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  • inhibitor
  • This sulphonanilide NSAID, which is effective in treating a wide spectrum of inflammatory and painful conditions, 7 was first marketed in 1985 and 10 years later it was found to be a preferential inhibitor of COX-2. (bmj.com)
  • If COX is involved in CMV-induced generation of ROS and if CMV plays a causal role in restenosis and in atherosclerosis, then aspirin, a potent inhibitor of COX, might exert therapeutic effects in such patients through its antiviral properties, in addition to its antiplatelet actions. (ahajournals.org)
  • We sought to systematically evaluate changes in symptoms and pulmonary function after acute selective NSAID or COX-2 inhibitor exposure in patients with the AERD phenotype. (ovid.com)
  • A systematic review of databases was performed to identify all blinded, placebo-controlled clinical trials evaluating acute selective NSAID or COX-2 inhibitor exposure in patients with AERD. (ovid.com)
  • If a COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time. (wikipedia.org)
  • With colleagues, he discovered that BCC produce soluble factors increasing osteoclast activity, notably interleukin-11, the production of which is reduced by the cyclooxygenase inhibitor aspirin. (wikipedia.org)
  • Often a combination of aspirin plus an ADP/P2Y inhibitor (such as clopidogrel, prasugrel, ticagrelor, or another) is used in order to obtain greater effectiveness than with either agent alone. (wikipedia.org)
  • prostaglandin
  • Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. (cogprints.org)
  • Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress. (cogprints.org)
  • Cycloxygenase: Cells can use prostaglandin-endoperoxide synthase 1 (i.e. cyclooxygenenase-1 or COX-1) and Prostaglandin-endoperoxide synthase 2 (COX-2) to metabolize arachidonic acid primarily to prostaglandins but also to small amounts of 11(R)-HETE and a racemic mixture of 15-HETEs composed of ~22% 15(R)-HETE and ~78% 15(S)-HETE. (wikipedia.org)
  • NSAID
  • In accordance to the mathematical model, aspirin/NSAID interaction was more pronounced in presence of high (1mmol/L) versus low (0.3mmol/L) concentration of arachidonic acid. (ahajournals.org)
  • Interestingly, the concentration of arachidonic acid also influences the NSAID/aspirin interaction, suggesting that "fatty acid tone" and lipid metabolism may influence this unfavourable drug/drug interaction. (ahajournals.org)
  • Since PGE 2 and other prostanoids are formed by both constitutive COX-1 and induced COX-2, the effect on the lung may partly reflect the relative activities of each NSAID on the enzymes. (bmj.com)
  • These combined analgesics contained aspirin or other NSAID with phenacetin, paracetamol, or salicylamide, and caffeine or codeine. (wikipedia.org)
  • prostaglandins
  • Generally, in various tissues and organs such as the gastrointestinal mucosa and kidney, COX-1 produces prostaglandins that have physiological protective roles, whereas COX-2 induced at sites of inflammation forms prostaglandins that contribute to the disease. (bmj.com)
  • antiplatelet
  • Cox proportional hazards models were used to assess the interaction of hsCRP levels with the effects of dual and single antiplatelet therapy. (readbyqxmd.com)
  • Thus, it is possible that aspirin has previously unrecognized therapeutic effects in various clinical situations, such as in viral infections (when used as an antipyretic agent) and in atherosclerosis (when used as an antiplatelet agent). (ahajournals.org)
  • Ibuprofen
  • The most prominent members of this group of drugs are aspirin, ibuprofen and naproxen, all available over the counter in most countries. (wikipedia.org)
  • Furthermore
  • Furthermore, in view of previous discrepancies between the results of observational studies and randomized control trials (RCTs), it is crucially important to investigate the effects of aspirin by RCTs. (eurekaselect.com)
  • Furthermore, by reducing ROS, aspirin and sodium salicylate inhibit CMV-induced NFκB activation, the ability of IE72 to transactivate its promoter, CMV IE gene expression after infection of SMCs, and CMV replication in SMCs. (ahajournals.org)
  • TXA2
  • Aspirin affords cardioprotection through the acetylation of serine529 in human cyclooxygenase-1 (COX-1) of anucleated platelets, inducing a permanent defect in thromboxane A2 (TXA2)-dependent platelet function. (unich.it)
  • This inhibition appeared to reflect the ability of these metabolites to a) inhibit the activities of COX-1 and COX-2 thereby blocking the production of TXA2 and b) interfere with the activation of the TXA2 receptor (Thromboxane receptor) by TXA2. (wikipedia.org)
  • doses
  • rates of daily blood loss of 5 ml/day or 10 ml/day were 31% and 10%, respectively, for aspirin at daily doses of 1,800 mg or greater. (ox.ac.uk)
  • arachidonic acid primarily
  • While metabolizing arachidonic acid primarily to PGG2, COX-1 also converts this fatty acid to small amounts of a racemic mixture of 15-Hydroxyicosatetraenoic acids (i.e., 15-HETEs) composed of ~22% 15(R)-HETE and ~78% 15(S)-HETE stereoisomers as well as a small amount of 11(R)-HETE. (wikipedia.org)
  • cardiovascular events
  • Aspirin use is now recommended in both men and women to treat mini-strokes (transient ischemic attack --TIA) or ischemic stroke to prevent subsequent cardiovascular events or death. (pharmacycode.com)
  • acid
  • This study is looking at the effect that aspirin and/or an omega-3 fatty acid supplement has on COX-2 protein levels in postmenopausal women (at any weight) who have or have not been diagnosed with breast cancer. (her2support.org)
  • The cyclooxygenase activity incorporates two oxygen molecules into arachidonic acid or alternate polyunsaturated fatty acid substrates, such as linoleic acid and eicosapentaenoic acid. (wikipedia.org)
  • COX-1 promotes the production of the natural mucus lining that protects the inner stomach and contributes to reduced acid secretion and reduced pepsin content. (wikipedia.org)
  • whereas
  • The term "preferential" is used here to denote activity that is somewhat greater against COX-2 than against COX-1, whereas the term "specific" is used here to denote that the activity is (usually) much greater against COX-2 than against COX-1. (bmj.com)
  • metabolites
  • Although most attention has focused on PGs 2 and other COX-derived metabolites, mounting evidence suggests that LO-catalyzed products, LTs, and HETEs also exert profound biological effects on the development and progression of human cancers. (aacrjournals.org)
  • These alternate metabolites of COX-1 may contribute to its activities. (wikipedia.org)
  • eicosanoids
  • Two isoforms of COX, encoded by different genes, catalyze the reactions whereby eicosanoids and ROS are formed from AA. (ahajournals.org)
  • platelets
  • The recent recognized capacity of platelets to make proteins de novo paves the way to identify new mechanisms involved in the variable response to aspirin. (unich.it)
  • toxicity
  • Information on the use of aspirin for rheumatologic diseases has also been expanded to include specific dosing information as well as information about side effects and toxicity. (pharmacycode.com)
  • clinical
  • However, heterogeneity of COX-1 suppression by aspirin has been detected in cardiovascular disease and may contribute to failure to prevent clinical events. (unich.it)
  • patients
  • Thus, aspirin is commonly used in patients with atherosclerosis. (ahajournals.org)
  • 3) OTHER CORONARY CONDITIONS: Aspirin can be used to treat patients who have had certain revascularization procedures such as angioplasty, and coronary bypass operations -- if they have a vascular condition for which aspirin is already indicated. (pharmacycode.com)
  • arachidonic
  • The PTGS (COX) enzymes catalyze the conversion of arachidonic acid to prostaglandins in two steps. (wikipedia.org)
  • Figure 2) While metabolizing arachidonic acid primarily to PGG2, COX-2 also converts this fatty acid to small amounts of a racemic mixture of 15-Hydroxyicosatetraenoic acids (i.e., 15-HETEs) composed of ~22% 15(R)-HETE and ~78% 15(S)-HETE stereoisomers as well as a small amount of 11(R)-HETE. (wikipedia.org)
  • Furthermore, aspirin-treated COX-2 metabolizes arachidonic acid almost exclusively to 15(R)-HETE which product can be further metabolized to epi-lipoxins. (wikipedia.org)
  • PTGS
  • In genetics, "PTGS" is officially used for this family of genes and proteins, because the root symbol "COX" was already used for the cytochrome c oxidase family. (wikipedia.org)
  • similar
  • In terms of their molecular biology, COX-1 and COX-2 are of similar molecular weight, approximately 70 and 72 kDa, respectively, and having 65% amino acid sequence homology and near-identical catalytic sites. (wikipedia.org)
  • pain
  • It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body. (russky.me)
  • upon
  • Both of these markers were increased upon COX-2 suppression by aspirin pretreatment prior to DCA exposure. (beds.ac.uk)
  • high
  • It is thought that inhibiting COX, but stated her levels are extremly high. (russky.me)
  • levels
  • Following exposure of SKGT-4 cells to DCA, protein levels of COX-2, MAPK and PARP were examined by immunoblotting. (beds.ac.uk)
  • uses
  • While the above two uses of Aspirin are relatively well established, it's role in cancer prevention/cure has been debated since the 70's by Bennett and Del Tacca. (blogspot.com)
  • potential
  • DCA regulates both apoptosis and COX-2-regulated cell survival in esophageal cells suggesting that the balance between these two opposing signals may determine the transformation potential of DCA as a component of the refluxate. (beds.ac.uk)