Cypher stents. Medical search. Frequent questions

The rate of definite stent thrombosis at 12 months was lower in patients treated with DP-EES (0% vs. 2.0%, p = 0.036). (unimore.it)
Conclusions: Among women undergoing PCI, DP-EES was associated with a small but probably clinically relevant increase in in-stent LLL at 9 months as compared to DP-SES and with a lower risk of definite stent thrombosis at 12 months. (unimore.it)
64-slice multidetector CT (MDCT) coronary angiography has been shown to detect poststent complications such as instent stenosis, thrombosis, stent migration and stent fractures. (hindawi.com)
We report a case of stent fracture in a patient who underwent RCA stenting with associated RCA perforation and almost complete thrombosis of the RCA and peristent fibrinoid collection. (hindawi.com)
And of the nine stents that fractured most severely, 67 percent showed signs of thrombosis (blood clots), restenosis (scar tissue) or other adverse conditions. (massdevice.com)
In nine cases, stent deformation was recognized and treated, typically through reexpansion, although in one of the cases, deformation of the stent inlet was recognized after a previously treated patient returned to hospital with anterior STEMI due to stent thrombosis. (medscape.com)
It's important to recognize and treat, as it may be associated with late stent thrombosis. (medscape.com)
A stent thrombosis is far from a surprise. (medscape.com)
Referring to the stent-thrombosis "firestorm that gripped the DES field five years ago, Walsh quipped, "This is not another ESC 2006. (medscape.com)
This massive study, sponsored by all the major stent makers, as well as the manufacturers of antiplatelet meds, will enroll 20,000 patients and test them at 12 and 30 months to determine the rates of MACCE (death, heart attack and stroke) stent thrombosis and major bleeding complications. (ptca.org)
The short back story here is that when drug-eluting stents first came on the market in 2003-2004, the FDA recommended six months of DAPT to keep the blood from clotting in and around the stent (a.k.a. stent thrombosis). (ptca.org)
Within a couple of years, reports surfaced about a small number of patients who suffered late stent thrombosis (six months or more after stenting). (ptca.org)
There is some data (though perhaps not very good data) to suggest there is a higher thrombosis rate, especially in the first 30 days, with the drug coated rather than bare metal stents, but if you take your Plavix and aspirin this shouldn't be much of a problem. (healingwell.com)
Delayed arterial healing, characterized by poor endothelialization, is the primary cause of late (1 month-1 year postimplantation) and very late stent thrombosis following implantation of drug-eluting stents. (nature.com)
The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
The Cordis-Johnson and Johnson heart stent, however, poses a high risk of stent thrombosis. (injurylawyer.com)
Caused when blood clots form on the surface of stents, stent thrombosis greatly increases the risk experiencing a heart attack. (injurylawyer.com)
Laura Mauri, MD, of the Harvard Clinical Research Institute, said DAPT should provide the evidence needed to confirm whether the current guideline recommendation of 12 months of dual antiplatelet therapy with clopidogrel (Plavix) or prasugrel (Effient) plus aspirin is long enough to reduce the risk of very late stent thrombosis. (medpagetoday.com)
The trial, which officially kicked off on Oct. 2, has been in the planning stages since concerns about long-term safety of drug-eluting stents reached a fever pitch in 2006, when registry data and meta-analyses suggested that drug-eluting stents were associated with a significant risk of stent thrombosis a year or longer after implantation. (medpagetoday.com)
The co-primary endpoints for the study are incidence of death, MI, or stroke between 12 and 33 months after a stent is implanted and the incidence of stent thrombosis between 12 and 33 months. (medpagetoday.com)
Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. (jamanetwork.com)
Safety and efficacy of only 2 weeks of ticlopidine therapy in patients at increased risk of coronary stent thrombosis: results from the Antiplatelet Therapy alone versus Lovenox plus Antiplatelet therapy in patients at increased risk of Stent Thrombosis (ATLAST) trial. (jamanetwork.com)
Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. (jamanetwork.com)
We worried for a very high frequency of late stent thrombosis, after a year. (diagnosticdetectives.com)
It was done to avoid the potential bleeding or stent thrombosis when the patient came off therapy. (diagnosticdetectives.com)
The occurrence of coronary stent thrombosis may be as good or even a little less now. (diagnosticdetectives.com)
We hope patients stay without the risk of stent thrombosis. (diagnosticdetectives.com)

Drug-eluting stents (DES) were developed in the early 2000s to reduce restenosis (ie, recurrent narrowing) rates in stented coronary lesions. (medscape.com)
[ 2 , 3 ] There was significant improvement in angiographic results (in stent late lumen loss: 0.17 mm vs 1.00 mm) as well as clinical outcomes (binary in-lesion restenosis: 8.9% vs 36.3%) in the sirolimus stent treatment group relative to the BMS group. (medscape.com)
[ 4 ] Restenosis remains an issue in coronary drug-eluting stent implantation for ostial RCA lesions. (medscape.com)
Secondary angiographic end points included in-segment LLL, in-stent and in-segment binary restenosis and percent diameter stenosis. (unimore.it)
Stents reduced the restenosis rate slightly, but it was still high. (technologyreview.com)
Today, restenosis in coronary arteries afflicts less than 10 percent of patients thanks to the development of the drug-eluting stent (DES), which slowly releases a drug that inhibits the growth of scar tissue. (technologyreview.com)
The project dates to 1996, when Bill Hunter, cofounder and chief scientific officer of Angiotech Pharmaceuticals, approached J&J and other stent makers with his own solution to the restenosis problem. (technologyreview.com)
Companies had tinkered with stent designs, trying to prevent restenosis, but with little success. (technologyreview.com)
Stent Anticoagulation Restenosis Study Investigators. (jamanetwork.com)
Intracoronary in-stent restenosis (ISR) is more common with bare metal stents. (ijcdw.org)
Those regulatory nods cover occlusive disease of the superficial femoral artery (SFA) and coronary in-stent restenosis (ISR). (drugdeliverybusiness.com)
Drug eluting stents (DES) are coated in anti-proliferative drugs to precent scar tissue growth which can cause restenosis and occlude the vessel. (dicardiology.com)

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The two companies signed a pact in 1997 that led to the development of Boston Scientific's Taxus stent, which was introduced in the U.S. in March 2004. (technologyreview.com)
Researchers examined 177 coronary lesions that had been treated with either Boston Scientific Corp. 's (BSX) Taxus or the Johnson & Johnson(JNJ) subsidiary's Cypher model, retrieved from autopsies. (massdevice.com)
The study provides some welcome good news for BSX's Taxus, which took a beating in recent studies when compared with the Cypher and Abbott 's (ABT) Xience stent. (massdevice.com)
The 10 stent cases presented by Williams involved one Endeavor , one Biomatrix , one Taxus , and seven Promus Elements . (medscape.com)
Its analysis, using a specially designed bench test, found Abbott's MultiLink 8 (same design as Xience Prime ) and MultiLink Vision (same as Xience V ) stents to be associated with the greatest "compression resistance," while those of competitor Boston Scientific ( Omega --"same stent design as the Promus Element, Taxus Element , and Ion ) have the lowest. (medscape.com)
He found significant incomplete coverage in the CYPHER and TAXUS stents, but complete healing in the ENDEAVOR. (ptca.org)
For example, in March 2004, Cordis competitor Boston Scientific received FDA approval to market Taxus drug-coated heart stents. (injurylawyer.com)
Less than six months later, the company announced a partial recall of the Taxus heart stents due to safety concerns. (injurylawyer.com)
As worries mounted, the Taxus heart stent recall grew to over 100,000 recalled heart stents. (injurylawyer.com)
At least three people have died, and dozens more injured, because of serious Taxus heart stent side effects. (injurylawyer.com)
And the study throws a wide net -- all approved drug-eluting stents, Cypher (sirolimus-eluting), Taxus (paclitaxel-eluting), Endeavor (zotarolimus-eluting), and Xience (everolimus-eluting) are included, with the choice of DES and the choice of antiplatelet agent left to the discretion of physician and patient. (medpagetoday.com)
Dr. Jeffrey Popma, MD. We had two stents, the Taxus and Cypher stents. (diagnosticdetectives.com)

Initially, drug-eluting stents (DES) were compared to bare-metal stents (BMS) for efficacy. (medscape.com)
In 1996, Johnson & Johnson was the undisputed king of bare-metal stents. (technologyreview.com)
Bare-metal stents tend to re-clog more often than drug-coated stents, so physicians are quick use drug-coated stents, even in those patients with complex heart disease, not the patients in whom the devices were tested. (yourlawyer.com)
If your cardiologist prefers to use bare metal stents, I'd want to know why, as my belief is that the drug eluting kind are the "standard of care" these days. (healingwell.com)
Doctors also need to inform the patient about bare metal stents/pros and cons as both types are not without problems. (healingwell.com)
Bare metal stents does not require long term use of Plavix, the article stated. (healingwell.com)
My sister was on Plavix for 2 years with her 2 bare metal stents. (healingwell.com)
Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
The process of neoatherosclerosis occurs more rapidly, and more frequently, following deployment of drug-eluting stents than bare-metal stents. (nature.com)
Most of the 15,000 patients will be randomized to one of the drug-eluting stents, but 5,000 will be treated with bare-metal stents. (medpagetoday.com)
Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents [published online ahead of print November 1, 2006]. (jamanetwork.com)
Use of drug-eluting coronary artery stents or bare-metal stents is controversial. (diagnosticdetectives.com)
Dr. Anton Titov, MD. In which coronary artery disease situations the bare metal stents might be enough? (diagnosticdetectives.com)
The answer to the question about whether one should use drug-eluting coronary stents or bare metal stents is one that has a time component to it. (diagnosticdetectives.com)
In those circumstances patients might get bare metal stents rather than drug-eluting stents. (diagnosticdetectives.com)
Dr. Jeffrey Popma, MD. This is compared to the bare metal stents. (diagnosticdetectives.com)
In 5% when I might be using bare metal stents, I have to have a good reason for using a bare metal coronary artery stents. (diagnosticdetectives.com)
DES require antiplatelet therapy because the drug carrier polymer on DES can cause thrombus inside the stent, even years after treatment, which is why bare metal stents are still used in some patients. (dicardiology.com)

A federal appeals court says that a Johnson & Johnson heart stent does not infringe a patent held by a doctor and inventor, overturning a $482 million decision against the company. (manufacturing.net)
Once a heart stent is implanted into the heart's arteries, it becomes part of the artery itself, remaining there permanently. (injurylawyer.com)
In less than six months following FDA approval, at least 290 people had suffered life-threatening injuries and 60 people had died due to heart stent side effects . (injurylawyer.com)
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In a 5-year study of outcomes from the j-CYPHER registry which compared sirolimus-eluting stent treatment in 397 patients with ostial right coronary artery (RCA) lesions with 3716 patients with nonostial RCA lesions, researchers concluded that sirolimus-eluting stent implantation for ostial RCA was associated with a higher risk of target legion revascularization than when used in patients with nonostial RCA lesions. (medscape.com)
Incidence of thrombotic stent occlusion during the first three months after sirolimus-eluting stent implantation in 500 consecutive patients. (jamanetwork.com)

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This case also highlights the role of CT coronary angiography (CTCA) in detecting stent fracture and associated coronary occlusion and perforation. (hindawi.com)
A catheter angiography done at that time revealed total occlusion of the RCA stent, with grade III collaterals. (hindawi.com)
Possibility of doing angioplasty or stenting on a 100% total occlusion? (ptca.org)
What are the chances of occlusion reoccurring after angioplasty with stent? (ptca.org)
Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation. (jamanetwork.com)

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This is a rare case of stent fracture with perforation of the RCA. (hindawi.com)
Walsh also recommended using intravenous ultrasound (IVUS) or optical coherence tomography (OCT) imaging when a case of stent compression is suspected. (medscape.com)

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[ 1 ] which compared the sirolimus-eluting CYPHER stent with its noncoated counterpart, the BX velocity stent, in 238 patients with de novo lesions less than 18 mm in length in native coronary arteries 2.5-3.5 mm in diameter. (medscape.com)
Stents revolutionized the treatment of atherosclerosis in coronary and peripheral arteries, but they did little to address one of the chief problems with balloon angioplasty. (technologyreview.com)
Stents coated with the drug worked remarkably well in animals, keeping rat arteries clearer than uncoated control stents did. (technologyreview.com)
Tiny wire-mesh tubes, stents prop open arteries once doctors clear them of blockages. (yourlawyer.com)
Can small arteries be stented? (ptca.org)
Heart stents are mesh-wire tubes that prop open arteries affected by coronary artery disease. (manufacturing.net)
The dispute centered over drug-eluting stents, which release a drug to help keep arteries from clogging. (manufacturing.net)
One way to treat clogged arteries is through the use of heart stents. (injurylawyer.com)
Every year, when hundreds of thousands of people need procedures to unclog their arteries, the procedure is usually performed with heart stents. (injurylawyer.com)

Drug-eluting stents (DES) are a standard metallic coronary stent with a polymer coating and an antiproliferative drug, which allows drug elution into the coronary wall for weeks to months after stent implantation. (medscape.com)
Attached to the stent is a polymer that is embedded with an antiproliferative drug, which allows drug elution into the coronary wall for weeks to months after stent implantation to reduce the local proliferative healing response. (medscape.com)
Objectives: The SPIRIT Women Clinical Evaluation trial compared the durable polymer everolimus-eluting XIENCE stent (DP-EES) with the durable polymer sirolimus-eluting Cypher stent (DP-SES) in women undergoing percutaneous coronary intervention (PCI). (unimore.it)
BioMatrix NeoFlex retains the same unique combination of abluminal biodegradable polymer coating, proprietary limus drug Biolimus A9™ (BA9™) and flexible platform which has made the BioMatrix stent family an increasingly popular choice of DES in the global markets where it is available. (medgadget.com)
Dr. Jeffrey Popma, MD. This coronary artery stent has a bio-resorbable polymer that disappears over 90 days along with the medications. (diagnosticdetectives.com)
Cordis' product sprays an antibiotic-containing polymer onto the stent, and the polymer bonds at room temperature. (decodingip.com)

The powered angiographic outcome of the trial was in-stent late lumen loss (LLL) at 9 months after the index procedure. (unimore.it)

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Coronary stent fracture is a known complication of coronary arterial stent placements. (hindawi.com)
The stent itself was bent at two sites, with a complete fracture in its mid part (Figures 2 and 3 ). (hindawi.com)
A relook at the previous catheter angiography revealed the stent fracture (retrospectively), which was missed during catheter angiography. (hindawi.com)
A study of first-generation drug-eluting stents in the Journal of the American College of Cardiology shows that first-generation drug-eluting stents, especially Cordis Corp.'s Cypher, are more likely to fracture than previously thought. (massdevice.com)
Older stents, longer stents and overlapping stents all showed a greater incidence of fracture. (massdevice.com)

Following claims of inconsistent manufacturing processes and poor sales, Johnson & Johnson have announced that it will stop selling Cypher stents by the end of 2011. (wikipedia.org)
Johnson & Johnson pioneered the new generation of stents, but the $50 billion company lost its dominant market position to a partnership between medical-device company Boston Scientific of Natick, MA, and Angiotech Pharmaceuticals of Vancouver, BC. (technologyreview.com)
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The stent was completely thrombosed and the distal post-stent RCA showed faint opacification beyond the fractured site (Figures 3 and 4 ). (hindawi.com)
The mechanism of stent deformation involved the guide catheter (two cases), the guide extension (two cases), the balloon catheter (four cases), the thrombectomy catheter (one case), and distal crush (one case). (medscape.com)

Although stents provide a great benefit for those who suffer coronary artery disease, they can also cause serious and life-threatening side effects. (injurylawyer.com)
A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. (jamanetwork.com)
Bare metal stent or drug-eluting coronary artery stent. (diagnosticdetectives.com)
Coronary artery stent technology rapidly evolves. (diagnosticdetectives.com)
Limits to anticoagulation therapy, other pending procedures, and diameter of coronary artery to be stented all factor in. (diagnosticdetectives.com)
Dr. Anton Titov, MD. In which situations the drug-eluting coronary artery stents are preferable? (diagnosticdetectives.com)
There were once the early days of coronary artery stent development. (diagnosticdetectives.com)
So in coronary artery stent cases we were limited by how long we could give the dual antiplatelet therapy. (diagnosticdetectives.com)
Dr. Anton Titov, MD. Well, that was coronary artery stents in the 2003 - 2004 timeframe. (diagnosticdetectives.com)
We use the drug-eluting coronary artery stents. (diagnosticdetectives.com)
We have some other clinical trials that are ongoing right now in patients with the coronary artery Synergy stent. (diagnosticdetectives.com)

Cook and Boston Scientific were longtime competitors, but in order to make a more attractive offer to Angiotech, they had decided to band together, proposing a joint agreement that would allow both to develop paclitaxel-coated stents. (technologyreview.com)

It is hence a rare case of stable RCA perforation following stent placement. (hindawi.com)
However, the patient had recurrent angina within a month of stent placement. (hindawi.com)
DAPT or clopidogrel plus aspirin) after drug-eluting stent placement. (ptca.org)
The answer to a question with significant clinical and economic implications -- how long should dual antiplatelet therapy continue after placement of a drug eluting stent? (medpagetoday.com)
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry. (jamanetwork.com)

We will have very narrow lumen drug-eluting stents soon. (diagnosticdetectives.com)

Stents are used to help prop open a vessel treated by balloon angioplasty because of the barotrauma caused by the extreme stretching of vessel walls. (dicardiology.com)

We know if these medicines are stopped early, there are risks of blood clots forming inside the stent," she said. (yourlawyer.com)
The serious injuries and deaths of patients with Cypher heart stents are largely caused by blood clots . (injurylawyer.com)
According to the National Heart Lung and Blood Institute , between 1-2 percent of patients who undergo stent surgery develop blood clots as a side effect. (injurylawyer.com)

This page includes news on coronary stents, carotid stents , peripheral stents , bioresorbable stents , and renal stents. (dicardiology.com)

With the introduction of drug-eluting stents (DESs), the incidence of ISR has markedly decreased. (ijcdw.org)

These stents are FDA approved for single de novo coronary lesions of limited length within specific diameter size ranges. (medscape.com)
The SIRIUS trial, which included 1058 patients with workhorse lesions who were randomly assigned to either sirolimus-eluting stents or BMS, demonstrated the long-term efficacy and safety of sirolimus-eluting stents. (medscape.com)
Drug-coated stents are recommended for patients with an increased risk of suffering from reclosure, Tu said, such as those with diabetes, smaller-than-normal blood vessels, or long lesions left by heart disease. (yourlawyer.com)

Coronary stents are generally indicated to increase coronary vessel diameter in the setting of ischemia due to coronary blockage, either by a combination of acute recoil, arterial contraction of a previously treated segment, and/or local neointimal hyperplasia. (medscape.com)
Stents are the mesh tubes that prevent arterial collapse after balloon angioplasty, the principal treatment for atherosclerosis: A balloon is inserted into an artery to clear away plaque and is removed. (technologyreview.com)
Stents work on a simple principle: a balloon expands the stent to support the arterial wall and is then deflated and removed. (technologyreview.com)
In either case, stents are implanted to maintain arterial blood flow. (yourlawyer.com)

Cypher is a brand of drug-eluting coronary stent from Cordis Corporation, a Cardinal Health company. (wikipedia.org)
NEW YORK: Cordis Corporation has hired Edelman to handle PR for the company's drug-coated stent Cypher, as the device maker attempts to market the stents directly to consumers for the first time. (prweek.com)

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During a balloon angioplasty, the stent is inserted into the artery to provide a "scaffold" to open the artery. (wikipedia.org)
Then a stent containing another balloon is inserted into the artery. (technologyreview.com)

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Patents who are unable to comply with this regimen should be treated with bare-metal stent implantation," said Dr. Murtuza J. Ali, an interventional cardiology fellow at the Boston University Medical Center. (yourlawyer.com)

Mauri said the DAPT trial is the result of that request, and she explained that the study is a "unique public-private collaboration" that included eight makers of stents or antiplatelet medications. (medpagetoday.com)

In some cases, emergency surgery may even be required for removal of the stent from the artery. (injurylawyer.com)

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When a patient should still get a bare metal stent instead of drug-eluting coronary stent? (diagnosticdetectives.com)
Now I really limit my bare metal stent use to patients who have two millimeter vessels or smaller. (diagnosticdetectives.com)

Drug-eluting stents (DES) are balloon-mounted, expandable, slotted tubular or multilink scaffolds constructed of a stainless steel or cobalt chromium matrix. (medscape.com)
Some stents have a drug coating meant to keep vessels from re-clogging following balloon angioplasty procedures. (yourlawyer.com)

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J&J held a strong patent portfolio that gave it dominance in the U.S. stent market. (technologyreview.com)
Drug-eluting stents now command more than 90 percent of the $3 billion U.S. coronary-stent market, according to the Millennium Research Group. (technologyreview.com)
New stents entered the market often, and "other companies were taking market share from J&J," says Hunter. (technologyreview.com)
The FDA issued two major warnings about this product in 2003, yet heart stents remain on the market. (injurylawyer.com)
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Scar tissue causes stents to re-close in about one in five patients, who then require a follow-up procedure to remove and replace the device. (yourlawyer.com)
however, research indicates that the drug can increase the risk of too little scar tissue forming and a blood clot appearing in the stent. (yourlawyer.com)
If not enough scar tissue forms to cover the stent, the metal can create a blood clot on its own," said Dr. Jack Tu, a senior scientist at Canada's Institute for Clinical Evaluative Sciences and a professor with the University of Toronto. (yourlawyer.com)
You want some scar tissue to form around the stent, but you don't want too much to form. (yourlawyer.com)

This was seen clearly in the ODESSA trial , where Dr. Giulio Guagliumi used OCT intravascular imaging to measure stent coverage at six months. (ptca.org)

His recommendations: recross all deployed stents with care, always optimize the proximal segment, beware of long stents in tapered vessels, and watch out for wire bias/tortuosity. (medscape.com)

Anatomy12

Organisms2

Diseases31

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes5

Disciplines and Occupations1

Technology, Industry, Agriculture9

Information Science1

Health Care15

Thrombosis27

Restenosis12

202217

TAXUS12

Metal stents18

Heart stent4

Sirolimus-eluting stent impl2

Left dream market darknet link1

Occlusion5

Link to cypher market link1

Links darknet2

Case of stent2

Metaverse Inc Com1

Arteries9

Polymer6

Late lumen loss1

Crypto3

Daeva Darknet Market2

Fracture5

Johnson4

Distal2

Coronary-artery11

Paclitaxel1

Placement5

Lumen1

Prop open1

Blood clots3

Peripheral1

Incidence1

Lesions3

Arterial4

Cordis Corporation2

BKLLF1

Inserted into the artery2

Torrez market2

Treated with bare-metal1

Antiplatelet Medications1

Artery1

Onion5

Bare2

Balloon2

Alphabay market1

Deepweb1

Market60

Scar tissue4

Intravascular1

Proximal1