• Gold-catalyzed and NaH-supported intramolecular cyclization of N-propargyl indole derivatives with pyrazole and pyrrole units attached to indole is described. (metu.edu.tr)
  • In general, the reaction of 1,3-diketones and hydroxylamine affords isoxazoles through intramolecular cyclization followed by dehydration of isolable monoxime intermediates. (tracks-movie.com)
  • Hamme, A. T. II "Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation" Synthesis 2006 , 3815-3818. (jsums.edu)
  • Reductive cyclization gave the target compounds in excellent overall yield from readily available bulk chemicals. (chimia.ch)
  • Reductive cleavage of phthalimides using hydrazine hydrate afforded the primary amines. (uni-regensburg.de)
  • Finally, the use of elemental hydrogen as a terminal reductant in the rhodiumcatalyzed enantioselective reductive cyclization of 1,6-enynes is described. (utexas.edu)
  • Whereas 1,6- enynes containing 1,2-substituted alkenes fail to provide reductive cyclization products due to competitive cycloisomerization, related alkenes in the form of conjugated enones afford reductive cyclization products in good to excellent yield and enantioselection. (utexas.edu)
  • In the final phase of this investigations it was explored the use of chiral derivatives of the chiral pool molecule citronellal as well as an achiral analogue in an effort to afford novel chiral aldehydes for propargylation and cyclisation. (bl.uk)
  • Diastereotopic differentiation is achieved through cyclization via ring-closing metathesis (RCM), affording a chiral, non-racemic bicyclic P-heterocycle, which is stereogenic at phosphorus. (ku.edu)
  • Cyclization of chiral diols proceeded via stereoselective SN2 Mitsunobu reaction by using Bu3P-ADDP (Azodicarbonyl dipiperidine) to obtain cyclic building blocks. (uni-regensburg.de)
  • The reaction afforded the cross-coupled product in high yield. (organic-chemistry.org)
  • This was successfully carried out using a Carreira asymmetric alkynylation reaction to afford optically active propargyl alcohols with good to excellent enantiomeric excess (50%-82% ees). (bl.uk)
  • An efficient copper-mediated three-component reaction of one molecule of amine and two molecules of nitriles affording fully substituted 1,2,4-triazoles has been developed. (rsc.org)
  • The reaction of the title cyclic imidate with o -phenylene dinucleophiles affords the 2-substituted benzazoles ( 3a - c ). (heterocycles.jp)
  • Reaction at 170° under high pressure afforded 3 moles of cyclohexanesulfamate from 1 mole of ammonium nitri-dotrisulfate, but only 1 mole of cyclohexanesulfate was obtained from 1 mole of metal nitridotrisulfate. (go.jp)
  • In the reaction of sodium nitridotrisulfate and cyclohexylamine, addition of the acid of cyclohexylammono system, such as ammonium chloride, ammonium sulfate, cyclohexylamine hydrochloride, or cyclohexylamine sulfate, afforded cyclohexanesulfamate in a good yield. (go.jp)
  • The reaction was essentially a conjugate addition (that is, the Sulphur electrons attacking the back end of a C=C-C=O system), followed by in situ base-mediated cyclisation and dehydration to afford the fused thiophene system. (chemicalforums.com)
  • The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. (ru.ac.za)
  • A novel 2- Cyanomethine- 4,5dihydro-4-oxo-5-(2,4dichlorophenyl) methylidine 1,3 thiazole (2) was obtained via the reaction of 4-thiazolidinone (1) with 2,4 dichloro- benzaldehyde .Treatment of 4-thiazolodinone derivatives(2) with 2,4 dichlorobe-nzaldhyde afforded 2,5-bis arylmethylidine derivatives (3a-d). (researchcommons.org)
  • The transitional reaction intermediate named ortho-hydroxycinnamic acid affords the target product via a spontaneous lactonization [19]. (jmchemsci.com)
  • A method for the production of cyclic polyammonium ions is presented which utilizes a polymer cyclization of azide terminated linear polymer based on the "click" reaction. (caltech.edu)
  • Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system. (jsums.edu)
  • Cyclization with formic acid completed the synthesis of phendimetrazine (5). (wikipedia.org)
  • A tandem double addition-oxidative cyclization mechanism has been proposed for the synthesis of 1,2,4-triazoles. (rsc.org)
  • The N-aryl benzophenone hydrazones are converted to indole products via an in situ hydrolysis/Fischer cyclization protocol, A procedure that extends this methodology to the synthesis of N-alkylindoles via the intermediacy of N-aryl-N-alkyl benzophenone hydrazones is described. (mit.edu)
  • Protection of amine followed by selective hydrolysis of methyl ester afforded the corresponding acid which was converted to acid chloride. (uni-regensburg.de)
  • subsequent hydrolysis would have afforded a carbonyl compound hence creating a g-acylvinyl anion equivalent. (soton.ac.uk)
  • Additionally, the Pd-catalyzed preparation of diaryl benzophenone hydrazones, followed by a hydrolysis/Fischer cyclization protocol, affords N-arylindole products in good yields. (mit.edu)
  • Cyclization of peptides with two chemical bridges affords large scaffold diversities. (epfl.ch)
  • Backbone head-to-tail cyclization, i.e., setting a covalent peptide bond linking the last amino acid with the first one, is one effective strategy of peptide-based drug design to stabilize the conformation of bioactive peptides while preserving peptide properties in terms of low toxicity, binding affinity, target selectivity, and preventing enzymatic degradation. (bvsalud.org)
  • We prepared a collection of complex cycloheptatriene-containing azetidine lactones by applying two key photochemical reactions: "aza-Yang" cyclization and Buchner carbene insertion into aromatic rings. (ku.edu)
  • We present highly diastereoselective tethered aza-Wacker cyclization reactions of alkenyl phosphoramidates. (ku.edu)
  • A visible light catalyzed cyclization of bis(enones) to afford enantiomerically enriched cyclopentane rings, the use of packed-bed reactors in light-driven reactions and a continuous flow approach to access alpha-trifluoromethylthiolated esters and amides starting from commercially available arylacetic acids will be also described, as well as in-flow on water ultrafast organic transformations. (selectbiosciences.com)
  • Electrophilic cyclization, oxyboration, and iodocyclization reactions are also known to afford isocoumarins. (web.app)
  • The cyclization of various β-amino acids with PhP(O)Cl 2 affords cyclo-β-dipeptides, whose boat conformation is probably responsible for the high diastereoselectivity observed in the alkylation reactions of their lithium enolate derivatives. (iupac.org)
  • In addition, the efficacy of this protocol allows for the preparation of a fused seven-membered pyridone and for intermolecular cyclizations. (unboundmedicine.com)
  • Several MO caging strategies have been devised, employing hairpin structures, 7 intermolecular duplexes, 8 , 9 nucleobase modifications, 10 or oligonucleotide cyclization. (cdc.gov)
  • A cooperative catalytic process through Palladium and Brønsted acid activation has been developed for the conjugate addition of cyclic ß -keto esters 2 to azoalkenes 1 directly followed by hemiaminal formation upon cyclization. (uni-leipzig.de)
  • The key transformations involved addition of a trimethylsilylnitro benzene to an aromatic aldehyde which afforded the key nitroalcohol intermediate. (chimia.ch)
  • The chloride anion then acts as a base to afford the aldehyde product and chromium(IV). (kiddle.co)
  • Also, compound 2 condensed with aryl aldehyde 4a in ethanol containing 10% sodium hydroxide to afford the condensation product 5 based on its elemental and spectral data (Scheme 1 ) [ 21 ]. (biomedcentral.com)
  • It was also realised that chloropolyols undergo regio- and stereoselective cyclisation by simply heating them in water to provide highly functionalised tetrahydrofuranols, including carbohydrate analogues. (sfu.ca)
  • Subsequent cyclization between the amino and carbonyl groups followed by aromatization provides 3,4'-biquinoline products. (korea.ac.kr)
  • Cyclisation of the adducts in the presence of HCI afforded the corresponding 3-(chloromethyl)coumarin derivatives, which have been reacted with various amine hydrochlorides in the presence of Proton Sponge® to afford a series of novel 3- (aminomethyl)coumarin derivatives, which were fully characterised by NMR and HRMS methods. (ru.ac.za)
  • Cyclization of compound (2) with various α-Cyanocinnamonitriles(4a-c) afforded the corresponding thiazolopyrid-ine enaminonitrile derivatives (5a-c). (researchcommons.org)
  • Thus cyclocondensation of 2 with active methylene reagent such as malononitrile in ethanol under reflux in the presence catalytic amount of piperidine afforded indazole derivative 3 on the basis of analytical and spectral data (Scheme 1 ). (biomedcentral.com)
  • We report herein the catalytic asymmetric cyclization of 1-aryl terpenols to afford enantiomerically highly enriched cis-tetrahydrocannabinoid scaffolds in a single step. (uni-leipzig.de)
  • Upon ion exchange, the method selectively affords atropisomeric acridinium tetrafluoroborate salts in high yields and an enantioenrichment of up to 93 : 7 e.r. (unibas.ch)
  • Oxidation (via squalene monooxygenase) of one of the terminal double bonds of squalene yields 2,3-squalene oxide, which undergoes enzyme-catalyzed cyclization to afford lanosterol, which is then elaborated into cholesterol and other steroids. (selfdecode.com)
  • We have developed a highly stereospecific cyclization of aziridine silanols into 1′-amino-tetrahydrofurans. (ku.edu)
  • Second, and more importantly, we show that it seems possible to elaborate on the information inferred from protein structures to propose effective candidate linker sequences constrained by length and amino acid composition, providing the first framework for the rational design of head-to-tail cyclization linkers. (bvsalud.org)
  • We report here that the silver triflate-catalyzed cyclization of 2-amino-6-propargylamineazines affords new and highly functionalized iminoimidazoazines. (uaeu.ac.ae)
  • The procedure is illustrated in Scheme 2 (see compounds 1 6) from a d-arabinofuranosylamine, using octylmagnesium bromide, and from a d-glucopyranosylamine using allylmagnesium bromide, and cyclization promoted by reacting the intermediate amino alditol with triflic anhydride. (enscada.com)
  • The desired optical active propargyl alcohols were then complexed, with dicobalt octacarbonyl, to afford the corresponding dicobalt hexacarbonyl complexes. (bl.uk)
  • Gold-catalyzed cyclization- of pyratoles having a terminal alkyne afforded the 6-exo-dig cyclization:product. (metu.edu.tr)
  • cyclization with NaH only resulted in the formation of 6-exo-dig cyclization products regardless of the substitution of the alkyne functionality. (metu.edu.tr)
  • These authors have shown, for the first time, that the addition of Grignard reagents to N-benzyl and N-alkyl glycosylamines derived from perbenzylated pentofuranoses or hexopyranoses followed by a simple cyclization procedure afforded a short and convenient approach to imino-C-glycosides in the pyrrolidine and piperidine series [43,44]. (enscada.com)
  • In particular, this thesis describes the addition of organolithium reagents and lithium enolates to optically pure ɑ-chloroaldehydes to afford 1,2-anti-chlorohydrins in a highly diastereoselective manner. (sfu.ca)
  • Conjugate addition of tert-butoxide to 2-aminochalcones provided the corresponding enolates, which underwent Michael addition to another molecule of 2-aminochalcone to afford a dimeric species of 2-aminochalcones. (korea.ac.kr)
  • The anion of vinyl dithiocarbamate was also alkylated and the products hydrolysed with titanium tetrachloride to afford the corresponding ketones thus providing an acyl anion equivalent. (soton.ac.uk)
  • Ring-closing olefin metathesis has been shown to provide a very high yielding route to [c2]daisy-chains suitably functionalized to allow their one-step conversion to bis-olefins which can be used as monomers in ADMET polymerizations to afford mechanically interlocked polymers. (caltech.edu)
  • The route involves stereospecific displacement of iodide by a cuprate to form a trisubstituted double bond, followed by cyclisation. (soton.ac.uk)
  • Our route uses a sulfamate-tethered aza-Wacker cyclization as a key step and commences from d-erythrono-1,4-lactone. (ku.edu)
  • A disulfonimide catalyst activates racemic trichloroacetimidate substrates and imparts stereocontrol in the cyclization step, providing a new avenue for selective ortho-quinone methide iminium functionalization. (unibas.ch)
  • Treatment of lactol with bisprotected imidazole in the presence of n-butyl lithium afforded diols as two diastereomers. (uni-regensburg.de)