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  • mycophenolate
  • Chlorambucil Cyclosporine Tacrolimus Cyclophosphamide Mycophenolate mofetil Rituximab Perhaps the most difficult aspect of membranous glomerulonephritis is deciding which people to treat with immunosuppressive therapy as opposed to simple "background" or anti-proteinuric therapies. (wikipedia.org)
  • dose
  • Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair and lethargy. (wikipedia.org)
  • High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. (wikipedia.org)
  • When given on days 3 and 4 after HLA-haploidentical T-cell replete blood or marrow transplantation, high-dose cyclophosphamide depletes dividing alloreactive T-cells, resulting in low rates of acute graft -versus- host disease, comparable to HLA-matched transplantation, and chronic graft -versus- host disease incidence below that seen with T-cell replete HLA-matched transplantation. (springer.com)
  • Depending on the dose and length of time you have been on cyclophosphamide, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. (drugs.com)
  • Not more than 20% of injected cyclophosphamide was excreted intact in urine at any dose level. (aacrjournals.org)
  • Although patients with and without prior exposure to microsomal enzyme-inducing drugs demonstrated marked variation in plasma cyclophosphamide half-life and peak alkylating levels, the total concentration × time product remained relatively constant for a given cyclophosphamide dose, suggesting that alterations in the rate of cyclophosphamide metabolism by drugs or liver metastases in the absence of renal failure will not change toxicity or therapeutic effect. (aacrjournals.org)
  • toxic
  • It has not been demonstrated that any single metabolite is responsible for either the therapeutic or toxic effects of cyclophosphamide. (nih.gov)
  • pregnancy
  • Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women ( pregnancy category D) except for life-threatening circumstances in the mother. (wikipedia.org)
  • Disease
  • In children whose disease fails to respond adequately to appropriate adrenocorticosteroid therapy or in whom the adrenocorticosteroid therapy produces or threatens to produce intolerable side effects, cyclophosphamide may induce a remission. (nih.gov)
  • Cyclophosphamide is not indicated for the nephrotic syndrome in adults or for any other renal disease. (nih.gov)
  • doctor
  • If you are currently being treated or have recently been treated with cyclophosphamide, you should let your doctor know before receiving smallpox vaccine. (drugs.com)