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  • nitric oxide sy
  • 0.05) in plasma TNF-alpha, IL-1beta and nitrate/nitrite (NO(x)) concentrations, liver H2S synthesis (from added cysteine), CSE mRNA, inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) activity (marker for neutrophil infiltration) and nuclear factor-kappa B (NF-kappaB) activation. (nih.gov)
  • The gasotransmitter nitric oxide (NO) is generated by nitric oxide synthase (NOS) and can affect protein function by modifying cysteine residues in a process called S-nitrosylation. (sciencemag.org)
  • transgenic
  • Publications] K.Saito 他: 'Tissueーspecific and stressーenhancing expression of the TR promoter for mannopine synthase in transgenic plants' Planta. (nii.ac.jp)
  • Publications] K. Saito, M. Yamazaki, H. Kaneko, I. Murakoshi, Y. Fukuda & M. Van Montagu: ''Tissue-specific and stress-enhancing expression of the TR promoter for mannopine synthase in transgenic medicinal plants, '' Planta. (nii.ac.jp)
  • product
  • In the absence of any detailed study on the energetics of ligand binding, we have studied the thermodynamics of OASS from Salmonella typhimurium (StOASS), Haemophilus influenzae (HiOASS), and Mycobacterium tuberculosis (MtOASS) binding to their substrate O-acetylserine (OAS), substrate analogue (methionine), and product (cysteine). (nih.gov)
  • metabolic
  • Currently metabolic networks (e.g. folate metabolism) are being used to develop a deeper understanding of the functional relationships between genetic variation and trait variation, and of the mechanisms by which genetic and environmental variables interact to produce phenotypes. (duke.edu)
  • Energy
  • Cysteine binding to OASS shows that both enthalpy and entropy contribute significantly to the binding free energy at all temperatures (10-30°C) examined.Our salt dependent ligand binding studies indicate that methionine binding affinity is more sensitive to [NaCl] as compared to cysteine affinity.We speculate that OASS in general, may exhibit two different binding mechanisms for recognizing substrates and products. (nih.gov)
  • Cysteine binding to OASS shows that both enthalpy and entropy contribute significantly to the binding free energy at all temperatures (10-30°C) examined. (nih.gov)
  • acid
  • Further provided are methods for modulating or altering metabolism in a cell using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius. (osti.gov)
  • Results
  • Our results are integrated to form working models for further detailed investigations with a focus on regulatory aspects of metabolism. (mpg.de)
  • found
  • β-Cyanoalanine synthase in etiolated seedlings of Lupinus angustifolius is found mainly in the mitochondrial fraction of the cotyledons and stems. (massey.ac.nz)