MetastasisImmuneLymphomasProteinsUndergoReceptorMembraneEfficacyStudiesCancerNormalSignificantPrimaryGrowthTransportationStromal cellsMammalianEndogenousVitroMetabolicToxicityPopulationsPrerequisiteSecretoryStagesPathwayGenesInductionComplexSpecificallySpeciesCancer cellsProductionMainProcessFeaturesMassFoundFemaleFunctions
Metastasis2
- Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
- Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
Immune3
- Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
- Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
- LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
Lymphomas1
- Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
Proteins1
- Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
Undergo2
- Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
- During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
Receptor1
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Membrane1
- Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane. (wikipedia.org)
Efficacy1
- Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
Studies1
- Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
Cancer1
- The metabolism of cancer cells is also different from the metabolism of normal cells, and these differences can be used to find targets for therapeutic intervention in cancer. (wikipedia.org)
Normal2
- This figure shows the idealized cyclic changes in pituitary gonadotropins, estradiol (E2), progesterone (P), and uterine endometrium during the normal menstrual cycle. (msdmanuals.com)
- However, amenorrhea can occur when ovulation is normal, as occurs when genital anatomic abnormalities (eg, congenital anomalies causing outflow obstruction, intrauterine adhesions [Asherman syndrome]) prevent normal menstrual flow despite normal hormonal stimulation. (msdmanuals.com)
Significant1
- In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
Primary1
- Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Growth2
- Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
- Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
Transportation1
- The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. (wikipedia.org)
Stromal cells2
- In the receptive uterus on day 4 of pregnancy (day 1 = vaginal plug), the onset of embryo implantation elicits the prerequisite transformation of stromal cells into decidual cells (decidualization), which is a gateway to pregnancy establishment. (plos.org)
- Yibin Kang, Ph.D., Princeton University Dr. Kang's team focuses on the molecular mechanisms driving breast cancer metastasis, in particular exploring how stromal cells in secondary organs provide cellular "niches" that allow cancer cells to metastasize. (cancer.org)
Mammalian1
- Nevertheless, the recapitulation of female germ cell development from the early preantral stage is challenging and remains in its rudimentary stage for mammalian species. (nature.com)
Endogenous2
- The two most sensitive DT40 mutants (FANCD1 (BRCA2) and FANC2 -deficient cells) show sensitivity to formaldehyde at concentrations between 10-15 µmol/L, which lay below or in the very low range of those of endogenous formaldehyde. (europa.eu)
- Specifically, L-glutamate induced and partially mimicked endogenous feeding cycles, whereas glycine and GABA suppressed feeding. (frontiersin.org)
Vitro2
- Artificial reproductive technology (ART) such as, germ cell cryopreservation and in vitro embryo production can potentially contribute to species conservation when populations decline to a critically small size 1 . (nature.com)
- The inhibition of mitochondrial activity by various pharmacological inhibitors, as well as by gene-specific targeting using siRNA-mediated technology showed a dramatic attenuation of polyploidy and bi-nucleation development during in vitro stromal cell decidualization, suggesting mitochondria play a major role in positive regulation of decidual cell polyploidization. (plos.org)
Metabolic3
- Enzymes act as catalysts - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction, for example in response to changes in the cell's environment or to signals from other cells. (wikipedia.org)
- As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or on breaking them down and using them to obtain energy, by their digestion. (wikipedia.org)
- Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
Toxicity2
- No correlation was found between GHS concentrations and formaldehyde-induced cell toxicity, revealing that the homologous recombination pathway rather than the NHEJ pathway is involved in repair of DNA-protein crosslinks (DPC). (europa.eu)
- The recommended dose of PADCEV is 1.25 mg/kg (up to a maximum dose of 125 mg) given as an intravenous infusion over 30 minutes on Days 1, 8 and 15 of a 28-day cycle until disease progression or unacceptable toxicity. (nih.gov)
Populations2
- During such transitions, the canonical, synaptically-wired nervous systems could be preceded by the so-called "volume transmission type integrative systems," composed of heterogeneous populations of secretory cells releasing signal molecules ( Moroz, 2009 , 2021 ). (frontiersin.org)
- In the present study, to better define the aspects of decidual cell polyploidy, we isolated pure polyploid and non-polyploid decidual cell populations from the in vivo decidual bed. (plos.org)
Prerequisite1
- With a strong consumer push to reduce electric vehicle prices, large-scale and cost-efficient li-ion battery cell assembly is a prerequisite for every automotive OEM. (greencarcongress.com)
Secretory2
- [7] This complex consists of structural components and secretory organelles required for invasion of host cells during the parasitic stages of the Apicomplexan life cycle . (eol.org)
- The lower epithelium acts as the densely ciliated locomotory surface with a vertical orientation of digestive/secretory cells supporting feeding. (frontiersin.org)
Stages2
- [7] Apicomplexa have complex life cycles, involving several stages and typically undergoing both asexual and sexual replication . (eol.org)
- [7] All Apicomplexa are obligate parasites for some portion of their life cycle, with some parasitizing two separate hosts for their asexual and sexual stages. (eol.org)
Pathway3
- Upstream and downstream components of the FA DNA-repair pathway were tested using mutant chicken DT40 cell lines. (europa.eu)
- Mutations in all components of the FA pathway tested sensitized cells to formaldehyde. (europa.eu)
- Davide Ruggero, Ph.D., University of California, San Francisco Dr. Ruggero's lab will build on its work aiming to repair the processes that prevent cell proliferation as part of the pathway that translates mRNA into proteins, a hallmark of cancer. (cancer.org)
Genes1
- Assessment of DNA damage response to plasma levels of formaldehyde in chicken DT40 and colorectal cancer (RKO) cells with targeted mutations in various DNA repair genes. (europa.eu)
Induction2
- The cells also showed enhanced induction of Ser139 phosphorylation of histone H2AX. (europa.eu)
- Consistently, studies revealed a marked induction of mitochondrial mass and ATP production in polyploid cells. (plos.org)
Complex2
- A further group of spherical organelles is distributed throughout the cell rather than being localized at the apical complex and are known as the dense granules. (eol.org)
- ATP-modified feeding is complex, first causing feeding-like cycles and then suppressing feeding. (frontiersin.org)
Specifically1
- During the interim between FMD cycles, the participants were instructed to specifically eat adequate calories (20-30 kcal/kg weight/day) and protein (1.2-1.5 g protein/kg weight/day, mainly derived from fish, legumes, eggs, and dairy products). (naturalmedicinejournal.com)
Species1
- For example, the set of carboxylic acids that are best known as the intermediates in the citric acid cycle are present in all known organisms, being found in species as diverse as the unicellular bacterium Escherichia coli and huge multicellular organisms like elephants. (wikipedia.org)
Cancer cells1
- The metabolism of cancer cells is also different from the metabolism of normal cells, and these differences can be used to find targets for therapeutic intervention in cancer. (wikipedia.org)
Production1
- It provides strong adhesion to the substrate material and offers production adaptability through long open times and short cure cycles. (greencarcongress.com)
Main1
- Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane. (wikipedia.org)
Process2
- High-volume manufacturing operations with short cycle times and process flexibility are essential. (greencarcongress.com)
- The activation, growth, and development of an ovarian follicle, a process termed ovarian folliculogenesis, is finely regulated by cell-to-cell interactions and coordinated gene expression in the oocyte and surrounding granulosa cells (GCs) 4 . (nature.com)
Features2
- Each follicle stage is characterised by cell-specific morphological and physiological features of the oocyte and the surrounding follicular cells 4 . (nature.com)
- The work will uncover previously unknown features of myeloid cells in cancer and, more importantly, will provide new approaches to their therapeutic targeting. (cancer.org)
Mass1
- Body composition: Measures included fat-free mass, fat mass, phase angle, extracellular mass-to-body cell mass ratio (ECM/BCM), total body water, and intracellular water. (naturalmedicinejournal.com)
Found1
Female1
- There were 90 original participants (86% female), with 81 completing at least 1 FMD cycle and 65 participants completing 2 to 21 FMD cycles. (naturalmedicinejournal.com)
Functions1
- Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)