Cyclophosphamide in solid tumor. Medical search. Frequent questions

Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
Objective: The purpose of this study was to test the potential of Carfilzomib (CFZ), a proteasome inhibitor, in refractory pediatric solid tumors which is currently unknown. (eurekaselect.com)
Methods This ongoing first-in-human, dose escalation, multi-indication trial enrolls HLA-A*02:01- and PRAME-positive recurrent and/or refractory solid cancer patients, who failed all available standard treatments. (bmj.com)
Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors. (utsouthwestern.edu)
This study evaluates the use of carfilzomib in combination with cyclophosphamide and etoposide for children with relapsed/refractory solid tumors or leukemia. (thirdopinion.io)
However, this drug is not approved to treat children with relapsed/refractory solid tumors or leukemia. (thirdopinion.io)
With this research, we plan to determine the DLTs and MTD of Carfilzomib given in combination with cyclophosphamide and etoposide in pediatric patients with relapsed/refractory leukemias and solid tumors. (thirdopinion.io)
Currently, refractory lymphoma or advanced solid tumors have an unfavorable prognosis as conventional therapies are often not curative while providing high levels of toxicity. (biomedcentral.com)

Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
The incidence of acute myeloid leukemia following treatment of neuroblastoma is rare, however, only recently have patients with neuroblastoma received high doses of leukomogenic agents like etoposide and cyclophosphamide. (oncolink.org)
This study looks at how well a medicine called carfilzomib works with other drugs called cyclophosphamide and etoposide to treat children with cancer that has come back or didn't go away after treatment. (thirdopinion.io)
The medications cyclophosphamide and etoposide are standard drugs often used together for the treatment of cancer in children with solid tumors or leukemia. (thirdopinion.io)

Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (survivornet.com)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
Treatment involves maximal safe tumor resection, craniospinal irradiation, and high-dose chemotherapy. (biomedcentral.com)
For example, alkylating chemotherapy medications such as cyclophosphamide are associated with acute myeloid leukemia that commonly occur four to seven years after treatment and have abnormalities of chromosomes 5 and/or 7. (oncolink.org)
As SCLC is a very chemosensitive tumour, rapid responses, with symptomatic improvement, are often seen with chemotherapy. (ersjournals.com)
The main use of cyclophosphamide is with other chemotherapy agents in the treatment of lymphomas , some forms of brain cancer , leukemia [ 3 ] and some solid tumors. (curecrowd.com)
4 Importantly, once a tumour has disseminated and metastasised, chemotherapy is the only of the three treatment options mentioned above that can be applied systemically, immunotherapy being an additional future option. (touchoncology.com)
Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)

Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Immunotherapy with monoclonal antibodies, such as ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (survivornet.com)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
Among the different approaches of anti-tumor adoptive cell transfer, allogeneic stem cell transplantation (allo-SCT) represents the first and most consolidated form of immunotherapy on the basis of its graft versus tumor (GvT) effect. (biomedcentral.com)

Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)

Background: Most children with recurrent metastatic solid tumors have high mortality rates. (eurekaselect.com)

This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Evaluate the influence of anti-CTLA4 on the induction of T cells to non-targeted tumor-associated antigens (antigen-spreading) following adoptive transfer antigen-specific CTL, and the correlation of these responses with clinical outcome. (survivornet.com)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
GEN-011 is made up of CD4+ and CD8+, which are NPTs that are specific for up to 20 antigens designed to limit tumor escape. (cgtlive.com)

And while physicians argue over the (unlikely) risk for solid tumors, lymphoma, or melanoma with anti-TNF agents, these drugs do confer increased risk for nonmelanoma skin cancer . (medscape.com)
Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)

Single agent: oral cyclophosphamide is usually administered at dosages in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. (wikidoc.org)

This target was selected due to homogenous expression and exceptionally high target peptide density per tumor cell (assessed by quantitative mass spectrometry), two features we hypothesize to be critical determinants of anti-tumor activity in TCR-T trials. (bmj.com)
Secondary objectives are to evaluate the anti-tumor activity and pharmacodynamics using molecular and immunological methods. (bmj.com)

This phase II trial studies the side effects and how well white blood cells taken from person's own (autologous) cluster of differentiation (CD)8+ antigen-specific T cells, cyclophosphamide, aldesleukin, and ipilimumab work in treating patients with melanoma that has spread to another place in the body. (survivornet.com)
Giving autologous CD8+ antigen-specific T cells with cyclophosphamide, aldesleukin, and ipilimumab may be an effective treatment for patients with metastatic melanoma. (survivornet.com)
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial. (moffitt.org)

I. Evaluate the safety and efficacy of adoptively transferred cytotoxic T-lymphocytes (CTL) targeting melanoma tumors combined with anti-CTLA4. (survivornet.com)
The solid tumors being assessed in the study include melanoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, urothelial carcinoma, small cell lung cancer, cutaneous squamous cell carcinoma, or anal squamous cell carcinoma. (cgtlive.com)

This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
Background Adoptive cell therapy demonstrated significant clinical benefit in patients with hematological malignancies but results in most solid tumors have been less encouraging so far. (bmj.com)
Several protocols of adjuvant therapies based on NK cell allo-reactivity have been extensively used in clinics for both hematologic and non-hematologic malignancies either alone or in combination with antibodies and tumor-sensitizing drugs. (biomedcentral.com)
6. Malignancies, including a history thereof, with the exception of cured basal cell carcinoma, cervical cancer in situ, as well as cured solid tumors with a remission of more than 5 years. (who.int)

After lymphodepletion with fludarabine and cyclophosphamide, T cells are infused, followed by low-dose IL-2. (bmj.com)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

Methods: A panel of pediatric solid tumor cell lines, including neuroblastoma, Ewing's sarcoma, osteosarcoma, rhabdomyosarcoma and atypical teratoid rhabdoid tumor (ATRT), was used to evaluate the cytotoxic and proteasomal inhibitory effects of CFZ. (eurekaselect.com)
This study provides initial in vitro data on the potential of CFZ to treat pediatric solid tumors and supports further investigations into the components of drug scheduling, biological correlates and drug combinations for future early phase clinical trials in children. (eurekaselect.com)

The traditional procedure of TIL production is assayed for specific tumor recognition and usually takes 6-8 weeks. (biomedcentral.com)
With increasingly high therapeutic efficacy being achieved recent years and owing to the unique features such as specific tumor tropism, low cytotoxicity against normal cells, OVT has been inviting a great attention as an ideal weapon against cancers. (biomedcentral.com)

It is well known that all these low-dose schedules have a favorable safety profile and may provide an adequate tumor control in patients with metastatic breast cancer. (scirp.org)
Patients must have adequate tumor tissue available for PD-L1 testing. (bcan.org)

The team also worked to deliver the CAR T cells directly to the tumor site using regional delivery techniques. (aacr.org)
Biological therapies, such as aldesleukin, use substances made from living organisms that may stimulate the immune system in different ways and stop tumor cells from growing. (survivornet.com)
Recent studies have shown that proteasome inhibition leads to effective tumor killing in cells that have acquired treatment resistance and metastatic properties. (eurekaselect.com)
In the IMA203 trial we are treating advanced solid cancer patients utilizing TCR-engineered T cells (TCR-T) directed against an HLA-A*02-restricted peptide derived from the highly prevalent cancer testis antigen PRAME. (bmj.com)
Absolute IMA203 doses infused ranged from 0.08 to 0.81x10 9 transduced CD8 T cells per patient, which to our knowledge did not lead to anti-tumor responses in other TCR-T trials. (bmj.com)
Robust engraftment of T cells was observed in all patients and tumor infiltration by TCR-modified T cells was demonstrated in patients with evaluable on-treatment biopsies. (bmj.com)
Conclusions To our knowledge IMA203 is the first TCR-T product candidate that induced frequent tumor responses across multiple solid cancers using transduced T cells at doses below 1 billion and has a manageable safety profile. (bmj.com)
Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
Currently, the most widely-used TIL production method is to isolate infiltrating lymphocytes from tumor tissues and then culture and expand these cells in vitro. (biomedcentral.com)
The agents have minimal non-tumor-specific bystander cells, and do not contain Inhibigen-specific cells that may be detrimental to clinical response. (cgtlive.com)
Other end points include immune cell phenotyping, epitope spread, and tumor-infiltrating immune cells. (cgtlive.com)
We believe our GEN-011 therapy employs better targeting - using our ATLAS™ platform to select optimal neoantigen targets that drive anti-tumor immune responses and avoid immunosuppressive Inhibigens™ - and better T cells, derived from easily accessible peripheral blood as opposed to the tumor itself. (cgtlive.com)
With the understanding particularly in the characteristics of viruses and tumor cells, numerous innovative OVs have been engineered to conquer cancers, such as Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401). (biomedcentral.com)
OVT has its unique advantages and prospects, because oncolytic viruses (OVs) preferentially infect and replicate in tumor cells and destroy them, while leaving healthy cells largely untouched [ 7 ]. (biomedcentral.com)
Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
The novelty of our study is that the CAR T cells target the cancer cell-surface protein, mesothelin, which is expressed on the majority of cancer cells, and they are delivered directly to the tumor site using regional delivery techniques," Adusumilli said. (healthmedicinet.com)
After cyclophosphamide preconditioning, IcasM28z CAR T cells were injected directly into the pleural cavity using an interventional radiology procedure. (healthmedicinet.com)
CAR T cells were found to be persistent in the peripheral blood of 13 patients during the 38-week evaluation, and their presence was associated with more than 50 percent decrease in the levels of a mesothelin-related peptide in the blood and evidence of tumor regression on imaging studies. (healthmedicinet.com)
In preclinical studies, the researchers found that in large tumors, the CAR T cells became functionally exhausted even while residing in the tumor. (healthmedicinet.com)
Treatment with anti-PD-1 agents could reactivate the exhausted CAR T cells and eradicate the tumors in a proportion of mice. (healthmedicinet.com)
Radiation therapy uses high-energy x-rays to kill tumor cells. (ucbraid.org)
Indeed, the use of check-point inhibitors, T cells with engineered chimeric antigen receptors (CARs) and bi-specific T cell engagers (BiTE) showed impressive therapeutic potentials in the cure of advanced tumors and are currently being included in the in the armamentarium of clinicians [ 1 ]. (biomedcentral.com)
In the early 80s' donor lymphocyte infusions (DLI) with allo-activated haplo-identical cells from family members were infused in patients affected by hematological diseases or solid tumors. (biomedcentral.com)
Important insights into NK cell function in cancer eradication originated from the knowledge gained from mismatched NK cells in allo-SCT setting, where these innate immune effectors mediate a remarkable graft-versus-leukemia (GvL) effect towards tumor cells of recipient without attacking their normal tissues, thus limiting the onset of GVHD. (biomedcentral.com)
Moreover, it has been demonstrated HLA-mismatched NK cells in haploidentical allo-SCT improve the overall survival of patients affected by acute myeloid leukemia by controlling tumor relapse without causing GVHD. (biomedcentral.com)
Applying Darwinian principles to tumour heterogeneity helps to define alternative therapeutic end points, while targeting microenvironmental interactions between mutated tumour cells and their surroundings provide a genetically more stable target. (touchoncology.com)
If the estrogen receptor (ER) is present in breast cancer cells, estrogen enters into tumor cells and binds with ER, promoting mRNA and DNA synthesis of tumor cells, stimulating tumor cell growth. (lookchem.com)
It was developed to overcome drug resistance, partly by shifting the therapeutic target from tumor cells to the tumor vasculature, with less toxicity. (unica.it)

Methods: We retrospectively analyzed 40 patients with metastatic breast cancer treated with low doses of Cyclophosphamide and/or Methotrexate and/or Capecitabine in a single center from June 2009 to April 2014. (scirp.org)
The most frequent drugs administered were cyclophosphamide, methotrexate and capecitabine alone. (scirp.org)
Also used in some autoimmune disorders such as rheumatoid arthritis (cyclophosphamide, methotrexate). (unboundmedicine.com)

KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)

Used in the treatment of various solid tumors, lymphomas, and leukemias. (unboundmedicine.com)

Cyclophosphamide ( INN , trade names Endoxan , Cytoxan , Neosar , Procytox , Revimmune ), also known as cytophosphane , is a nitrogen mustard alkylating agent , from the oxazophorines group. (curecrowd.com)

A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
In the last few years, a renewed interest on adoptive cellular therapies emerged in the field of tumor-immunology due to the remarkable advances in regard to our knowledge of the mechanisms employed by immune system to fight cancer counterbalanced by the pathogenic loops deployed by tumors to escape immune responses. (biomedcentral.com)

If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
Historically, most cytotoxic treatment regimens have been developed to be used at its maximum tolerated dose (MTD), in order to achieve better tumor control. (scirp.org)
Cyclophosphamide is a antineoplastic , immunosuppressive agent that is FDA approved for the treatment of malignant diseases , minimal change nephrotic syndrome in pediatric patients. (wikidoc.org)
Late Effects of Treatment for Brain Tumors. (utsouthwestern.edu)
For pre-treatment archival tissue, representative urothelial carcinoma FFPE tumor specimens (tumor blocks or 30 unstained slides) must be provided. (bcan.org)
The scientists have been pursuing the ideal tumor prevention and treatment strategies all the time. (biomedcentral.com)
At that time, the application of tumor treatment with the spontaneous viruses or wild type viruses which quite often being scavenged by immune system, merely induces a subtle inhibition to tumor progression in patients. (biomedcentral.com)
Patients with advanced-stage solid tumors, such as mesothelioma, and lung and breast cancers, that are metastatic to the chest cavity have poor outcomes despite treatment," said Prasad S. Adusumilli, MD, deputy chief of thoracic surgery at Memorial Sloan Kettering Cancer Center (MSK). (healthmedicinet.com)
KEYTRUDA is approved for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (businesswire.com)
The present review addresses the systemic tumour-directed treatment of ES-SCLC. (ersjournals.com)
For example, systemic lupus erythematosus with severe lupus nephritis [ 5 ] may respond to pulsed cyclophosphamide (in 2005, however, standard treatment for lupus nephritis changed to mycophenolic acid from cyclophosphamide). (curecrowd.com)
Finally, we discuss the possible role of tumour-associated macrophages in future treatment options. (touchoncology.com)

The levels of serum or urine beta-hCG are good tumor marker for the progression or remission of disease. (atlasgeneticsoncology.org)
Study of the MIB-1 labeling index as a predictor of tumor progression in pilocytic astrocytomas in children and adolescents. (utsouthwestern.edu)
The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)

This will be completed after the patient had undergone a ludarabine/cyclophosphamide lymphodepletion regimen. (cgtlive.com)

The nongestational type is as a component of a mixed germ cell tumor and a pure ovarian choriocarcinoma is a very rare malignant tumor. (atlasgeneticsoncology.org)
Nongestational choriocarcinoma arises in women under 40 years old because of germ cell tumor, and the frequency is reported less than 0.6% of all ovarian tumors. (atlasgeneticsoncology.org)

indicate tative comparisons of carcinogens been narrowed and their therapeutic that no agents classified as carci- with respect to potency in humans use has declined, with the possible nogenic to humans (Group 1) are and in experimental animals are exception of cyclophosphamide. (who.int)

The ORAL Surveillance study demonstrated that tofacitinib (Xeljanz) at any dose conferred an increased risk for malignancy, compared with anti-tumor necrosis factor (TNF) agents. (medscape.com)

The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
Conclusion: CFZ showed cytotoxic activity against all the solid pediatric cancer cell lines tested. (eurekaselect.com)

Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. (biomedcentral.com)

This is COOL SCIENCE: Cristae inside mitochondria (purple) align themselves to keep 'feeding' certain lung cancer tumors. (cancer.org)
Cyclophosphamide increases the risk for bladder cancer, myelodysplastic syndrome, and myeloproliferative disorders. (medscape.com)
Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. (utsouthwestern.edu)
Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience. (viictr.org)
Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. (biomedcentral.com)
As the most common malignant brain cancer in children, medulloblastoma (MB) accounts for 20% of CNS tumors and occurs most commonly in the pediatric population, particularly in those younger than 15 years of age [ 4 , 5 ]. (biomedcentral.com)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
Recent data suggest that the tumour, node, metastasis classification traditionally reserved for the staging of nonsmall cell lung cancer (NSCLC) can also be applied for the staging of SCLC 3 . (ersjournals.com)
An additional source of quantita- erations for compounds that cause of tumour-free animals by 50% (Gold tive data on cancer risks is the group cancer in experimental animals. (who.int)
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)

HS-130 is in Phase I clinical trial for patients with solid tumors. (wikipedia.org)
Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials. (utsouthwestern.edu)
OVs, which are advancing into clinical trials, are being envisioned as the frontier clinical anti-tumor agents coming soon. (biomedcentral.com)

TIL therapy is a type of adoptive cellular therapy leveraging the patient's own immune system to treat tumors. (biomedcentral.com)

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in patients with advanced solid tumors. (ucbraid.org)

HS-110, also called viagenpumatucel-L, is in Phase II in NSCLC, in combination with cyclophosphamide. (wikipedia.org)

Neuroblastoma is the most common solid childhood tumor occurring outside the brain. (oncolink.org)

1970. Tumors of the urinary bladder: An analysis of the occupations of 1030 patients in Leeds, England. (cdc.gov)

PAVO is an open-label Phase II study investigating if the study drug, a PARP inhibitor called niraparib (Zejula), is safe and effective for certain people who have been diagnosed with an advanced solid tumor with either an inherited or tumor PALB2 mutation. (facingourrisk.org)

Beginning 48 to 72 hours prior to T cell infusion, patients receive cyclophosphamide intravenously (IV) over 30-60 minutes. (survivornet.com)
This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
In nongestational choriocarcinoma, no factors have been associated with the etiology of germ cell tumor, apart from an increased incidence associated with dysgenetic gonads. (atlasgeneticsoncology.org)
After tumor excision from the patient, tumor is digested into small fragments or a single cell suspension and then expanded in culture with IL-2. (biomedcentral.com)
The trial is evaluating safety, tolerability, and efficacy of GEN-001, a next-generation neoantigen adoptive cell therapy, on solid tumors . (cgtlive.com)

I. Evaluate the influence of anti-CTLA4 on the duration of in vivo persistence and anti-tumor efficacy achieved following adoptive transfer of antigen-specific CTL. (survivornet.com)

The most common underlying diseases were neurologic disorders, such as cerebrovascular disease and motor neuron disease (3 patients), followed by diabetes mellitus (2 patients) and solid tumor (1 patient) (1 patient had both motor neuron disease and diabetes mellitus). (cdc.gov)
Cyclophosphamide also decreases the immune system's response to various diseases and conditions. (curecrowd.com)

It also tests whether combination of selinexor and standard radiation therapy works to shrink tumors in this patient population. (ucbraid.org)

Anatomy11

Organisms8

Diseases81

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Health Care14

Refractory8

Etoposide4

Chemotherapy8

Immunotherapy4

Microenvironment1

Recurrent1

Antigens5

Lymphoma2

Oral cyclophosphamide1

Anti-tumor activity2

Autologous3

Melanoma2

Malignancies4

Fludarabine2

Pediatric solid2

Specific tumor2

Adequate tumor2

Cells30

Methotrexate3

Endometrial carcinoma3

Leukemias1

Cytoxan1

Therapies5

Treatment12

Progression3

Lymphodepletion1

Ovarian2

Therapeutic1

Necrosis1

Cytotoxic2

Tissues1

Cancer10

Clinical3

Patient's1

Dose1

NSCLC1

Neuroblastoma1

Bladder1

Study1

Cell5

Evaluate1

Diseases2

Combination1