DoxorubicinChemotherapyMedicationsMethotrexateInterfereWorks by damaging thAssessWidelyDosesPatientsCancer cellsClinicalAlkylating agentsCellularCellsGenerallyGrowthBreastResultDose of epirubicinDocetaxelHydrochloride InjectionTrastuzumabToxicityPatientsBiomarkersCancerTreatmentParticipantsEnterRiskIncrease
Doxorubicin3
- Representatives of the anthracyclines are doxorubicin and epirubicin . (drsymptoms.com)
- The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
- In the use of chemotherapy drugs, anthracyclines, such as doxorubicin and epirubicin, are generally used in combination with drugs such as cyclophosphamide, epirubicin, and fluorouracil. (encyclopedia.pub)
Chemotherapy3
- Some chemotherapy ("chemo") drugs damage the genetic material of the cells. (healthline.com)
- For example, alkylating chemotherapy medications such as cyclophosphamide are associated with acute myeloid leukemia that commonly occur four to seven years after treatment and have abnormalities of chromosomes 5 and/or 7. (oncolink.org)
- In contrast, the topoisomerase class of chemotherapy drugs that include adriamycin and etoposide cause acute myeloid leukemia quicker and with different genetic alterations. (oncolink.org)
Medications1
- The recommended dose of epirubicin varies widely according to the specific condition being treated, the response to therapy, the other medications being used, and the body size of the recipient person receiving treatment. (medbroadcast.com)
Methotrexate1
- Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Interfere1
- As well as interfering with the genetic material DNA of cancer cells, epirubicin can interfere with some of your normal cells. (medbroadcast.com)
Works by damaging th1
- It works by damaging the genetic material (DNA and RNA) of the cancer cells. (healthcaresurety.com)
Assess1
- Regardless of assumptions about the genetic model of tom clancy's rainbow six siege aim lock trait, or the technology used to assess genetic variation, no genetic study will have meaningful results without a thoughtful approach to characterize the phenotype of interest. (gov.np)
Widely3
- Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. (researchwap.com)
- Many natural products have been widely reported to ameliorate at varying degrees the side effects of oxazophosphorines e.g. cyclophosphamide and ifosphamide (Łukasz and Piotr, 2012). (researchwap.com)
- Cyclophosphamide, [2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxzaphosphorine-2- oxide] is one of the most effective and widely used cytotoxic antitumor agents. (researchwap.com)
Doses1
- The incidence of acute myeloid leukemia following treatment of neuroblastoma is rare, however, only recently have patients with neuroblastoma received high doses of leukomogenic agents like etoposide and cyclophosphamide. (oncolink.org)
Patients3
- an organization that supports research, educational materials and programs, and offers many other services to cancer patients and their families. (thewomenofhope.org)
- MATERIALS AND METHODS:This study included a total of 47 consecutive Japanese mCRPC patients treated with cabazitaxel and assessed the prognostic significance of cabazitaxel, focusing on patient age and the correlation of efficacy between docetaxel and cabazitaxel. (shengsci.com)
- Combining sequential treatment options, evolving treatment options, and advanced genetic and genomic testing along with shared decision making between patients and physicians, this review aims to outline the key factors that ultimately drive the decisions for treatment in hormone-positive metastatic breast cancer. (amegroups.org)
Cancer cells4
- As so-called "antitumor antibiotics", similar to conventional antibiotics in bacteria, they break apart the genetic material in the cancer cells and it change the cell membrane. (drsymptoms.com)
- Epirubicin prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (medbroadcast.com)
- It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. (healthcaresurety.com)
- It works by inhibiting the genetic material's development (DNA) in a cell (cancer cell), thereby stopping cancer cells from dividing. (ygiispharma.com)
Clinical1
- The clinical and genetic findings of the acute myeloid leukemia cases were consistent with what is described in the literature for treatment related acute myeloid leukemia. (oncolink.org)
Alkylating agents1
- A representative of the alkylating agents is cyclophosphamide . (drsymptoms.com)
Cellular2
- Malignant tumor, characterized by strengthened and unlimited cell division during the cellular genetic process [ 1 ], is the leading cause of death in the world. (jcancer.org)
- It can be inherented, as a genetic mutation, or it can be acquired, as a cellular response to drug exposure. (savedelicious.com)
Cells2
- The active ingredients are primarily aimed against the genetic material of those cells that are in the growth phase and have active division. (drsymptoms.com)
- On account of mutations in the DNA, normal breast cells become cancerous and while many are genetic, others result from DNA changes to breast cells acquired during one's life. (healthresource4u.com)
Generally1
- It is generally used in the production of thin sheet and wire where cold working is used to produce material to very close tolerances. (gov.np)
Growth1
- The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (wikipedia.org)
Breast3
- Using genetic mouse-models, we and others identified the RANKL/RANK system as a key regulator of sex hormone, BRCA1 -mutation, and oncogene-driven breast cancer and we proposed that RANKL/RANK might be involved in the initiation of breast tumors. (oncotarget.com)
- Breast cancer is likely caused by a complex interaction of genetic makeup and environment. (rxwiki.com)
- Testing eventually showed she had no genetic markers for breast cancer. (lbbc.org)
Result1
- These characteristics are caused by altered gene expression, as a result of genetic mutations that inactivate tumour suppressor genes and / or activate oncogenes. (savedelicious.com)
Dose of epirubicin1
- The recommended dose of epirubicin varies widely according to the specific condition being treated, the response to therapy, the other medications being used, and the body size of the recipient person receiving treatment. (mediresource.com)
Docetaxel1
- Of the chemotherapeutic regimens of EC (epirubicin + cyclophosphamide), TC (docetaxel + cyclophosphamide), TEC (docetaxel + epirubicin + cyclophosphamide), and EC-T(H) [epirubicin + cyclophosphamide-docetaxel and/or trastuzumab], EC regimen had the least adverse impact on BMD, while the EC-TH regimen reduced BMD most (P (bvsalud.org)
Hydrochloride Injection3
- Epirubicin Hydrochloride Injection by Accord is no longer being manufactured for sale in Canada. (mediresource.com)
- These highlights do not include all the information needed to use Epirubicin Hydrochloride Injection safely and effectively. (nih.gov)
- See full prescribing information for Epirubicin Hydrochloride Injection. (nih.gov)
Trastuzumab1
- then 12 weeks with epirubicin (90 mg/m(Two)/3 several weeks), cyclophosphamide (Six-hundred mg/m(Only two)/3 several weeks), along with trastuzumab prior to surgical procedure. (raf-signal.com)
Toxicity2
- Polymorphisms involving the target mechanism, such as polymorphisms in folate metabolizing enzymes, polymorphisms in DNA repair systems, and those influencing cytokine activity, APOE, and COMT polymorphisms could be important genetic determinants of the risk of chemotherapy-induced CNS toxicity. (medscape.com)
- Research in patients treated with a MTX-based regimen is especially recommended, as MTX most frequently causes central neurotoxicity, and several polymorphisms in the folate metabolic pathway have been proposed as genetic determinants of MTX-induced CNS toxicity. (medscape.com)
Patients2
- To assess the impact of single-nucleotide polymorphisms (SNPs) on predefined severe adverse events in breast cancer (BC) patients receiving (neo-)adjuvant 5-fluorouracil (FU), epirubicin and cyclophosphamide (FEC) chemotherapy. (nih.gov)
- In these patients, prechemotherapy and follow-up measurements of neuropsychological performance, MRI, PET, genetic profiles and biomarkers particularly relevant for the proposed target, but also for the transporter mechanisms, have to be analyzed. (medscape.com)
Biomarkers1
- particularly by exploring biomarkers using genetic approaches or establishing therapeutic strategies based on the response to early treatment. (biomedcentral.com)
Cancer7
- Setting the stage for the panel's consideration of the draft monograph, Dr. Howdeshell presented introductory material regarding the incidence of cancer chemotherapy during pregnancy, the sources of literature reviewed in the preparation of the draft monograph, the purpose of the monograph, and the five health outcomes focused on within the document. (nih.gov)
- Their study used a pioneering genetic technique to analyse maps of DNA regions linked to an inherited risk of breast cancer and identify the actual genes involved in raising a woman's risk. (breastcancer.org)
- Dr Olivia Fletcher, Team Leader in Functional Genetic Epidemiology at The Institute of Cancer Research, London, said: "Our study took the high-level maps of breast cancer risk regions and used them to pull out specific genes that seem to be associated with the disease. (breastcancer.org)
- We urgently need to unravel how the genetic changes in the building blocks of our DNA influence a woman's risk of breast cancer, and this study adds another vital piece to this jigsaw. (breastcancer.org)
- Epirubicin prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. (mediresource.com)
- As well as interfering with the genetic material DNA of cancer cells, epirubicin can interfere with some of your normal cells. (mediresource.com)
- The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (wikipedia.org)
Treatment2
- Ultimately, our study could pave the way for new genetic tests to predict a woman's risk, or new types of targeted treatment. (breastcancer.org)
- Serum total bilirubin and AST levels should be evaluated before and during treatment with epirubicin hydrochloride. (nih.gov)
Participants2
Enter1
- Materials that provide us with key metabolites enter our body as food. (cancerquest.org)
Risk1
- Certain genetic conditions increase the risk of childhood medulloblastoma. (oncolink.org)
Increase1
- We've seen some positive gains, including an increase in the number of young women accessing genetic counseling and testing, but we cannot rest until those gains are seen across all groups of women impacted by the disease. (lbbc.org)