• Airway wall and lumen areas were measured from three 1-mm-thick cross-sectional images obtained from upper, middle, and lower lobes during a respiratory pause with the lungs inflated to an airway pressure of 20 cm H2O. (nih.gov)
  • Airway dimensions were measured in lungs obtained from CF patients who had undergone lung transplantation (n=12), lobectomy (n=1), or autopsy (n=4). (ersjournals.com)
  • Children with cystic fibrosis have a higher risk of developing bacterial infections in their lungs and sinuses, because mucus blocks these airways. (nyulangone.org)
  • Other lung tests measure the amount of oxygen in the lungs and in the blood, which is an additional way to see if mucus in the airways is interfering with breathing and the absorption of oxygen. (nyulangone.org)
  • Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. (wikipedia.org)
  • Airway clearance techniques (ACTs) loosen thick, sticky mucus so it can be cleared from your lungs by coughing or huffing. (cff.org)
  • Lower respiratory tract infections are those that affect the lungs or airways. (medicalnewstoday.com)
  • The bronchi are the airways that enable airflow into the lungs. (medicalnewstoday.com)
  • In the lungs of cystic fibrosis patients, the appearance of SCVs correlates with a prolonged persistence of infection and poor lung function. (unibas.ch)
  • CFTR is a protein essential to wet surfaces throughout your body, like the airways of your lungs. (healthline.com)
  • The airways of your lungs are lined with mucus. (healthline.com)
  • Cystic fibrosis affects mostly the lungs and makes it difficult to breathe. (ncaa.com)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Cystic fibrosis is a hereditary disease that causes certain glands to produce abnormally thick secretions, resulting in tissue and organ damage, especially in the lungs and the digestive tract. (msdmanuals.com)
  • Cystic fibrosis is caused by inherited genetic variants that cause thick, sticky secretions to clog the lungs and other organs. (msdmanuals.com)
  • Cystic fibrosis affects the lungs and also several other organs. (msdmanuals.com)
  • In the lungs, thick bronchial secretions block the small airways, which become infected and inflamed. (msdmanuals.com)
  • While it was already known that mucus hydration and the presence of sufficiently tight junctions preserved the integrity of the airways, the mechanisms involved and the links between these two mechanisms remained mysterious, which hindered the development of new therapies," explains Marc Chanson, a professor in the Department of Cell Physiology and Metabolism and the Geneva Centre for Inflammation Research at the UNIGE Faculty of Medicine, who led this research. (sflorg.com)
  • Cystic fibrosis (CF) is commonly characterised by thick respiratory mucus . (bvsalud.org)
  • Lung disease results from clogging of the airways due to mucus build-up, decreased mucociliary clearance, and resulting inflammation. (wikipedia.org)
  • Producing mucus while coughing is typically a response to allergens and irritants, airway infections, or an underlying condition. (medicalnewstoday.com)
  • In most cases, coughing is an automatic reflex that helps clear the airways of mucus or irritants. (medicalnewstoday.com)
  • It produces thick mucus that clogs the airways, O'Grady said. (ncaa.com)
  • Reactive airway disease has a large differential diagnosis and must not be confused with asthma. (medscape.com)
  • This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug. (nih.gov)
  • ABPA most commonly affects people with asthma or cystic fibrosis. (aaaai.org)
  • Asthma medications such as oral corticosteroids open the airways and make it easier to cough and clear out the fungus. (aaaai.org)
  • Examples of such disorders and the listings we use to evaluate them include chronic obstructive pulmonary disease ( 103.02 ), chronic lung disease of infancy (also known as bronchopulmonary dysplasia, 103.02C or 103.02E ), pulmonary fibrosis ( 103.02 ), asthma ( 103.02 or 103.03 ), and cystic fibrosis ( 103.04 ). (ssa.gov)
  • COPD, asthma, and cystic fibrosis (CF) together affect a large number of individuals and no curative treatments are available. (lu.se)
  • Our objectives were to characterise the microbiota in cystic fibrosis (CF) bronchoalveolar lavage fluid (BALF), and determine its relationship to inflammation and disease status. (ersjournals.com)
  • Microbial diversity and relative abundance of Streptococcus , Prevotella and Veillonella were inversely associated with airway inflammation. (ersjournals.com)
  • Progressive lung disease secondary to chronic airway infection and inflammation is the leading cause of morbidity and mortality in cystic fibrosis (CF) [ 1 ]. (ersjournals.com)
  • In the largest study of its kind, researchers found that the lower airways in children with cystic fibrosis (CF) have a higher burden of infection, more inflammation and lower diversity of microorganisms, compared to children with other illnesses who also have lung issues. (luriechildrens.org)
  • Chronic airway infection and inflammation resulting in progressive, obstructive lung disease is the leading cause of illness and death in people with cystic fibrosis. (luriechildrens.org)
  • Establishing key age-related differences in lower airway bacterial communities and inflammation in patients with CF, especially during early childhood, may give us a window of opportunity for earlier and more precise treatment," said senior author Theresa Laguna, MD, MSCS , Division Head of Pulmonary and Sleep Medicine at Lurie Children's and Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine. (luriechildrens.org)
  • Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. (frontiersin.org)
  • Numerous environmental stimuli induce an allergen-antibody interaction, causing a release of mediators that create airway inflammation. (medscape.com)
  • Airway inflammation is the primary factor responsible for smooth muscle hyperresponsiveness, edema, and increased mucous production. (medscape.com)
  • The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected with HIV. (nih.gov)
  • The information learned from this research may help the investigator to better understand the link between cardiac fibrosis and cardiac dysfunction and inflammation in those with perinatally acquired HIV infection compared to the uninfected. (nih.gov)
  • In this project, we study innate host defense, with a focus on roles for chemokines and innate antibiotics during airway inflammation. (lu.se)
  • Objectives/Hypothesis: To determine the relationship between mucosal-associated sinus and bronchial microbiota in cystic fibrosis (CF) patients compared to non-CF patients with chronic rhinosinusitis (CRS). (nau.edu)
  • Treatment plans help people with cystic fibrosis maintain their health so they can live longer, more fulfilling lives. (cff.org)
  • The Cystic Fibrosis Foundation made a strategic commitment to develop a multi-pronged approach to help people with cystic fibrosis stick with their treatment plans called Partnerships for Sustaining Daily Care (PSDC). (cff.org)
  • It is not clear how airway pathology relates to the severity of airflow obstruction and increased bronchial responsiveness in cystic fibrosis (CF) patients. (ersjournals.com)
  • The changes in airway dimensions of cystic fibrosis patients probably contribute to the severe airflow obstruction, and to increased bronchial responsiveness, in these patients. (ersjournals.com)
  • Bronchial secretions are difficult to obtain, and little is known about lower airway flora in these patients. (elsevierpure.com)
  • We collected simultaneous bronchial and oropharyngeal specimens in 43 CF patients in optimal respiratory status, including both expectorating (17) and nonexpectorating (26) patients, to determine the predictive value of oropharyngeal cultures for identifying lower airway pathogens. (elsevierpure.com)
  • Levels of LXA4 are decreased in the airways of patients with CF. We have previously shown that in normal human bronchial epithelial cells, LXA4 produced a rapid and transient intracellular Ca2+ increase. (rcsi.com)
  • We found, using confocal imaging, that LXA4 increased the ASL height in non-CF and in CF airway bronchial epithelia. (rcsi.com)
  • As the disease progresses, the bronchial walls thicken, the airways fill with infected secretions, areas of the lung contract, and lymph nodes enlarge. (msdmanuals.com)
  • However, it only targets certain mutations of the CFTR gene and is only prescribed for a specific population of people with cystic fibrosis. (sflorg.com)
  • It is caused by the presence of mutations in both copies (alleles) of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. (wikipedia.org)
  • CF results from mutations (changes) in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene , which has instructions for making the CFTR protein. (cdc.gov)
  • The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC). (nih.gov)
  • It's due to a genetic mutation that affects the production or function of a protein called cystic fibrosis transmembrane conductance regulator (CFTR). (healthline.com)
  • What happens to CFTR in cystic fibrosis? (healthline.com)
  • Reduced CFTR function causes less chloride to make it to the surface of the cells in your airways. (healthline.com)
  • The sensitivity and specificity of such testing can now be improved as a result of the recent discovery of the Cystic Fibrosis Transmembrane Conductance Regulatory (CFTR) gene. (cdc.gov)
  • The discovery of the Cystic Fibrosis Transmembrane Conductance Regulatory (CFTR) gene (5) renewed interest in this possibility, as the sensitivity and specificity of testing could be improved through DNA-based testing. (cdc.gov)
  • The cystic fibrosis transmembrane conductance regulator (CFTR), ivacaftor (Kalydeco), was approved by the FDA in January 2012. (medscape.com)
  • This gene is called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)
  • Airway clearance physiotherapy and health-related quality of life in cystic fibrosis. (qxmd.com)
  • Airway clearance physiotherapy is recommended in cystic fibrosis, but limited evidence exists to suggest how much treatment is enough. (qxmd.com)
  • Each subject performed spirometry before their airway clearance session and then immediately after, 30 min after, and 1, 2, and 3 h after their physiotherapy session for 2 consecutive days. (rcjournal.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/438255/all/Positive_expiratory_pressure_physiotherapy_for_airway_clearance_in_people_with_cystic_fibrosis. (unboundmedicine.com)
  • From diagnosis , people with CF are prescribed daily physiotherapy, including airway clearance techniques (ACTs). (bvsalud.org)
  • Airway clearance techniques such as chest physiotherapy may have some short-term benefit, but long-term effects are unclear. (wikipedia.org)
  • The epithelial cells that line the airways are usually sealed together and thus protect the airways from bacterial colonization. (sflorg.com)
  • Here we show that ASL pH in children with CF is similar to that of children without CF. Findings were supported by highly controlled direct pH measurements in primary human airway epithelial cell culture models, which also suggest that the potential ASL pH gradient produced by defective apical ion transport is balanced out by paracellular shunting of acid/base. (telethonkids.org.au)
  • Cystic Fibrosis (CF) is a genetic disease characterised by a deficit in epithelial Cl- secretion leading to airway dehydration and a reduced Airway Surface Liquid (ASL) height. (rcsi.com)
  • It is therefore important to increase the knowledge concerning mechanisms regulating their expression in airway epithelial cells. (lu.se)
  • Acute and chronic airway infections are common, and the patients often become colonized with pathogens that rarely cause disease in lung healthy individuals. (lu.se)
  • What bacterial virulence factors are important for the establishment of acute and chronic airway infections? (lu.se)
  • In later stages, changes in the architecture of the lung, such as pathology in the major airways (bronchiectasis), further exacerbate difficulties in breathing. (wikipedia.org)
  • The development of early lung disease in patients with cystic fibrosis (CF) remains poorly defined. (nih.gov)
  • This model, which was awarded the UNIGE 3R Prize in 2021 for reducing animal experimentation, reproduces airways epithelium of healthy and cystic fibrosis patients in a way that is both accurate and close to clinical reality. (sflorg.com)
  • The aim of this study was to measure the airway dimensions of CF patients and to estimate the importance of these dimensions to airway resistance using a computational model. (ersjournals.com)
  • These dimensions were compared to those of airways from lobectomy specimens from 72 patients with various degrees of chronic obstructive pulmonary disease (COPD). (ersjournals.com)
  • The airway dimensions of the CF and COPD patients were introduced into a computational model to study their effect on airway resistance. (ersjournals.com)
  • The multicenter study analyzed lower airway samples from 191 patients (63 with cystic fibrosis) aged 0-21 years. (luriechildrens.org)
  • By using the more sensitive genetic sequencing instead of culture to detect a broader range of microorganisms in the lower airways, researchers were able to identify distinct pathogens that are more dominant at different ages in patients with cystic fibrosis. (luriechildrens.org)
  • S. prolifi cans was isolated from 28 patients only after trauma, burn, cystic fi brosis, heart and lung transplant, November 1999. (cdc.gov)
  • Immunocompromised cently, it has been isolated from patients with chronic patients were defi ned as those with impairment of either or lung disease, particularly cystic fi brosis ( 1 , 2 ), where the both natural and specifi c immunity to infection ( 22 ). (cdc.gov)
  • Identifying lower respiratory pathogens in young, nonexpectorating cystic fibrosis (CF) patients has been problematic. (elsevierpure.com)
  • A relatively high proportion of nonexpectorating CF patients less than 10 yr old had P. aeruginosa (11 of 24, 46%) or Klebsiella species (5 of 24, 21%) in their lower airways. (elsevierpure.com)
  • Our results suggest that oropharyngeal cultures yielding P. aeruginosa or S. aureus are highly predictive, but such cultures lacking these organisms do not rule out the presence of these pathogens in the lower airways of CF patients. (elsevierpure.com)
  • Paired airway samples from nine subjects with CF were compared with samples from 17 non-CF-CRS disease control patients. (nau.edu)
  • Conclusions: Patients with CF undergoing surgery for CRS exhibit substantial bacterial community collapse in the sinuses and a loss of niche specificity between the upper and lower airways compared to non-CF patients with CRS. (nau.edu)
  • Pletcher, SD, Goldberg, AN & Cope, EK 2019, ' Loss of Microbial Niche Specificity Between the Upper and Lower Airways in Patients With Cystic Fibrosis ', Laryngoscope , vol. 129, no. 3, pp. 544-550. (nau.edu)
  • High Expression of Midkine in the Airways of Patients with Cystic Fibrosis. (lu.se)
  • In addition to mucolytics such as dornase alfa, hypertonic saline inhalation has been proposed as a therapy to increase hydration of airway surface liquid in patients with CF. (medscape.com)
  • The Pulmonary Therapies Committee of Cystic Fibrosis Foundation recommends long-term use of hypertonic saline for patients with cystic fibrosis aged 6 years or older to improve lung function and to reduce the number of exacerbations. (medscape.com)
  • Perceptions of Genetic Testing: A Mixed-methods Study of Patients with Pulmonary Fibrosis and their First-degree Relatives. (cdc.gov)
  • Elexacaftor/Tezacaftor/Ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation and Advanced Lung Disease: A 48-Week Observational Study. (cdc.gov)
  • Effectiveness and safety of elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease with the Phe508del/minimal function genotype. (cdc.gov)
  • Family History of Pulmonary Fibrosis Predicts Worse Survival in Patients with Interstitial Lung Disease. (cdc.gov)
  • My research group studies the airway microbiome and respiratory tract infections in lung transplant recipients and patients with the genetic disorder cystic fibrosis (CF). Both groups of patients have an altered airway microbiome due to the underlying disease and frequent antibiotic treatments. (lu.se)
  • For many of the different microbes that are found in airway cultures from these patients, the clinical relevance in the long and short perspective is unknown. (lu.se)
  • What is the clinical significance of different microbes found in airway cultures from these patients? (lu.se)
  • The role of anaerobic organisms in the cystic fibrosis (CF) lung microbiome is unclear. (lww.com)
  • These results extend previous studies elucidating the lower airway microbiome in cystic fibrosis and provide support for the concept of microbial translocation in the cystic fibrosis airways. (nau.edu)
  • Can we identify specific microbes in the airway microbiome that cause or protect against airway infections? (lu.se)
  • Determine whether asymptomatic infants with CF have evidence for changes in airway structure when assessed by high-resolution computed tomography, and whether airway structure correlates with airway function in this age group. (nih.gov)
  • Lung function parameters are used as end points in most clinical and therapeutic trials in cystic fibrosis (CF) and to evaluate the effects of airway clearance techniques. (rcjournal.com)
  • Clearing the airways may help decrease lung infections and improve lung function. (cff.org)
  • The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measures to lung function assessed by spirometry and multiple breath nitrogen washout. (nih.gov)
  • Seasonal variation of lung function in cystic fibrosis: longitudinal modeling to compare a Midwest US cohort to international populations. (cdc.gov)
  • Airway infections are important complications in people with CF and lung transplant recipients, and can lead to organ damage and lung function decline. (lu.se)
  • Using a model reproducing a respiratory epithelium - a protective tissue composed of a monolayer of cells - teams from the University of Geneva (UNIGE) have discovered that a simple film of liquid is sufficient to restore the airways' seal and reduce the risk of bacterial infection. (sflorg.com)
  • The epithelium was 53% greater in height in peripheral CF airways. (ersjournals.com)
  • A complex interaction occurs between inflammatory cells and airway epithelium. (medscape.com)
  • Treatments include antibiotics, bronchodilators, drugs to thin lung secretions, airway clearance treatments for respiratory problems, supplements of pancreatic enzymes and vitamins for digestive problems, and drugs to improve the function of the cystic fibrosis protein in people with certain genetic variants. (msdmanuals.com)
  • He currently serves as President of the Wisconsin Society for Respiratory Care and has been lecturing on the proper utilization of airway pressure release ventilation for nearly a decade, participating in numerous clinical studies, experiments, and abstracts on the topic. (rtmagazine.com)
  • BiPAP means bi-level positive airway pressure ventilation. (ssa.gov)
  • are the pathogens most frequently cultured from CF airway samples and are associated with pulmonary decline [ 2 ]. (ersjournals.com)
  • We compared lower airway samples from bronchoscopy in children with CF and disease controls across the age spectrum, and used genetic sequencing to identify microorganisms, finding that a few common cystic fibrosis pathogens begin to dominate at very early ages," said lead author Jack O'Connor from Ann & Robert H. Lurie Children's Hospital of Chicago. (luriechildrens.org)
  • Nasal potential difference measurements are valuable endpoint assays in clinical studies of novel treatments for cystic fibrosis (CF). Similar measurements made on the lower airway via the bronchoscope have been successful in adults, but have not been reported in children, the group most likely to benefit from such therapies. (nih.gov)
  • Analysis of the acute effect of tiotropium bromide in the pulmonary function of the children and teenagers with cystic fibrosis. (usp.br)
  • Examining the relationship between sleep quality and pulmonary function in children and young adults with cystic fibrosis. (chkd.org)
  • The two main areas of this research include how innate immune cells fail to regulate infection in chronic lung diseases as well as elucidating biomarkers/pathways of early inflammatory airway disease. (leukocytebiology.org)
  • These diseases have in common that they start at the airway mucosal surfaces and inflammatory bouts (exacerbations) are to a large extent triggered by infections. (lu.se)
  • Despite recent therapeutic advances, people with cystic fibrosis - one in every 2,500 births in Europe - have a life expectancy of no more than 46 years and altered quality of life. (sflorg.com)
  • Current and novel therapeutic strategies for the management of cystic fibrosis. (cdc.gov)
  • Verriere V, Higgins G, Al-Alawi M, Costello CW, Chiron R, Harvey BJ, Urbach V. Lipoxin A4 stimulates calcium-activated chloride secretion and increases airway surface liquid height in normal and cystic fibrosis airway epithelia. (rcsi.com)
  • This research can increase our knowledge about the pathogenesis of airway infections and identify new treatment approaches. (lu.se)
  • Cystic fibrosis (CF) affects about 70,000 people globally. (healthline.com)
  • Cystic fibrosis affects many organs throughout the body and nearly all the glands that secrete fluids into a duct (exocrine glands). (msdmanuals.com)
  • Distinguishing pathogenic bacteria that contribute to airway disease from commensal microbiota in sputum has proved challenging and remains an obstacle to clinical application of sequencing results [ 13 , 14 ]. (ersjournals.com)
  • Sinus X-rays may be used to diagnose sinusitis, another common complication of cystic fibrosis in which the sinuses are repeatedly infected with bacteria. (nyulangone.org)
  • Teams of dedicated health care professionals in a nationwide network of more than 130 Cystic Fibrosis Foundation-accredited care centers partner with people with CF and their families to provide expert care and specialized disease management. (cff.org)
  • As a result of the complex and multisystemic involvement of cystic fibrosis (CF) and the need for care by specialists, treatment and follow-up care at specialty centers with multidisciplinary care teams (ie, cystic fibrosis centers) is recommended. (medscape.com)
  • Among infants with CF, a greater ratio of wall to lumen area correlated with lower airway function. (nih.gov)
  • Our results indicate that infants with CF have thickened airway walls, narrowed airway lumens, and air trapping, when assessed by high-resolution computed tomography, and measurements of airway structure correlated with airway function. (nih.gov)
  • Speculation exists that all infants are born with highly responsive airways. (medscape.com)
  • Newborns and infants with cystic fibrosis tend to have frequent, large, greasy stools (a result of malabsorption) and are underweight for their age. (wikipedia.org)
  • Cystic fibrosis (CF) is a genetic disease that can be detected in newborn infants (i.e., those aged less than or equal to 1 month) by immunotrypsinogen testing. (cdc.gov)
  • Cystic fibrosis (CF) is the most common, life-shortening, autosomal recessive, inherited disease affecting white people. (rcjournal.com)
  • Work is needed to monitor and improve ACT quality and to increase the proportion of people doing effective airway clearance at home. (bvsalud.org)
  • Lung problems are responsible for death in 80% of people with cystic fibrosis. (wikipedia.org)
  • The primary cause of morbidity and death in people with cystic fibrosis is progressive lung disease, which eventually leads to respiratory failure. (wikipedia.org)
  • This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health. (nih.gov)
  • People with cystic fibrosis have a gene mutation that causes problems with the protein. (healthline.com)
  • Cystic fibrosis is the most common inherited disease leading to a shortened life span among White people. (msdmanuals.com)
  • Because improvements in treatment have extended life expectancy for people with cystic fibrosis, about half of the people in the United States with this disease are adults. (msdmanuals.com)
  • About 3 of 10,000 white people inherit two defective copies of the gene and develop cystic fibrosis. (msdmanuals.com)
  • Here we report the design and validation of a small, single-lumen catheter technique allowing baseline potential difference and chloride secretion to be assessed in the distal airways of children as young as 1 year of age. (nih.gov)
  • In airways between the third and seventh generation, perfusion with a zero chloride solution containing isoprenaline led to a significant change in potential difference in children without CF, whereas no change was seen in those with CF. This measure provided a reliable distinguishing test between the two disease groups. (nih.gov)
  • Cystic fibrosis (CF) is a genetic disorder that causes problems with breathing and digestion. (cdc.gov)
  • Cystic fibrosis results when a person inherits two defective copies (variants) of a particular gene, one from each parent. (msdmanuals.com)
  • Perceptions of airway gene therapy for cystic fibrosis. (cdc.gov)
  • Gene therapy for cystic fibrosis: Challenges and prospects. (cdc.gov)
  • The inner wall and smooth muscle areas of peripheral CF airways were increased 3.3- and 4.3-fold respectively compared to those of COPD airways. (ersjournals.com)
  • Since the development of the immunoreactive trypsinogen test (IRT) for cystic fibrosis (CF), experts in the field of CF have considered adding this test to the newborn screening panel. (cdc.gov)
  • Title : Improving newborn screening for cystic fibrosis using next-generation sequencing technology: a technical feasibility study Personal Author(s) : Baker, Mei W.;Atkins, Anne E.;Cordovado, Suzanne K.;Hendrix, Miyono;Earley, Marie C.;Farrell, Philip M. (cdc.gov)
  • Evaluating the effects of the different airway clearance techniques offered for CF care is thus essential. (rcjournal.com)
  • In addition, patient/parent education, including counseling and instructions regarding airway clearance techniques and the use of equipment (eg, nebulizer, spacer for metered-dose inhaler), is recommended. (medscape.com)
  • 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital and University College Dublin School of Medicine, Dublin, Ireland. (jci.org)
  • French National Institute of Health (INSERM), the Centre Hospitalier Universitaire (CHU) of Montpellier, the French Cystic Fibrosis Association (Vaincre La Mucoviscidose), a Career Enhancement and Mobility Programme Marie Curie Fellowship, the Higher Education Authority of Ireland under the Programme for Research in Third Level Institutions (PRTLI) Cycle 4 and the National Biophotonics and Imaging Platform, Ireland. (rcsi.com)
  • Cystic fibrosis is a rare genetic disease which can cause very serious symptoms. (sflorg.com)
  • The airway clearance intervention was associated with clinically meaningful changes in patient-reported symptoms on the CFQ-R in the majority of the participants. (qxmd.com)
  • Hydration restores the airway surface seal. (sflorg.com)