CCNA1CDKsKinasesDependent kinaseKinase inhibitorMitoticProliferationSubunitCDK2ProgressionInteractsAntigenCDK1Retinoblastoma proteinMitogen-activaMembrane proteinsPolyclonalSourcProteolysisMeioticMRNAReplicationGermTumorAmino acidsBindInteractionsMetastasisAldehyde DehydrogenaseAbsentNotablyResiduesELISA KitTransmembraneCytochromeDegradationExpressionRibosomalCellsGene proteinHumanMutationsFamilyModificationInduction
CCNA11
- Cyclin a1 (CCNA1) was identified as a potential ALT-associated gene in the analysis of in-house RNA sequencing data. (edu.au)
CDKs2
- Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). (ximbio.com)
- Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
Kinases2
- Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)
- Malumbres, M. Cyclin-dependent kinases. (nature.com)
Dependent kinase5
- Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. (aacrjournals.org)
- The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
- Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
- The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
- Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
Kinase inhibitor1
- BCA Protein Assay The exact protein concentration in each sample was Nalfurafine hydrochloride small molecule kinase inhibitor determined by applying the bicinchoninic acid (BCA) assay [38] using bovine serum albumin (BSA), in the range of concentration between 5 and 25 g/mL, to produce the calibration curves. (researchensemble.com)
Mitotic3
- The first of the three major projects involves understanding the function of the A and E-type cyclins during the mitotic and meiotic cell cycles mainly during spermatogenesis but also in oogenesis. (columbia.edu)
- We have demonstrated that cyclin A1 is essential for the progression of spermatocytes into the first meiotic division, that cyclin A2 is required for mitotic divisions of male germ cell stem cells, and that the E-type cyclins have unexpected function during meiosis, notably in the maintenance of telomere integrity. (columbia.edu)
- Browse our antibodies, ELISA kits and proteins related to mitotic G1-G1/S phases. (antibodies-online.com)
Proliferation3
- Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
- We decellularized the metastatic lung sections, measured the micromechanics of the tumor ECM, and stained the sections for ECM proteins, proliferation, and cell death markers. (ibecbarcelona.eu)
- In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. (nature.com)
Subunit6
- Recently, we have identified ULTRAVIOLET-B-INSENSITIVE4 (UVI4) as a plant-specific component of the APC/C. Here, we demonstrate that UVI4 uses conserved APC/C interaction motifs to counteract the activity of the CELL CYCLE SWITCH52 A1 (CCS52A1) activator subunit, inhibiting the turnover of the A-type cyclin CYCA2;3. (ugent.be)
- The IkB alpha antibody outcomes recommend a previously unidentified part from the 2/1 subunit in skeletal c-Kit-IN-2 muscle tissue and support the participation of this proteins in extracellular signalling. (cell-signaling-pathways.com)
- Small is well known about the contribution from the 2/1 subunit because lack of this proteins can be lethal in 2/1-null embryos (Joshi & Taylor, 2006). (cell-signaling-pathways.com)
- How the deletion from the 2/1 subunit offers such disparate outcomes as lethality in a single set of conditions and little impact in another can be intriguing and shows that this proteins may perform essential functions not linked to EC coupling. (cell-signaling-pathways.com)
- This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
- This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
CDK24
- Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
- NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
- Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
- Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
Progression2
- Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. (ximbio.com)
- The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction. (ugent.be)
Interacts1
- All of those other peptide is situated beyond your cell and interacts with the two 2 proteins via disulphide bridges. (cell-signaling-pathways.com)
Antigen1
- Simian virus 40 large T antigen associates with cyclin A and p33cdk2. (ximbio.com)
CDK11
- controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
Retinoblastoma protein1
- Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
Mitogen-activa1
- In addition, phosphorylated ERK1/2 and p38, key members of mitogen-activated protein kinase (MAPK) family regulating BCa tumorigenesis, were strongly decreased. (spandidos-publications.com)
Membrane proteins2
- These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)
- The EphA receptors (A1-A9) bind to EphrinA ligands, a group of glycosyl phosphatidylinositol-linked membrane proteins and EphB receptors (B1-B6) interact with EphrinB ligands [ 9 ]. (medsci.org)
Polyclonal1
- Associates out of this grouped family members are been shown to be involved with amino acidity Vismodegib biological activity sensing and signaling, and SLC38A2 was upregulated on both gene and proteins amounts after amino acidity hunger in BeWo Rabbit Polyclonal to Cyclin A1 cells (Novak et al. (bioshockinfinitereleasedate.com)
Sourc1
- protein interacting with cyclin A1 [Sourc. (gsea-msigdb.org)
Proteolysis1
- Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. (ximbio.com)
Meiotic1
- Subsequently, meiotic cohesin SMC1β, cohesin SMC3, and AE proteins SCP2 and SCP3 formed dots along REC8-AEs, which extended and fused until they lined REC8-AEs along their length. (rupress.org)
MRNA2
- In human BCa tissues, we observed that LAPTM5 was significantly induced at both mRNA and protein levels, which is consistent with our microarray result. (spandidos-publications.com)
- It has been proven both in the mRNA (Varadi 1989) as well as the proteins amounts (Morton & Froehner, 1989). (cell-signaling-pathways.com)
Replication3
- activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. (proteopedia.org)
- RPA, replication protein A. (rupress.org)
- This is accompanied by DNA double-strand break (DSB) induction and recruitment of the DNA repair proteins replication protein A, Rad51, and 53BP1 to damaged regions. (rupress.org)
Germ1
- A second area of research involves elucidating the function of the BET family of double bromodomain-containing proteins, proteins that read epigenetic marks, during germ cell differentiation and neural development. (columbia.edu)
Tumor3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Protein, Translationally Controlled 1 (TPT1) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (allelisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Protein, Translationally Controlled 1 (TPT1) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
- Description: A competitive ELISA for quantitative measurement of Human Translationally controlled tumor protein(TPT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (allelisakits.com)
Amino acids1
- Furthermore, principal embryonic cortex cells had been deprived of nine proteins, the most frequent amino acids carried with the SLC38 family, for 3 h, 7 h or 12 h, as well as the gene appearance was assessed using qPCR. (bioshockinfinitereleasedate.com)
Bind1
- Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
Interactions2
- The c-Kit-IN-2 VWA site is situated in cell adhesion and extracellular matrix proteins and it is regarded as involved with proteinCprotein interactions needing divalent cations. (cell-signaling-pathways.com)
- Integrated analysis uncovered interactions between Yes-associated protein 1 (YAP1) and TP53 mutation potentially plays a role in inducing this chemosensitivity. (edu.au)
Metastasis1
- Whereas the disruption of cell-cell contacts alone does not enable metastasis, the loss of E-cadherin protein does, through induction of an epithelial-to-mesenchymal transition, invasiveness, and anoikis resistance. (gsea-msigdb.org)
Aldehyde Dehydrogenase1
- The other 2 genes encoded phase 2 enzymes [NAD(P)H-quinone oxidoreductase1and aldehyde dehydrogenase family 3, subfamily A1]. (thieme-connect.com)
Absent1
- Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. (ximbio.com)
Notably1
- The VWA occurs most in integrins and extracellular matrix proteins notably. (cell-signaling-pathways.com)
Residues1
- Post-translation cleavage outcomes within an extracellular 2 proteins including 950 N-terminal residues and a proteins with 130 C-terminal residues. (cell-signaling-pathways.com)
ELISA Kit1
- Description: A sandwich ELISA kit for detection of Apolipoprotein A1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisastrip.com)
Transmembrane3
- GSE76211) ( 3 , 4 ), revealing a significantly upregulated gene in BCa tissues, the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5). (spandidos-publications.com)
- transmembrane protein 98 [Source:HGNC Sym. (gsea-msigdb.org)
- Although the complete proteins topology isn't known, evidence shows that a little part of the peptide can be a transmembrane section with a brief cytoplasmic tail. (cell-signaling-pathways.com)
Cytochrome1
- Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)
Degradation1
- p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. (nature.com)
Expression8
- In disorders such as leukemia, increased expression of antiapoptotic proteins, such as Bcl-2, is required for disease maintenance ( 3 ), confers drug resistance ( 4 ), and is associated with poor clinical outcome ( 5 ). (aacrjournals.org)
- To determine the antiproliferative effect of gamma-tocotrienol (GTT) treatment on differential protein expression in HepG2 cells. (biomedcentral.com)
- In MDA-MB-231 cells, treatment by tocotrienols led to several fold increase of NRF2 expression marked by corresponding decrease in Kelch-like ECH-associated protein 1 (KEAP1) levels [ 15 ]. (biomedcentral.com)
- Amino acidity signaling and sensing is essential for cells, and both gene protein and expression degrees of amino acid transporters are regulated in response to amino acid availability. (bioshockinfinitereleasedate.com)
- Accordingly, we review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D-related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ . (biomedcentral.com)
- Two proteins have been implicated in expression-independent vitamin D action: membrane VDR and the membrane-associated rapid response steroid binding (1,25D 3 -MARRS) protein. (biomedcentral.com)
- To demonstrate the utility of CompNet, we have compared a (time-series) human gene-expression dataset, post-infection by two strains of Mycobacterium tuberculosis , overlaid on the human protein-protein interaction network. (biomedcentral.com)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
Ribosomal1
- ribosomal protein S6 kinase related [Sour. (gsea-msigdb.org)
Cells8
- Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
- LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
- Cyclin A is a marker for actively proliferating cells and for cells in S phase. (ximbio.com)
- HepG2 cells were treated with 70 μM GTT for 48 hours and differentially expressed protein spots were determined by two-dimensional electrophoresis (2DE), identified by MALDI-TOF mass spectrometer (MS) and validated by quantitative real-time polymerase chain reaction (qRT-PCR). (biomedcentral.com)
- GTT treatment on HepG2 cells showed a total of five differentially expressed proteins when compared to their respective untreated cells where three proteins were down-regulated and two proteins were up-regulated. (biomedcentral.com)
- The involvement of multiple signaling pathways (NF-κB and JNK) and proteins (EGF-R, Id-1 and Id-3) was suggested to explain the antiproliferative effect of GTT in prostate cancer (PCa) cells [ 14 ]. (biomedcentral.com)
- A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
- An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
Gene protein1
- What does this gene/protein do? (cancerindex.org)
Human1
- The protein interaction landscape of the human CMGC kinase group. (nature.com)
Mutations1
- The Omicron variant is the most divergent, displaying more mutations than previous SARS-CoV-2 variants, particularly in the gene that encodes the spike protein. (bvsalud.org)
Family1
- WAS/WASL interacting protein family membe. (gsea-msigdb.org)
Modification1
- A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin. (reactome.org)
Induction1
- 8 Visanji J M, Thompson D G, Padfield P J. Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. (thieme-connect.com)