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  • selectivity
  • Structure activity relationship (SAR) studies for diaryl heterocyclic compounds have indicated that a cis-stilbene moiety and changes in the para-position of one of the aryl rings play an important role in COX-2 selectivity. (wikipedia.org)
  • therapeutic
  • Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced gastrointestinal and cardiovascular toxicity. (google.co.in)
  • Some studies have demonstrated that gestational age, birth weight, B-type natriuretic peptide (BNP), and ductal diameter can predict the therapeutic responsiveness to COX inhibitors. (springer.com)
  • Drugs
  • After several COX-2 inhibiting drugs were approved for marketing, data from clinical trials revealed that COX-2 inhibitors caused a significant increase in heart attacks and strokes, with some drugs in the class having worse risks than others. (wikipedia.org)
  • pathways
  • COX-2 inhibitors have been found to be effective in suppressing inflammatory neurodegenerative pathways in mental illness, with beneficial results in trials for major depressive disorder as well as schizophrenia . (wikipedia.org)
  • studies
  • This GMI PUB document will greatly reduce your research time due to the Cumulative Knowledge feature, and contains a condensed form of the studies that we have accumulated on Cyclooxygenase Inhibitors. (greenmedinfo.com)
  • The National Cancer Institute has done some studies on COX-2 and cancer. (wikipedia.org)
  • Studies of breast, colon, and pancreatic cancers have led researchers to believe COX-2 plays a key role in the development and growth of tumors. (innovations-report.com)
  • However, with additional studies, we may find COX-2 inhibitors could help prevent pancreatic cancer in high risk populations. (innovations-report.com)
  • effects
  • To study the effects of COX-2 on PanIN progression, Dr. Eibl and colleagues focused on the KrasG12D mouse, an animal model that mimics the early stages of pancreatic cancer. (innovations-report.com)
  • In the future, Dr. Eibl and others plan to study the long-term effects of nimesulide and additional COX-2 inhibitors on the onset and progression of pancreatic cancer. (innovations-report.com)
  • gene
  • The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991. (wikipedia.org)
  • novel
  • Another group discovered a novel cDNA species encoding a protein with similar structure to COX-1 while studying phorbol-ester-induced genes in Swiss 3T3 cells. (wikipedia.org)
  • high
  • The study, published in the August 1 issue of Cancer Research, a journal of the American Association for Cancer Research, suggests a potential role for COX-2 inhibitors in pancreatic cancer prevention among high-risk patients. (innovations-report.com)
  • If a patient is at a high-risk for developing pancreatic cancer, a COX-2 inhibitor may offer some protection. (innovations-report.com)
  • development
  • To date, which COX isoform (COX-1 or COX-2) plays a more important role in during fetal development and influences kidney function early in life is not known, though evidence points to a predominant role for COX-2. (mdpi.com)
  • Encouraged by the "concept testing" experiments with selective inhibitors, and armed with several solid leads and clear idea of the nature of the binding site, development of this field was rapid. (wikipedia.org)
  • Store
  • Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. (selleckchem.com)