- The immunophilin inhibitor cyclosporin A (CsA) combines antiviral and immunomodulatory effects and is a promising candidate for COVID-19 treatment. (fraunhofer.de)
- Systemic cyclosporin A and tacrolimus are effective treatments for psoriasis. (ncl.ac.uk)
- The principal cyclosporin A and tacrolimus binding proteins cyclophilin A and FKBP12 were also expressed by keratinocytes and nonimmune cells in skin. (ncl.ac.uk)
- This is compatible with the hypothesis that cyclosporin ameliorates asthma, at least partly, by inhibition of T-lymphocyte activation. (ersjournals.com)
- In this study, we further characterize a mutant P-glycoprotein (P-gp) that has a deletion of Phe 335 and is resistant to inhibition by cyclosporins. (aspetjournals.org)
- Inhibition of this pathway in epidermal keratinocytes may account, in part, for the therapeutic effect of cyclosporin A and tacrolimus in skin diseases such as psoriasis. (ncl.ac.uk)
- Cyclosporin A (ciclosporin) Cyclosporin B Cyclosporin C Cyclosporin D Cyclosporin E Cyclosporin F Cyclosporin G Lawen A (October 2015). (wikipedia.org)
- Cyclosporin A and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor nuclear factor of activated T cells (NFAT). (ncl.ac.uk)
- We investigated whether nonimmune cells in human skin express calcineurin and NFAT1 and whether cyclosporin A and tacrolimus block activation of calcineurin/NFAT in epidermal keratinocytes. (ncl.ac.uk)
- We assessed calcineurin/NFAT activation in cultured keratinocytes by measuring the degree of nuclear localization of calcineurin and NFAT1 using immunofluorescence/confocal microscopy and assessed if cyclosporin A and tacrolimus blocked nuclear translocation of these proteins. (ncl.ac.uk)
- Agonists that induce keratinocyte differentiation, specifically 12:0-tetradecanoyl-phorbol-13-acetate (TPA) plus ionomycin, TPA, and raised extracellular calcium, induced nuclear translocation of NFAT1 and calcineurin in keratinocytes that was inhibited by pretreatment with cyclosporin A or tacrolimus. (ncl.ac.uk)
- Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. (ox.ac.uk)
- We assessed the effect of a range of intravenous cyclosporin A doses upon axonal injury attenuation to determine the ideal dose. (usuhs.edu)
- Rats were subjected to experimental TBI and given one of five intravenous doses of cyclosporin A. At 3 h post-injury, brains were processed for brain tissue cyclosporin A concentration. (usuhs.edu)
- Intravenous administration produced therapeutic levels of cyclosporin A in brain parenchyma. (usuhs.edu)
- Intravenous cyclosporin A administration achieves therapeutic levers in brain parenchyma and 10 mg/kg is the most effective dose in attenuating axonal damage after traumatic brain injury. (usuhs.edu)
- Cyclosporin A-induced central neurotoxicity has been rarely reported in patients with nephrotic syndrome. (chikd.org)
- Further experience with a variety of high-risk patients have reinforced this early experience, showing few kidneys lost to rejection and low incidence of infectious complications using cyclosporin-A and low dose steroid combination. (pitt.edu)
- Background: Cyclosporin (CsA) dose selection is complicated by significant pharmacokinetic variability between patients. (uri.edu)
- Cyclosporin A, given as a single-dose intrathecal bolus, has previously been shown to attenuate mitochondrial damage and reduce axonal injury in experimental TBI. (usuhs.edu)
- Cyclosporin H is a potent and selective formyl peptide receptor antagonist. (rspharmchem.com)
- The cyclic undecapeptide, cyclosporin (Cs) H, is a potent inhibitor of FMLP-induced superoxide anion (O2-) formation in human neutrophils. (rspharmchem.com)
- The microbial products cyclosporin A (CsA), FK506 and rapamycin are potent immunosuppressive agents. (ox.ac.uk)
- This study was performed to examine the effect of cyclosporin A (CsA) on acute exacerbation of IPF. (go.jp)
- Theophylline: A new concept of nephroprotection in acute cyclosporin a nephrotoxicity? (uni-luebeck.de)
- In a recent randomized, cross-over trial we showed that cyclosporin, an inhibitor of T-lymphocyte activation, improved lung function in patients with chronic severe asthma. (ersjournals.com)
- These data demonstrate that in patients with chronic severe asthma, cyclosporin therapy which results in clinical improvement is associated with a decrease in serum concentrations of sIL-2R. (ersjournals.com)
- Summary: The mechanisms responsible for cyclosporin-induced encephalopathy remain controversial. (ajnr.org)
- Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. (ox.ac.uk)
- Cyclosporin A has emerged as a promising therapeutic agent in traumatic brain injury (TBI), although its precise neuroprotective mechanism is unclear. (usuhs.edu)
- Patients treated with cyclosporin A should have their blood pressure and renal function monitored regularly. (gpnotebook.com)
- To investigate the effect of cyclosporin A (CsA) on baroreceptor reflex and renal function. (vin.com)
- To investigate whether changes in serum sIL-2R concentration could be related to clinical response we prospectively compared serum sIL-2R concentrations in patients during cyclosporin and placebo treatment. (ersjournals.com)
- Peripheral venous blood was obtained from 22 patients during the last 4 weeks of both the cyclosporin and placebo treatment periods and serum stored at -80 degrees C pending measurement of sIL-2R concentration by enzyme immunoassay. (ersjournals.com)
- The decreases in serum sIL-2R concentrations associated with cyclosporin therapy in these patients correlated with the percentage increases in their morning peak expiratory flow rate (PEFR) measurements on cyclosporin as compared with placebo. (ersjournals.com)
- The bioavailability of cyclosporin A is dependent on the presence of bile salts which may be reduced in patients with liver transplantation. (gpnotebook.com)
- Cyclosporin A and steroid was compared to Imuran and prednisone in a prospective, randomized study of patients undergoing primary cadaver renal transplantation. (pitt.edu)
- The aim of this study was to evaluate the incidence of neurological manifestations of Behçet's disease (BD) in patients on cyclosporin A (CSA) compared with those on other medications. (uni-luebeck.de)
- Mean serum concentrations of sIL-2R were significantly lower on cyclosporin therapy (560 U.ml-1) as compared with placebo (676 U.ml-1). (ersjournals.com)
- The use of cyclosporin A (CsA) in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. (portlandpress.com)
- Clinical review: topical ophthalmic use of cyclosporin A. (irosacea.org)
- Cyclosporin A (CsA) has shown promising results as a immunosuppresive agent in the cat for the treatment of eosinophilic plaque and granulomas, allergic cervico-facial pruritus, feline atopy and other immune-mediated dermatoses. (uky.edu)
- Gulati, AK & Zalewski, AA 1982, ' Further studies on the immunosuppressive effect of Cyclosporin-A on nerve and muscle allografts ', Anatomical Record , vol. 202, no. 3, pp. 72a. (elsevierpure.com)
- Effect of cyclosporin a on murine natural killer cells. (jax.org)
- This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. (montclair.edu)
- The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. (nih.gov)
- We hypothesised that, in view of the predominant T cell nature of LIP, cyclosporin A would be a more appropriate choice of immunosuppressive agent and report the first case of its successful use in a woman with LIP associated with CVID. (ox.ac.uk)
- The cyclosporins are a group of macrolides isolated from fungi and used as immunosuppresant drugs, for example after transplant surgery. (wikipedia.org)
- Graft survival was superior in the cyclosporin-A-treated group, with 1-year kidney function of 92% and less infections. (pitt.edu)
- Administration of cyclosporin after syngeneic bone marrow transplantation paradoxically elicits a T lymphocyte-dependent autoaggression syndrome termed syngeneic graft-vs-host disease (SGVHD). (johnshopkins.edu)
- This problem however has been significantly reduced since the advent of a micro-emulsion formulation of cyclosporin whose absorption is independent of bile in the small intestine. (gpnotebook.com)
- These characteristics were used to develop an assay for antiviral compound screening in 96-well format, which was used to identify cyclosporin A as an inhibitor of MERS-CoV replication in cell culture. (microbiologyresearch.org)