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Cyclodextrinsbeta-Cyclodextrinsalpha-CyclodextrinsSolutionsgamma-CyclodextrinsGlucosyltransferasesDextrinsAcarboseBacillusalpha-AmylasesAcetic AnhydridesDrug CompoundingHesperidinSolubilityStarchGram-Positive Asporogenous Rods, IrregularDosage FormsExcipientsCalorimetry, Differential ScanningChemistry, PharmaceuticalGlucan 1,4-alpha-Glucosidasebeta-AmylaseCholesterolNiemann-Pick Disease, Type CGlycogen Debranching Enzyme SystemSorboseIsotonic SolutionsPharmaceutical SolutionsCarboxymethylcellulose SodiumOligo-1,6-GlucosidaseModels, MolecularSalaciaHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyCapsulesDrug StabilityWaterKineticsRotaxanesSpectroscopy, Fourier Transform InfraredMolecular StructurePaenibacillusAndrostenesDrug CarriersPiroxicamX-Ray DiffractionAdministration, BuccalEnzyme StabilityEnzymes, ImmobilizedMembrane Microdomains1-DeoxynojirimycinAlkaliesCholesterol OxidaseFilipinOrgan Preservation SolutionsChemistry, OrganicHypertonic SolutionsChromatography, High Pressure LiquidOligosaccharidesDialysis SolutionsGeobacillus stearothermophilusItraconazoleBinding SitesTechnology, PharmaceuticalMaltoseMolecular Sequence DataMolecular ConformationModels, ChemicalSphingomyelinsProtein ConformationSubstrate SpecificitySolventsGranisetronCrystallography, X-RayDrug Delivery SystemsStereoisomerismCaveolinsSpectrophotometry, UltravioletGlycoside HydrolasesGlucansProtein EngineeringAmino Acid SequenceElectrophoresis, CapillaryAdsorptionHydrophobic and Hydrophilic InteractionsGlucosidesCell MembraneCaveolaePowdersTabletsHardnessHydrogen BondingCaveolin 1Biological TransportDetergentsTime FactorsCarbohydrate SequenceGlycosidesHydrolysisATP Binding Cassette Transporter 1
Beta cyclodextrinHydroxypropylCyclicComplexationApplications of cyclodextrinsPolymersAqueous solutionsDerivativesMolecularFormulationsOdorComplexesSolubilityHPBCDHydrophobicDecompositionChiralIntravenousPolymer solutionStabilitySolventComplexDMSOProductsRoquetteWidelyToxicityFormStudyFunctionalSyntheticEncapsulationCompoundsReductionIngredientsDrugsPossibilityDrugOralEfficientWaterEffectTimeIncreaseStructure
Beta cyclodextrin13
  • In Pharmaceuticals, 40% Hydroxypropyl Beta Cyclodextrin Aqueous Solution could increase the drug solubility and control the release rate of the drug,increase the drug's bioavailability and reduce the toxic side-effets. (cyclodexlab.com)
  • In Cosmetics, 40% Hydroxypropyl Beta Cyclodextrin Aqueous Solutionused as stabilizer,emulsifier and odor absorber.It could reduce organic molecules stimulation to skin mucosal and enhance the stability of the effective components.Prevent volatile ,oxidation of nutrient composition ,increase the solubility of insoluble flavours and fragrances and keep the fragrance slow releasing and lasting. (cyclodexlab.com)
  • In contrast to these observations, the threefold amount of beta-cyclodextrin with hexahydroxidostannate(IV) showed a single signal, whose chemical shift indicates a new, hexacoordinate, tin-containing species. (uni-muenchen.de)
  • The results from the structural analysis were consistent with the spectroscopic results and show a supramolecular assembly with threefold rotational symmetry that consists of three components: three beta-cyclodextrin dianions, three tetrahedral tetraaqualithium cations and the tetravalent metal center. (uni-muenchen.de)
  • Surprisingly, beta-cyclodextrin could avoid decomposition and formed single crystals. (uni-muenchen.de)
  • Phenanthrene (PHE) and hydroxypropyl-beta-cyclodextrin (HPCD) were chosen respectively as a polycyclic aromatic hydrocarbon (PAH) representative and as a solubilizing agent. (univ-lorraine.fr)
  • The active ingredient in several Febreze products is hydroxypropyl beta-cyclodextrin (HPβCD). (wikipedia.org)
  • Dr. Caroline Hastings at Children's Hospital Research Center Oakland filed a 400+ page document with the FDA yesterday on behalf of the twins seeking a permanent solution to deliver hydroxyl-propyl-beta-cyclodextrin (HPBCD) past the blood-brain barrier and into the cerebrospinal fluid (CSF) by utilizing a Medtronic SynchroMed® II Drug Infusion Pump System . (addiandcassi.com)
  • We're proposing to the FDA to use a new drug (hydroxyl-propyl-beta-cyclodextrin) in an existing device (a SynchroMed pump). (addiandcassi.com)
  • We have now completed 11 intratehcal injections of hydroxyl-propyl-beta-cyclodextrin into the twins' spines via lumbar punctures. (addiandcassi.com)
  • A capillary electrophoretic method for the separation of the aminoglutethimide (AGT) enantiomers using methylated-beta-cyclodextrin (M-beta-CD) as chiral selector is described. (unboundmedicine.com)
  • An inclusion complex formation between alpha- and beta-cyclodextrin and four phenylurea analogues, namely metobromuron, monolinuron, monuron and fenuron, is reported. (ad-astra.ro)
  • Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is an alkylated derivative of beta-CD with the capacity to form inclusion complexes with suitable molecules. (scite.ai)
Hydroxypropyl3
  • Three native (α-CD, β-CD and γ-CD) and two modified (hydroxypropyl-β-CD (HP- β-CD) and heptakis-(2,3,6-tri-O-methyl)-β-CD (TRIMEB)) cyclodextrins were used. (fortunejournals.com)
  • A new formulation of phenobarbital with hydroxypropyl-β-cyclodextrins (HPBCD) was developed, and the physicochemical stability of the solution was evaluated. (bmj.com)
  • Beauté by Roquette® CD 110 hydroxypropyl cyclodextrin encapsulates fragrances with a high ethanol content. (premiumbeautynews.com)
Cyclic3
  • However, the complexation of APIs with cyclodextrins (cyclic oligosaccharides) resulting in the formation of inclusion complexes, has proven to be a versatile technology for overcoming not only the poor aqueous solubility of APIs, but also unfavourable properties such as their chemical instability, adverse side effects such as gastrointestinal irritation, and unpleasant tastes and odours [1-5] . (beilstein-journals.org)
  • We describe here the impact of linear (maltodextrin) or cyclic (cyclodextrins, CDs) dextrins and their interaction with two fungicides (difenoconazole and tebuconazole), through measurements of growth in 20 A. fumigatus strains. (fortunejournals.com)
  • Simultaneously, experiments on solubilization of the first chromone-2-carboxamides with cyclodextrins, cyclic oligosacharides known to form water-soluble inclusion complexes, were performed. (uni-wuerzburg.de)
Complexation3
  • This study addresses the poor solubility of two potent steroid hormones, 17β-estradiol (BES) and progesterone (PRO), via their complexation with two water-soluble native cyclodextrins (CDs) namely β-CD and γ-CD. (beilstein-journals.org)
  • In this thesis the complexation of carbohydrates in the presence of tin(IV) and lead(IV) central metals in aqueous solution was studied. (uni-muenchen.de)
  • By complexation with WACKER's CAVAMAX® gamma-cyclodextrin, curcumin's bioavailability is enhanced considerably. (foodprocessing-technology.com)
Applications of cyclodextrins2
Polymers2
  • We examine a new approach to reversibly modulate hydrophobic interactions in associative polymers using cyclodextrins (CD) and enzymes that cause scission of the α-1, 4 linkages in cyclodextrins. (rsc.org)
  • The helix reversal is a structural motif found in helical polymers in the solid state, but whose existence is elusive in solution. (nature.com)
Aqueous solutions3
  • We quantified the energetic aspects, for different thermal conditions, in which both aqueous solutions interact with CBDs and CDs and the CBD-CDs complex itself. (bvsalud.org)
  • Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. (sigmaaldrich.com)
  • At each time point, the microcosms were amended with aqueous solutions of cyclodextrin (HP-beta-CD) at a range of concentrations (0-40 mM). (lancs.ac.uk)
Derivatives1
  • Different cyclodextrin derivatives are available, and successful development relies on the ability to select the best analogue at the right concentration. (pharmtech.com)
Molecular5
  • Those observations were more investigated thanks to molecular modeling in order to clarify cyclodextrin/fungicide interactions. (fortunejournals.com)
  • Energetic and thermodynamical aspects of the cyclodextrins-cannabidiol complex in aqueous solution: a molecular-dynamics study. (bvsalud.org)
  • In this framework, we employed molecular dynamics and docking techniques for investigating the interaction energy and thermodynamical issues between different CDs (α, ß, and γ type) and CBD immersed in water and a solution mimicking a physiological environment . (bvsalud.org)
  • WACKER offers molecular encapsulation solutions based on its cyclodextrin technology for odour or taste-masking, to stabilise food ingredients against heat and oxidation and to increase the bioavailability of functional ingredients, such as curcumin. (foodprocessing-technology.com)
  • Nanoparticulate suspensions, therefore, behave in a similar fashion to a molecular solution, and from a manufacturing standpoint, Lee states that the process overall is efficient, reproducible, and highly scalable. (pharmtech.com)
Formulations1
  • Yet, Lee goes on to explain that as cyclodextrin formulations are intended to be solutions, the complexes are governed by thermodynamics and have different equilibrium binding constants. (pharmtech.com)
Odor2
  • The use of cyclodextrin as a sprayable odor absorber was patented by Procter & Gamble. (wikipedia.org)
  • Uncomplexed cyclodextrin solutions for odor control on inanimate surfaces. (wikipedia.org)
Complexes4
  • The hydrated inclusion complexes β-CD·BES, β-CD·PRO, γ-CD·BES and γ-CD·PRO were prepared via kneading and co-precipitation, and 1 H NMR spectroscopic analysis of solutions of their pure complex crystals yielded the host-guest stoichiometries 2:1, 2:1, 1:1 and 3:2, respectively. (beilstein-journals.org)
  • These findings may be helpful to develop other cyclodextrin-metal complexes with metals which show catalytic activity. (uni-muenchen.de)
  • In both water and artificial physiological solutions , the γ-CD appears more stable than the other complexes. (bvsalud.org)
  • Cyclodextrins are non-toxic, sugar-based substances that form complexes with many contaminants. (uri.edu)
Solubility5
  • to overcome this limitation we studied the feasibility of the use of cyclodextrins (CDs) as solubility-enhancing agents. (unipv.it)
  • Cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of poorly soluble actives," Lee says. (pharmtech.com)
  • Two different cyclodextrin varieties were investigated and it was shown that their presence in solution results in a significant increase of the apparent solubility of tetrachloroethylene (PCE) and trichloroethylene (TCE). (uri.edu)
  • Although the assessed solubility of the chromone 3b/DIMEB (1:3) mixture exceeded 14-fold the intrinsic one, the achieved 100 µM solubility was still not sufficient to be used as a stock solution in the binding assay. (uni-wuerzburg.de)
  • 1 - 3 Various approaches have been utilized for the enhancement of solubility and dissolution rate of poorly soluble drugs such as solid dispersions preparation, 4 inclusion in cyclodextrins, 5 and particle size (PS) reduction. (dovepress.com)
HPBCD1
  • Conclusions HPBCD solubilise phenobarbital and create a homogeneous solution. (bmj.com)
Hydrophobic4
  • The intermolecular interaction between hydrophobic groups forms a transient network resulting in thickening of solutions containing the polymer . (rsc.org)
  • Cyclodextrins (CDs) are well-known carriers for encapsulating hydrophobic molecules, while among cannabinoids , cannabidiol (CBD) has attracted considerable attention due to its therapeutic capability. (bvsalud.org)
  • The structure of a typical cyclodextrin, β-cyclodextrin sulphobutylether (β-CDSBE) is given in [ Fig. 1 ], together with a schematic representation showing the hydrophilic exterior and hydrophobic (lipophilic) core in which dyes are held. (thieme-connect.com)
  • Owing to high material costs necessary for the appropriate cyclodextrin amounts, the aim focused on structural modification of the hydrophobic products. (uni-wuerzburg.de)
Decomposition2
  • Attempts to prepare chelates using lead(IV) as the central metal by adding potential chelators such as oxalate, catecholate, or glycosides to hexahydroxidoplumbat(IV) solutions result in the formation of decomposition products. (uni-muenchen.de)
  • Decomposition is accompanied by discoloration of the solution. (sigmaaldrich.com)
Chiral1
  • Good chiral separation of the racemic mixture was achieved in less than 9 min with resolution factor Rs=2.1, using a fused-silica capillary and a background electrolyte (BGE) of tris-phosphate buffer solution (50 mmol L(-1), pH 3.0) containing 30 mgm L(-1) of M-beta-CD. (unboundmedicine.com)
Intravenous3
  • Trials regarding the use of intravenous itraconazole and cyclodextrin oral solution for the prophylaxis of aspergillosis are in progress. (medscape.com)
  • Data relevant to the use of tecovirimat, brincidofovir, cidofovir, trifluridine ophthalmic solution, and vaccinia immune globulin intravenous were reviewed. (cdc.gov)
  • MCMs developed for smallpox preparedness or shown to be effective against other OPXVs (i.e., tecovirimat, brincidofovir, cidofovir, trifluridine ophthalmic solution, and vaccinia immune globulin intravenous [VIGIV]) have been used to treat severe mpox. (cdc.gov)
Polymer solution2
  • The reaction is assumed to follow Michaelis Menten kinetics and the kinetic parameters are determined by tracking the changes in the viscoelastic properties of the polymer solution during the enzymatic scission of CD. (rsc.org)
  • Herein, we have shown how the photochemical electrocyclization (PEC) of poly(phenylacetylene)s (PPAs) can be used to determine not only the presence of helix reversals in polymer solution, but also to estimate the screw sense excess. (nature.com)
Stability3
  • During stability study, content of phenobarbital, pH, osmolality of the phenobarbital solution and degradation products were followed up for 6 months in line with GERPAC guidelines. (bmj.com)
  • These stability data set the shelf life of this new phenobarbital solution at up to 6 months. (bmj.com)
  • A microbiological stability study will be carried out to ensure the possibility of using this solution in children. (bmj.com)
Solvent4
  • This behaviour is only ever seen in two situations-where solvent becomes more polar or where an electric field is applied to solutions of dyes. (thieme-connect.com)
  • Encapsulating solvatochromic dyes with cyclodextrins excludes solvent-that is, water[ 5 ]-from the vicinity of dyes and prohibits dye aggregation. (thieme-connect.com)
  • Use of cyclodextrins for the remediation of solvent contaminated porou" by Thomas Boving, Xianjiang Wang et al. (uri.edu)
  • The substance which is to be dissolved is known as solute and the fluid (medium) in which the solute to be dissolve is known as solvent and the process of dissolving solute into solvent is called as solution. (scialert.net)
Complex3
  • X-ray analysis of the product showed lead(IV) complexed by three cyclodextrin dianions isotypic to the tin(IV)-cyclodextrin complex. (uni-muenchen.de)
  • This can be explained by considering the formation of an inclusion complex between PABA and β-cyclodextrin. (bioone.org)
  • Complex formation was established using solution 1H NMR spectroscopy. (ad-astra.ro)
DMSO1
  • The experiments with cyclodextrin in combination with DMSO were ineffective. (uni-wuerzburg.de)
Products1
  • In particular, the company provides an inventive range of materials and solutions for improving products and processes in the functional food and nutraceutical industry. (foodprocessing-technology.com)
Roquette4
  • Roquette offers innovative plant-based solutions to meet the needs of your customers. (roquette.com)
  • Roquette provides high performing, innovative and sustainable plant-based solutions for industrial customers! (roquette.com)
  • Roquette Beauté Solutions in Deodorant Answer Consumers' Demand for Safe and Plant-Based Ingredients. (premiumbeautynews.com)
  • Besides encapsulation of axillary malodorous compounds and fragrances, Beauté by Roquette® CD 100 cyclodextrin also brings sensorial benefits. (premiumbeautynews.com)
Widely1
  • Aims and Methods The present study uses β-cyclodextrins to encapsulate solvatochromic dyes of widely varying structures. (thieme-connect.com)
Toxicity2
  • Toxicity (Microtox®) and biodegradability (BOD5/COD) of treated solutions during the treatment were assessed. (univ-lorraine.fr)
  • This is a relatively high dose of cyclodextrin and may be associated with real or perceived toxicity. (pharmtech.com)
Form2
  • Since the end of marketing of the oral solution KANEURON in 2017, phenobarbital tablets remain the only available dosage form. (bmj.com)
  • Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. (scialert.net)
Study1
  • A parallel study was conducted of the inclusion of alkyl parabens (guests) in the host β-cyclodextrin (β-CD). (ad-astra.ro)
Functional1
  • It could be shown, that the functional groups of the oligosaccharide cyclodextrin are able to assemble into a nanoscaled trimer that provides a mononuclear binding site for high valent metal centers. (uni-muenchen.de)
Synthetic2
  • Treatment of synthetic soil washing solutions containing phenanthrene and cyclodextrin by electro-oxidation. (univ-lorraine.fr)
  • Electrochemical advanced oxidation processes were applied to treatment of highly loaded synthetic soil washing solution. (univ-lorraine.fr)
Encapsulation1
  • Also, we have encountered cases where we had to optimize the encapsulation process to obtain a true solution. (pharmtech.com)
Compounds1
Reduction1
  • This results in several orders of magnitude reduction in solution viscosity and other viscoelastic properties. (rsc.org)
Ingredients1
Drugs1
Possibility1
  • With alpha-cyclodextrin CAVAMAX® W6 FOOD, WACKER offers manufacturers a possibility to replace emulsifiers with a soluble fibre. (foodprocessing-technology.com)
Drug1
  • Once we get the Medtronic pump solution approved by FDA, Dr. Peter Sun , Chief of Pediatric Neurosurgery at Children's Hospital & Research Center Oakland, will surgically implant a SynchroMed® II Drug Infusion System into Addi and Cassi. (addiandcassi.com)
Oral1
  • Development of an oral phenobarbital solution for paediatric use is therefore essential to fulfil clinical needs. (bmj.com)
Efficient2
  • Pt anode was found to be the most efficient one in degradation of PHE, while BDD anode showed better ability to degrade HPCD and to mineralize the solution. (univ-lorraine.fr)
  • β-Cyclodextrin can act as an efficient inhibitor of the photosensitized dimerization of thymine by para -aminobenzoic acid (PABA) in aqueous solution. (bioone.org)
Water1
  • Depending on the air flow rate, the necessary residence time of the cyclodextrin solution in the air stripper approaches that of cyclodextrin-free water. (uri.edu)
Effect1
  • Maria Nowakowska , Mirosław Grebosz , Mirosława Smoluch , and Wiktor Tatara "Inhibiting Effect of β-Cyclodextrin on Thymine Dimerization Photosensitized by para -Aminobenzoic Acid," Photochemistry and Photobiology 75(2), 92-96, (1 February 2002). (bioone.org)
Time1
  • In such a case, photochemical electrocyclization (PEC) of the polyene backbone is used 40 , 54 , where the half-time t 1/2 of the process to reach a null ECD signal in the vinylic region in solution depends directly on the ω 1 adopted by the PPA (Fig. 1 ). (nature.com)
Increase1
  • The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. (mdpi.com)
Structure1
  • Solution structure of urotensin-II receptor extracellular loop III and characterization of its interaction with urotensin-II. (uni-bielefeld.de)