• Tranexamic acid (TXA) is chemically designed as trans -4-(aminomethyl) cyclohexanecarboxylic acid, with chemical formula C 8 H 14 NO 2 . (hindawi.com)
  • The kringle 2 (K2) module of human plasminogen (Pgn) binds L-lysine and analogous zwitterionic compounds, such as the antifibronolytic agent trans-(aminomethyl)cyclohexanecarboxylic acid (AMCHA). (rcsb.org)
  • Tranexamic acid ( TXA ) is a medication used to treat or prevent excessive blood loss from major trauma , post partum bleeding , surgery, tooth removal , nose bleeds , and heavy menstruation . (wikipedia.org)
  • [3] [5] Tranexamic acid is in the antifibrinolytic family of medications. (wikipedia.org)
  • Tranexamic acid was discovered in 1962 by Utako Okamoto . (wikipedia.org)
  • [7] Tranexamic acid is available as a generic medication . (wikipedia.org)
  • Tranexamic acid is frequently used following major trauma. (wikipedia.org)
  • [10] Tranexamic acid is used to prevent and treat blood loss in a variety of situations, such as dental procedures for hemophiliacs, heavy menstrual bleeding, and surgeries with high risk of blood loss. (wikipedia.org)
  • Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma . (wikipedia.org)
  • Tranexamic acid is used to treat heavy menstrual bleeding. (wikipedia.org)
  • Tranexamic acid is used in orthopedic surgery to reduce blood loss, to the extent of reducing or altogether abolishing the need for perioperative blood collection. (wikipedia.org)
  • In the United States, tranexamic acid is FDA approved for short-term use in people with severe bleeding disorders who are about to have dental surgery. (wikipedia.org)
  • [20] Tranexamic acid is used for a short period of time before and after the surgery to prevent major blood loss and decrease the need for blood transfusions. (wikipedia.org)
  • In obstetrics, tranexamic acid is used after delivery to reduce bleeding, often with syntocinon/oxytocin and fundal massage. (wikipedia.org)
  • Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL. (rxlist.com)
  • Tranexamic acid is a white crystalline powder. (rxlist.com)
  • Thromboembolic events (e.g., deep vein thrombosis , pulmonary embolism , cerebral thrombosis, acute renal cortical necrosis, and central retinal artery and vein obstruction) have been rarely reported in patients receiving tranexamic acid for indications other than hemorrhage prevention in patients with hemophilia . (rxlist.com)
  • Tranexamic Acid BP2017 stock with comp. (lookchem.com)
  • Tranexamic Acid[CAS:1197-18-8/701-54-2. (lookchem.com)
  • Tranexamic Acid is only found in individuals that have used or taken this drug. (hmdb.ca)
  • PubChem]Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. (hmdb.ca)
  • Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation. (hmdb.ca)
  • Return to Tranexamic acid . (biology-online.org)
  • 7,8 Bleeding patients demonstrate increases in D-dimer and plasmin-antiplasmin complexes, both byproducts of fibrinolysis, compared to non-bleeding patients, and these increases are attenuated by treatment with tranexamic acid (TXA, Figure 1). (apsf.org)
  • 9 Tranexamic acid was developed in 1962 by Utako Okamoto, a Japanese scientist, in her pursuit of a pharmacologic treatment for postpartum hemorrhage. (apsf.org)
  • This paper demonstrates colorimetric visible spectrophotometric quantification methods for amino acid, namely, tranexamic acid and pregabalin. (hindawi.com)
  • The analytical methods under proposal were successfully applied to determine tranexamic acid and pregabalin in commercial products. (hindawi.com)
  • Primary objective of the study is to compare requirement of blood transfusion and mortality in patients receiving Tranexamic acid (Cyklokapron┬«) and those not receiving it. (clinicaltrials.gov)
  • It involved 274 hospitals across 40 countries and started in 2005 and concluded that tranexamic acid could safely reduce the risk of death in bleeding trauma patients.9 Intraoperative use of low dose tranexamic acid has been observed to be safe and effective in reducing the rate of perioperative blood transfusions in patients undergoing radical retropubic prostatectomy.10 It has also been approved by FDA for use in menorrhagia. (clinicaltrials.gov)
  • In this context, this study is undertaken to evaluate the efficacy of tranexamic acid in major gastrointestinal surgeries. (clinicaltrials.gov)
  • Investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements. (clinicaltrials.gov)
  • It is the carboxylic acid of cyclohexane. (wikipedia.org)
  • The invention also provides a process for producing the novel avermectin and milbemycin derivatives by adding a carboxylic acid or derivative thereof to a fermentation of an avermectin or milbemycin producing organism. (google.com)
  • Inhibition of neuronal cytosolic branched chain amino acid transamination by gabapentin or branched chain amino acid transport by the L-system substrate analog, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylic acid, lowered total de novo synthesis of glutamate by 30%, suggesting that branched chain amino acids may account for half of the glutamate nitrogen contributed by transamination reactions. (biomedsearch.com)
  • Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. (nih.gov)
  • an acid chloride from a carboxylic acid. (libretexts.org)
  • an alcohol from carboxylic acid. (libretexts.org)
  • write the detailed mechanism for the reaction of a carboxylic acid with thionyl chloride. (libretexts.org)
  • identify the reagents necessary to convert a given carboxylic acid to a given acid chloride, ester, amide or alcohol. (libretexts.org)
  • identify the carboxylic acid required for a direct synthesis of a given acid chloride, amide, ester or alcohol. (libretexts.org)
  • explain why the direct conversion of a carboxylic acid to an amide can only be achieved with difficulty and at a high temperature. (libretexts.org)
  • During the reaction the hydroxyl group of the carboxylic acid is converted to a chlorosulfite intermediate making it a better leaving group. (libretexts.org)
  • The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. (libretexts.org)
  • The direct conversion of a carboxylic acid to an amide is difficult because amines are basic and tend to convert carboxylic acids to their highly unreactive carboxylates. (libretexts.org)
  • In this reaction the carboxylic acid adds to the DCC molecule to form a good leaving group which can then be displaced by an amine during nucleophilic substitution. (libretexts.org)
  • Cyclohexane carboxylic acid accumulated to a concentration of 260 ╬╝M, accounting for about 18% of the initial benzoate added. (asm.org)
  • This study provides the first example of an efficient alkane hydrocarboxylation to carboxylic acid, in an ionic liquid and under mild conditions. (rsc.org)
  • The antibacterial erythromycin A, like other macrocyclic polyketides, is derived from simple carboxylic acid precursors by stepwise chain assembly on a modular polyketide synthase (PKS). (sciencemag.org)
  • A 5'-amine modified DNA oligonucleotide (5'-ACC AGC TGT GCA GGC CTC GC-3') purchased from Integrative DNA Technologies (Coralville, IA) was conjugated to the bifunctional linker 4-(maleimidomethyl)-1-cyclohexane carboxylic acid N-hydroxysuccinimide ester (SMCC, Sigma Aldrich) by combining 1 mL of SMCC (1 mg/mL) in acetonitrile with 2 mL of DNA (195 nmol) in 0.1 M KHPO4 buffer (pH 7.8). (psu.edu)
  • S. aciditrophicus metabolizes various saturated and unsaturated fatty acids, methyl esters of butyrate and hexanoate, and benzoate in coculture with hydrogen/formate-using microorganisms. (asm.org)
  • Pregabalin (PG) chemically is 3-amino methyl hexanoic acid, with the chemical formula C 8 H 17 NO 2 . (hindawi.com)
  • Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat. (aspetjournals.org)
  • D , Raw data for five representative ineffective odorants (methyl butyrate, cyclohexanecarboxylic acid, benzyl acetate, 2-pentanol, and 2-methylvaleraldehyde) and two odorants evoking strong responses (eucalyptol and pentyl propionate). (jneurosci.org)
  • Novel poly(etherimide esters) are prepared by reacting a diol, a dicarboxylic acid, a poly(oxy alkylene) diamine and a tricarboxylic acid having two vicinal carboxyl groups or the anhydride thereof. (google.com)
  • Note that NaBH 4 is not strong enough to convert carboxylic acids or esters to alcohols. (libretexts.org)
  • Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. (biologists.org)
  • Quinic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Quinic Acid" by people in Harvard Catalyst Profiles by year, and whether "Quinic Acid" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Quinic Acid" by people in Profiles. (harvard.edu)
  • Development of quinic acid-conjugated nanoparticles as a drug carrier to solid tumors. (harvard.edu)
  • Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. (wikipedia.org)
  • Quinic acid is implicated in the perceived acidity of coffee. (wikipedia.org)
  • Quinic acid is also implicated in the perceived acidity of coffee. (wikipedia.org)
  • Dehydrogenation and oxidation of quinic acid affords gallic acid. (wikipedia.org)
  • Quinic acid is used as an astringent. (wikipedia.org)
  • Quinic acid is named on p. 167. (wikipedia.org)
  • D(-)-Quinic Acid is used in the synthesis of anti-influenza/anti-swine flu medication. (chemicalbook.com)
  • Quinic acid crystallises from H2O with m 174o, and from EtOH with m 168-169o. (chemicalbook.com)
  • We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin. (uea.ac.uk)
  • First, an ester such as the 1,1-dimethyl-ethylthiol ester serves as an excellent protective group, surviving both relatively mild alkaline and acid conditions, and has been used successfully in the synthesis of many macrolide natural products. (orgsyn.org)
  • This acid is a versatile chiral starting material for the synthesis of pharmaceuticals. (wikipedia.org)
  • Cyclohexanecarboxylic acid exhibits the reactions typical of carboxylic acids, including its conversion to the acid chloride cyclohexanecarbonyl chloride. (wikipedia.org)
  • Shikimic acid, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. (sbwire.com)
  • A monocarboxylic acid amide obtained by the formal condensation of cyclohexanecarboxylic acid with the amino group of 5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-amine. (ebi.ac.uk)
  • This report basically covers Shikimic Acid (CAS 138-59-0) market in North America, Shikimic Acid (CAS 138-59-0) market in Europe, Shikimic Acid (CAS 138-59-0) market in Middle East and Africa, Shikimic Acid (CAS 138-59-0) Market in Latin America and Asia Pacific. (sbwire.com)
  • 3 Latin America Shikimic Acid (CAS 138-59-0) Market (Middle and Africa). (sbwire.com)
  • Blakley E (1974) The microbial degradation of cyclohexanecarboxylic acid: a pathway involving aromatization to form p -hydroxybenzoic acid. (springer.com)
  • The anaerobic degradation of saturated fatty acids and aromatic acids in the absence of terminal electron processes necessitates the presence of a hydrogen-consuming organism to maintain a hydrogen partial pressure low enough for these reactions to be thermodynamically favorable ( 9 , 28 , 29 , 34 ). (asm.org)
  • In characterising the structural requirements for this effect, we also identify a family of medium-chain fatty acids that show increased efficacy compared with VPA. (biologists.org)
  • Together, our data show that VPA and a newly identified group of medium-chain fatty acids reduce phosphoinositide levels independently of inositol regulation, and suggest the reinvestigation of these compounds as treatments for epilepsy. (biologists.org)
  • An acid anhydride (or just anhydride) is the product of formal condensation of two oxoacid molecules with the release of a water molecule. (libretexts.org)
  • 7. The composition of claim 1 wherein the dicarboxylic acid component (b) is selected from the group consisting of C 2 to C 19 aliphatic, cycloaliphatic, and/or aromatic dicarboxylic acids, the ester equivalents thereof and mixtures thereof. (google.com)
  • Corey's "double activation" method for lactone formation is patterned after Mukaiyama's procedure for peptide formation and involves refluxing a solution of the 2-pyridinethiol ester of a hydroxy acid in a high-boiling solvent for a prolonged period of time. (orgsyn.org)
  • Both drugs contain the amino group, and when they are reacted with 2,4-dinitrophenol and 2,4,6-trinitrophenol, they give rise to yellow colored complexes showing absorption maximum at 418 nm and 425 nm, respectively, based on the Lewis acid base reaction. (hindawi.com)
  • Pune, Mahrashtra -- ( SBWIRE ) -- 03/28/2017 -- The motive of this strategic research report entitled "Global Shikimic Acid (CAS 138-59-0) Market 2017-2022" is to provide company officials, industry investors, and Shikimic Acid (CAS 138-59-0) industry members with consequential insights to enable them make reliable strategic decisions regarding the opportunities in the global Shikimic Acid (CAS 138-59-0) market. (sbwire.com)
  • Shikimic acid is mainly used as pharmaceutical intermediates, with a certain irritation. (sbwire.com)
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  • It is made synthetically by hydrolysis of chlorogenic acid. (wikipedia.org)
  • 16. The composition of claim 1 wherein the tricarboxylic acid (d) is characterized by the following formula: ##STR3## where R is a C 2 to C 20 trivalent aliphatic, cycloaliphatic or aromatic radical and R' is hydrogen or a C 1 to C 6 aliphatic radical. (google.com)
  • For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions. (rxlist.com)
  • However, a number of fatty acid- and aromatic acid-degrading syntrophic bacteria grow in pure culture by fermenting crotonate ( 6 , 24 , 46 , 48 ). (asm.org)
  • Although high levels of pyruvate blunted the inhibitory effectiveness of L-cycloserine, the results indicate that, under physiological conditions, alanine as well as branched chain amino acids are probably the predominant sources of glutamate nitrogen in ex vivo retinas. (biomedsearch.com)
  • Expression of this hybrid enzyme in the erythromycin producer Saccharopolyspora erythraea produced several novel antibiotic erythromycins derived from endogenous branched-chain acid starter units typical of natural avermectins. (sciencemag.org)
  • Cyclohexanecarboxylic acid is the organic compound with the formula C6H11CO2H. (wikipedia.org)
  • belongs to the class of organic compounds known as amino acids. (hmdb.ca)
  • Within the group of active compounds is a little-studied group previously associated with seizure control, and analysis of two of these compounds (nonanoic acid and 4-methyloctanoic acid) shows around a threefold enhanced potency compared with VPA for protection in an in vitro acute rat seizure model. (biologists.org)
  • 2-ethoxy-3- (4- (2- (4-methanesulfonyloxyphenyl) ethoxy) phenyl) propanoic acid crystalline form (s). (google.com)
  • 10. The composition of claim 9 wherein the predominant dicarboxylic acid is dimethyl terephthalate. (google.com)
  • 18. The composition of claim 1 wherein the weight ratio of the amount of dicarboxylic acid (b) used to the theoretical amount of poly(oxy alkylene) diimide diacid formable from the diamine (c) and tricarboxylic acid (d) is from about 0.25 to about 2.0. (google.com)
  • 19. The composition of claim 1 wherein the weight ratio of the amount of dicarboxylic acid (b) to the theoretical amount of poly(oxy alkylene) diimide diacid formable from the diamine (c) and tricarboxylic acid (d) is from about 0.4 to about 1.4. (google.com)
  • write an equation to represent the formation of a cyclic anhydride from a dicarboxylic acid. (libretexts.org)
  • Cyclohexanecarboxylic acid is a precursor to the nylon-6 precursor caprolactam via its reaction with nitrosylsulfuric acid. (wikipedia.org)
  • The fine suspension in the reaction flask is agitated and siphoned into a vigorously stirred mixture of 27 ml. (0.32 mole) (Note 5) of concentrated hydrochloric acid and 400 ml. of water. (orgsyn.org)
  • 5. The quantity of hydrochloric acid used is normally insufficient to neutralize all the lithium hydroxide produced when the reaction mixture is quenched in the aqueous solution. (orgsyn.org)
  • The excess trifluoroacetic acid and the water formed in the reaction were removed under reduced pressure. (orgsyn.org)
  • This substance was isolated for the first time in 1806 by French pharmacist Nicolas Vauquelin and its transformation into hippuric acid by animal metabolism was studied by German chemist Eduard Lautemann in 1863. (wikipedia.org)