Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. (wikipedia.org)
For example, CYR61 induces angiogenic functions in endothelial cells through αvβ3, and in fibroblasts promotes cellular senescence and enables TNFα to induce apoptosis through binding to α6β1-HSPGs. (wikipedia.org)
Like a transcription element, YAP mediates the manifestation of several growth-promoting or anti-apoptotic genes, including connective cells growth element (CTGF), cysteine-rich angiogenic inducer 61 (CYR61), cyclin E, E2F1, myc and survivin 7, 10C13. (colinsbraincancer.com)
CCN18
Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa matricellular glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. (rndsystems.com)
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The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six members of the family in vertebrates and have been renamed CCN1-6 in order of their discovery by international consensus. (wikipedia.org)
CCN1 has unusually high cysteine residue content (10% or 38 in total). (wikipedia.org)
The number and spacing of cysteine residues are completely conserved among CYR61 (CCN1), CTGF (CCN2), NOV (CCN3), and WISP-1 (CCN4), and are largely conserved with WISP-2 (CCN5), which lacks precisely the CT domain, and WISP3 (CCN6), which lacks 4 cysteines in the vWC domain. (wikipedia.org)
Cysteine-rich protein 61 (CCN1/Cyr61) has been implicated as an important mediator in the proliferation and metastasis of breast cancer. (molcells.org)
Matricellular proteins1
CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, particularly in the context of wound repair. (wikipedia.org)
Epithelial cells2
CYR61 activates Akt signaling in thymic epithelial cells, promoting their proliferation and thus thymic size growth. (wikipedia.org)
The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
Induces2
Cyr61 induces VEGF upregulation, angiogenesis, and tumorigenesis through interactions with integrins alpha V beta 3, alpha V beta 5, alpha M beta 2, and alpha 6 beta 1. (rndsystems.com)
As a cell adhesive substrate, CYR61 induces the activation of focal adhesion kinase, paxillin, RAC, and sustained activation of MAPK/ERK1-2. (wikipedia.org)
Endothelial cells1
CYR61 binds directly to various integrin receptors in a cell type-dependent manner, including integrin αvβ3 in endothelial cells, α6β1 and heparan sulfate proteoglycans (HSPGs) in fibroblasts and smooth muscle cells αIIbβ3 in activated platelets, αMβ2 in monocytes and macrophages, and αDβ2 in macrophage foam cells. (wikipedia.org)
MRNA2
The 5th exon also contains the 3'-UTR sequences, which has 5 copies of AU-rich elements that confers a short mRNA half life, and a mir-155 target site. (wikipedia.org)
Realtime fluorescent quantitative PCR was used to determine thioredoxin protein (Trx) mRNA expression. (yydbzz.com)
Tyrosine phosphatase2
Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)
Transcriptional1
YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
Extracellular matrix2
CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). (wikipedia.org)
A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. (bvsalud.org)
Amino acids1
Full-length CYR61 protein contains 381 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains. (wikipedia.org)
Fibroblasts1
CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse fibroblasts. (wikipedia.org)
Receptors1
CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. (wikipedia.org)
Migration2
Cyr61 is cleaved by plasmin within its VWF domain which generates an N-terminal fragment that is not associated with the matrix but retains the ability to induce endothelial cell migration. (rndsystems.com)
In the present study, we report that baicalein significantly inhibits the expression of Cyr61 and migration and invasion of MDA-MB231 human breast cancer cells. (molcells.org)
Genes1
According to the PPI network, PTPN6 , HLA-A , C3AR1 , LCK and ITGB2 are hub genes among HT-DEGs, whereas FN1 , CDH2 , SERPINA1 , and CYR61 are PTC-DEG hub genes. (medsci.org)
Vascular1
During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. (wikipedia.org)
Tumor5
An alternative approach to tumor transcript profiling is protein profiling of serum. (biomedcentral.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
Ostensibly control of the tumor microenvironment and the consequent modified manifestation of relevant proteins may allow suppression of aggressive tumor growth and the metastatic potential characteristic of high-grade malignant tumors. (mdm2-inhibitors.com)
Kinase4
Exposure to baicalein led to increased E-cadherin expression, possibly due to the ubiquitination of Snail and Slug, which was mediated by the Cyr61/Akt/glycogen synthase kinase 3β (GSK3β) pathway. (molcells.org)
Description: A sandwich ELISA kit for detection of Death Associated Protein Kinase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Death Associated Protein Kinase 1 (DAPK1) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
Mediate2
Due to the cell type specificity of integrin expression, CYR61 acts through distinct integrins to mediate specific functions in different types of cells. (wikipedia.org)
Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). (blogspot.com)
Tissue4
In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers. (wikipedia.org)
Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin-3 (GAL-3). (biomedcentral.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) in Tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (worldcarecouncil.org)
Cells2
The Trx protein expression level was (26.230±0.857), (19.230±0.982) (22.440±0.888), (23.020±1.070) and (22.330±1.067), respectively.Conclusion Baicalin has protection effect on H 2 O 2 injured SH-SY5Y cells, likely due to resistance to oxidative stress and apoptosis through downregulation of Trx expression. (yydbzz.com)
Using a novel cell tradition system in which cells can be cultivated under elevated hydrostatic pressure Ccna2 we investigated the complex relationships of local pH pO2 and hydrostatic pressure separately and in combination to identify the element(s) that experienced probably the most profound effect on the growth of human OS cell lines and their manifestation of the proteins that contribute to metastatic potential. (mdm2-inhibitors.com)
ELISA2
ELISA was used to determine the Trx protein expression. (yydbzz.com)
Description: A sandwich ELISA kit for detection of Cold Shock Domain Containing Protein E1, RNA Binding from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
Members2
YAP activity could be also inhibited through the relationships with angiomotin (AMOT) family members proteins, which result in localization and sequestration from the YAP proteins to limited junction 29C31. (colinsbraincancer.com)
Our research isolated several previously reported YAP-binding companions - like the TEAD family members Rabbit Polyclonal to HSF2 protein, 14-3-3 protein, LATS1, the angiomotin protein AMOT/AMOTL2, PATJ, LIN7C and PALS1- and many book or not-well-studied YAP-associated protein, including PTPN14 and MUPP1 (Desk 1 and Desk S1). (colinsbraincancer.com)
Family1
Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein). (wikipedia.org)
Mouse1
The mouse CYR61 coding region spans ~3.2 Kb, containing 5 exons interspaced with 4 introns. (wikipedia.org)
The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand type C repeats (vWC) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. (wikipedia.org)
Order1
Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
Approach1
Therefore, searching for phytochemicals that attenuate Cyr61 signaling is a promising approach for cancer treatment. (molcells.org)
Cell lines1
In contrast, both proteins were jointly detectable in most CCA cell lines and showed nuclear/cytoplasmic shuttling in a cell density-dependent manner. (biomedcentral.com)
Potential1
This is the first study to investigate potential serum biomarkers based on over-expressed proteins in thyroid cancer versus benign pathology. (biomedcentral.com)