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  • histidine residues
  • The metal center of CDO is bound by a facial triad composed entirely of histidine residues in contrast to the previously ubiquitous 2-His/1-carboxylate facial triad found in other ferrous-dependent enzymes. (auburn.edu)
  • pathways
  • Several of the pathways of metabolism of the suspected carcinogen acrylonitrile (AN) were identified previously in this laboratory with the use of subcellular fractions and purified enzymes (Guengerich, F. P., Geiger, L. E., Hogy, L. L., and Wright, P. L., Cancer Res. (aacrjournals.org)
  • In order to establish the relative contributions of the various pathways leading to activated and detoxicated products, we examined AN metabolism in isolated Fischer 344 rat hepatocytes as a model. (aacrjournals.org)
  • In addition, Transcript analysis of ABA metabolism-related genes was much similar demonstrated that ABA pathways was similar in the regulation of vegetative and flower bud dormancy, whereas, expression patterns of ABA metabolism-related genes were different in seed dormancy showed that ABA pathway maybe different in regulating seed dormancy in peach. (frontiersin.org)
  • biochemical
  • By means of site-directed mutagenesis combined with other molecular-biological and biochemical methods, this work defines different combinations of minimal cysteine content that are consistent with ATPase function. (springer.com)
  • glucose
  • Due to their respiratory metabolism, cells grown in excess glucose or glycerol had very similar expression profiles. (biomedcentral.com)
  • Genes subject to glucose repression were mainly involved in the metabolism of alternative carbon sources including the control of glycerol uptake and metabolism. (biomedcentral.com)
  • PPAR γ is highly expressed in white and brown adipose tissue (WAT and BAT) and plays a pivotal role in the regulation of adipogenesis, fat storage, and glucose metabolism [ 11 - 15 ]. (hindawi.com)
  • For this reason, PPAR γ is the main target of thiazolidinediones (TZDs), a class of drugs used to improve lipid and glucose metabolism in type 2 diabetes [ 16 , 17 ]. (hindawi.com)
  • enzymes
  • The pyridoxal-P group is attached to a lysine residue located in the central section of these enzymes. (ebi.ac.uk)
  • metabolic
  • Aerobic energy metabolism, or oxidative phosphorylation, is a critical metabolic pathway within cells to provide the energy necessary to complete our daily tasks. (biomedcentral.com)
  • Free-living unicellular algae capable of a photoautotrophic lifestyle can also use a range of metabolic circuitry associated with different branches of fermentation metabolism. (frontiersin.org)
  • Fermentation metabolism in Chlamydomonas appears to be highly controlled, and the flexible use of the different branches of fermentation metabolism has been demonstrated in studies of various metabolic mutants. (frontiersin.org)
  • carbon
  • However, the industrial performance of microalgae is still challenged with potential conflict between cost of microalgae cultivation and revenues from them, which is mainly ascribed to the lack of comprehensive understanding of carbon metabolism and energy conversion. (biomedcentral.com)
  • However, thus far, the biotechnological application in microalgae has been limited under industrial conditions for the lack of comprehensive understanding of carbon metabolism and energy conversion. (biomedcentral.com)
  • reactions
  • These compounds can either be directly occurring (e.g. naturally occurring/endogenous compound, or parent drug) or result from phase I metabolism reactions creating reactive electrophilic groups. (archive.org)
  • addition
  • In addition, disruption of single genes or generation of respiratory deficiency (via abrogation of mitochondrial DNA) assists in revealing connections between metabolism and apoptosis. (biomedsearch.com)
  • cell
  • In contrast, Hsp40 overexpression increased nuclear import of D3 and minimized thyroid hormone effects in cell metabolism. (jneurosci.org)
  • mechanism
  • Inactivation of thyroid hormone in the nucleus, physically closer to where thyroid hormone receptors (TRs) are located, constitutes an advantageous mechanism to dampen thyroid hormone signaling and reduce metabolism. (jneurosci.org)
  • cannot
  • Here we show that hypoxia leads to nuclear import of D3 in neurons, without which thyroid hormone signaling and metabolism cannot be reduced. (jneurosci.org)
  • effects
  • They also highlighted the consequences of these effects on metabolism of drugs and volatile amines as well as on important physiological parameters, such as control of blood pressure, renal ion transport, and steroidogenesis. (aspetjournals.org)
  • review
  • In this review, we focus on fermentation metabolism in Chlamydomonas and other protists, with only a brief discussion of plant fermentation when relevant, since it is thoroughly discussed in other articles in this volume. (frontiersin.org)