facilities for cardiac electrophysiology and catheter ablation, pacemaker insertion, implantable cardiac defibrillator, transcatheter structural heart procedures such as valve implantation intensive care services. (wikipedia.org)
  • U.S. News and World Report's ranking of Best Children's Hospitals ranked University of Iowa Children's Hospital in seven specialties: Cancer Cardiology and heart surgery Diabetes and endocrinology Nephrology Neurology and neurosurgery Orthopedics Pulmonology First hospital in Iowa to receive Magnet designation for nursing excellence. (wikipedia.org)
  • interstitial
  • It was the first in the world to recognize and treat interstitial lung disease, the first to use nitric oxide to treat neonatal hypertension, and the first to initiate newborn cystic fibrosis screening. (wikipedia.org)
  • diagnosis
  • Younger age, female gender, white race, short stature, high antibody sensitization, college or post-college education, lower lung allocation score, and a cystic fibrosis diagnosis were independently associated with multiple listing. (stanford.edu)
  • Cystic fibrosis--an Indian perspective on recent advances in diagnosis and management. (mysciencework.com)
  • Therefore, the differential diagnosis should assess: Atrial myxoma Congestive heart failure Constrictive pericarditis Infiltrative cardiomyopathies Right heart failure (right ventricular infarction) Ventricular septal defect The treatment for cor pulmonale can include the following: antibiotics, expectorants, oxygen therapy, diuretics, digitalis, vasodilators, and anticoagulants. (wikipedia.org)
  • Abnormal
  • Knowles MR, Stutts MJ, Spock A et al: Abnormal ion permeation through cystic fibrosis respiratory epithelium. (springer.com)
  • IPF is believed to be the result of an aberrant wound healing process including/involving abnormal and excessive deposition of collagen (fibrosis) in the pulmonary interstitium with minimal associated inflammation. (wikipedia.org)
  • symptoms
  • citation needed] The symptoms/signs of pulmonary heart disease (cor pulmonale) can be non-specific and depend on the stage of the disorder, and can include blood backing up into the systemic venous system, including the hepatic vein. (wikipedia.org)
  • Play media The main signs and symptoms of cystic fibrosis are salty-tasting skin, poor growth, and poor weight gain despite normal food intake, accumulation of thick, sticky mucus, frequent chest infections, and coughing or shortness of breath. (wikipedia.org)
  • surgery
  • Surgeon Ben Milstein performed the first open-heart surgery at Papworth Hospital in September 1958. (wikipedia.org)
  • He is the William E. Connor Chair in Cardiothoracic Transplantation, and a Professor of Surgery and Medicine at UCLA School of Medicine, Division of Cardiothoracic surgery. (wikipedia.org)
  • The hospital and its affiliates at the University are responsible for virtually all of the pediatric research published in the Rocky Mountain region in the past decade, as well as several internationally recognized medical milestones, including the discovery of toxic shock syndrome and development of new pediatric heart surgery techniques now used around the world. (wikipedia.org)
  • patient's
  • The patient's own heart is either removed and replaced with the donor heart (orthotopic procedure) or, less commonly, left in place to support the donor heart (heterotopic procedure). (drsemitha.com)
  • The donor heart is trimmed to fit onto the patient's remaining left atrium and the great vessels are sutured in place. (drsemitha.com)
  • In the heterotopic procedure , the patient's own heart is not removed. (drsemitha.com)
  • renal
  • Also, TGF-beta activates the KCa3.1 K+ channel, which could be involved the detrimental effects of renal fibrosis. (wikipedia.org)
  • stem
  • The true benefit of stem cells to heart function, however, may be in promoting cardiomyogenesis (CM, the growth of cardiac muscle). (bio-medicine.org)
  • We believe that by looking at these new sources for stem cells, we will eventually be able to use our own stem cells to repair our own heart dysfunctions," said Sunichiro Miyoshi, M.D., of the Keio University in Japan, and one of the lead authors of the study. (bio-medicine.org)
  • Stem cell transplantation is a controversial, yet promising option for a number of areas of the body that need repair or replacement. (bio-medicine.org)
  • In a closer look at their regenerative function, researchers from Tulane University in Louisiana evaluated the stem cell transplant's effect on the thickness of the heart wall following a heart attack. (bio-medicine.org)
  • To test the hypothesis, the researchers induced heart attacks in 17 pigs by way of an angioplasty balloon and harvested stem cells from the animals' subcutaneous fat tissues (ADSC, adipose derived stem cells). (bio-medicine.org)