The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. (wikipedia.org)
The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
CYR612
The nuclear import of YAP was associated with a rapid decrease in YAP phosphorylation at Ser 127 and Ser 397 , sites targeted by LATS1/2 and with the expression of YAP-regulated genes, including connective tissue growth factor ( CTGF ), and cysteine-rich angiogenic inducer 61 (CYR61). (nih.gov)
Interestingly, NOV/CCN3, a founder member of the family of matricellular proteins called CCN (CYR61/CCN1, CTGF/CCN2, NOV/CCN3), has been involved in the regulation of cytokines, chemokines and MMP in several cell systems and therefore represents an attractive candidate for this role. (biomedcentral.com)
Transcriptional2
In this study, we examined the regulation of yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in human ECs challenged with Abs that bind HLA I. In unstimulated ECs, YAP localized mainly in the cytoplasm. (nih.gov)
Ste20-like kinase Hippo (Hpo) with its adaptor protein Salvador (Sav), the NDR family kinase Warts (Wts) with its adaptor Mats, and the transcriptional effector Yokie (Yki). (nature.com)
Hippo2
Moreover, knocking down lincRNA-p21 could elevate the expression of Yes associated protein (YAP), the core effector of Hippo signaling, by elevating mRNA levels and increasing its nucleus translocation instead of the canonical Hippo pathway. (oncotarget.com)
Extracellular hormones can modulate LATS1/2 kinase activity via G-protein-coupled receptors to regulate the Hippo pathway 19 , 23 . (nature.com)
Family1
C1q/tumor necrosis factor (TNF) related proteins (CTRPs), a newly discovered adipokine family with conservative structure and wide distribution, has attracted increasing attention. (bvsalud.org)
Expression1
The mRNA expression of NOV and pro-inflammatory factors were measured with real-time quantitative PCR, CCL2 protein expression was assessed using ELISA, MMP-2 and -9 activities using zymography. (biomedcentral.com)
Present1
Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. (wikipedia.org)