Cyclin B1 is phosphorylated by Polo kinase and Cdk1, again setting up a positive feedback loop that commits cyclin B1-Cdk1 to its fate. (wikipedia.org)
Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)
In recent years, cell cycle regulators have been shown to exhibit roles in both tumor suppression and tumor promotion, particularly cyclin-dependent kinase inhibitors (CKI) p27 kip1 and p21 cip1 14 . (biorxiv.org)
The model starts at mitotic entry initiated by the activities of Cyclin-dependent kinase 1 (CDK1) and Polo-like kinase 1 (PLK1), transitions through Anaphase-promoting complex (APC/C) bound to Cell division cycle protein 20 (CDC20), and ends upon mitotic exit mediated by APC/C bound to CDC20 homolog 1 (CDH1). (pharmafocusasia.com)
Kinases2
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
Cell cycle progression is governed by a complex network of cyclin-dependent kinases that define not only the phase of the cell cycle, but also the timing of transitions between phases 13 . (biorxiv.org)
Subunits1
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
Tumor6
High expression levels are usually seen before the tumor cells become immortalized and aneuploid which can contribute to the chromosomal instability and the aggressive nature of certain cancers. (wikipedia.org)
These high levels of cyclin B1 can also be associated to the extent of tumor invasion and aggressiveness therefore concentration of cyclin B1 can be used to determine the prognosis of cancer patients. (wikipedia.org)
For example, an increase in expression of cyclin B1/cdc2 is significantly higher in breast tumor tissue and shown to increase lymph node metastasis in breast cancer. (wikipedia.org)
While the exact mechanism that explains how cyclin B1 becomes overexpressed is not very well understood, previous work has shown that down regulation of cyclin B1 can lead to tumor regression. (wikipedia.org)
We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished). (plos.org)
A role of this pathway in tumor progression was recommended as PAI1, a target gene of TGFBSmad23, showed higher levels in higher grade tumors. (sirnalibrary.com)
Protein10
G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. (wikipedia.org)
Consistent with this, mRNA and protein levels of the invadopodia key components, cortactin and MT1-MMP, peak at 14 hours post-release. (biorxiv.org)
Cell cycle consists of oscillating changes in protein concentrations and activities within the cell allowing for duplication of the host genome and eventual cell division. (pharmafocusasia.com)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. (clairefrostacupuncture.com)
Acute exercise where to buy prozac in denver online suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. (clairefrostacupuncture.com)
Thus, the G-protein-coupled 5-HT1A-R is present at significant levels in the P6 hippocampus to. (thetechnoant.info)
The dendritic cells of elite controllers, however, were found to contain higher levels of HIV DNA, probably because of limited expression of a protein called SAMDH1 that usually blocks reverse transcription in several types of immune cells. (regenerativemedicine.net)
The dendritic cells of elite controllers also appear to produce higher levels of a DNA-sensing protein called cGAS that recognizes the presence of HIV and induces rapid expression of type 1 interferons. (regenerativemedicine.net)
Gene2
Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2-dependent transcription. (biomedcentral.com)
cDNA Libraries Can Be Prepared from Selected Populations of mRNA Molecules 19 When cDNAs are prepared from cells that express the gene of interest at extremely high levels, the majority of cDNA clones may contain the gene sequence, which can therefore be selected with minimal effort. (forexsignalx.com)
Transcription3
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
The role of cyclin B1 is to transition the cell from G2 to M phase but becomes unregulated in cancer cells where overexpression of cyclin B1 can lead to uncontrolled cell growth by binding to its partner Cdks. (wikipedia.org)
Cell cycle progression is faster in cells in which invadopodia are abolished (by Tks5 knockdown), evidenced by earlier induction of cyclins A and B. A close look at the regulators of G1 revealed that the overexpression of p27 kip1 , but not p21 cip1 , causes faster turnover of invadopodia and increased ECM degradation. (biorxiv.org)
Phosphorylation6
Phosphorylation of the lamins by cyclin B1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down. (wikipedia.org)
Phosphorylation of cyclin B1 causes it to be imported to the nucleus, and phosphorylation also prevents export from the nucleus by blocking the nuclear export signal. (wikipedia.org)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
Drepper F, Biernat J, Kaniyappan S, Meyer HE, Mandelkow EM , Warscheid B, Mandelkow E . A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications. (neurotree.org)
Cdk17
Its activation is well-regulated, and positive feedback loops ensure that once the cyclin B1-Cdk1 complex is activated, it is not deactivated. (wikipedia.org)
Cyclin B1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. (wikipedia.org)
Once activated, cyclin B1-Cdk1 promotes several of the events of early mitosis. (wikipedia.org)
Another important function of the cyclin B1-Cdk1 complex is to break down the nuclear envelope. (wikipedia.org)
Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. (wikipedia.org)
Another mechanism by which cyclin B1-Cdk1 activity is regulated is through subcellular localization. (wikipedia.org)
Cyclin B1 has been shown to interact with Cdk1, GADD45A and RALBP1. (wikipedia.org)
MRNA2
Here we demonstrate that Atf3 mRNA levels increase during mouse chondrocyte differentiation in vitro and in vivo . (biomedcentral.com)
In addition, Atf3 mRNA levels are increased in response to cytochalasin D treatment, an inducer of chondrocyte maturation. (biomedcentral.com)
A positive feedback from an oscillating MAPK cascade was shown to induce oscillations in an external signal processing module, uncovering a novel regulatory aspect of MAPK signal processing. (biomedcentral.com)
Significantly higher1
Cells synchronized in the G0/G1 phase of the cell cycle degrade at significantly higher levels during the first 20 hours post-synchronization release. (biorxiv.org)
Progression1
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
Transition1
At the end of the third instar, pulses of ecdysone, combined with a low level of JH, trigger the larval-pupal transition and metamorphosis. (sdbonline.org)
Functional1
It was observed that the positive feedback emerging from an oscillating MAPK cascade and functional in an external signal processing module can trigger oscillations in the target module, provided that the target module satisfy certain parametric requirements. (biomedcentral.com)
Cell5
Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. (wikipedia.org)
At the end of mitosis, cyclin B1 is targeted for degradation by the APC through its APC localization sequence, permitting the cell to exit mitosis. (wikipedia.org)
Previous work has shown that high cyclin B1 expression levels are found in variety of cancers such as breast, cervical, gastric, colorectal, head and neck squamous cell, non-small-cell lung cancer, colon, prostate, oral and esophageal. (wikipedia.org)
Activity1
Patients with uncomplicated myocardial infarctions are advised to increase activity and return to about 90 of the preinfarction level in three months. (forexsignalx.com)
In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
Found1
As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
Patients1
The duration of the PACU stay and patients' satisfaction levels in the PACU were also recorded. (bvsalud.org)
Activation1
Additionally, M alone did not alter the activation level of ERK1/2 in AGN 205327 the HN2-5 cells (Physique S1). (thetechnoant.info)
Variety1
Irradiation methods and apparatus configured to deliver power, via electromagnetic fields at a variety of frequencies and power levels, in a localized fashion to a target area. (patentsencyclopedia.com)
State1
We previously demonstrated that invasive cells oscillate between two distinct states, termed the Invadopodia state and the Migration state 10 . (biorxiv.org)
Phase1
The diurnal difference analysis revealed that the levels of most amino acids and peptides were higher in the light phase, while the levels of most lipids were higher in the dark phase. (bvsalud.org)
Mouse2
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. (neurotree.org)