Cyclin gene mitotic cyclin. Medical search. Frequent questions

Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding. (nih.gov)
Cyclin-dependent kinase 1 (Cdk1) is absolutely essential for cell division. (eur.nl)
Dampening Cdk1 activation, by reducing gene expression or upon treatment with cell-permeable Cdk1 inhibitors, is also detrimental for proliferating cells, but has been associated with defects in mitotic progression, and the formation of aneuploid daughter cells. (eur.nl)
Here, we used a large-scale RNAi screen to identify the human genes that critically determine the cellular toxicity of Cdk1 inhibition. (eur.nl)
We show that Cdk1 inhibition leads to fatal sister chromatid alignment errors and mitotic arrest in the spindle checkpoint. (eur.nl)
Our results show that, normally, Cdk1 activity must rise above the level required for mitotic entry. (eur.nl)
Here we show that cells transactivate the mitotic gene network as they exit the S phase through a CDK1 (cyclin-dependent kinase 1)-directed FOXM1 phosphorylation switch. (elsevierpure.com)
DTL depletion resulted in the disruption of the mitotic proteins cyclin B, CDK1 , securin, seprase, Aurora A, and Aurora B as well as the upregulation of the cell cycle arrest gene [i]p21[/i]. (transhumanist.ru)

Cyclins function as regulators of CDK kinases. (novusbio.com)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Increasing numbers of sequence and biochemical data show the involvement of cyclin-dependent kinases (CDKs) and cyclins in regulation of the cell cycle progression in higher plants. (bibbase.org)
The present yeast two-hybrid analyses showed differential interaction between defined D-type cyclins and Cdc2Ms kinases functioning in G2/M phases. (bibbase.org)
article{meszaros_multiple_2000, title = {Multiple cyclin-dependent kinase complexes and phosphatases control {G2}/{M} progression in alfalfa cells}, volume = {43}, issn = {1573-5028}, url = {https://doi.org/10.1023/A:1006412413671}, doi = {10/cb64mn}, abstract = {Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
Cell cycle progression is governed by a complex network of cyclin-dependent kinases that define not only the phase of the cell cycle, but also the timing of transitions between phases 13 . (biorxiv.org)
Access into S-phase and mitosis in the eukaryotic cell routine is controlled with the activation of cyclin-dependent kinases (CDKs). (bio2009.org)

The model is based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. (ebi.ac.uk)
Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. (wikipedia.org)
A set of cdc2-related genes (cdc2Ms A, B, D and F) was expressed in G2 and M cells. (bibbase.org)

Colocalizes with mitotic spindle. (nih.gov)
Localization of Cdc2Ms F kinase to the preprophase band (PPB), the perinuclear ring in early prophase, the mitotic spindle and the phragmoplast indicated a pivotal role for this kinase in mitotic plant cells. (bibbase.org)
The activity of NEK6 plays important roles in mitotic spindle kinetochore fiber formation, metaphase-anaphase transition, cytokinesis, and checkpoint regulation [ 3 , 4 ]. (hindawi.com)
It is predicted that MCPH gene mutations may lead to the disease phenotype due to a disturbed mitotic spindle orientation, premature chromosomal condensation, signalling response as a result of damaged DNA, microtubule dynamics, transcriptional control or a few other hidden centrosomal mechanisms that can regulate the number of neurons produced by neuronal precursor cells. (biomedcentral.com)

The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)

In Arabidopsis thaliana, the SIAMESE-RELATED proteins (SIM/SMR1 to 13) are a plantspecific family of Cyclin-dependent Kinase Inhibitors (CKIs), homologous to the Kip-Related Proteins. (hal.science)
Immediately following fertilization, the fruit fly embryo undergoes 13 rapid, synchronous, syncytial nuclear division cycles driven by maternal genes and proteins. (vt.edu)
Further, we review the corresponding genes and the proteins encoded by these genes, their possible role in the developing brain and reported mutations of these genes. (biomedcentral.com)
In budding fungus activation of S-phase Clbp-Cdc28p proteins kinase depends upon the last activation of Cdc28p connected with another course of G1 cyclins Cln1-3p. (bio2009.org)
Fu et al was the first to display cyclin D1 is definitely recruited in the context of local chromatin which in turn recruited chromatin modifying proteins (SUV39 HP1α p300 HDAC 1 and HDAC 3) and modified the acetylation and methylation of chromatin connected histones [5]. (healthyguide.info)

Mitotic cyclins stably associate with this protein and function as regulatory subunits. (fcgportal.org)

Tissue specificity of cyclin B expression in D. melanogaster]. (nih.gov)
We report the isolation of a p27(Xic1) genomic clone and we identify a 5' region capable of driving reporter gene expression specifically in the neural tube and the eye. (xenbase.org)
Western Blot: Cyclin H Antibody (1B8) [H00000902-M01] - CCNH monoclonal antibody (M01), clone 1B8 Analysis of CCNH expression in HeLa. (novusbio.com)
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (novusbio.com)
First, we illustrate how the abiotic forces of the intertidal environment drive the rhythmic coupling of gene expression to diel and tidal cycles in Mytilus californianus . (biologists.com)
This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (genetex.com)
Myeloid malignancy patients lacking one copy of this gene showed levels of MYBL2 expression that were less than 50% of those in healthy individuals. (elifesciences.org)
This suggests that additional mechanisms must be acting to reduce expression of their remaining copy of the gene. (elifesciences.org)
Hence, this finding reveals a more general role for MYBL2 as it indicates that more patients are likely to be affected by altered expression of this gene. (elifesciences.org)
used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The expression of SIM/SMRs genes is induced in response to stress. (hal.science)
During drought stress, the expression of SIM, SMR1, SMR3 and SMR5 genes is induced. (hal.science)
Despite extensive studies of specific genes that regulate this process, the global changes in transcript expression profiles at the point when a vegetative meristem transitions into an inflorescence have not been reported. (biomedcentral.com)
We analyzed gene expression during Arabidopsis thaliana meristem development under long day conditions from day 7 to 16 after germination in one-day increments. (biomedcentral.com)
This analysis revealed a developmental time point between 10 and 12 days after germination where FLC expression had decreased but LFY expression had not yet increased, which was characterized by a peak in the number of differentially expressed genes. (biomedcentral.com)
We discovered an unprecedented burst of differential expression of cell cycle related genes at one particular point during transition to flowering. (biomedcentral.com)
To demonstrate the utility of CompNet, we have compared a (time-series) human gene-expression dataset, post-infection by two strains of Mycobacterium tuberculosis , overlaid on the human protein-protein interaction network. (biomedcentral.com)
The worst prognosis is in Group 3 patients, who often have high MYC expression, a transcription factor that triggers or blocks any array of target genes. (childrenscolorado.org)
The gene expression profiles of GSE102484 were downloaded from the Gene Expression Omnibus (GEO) database. (biomedcentral.com)
Weighted gene co-expression network analysis (WGCNA) was used to screen for the most potent gene modules associated with the metastatic risk of breast cancer, and a total of 12 modules were identified based on the analysis. (biomedcentral.com)
Furthermore, the prognostic value and differential expression of these genes were validated based on data from The Cancer Genome Atlas (TCGA) and Kaplan-Meier (KM) Plotter. (biomedcentral.com)
Receiver operating characteristic (ROC) curve analysis revealed that the mRNA expression levels of these five hub genes showed excellent diagnostic value for breast cancer and adjacent tissues. (biomedcentral.com)
Weighted gene co-expression network analysis (WGCNA) is a systematic biological strategy for evaluating gene association patterns among different samples [ 11 ]. (biomedcentral.com)
By constructing a gene co-expression network and identifying related gene clusters, the correlation between gene modules and phenotypes can be calculated based on phenotypic information, and the most relevant gene modules can be found. (biomedcentral.com)
Two gene expression profiles (GSE12452 and GSE13597) containing 56 nasopharyngeal carcinoma samples and 13 normal control samples were analyzed to identify the differentially expressed genes. (oncotarget.com)
We found that the expression of Wnt2b or constitutively active (CA) β-catenin inhibited retinal progenitor gene(RPG) expression and the differentiation of retinal neurons. (biologists.com)
The expression of a dominant-negative (DN)allele of Lef1, or of a Lef1-engrailed fusion protein, led to the inhibition of expression of peripheral genes and iris hypoplasia, suggesting that canonical Wnt signaling is required for peripheral eye development. (biologists.com)
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. (nature.com)
These factors may cause mutations or abnormal expression of certain oncogenes and tumor suppressor genes, leading to the occurrence or development of CRC [ 2 ]. (hindawi.com)
The expression level of NEK6 in esophagitis tissue is similar to that in esophageal adenocarcinoma, and overexpression of the NEK6 gene increases in proportion to the severity of esophagitis [ 14 ]. (hindawi.com)
miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
Correction of chemistry hypercholesterol Chemistry and training Regression emissions foam was reached early somatic gene transfer making use of an adenovirus apoE vector.five but short apoE gene expression threshold a Restrict Restriction which prevents regression scientific studies sophisticated, additional clinically appropriate alterations Ver Ver. (alksignaling.com)
Within a mammary gland particular Tet-inducible model the severe expression profile governed by cyclin D1 after seven days was enriched in genes that rank extremely with CIN. (healthyguide.info)

Orthologous to several human genes including CCNB1 (cyclin B1). (nih.gov)

The results suggest ways to arrest the mitotic oscillator by altering the maximum rates of the converter enzymes. (ebi.ac.uk)
Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. (vt.edu)
The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. (vt.edu)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (genetex.com)
According to the PPI networks, five hub genes ( TPX2, KIF2C, CDCA8, BUB1B , and CCNA2 ) were identified as key genes associated with breast cancer progression. (biomedcentral.com)
Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. (platcovid.com)
Cell cycle progression is faster in cells in which invadopodia are abolished (by Tks5 knockdown), evidenced by earlier induction of cyclins A and B. A close look at the regulators of G1 revealed that the overexpression of p27 kip1 , but not p21 cip1 , causes faster turnover of invadopodia and increased ECM degradation. (biorxiv.org)

These problems start early in mitosis and are alleviated by depletion of isoform 1 of PRC1 (PRC1-1), by gene ablation of its binding partner KIF4, or by abrogation of KIF4 motor activity. (eur.nl)
For example, the exonuclease-dependent role of Kem1p is involved in the exit from mitosis, by degrading the mRNA of the mitotic cyclin CLB2. (tamu.edu)
most of the genes becoming involved in G2/M phase and cellular mitosis. (healthyguide.info)
We used ChIP to verify that cyclin D1 bound the regulatory regions of genes involved in mitosis and QT-PCR to demonstrate the LY2157299 gene transcripts were induced in cyclin D1 rescued fibroblasts. (healthyguide.info)

In conclusion, this study indicated that the identified differentially expressed genes and hub genes enrich our understanding of the molecular mechanisms of nasopharyngeal carcinoma, which could eventually translate into additional biomarkers to facilitate the early diagnosis and therapeutic approaches. (oncotarget.com)

This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (genetex.com)
Analysis of mutants with abnormal flowering time has allowed the identification of genes controlling floral transition [ 8 ]. (biomedcentral.com)
The complexity represented by different types of CDKs and cyclins in a single species such as alfalfa, indicates that multicomponent regulatory pathways control G2/M transition. (bibbase.org)

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. (nature.com)
of these intervals were within 10kb of 2 840 genes with a high denseness located within 500bp of the transcriptional start point. (healthyguide.info)
Understanding the transcriptional part of cyclin D1 in promoting CIN is definitely of considerable medical importance since it is commonly over indicated in breast pancreatic lung malignancy and lymphoma. (healthyguide.info)

The second option entails ubiquitin-mediated degradation of B-type cyclins which requires the cyclosome (Sudakin et al. (bio2009.org)
3) Clnp-Cdc28p protein kinase phosphorylates the cyclin-dependent kinase inhibitor (CKI) Sic1p focusing on it for ubiquitin-mediated degradation via the ubiquitin-conjugating enzyme Cdc34p (Schwob et al. (bio2009.org)

The Xenopus p27(Xic1) gene encodes a cyclin dependent kinase (CDK) inhibitor of the Cip/Kip family. (xenbase.org)
The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 . (nature.com)
The human ALK gene encodes a protein 1,620 amino acids long with a molecular weight of 180 kDa. (alksignaling.com)

In recent years, cell cycle regulators have been shown to exhibit roles in both tumor suppression and tumor promotion, particularly cyclin-dependent kinase inhibitors (CKI) p27 kip1 and p21 cip1 14 . (biorxiv.org)

Matches all models having model elements that were annotated with Gene Ontology term cell growth. (ebi.ac.uk)
Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
Gene Ontology (GO) has been widely used in biological databases, annotation projects, and computational analyses. (biomedcentral.com)
However, the existing cross-category ontology term similarity measures are either developed by utilizing the GO data only or based on manually curated term name similarities, ignoring the fact that GO is evolving quickly and the gene annotations are far from complete. (biomedcentral.com)

Although GSK3-marketed oncogenesis is certainly a paradoxical concern, compelling evidence shows that GSK3 is certainly a focus on gene in malignancy. (globaltechbiz.com)

The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772-81. (wikipedia.org)

This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
Interaction between alfalfa mitotic cyclin (Medsa;CycB2;1) and a kinase partner has been reported previously. (bibbase.org)

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. (wikipedia.org)

A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
Many individuals affected by these disorders possess a shortened form of chromosome 20 that lacks a number of genes. (elifesciences.org)
This deletion is only ever seen in one of their two copies of the chromosome-suggesting that at least some of these genes are essential for survival-but the identity of the gene(s) that are associated with the increased risk of myeloid malignancies is unknown. (elifesciences.org)
have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)
Our results demonstrated that targeting DTL reduced cell cycle regulators and chromosome segregation genes, resulting in increased cell micronucleation. (transhumanist.ru)

At least 60 genes have been described as participants in flowering regulation [ 9 ]. (biomedcentral.com)
He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. (nature.com)
Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans . (nature.com)
Addition to the regulation of cell cycle genes, such cell nuclear antigen cyclin cyclin A and B was immediately after mitotic Purkinje and K Rnerzellen AT people and ATM neurons observed M nozzles were uncovered to undergo DNA replication. (alksignaling.com)

After flowering initiation, the action of LFY and AP1 , as well as CAULIFLOWER ( CAL ) results in the upregulation of genes that control floral organ identity [ 20 - 23 ]. (biomedcentral.com)
Furthermore, Module analysis revealed that the ten hub genes except TOP2A were belonged to module 1, indicating the upregulation of these hub genes associated molecular pathways in nasopharyngeal carcinoma might activate nasopharyngeal carcinoma pathogenesis. (oncotarget.com)
by CG0009 resulted in slight upregulation from the -catenin focus on genes, c-Myc and c-Jun, however, not cyclin D1, indicating that CG0009-mediated cyclin D1 depletion overwhelms the pro-survival sign of -catenin, leading to cell loss of life. (globaltechbiz.com)

Our findings claim that the book GSK3 inhibitor, Tauroursodeoxycholate CG0009, inhibits breasts cancers cell development through cyclin D1 p53 and depletion activation, and may hence offer a forward thinking healing approach for breasts malignancies resistant to hormone-based therapy. (globaltechbiz.com)

SIM and SMR1 are positive regulators of the switch from mitotic cycle to endoreplication. (hal.science)
Cyclin D1 is definitely a modulator of co-regulators such as BRCA1 and nuclear receptors. (healthyguide.info)

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)

During these mitotic cycles, there are barely detectable oscillations in the total level of B-type cyclins. (vt.edu)
Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. (vt.edu)

Cyclin D1 therefore regulates transcription in the chromatin level by interacting with histone deacetylases and various transcription factors to regulate genes that contribute to differentiation and proliferation [4]. (healthyguide.info)

In addition to revealing a new tumor suppressor gene and its contribution to myeloid malignancies, the study by Heinrichs et al. (elifesciences.org)
p21 and other tumor suppressor genes' inactivation are therefore most likely involved in the first steps of the cancer model, with later stages possibly involving protooncogene activation and inflammation. (medscape.com)

In Lamivudine IC50 fission candida the CKI encoded from the rum1 gene takes on a crucial part in regulating the cyclin B-CDK activity in G1 (Moreno and Nurse 1994 blue right-pointing triangle). (bio2009.org)

We consider a minimal cascade model previously proposed for the mitotic oscillator driving the embryonic cell division cycle. (ebi.ac.uk)
The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. (wikipedia.org)
Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. (wikipedia.org)
and syncytial blastoderm mitotic cell cycle. (nih.gov)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. (fcgportal.org)
Functional and pathway enrichment analysis showed that up-regulated genes were significantly involved in cell cycle, oocyte meiosis, DNA replication and p53 signaling pathway, while down-regulated genes were enriched in Huntington's disease,metabolic pathways. (oncotarget.com)

Immunocytochemistry/ Immunofluorescence: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on HeLa cell. (novusbio.com)
Immunohistochemistry-Paraffin: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on formalin-fixed paraffin-embedded human testis. (novusbio.com)
Sandwich ELISA: Cyclin H Antibody (1B8) [H00000902-M01] - Detection limit for recombinant GST tagged CCNH is approximately 1ng/ml as a capture antibody. (novusbio.com)
WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
IHC-P analysis of human tonsil tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
There are currently no references for Cyclin D1 antibody [RM241] (GTX33611) . (genetex.com)

Five hub genes ( TPX2 , KIF2C , CDCA8 , BUB1B , and CCNA2 ) associated with the risk of distant metastasis were extracted for further research, which might be used as biomarkers to predict distant metastasis of breast cancer. (biomedcentral.com)

Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. (wikipedia.org)

The systems ensuring the timely inactivation and activation of cyclin B-CDK in G1 have been studied primarily in budding candida. (bio2009.org)

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (fcgportal.org)

What pathways are this gene/protein implicaed in? (cancerindex.org)
We next interrogated the practical pathways associated with the genes bound by cyclin D1. (healthyguide.info)

Enables cyclin-dependent protein serine/threonine kinase regulator activity. (nih.gov)
The photoperiod-dependent pathway of floral promotion converges on the gene CONSTANS ( CO ), which is known to be expressed in a circadian manner [ 10 ]. (biomedcentral.com)
Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes induced by the compound are systematically compared to the morphological changes in gene-deleted cells. (waseda.jp)

To be able to investigate the fidelity from the mitotic procedure we utilized high-resolution confocal microscopy to see fibroblasts stained with markers of spindles (α-tubulin) and centrosomes (γ-tubulin). (healthyguide.info)
In cyclin D1 rescued fibroblasts over 50% from the cells exhibited multiple centrosomes that provide rise to improve multipolar spindles in prometaphase/metaphase. (healthyguide.info)

In the networks, the frequently occurred MF-centered hub indicates that a molecular function may be shared by different genes in multiple biological processes, or a set of genes with the same functions may participate in distinct biological processes. (biomedcentral.com)
One technique that is garnering wide attention in this realm is the DNA array, in which a number of different genes from an individual can be processed to look at certain genotypes. (medscape.com)

Misregulation of genes that govern the mitotic phase often lead to chromosomal instability (CIN). (healthyguide.info)

For example, in the hereditary cancer syndromes familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, mutations have been discovered in the APC gene and DNA mismatch repair genes. (medscape.com)
MCPH is inherited in an autosomal recessive pattern in which both copies of the gene in each cell have mutations. (biomedcentral.com)

We prolonged these studies to the whole genome to map at high resolution using ChIP-Seq the global genomic footprint for cyclin D1 [7]. (healthyguide.info)

PLK1 is a top negatively selected gene. (childrenscolorado.org)
In CKD patients or obstructive mice model, we observed that Plk1, a critical mitotic regulator, was upregulated in kidneys. (nature.com)

The spaciotemporal pattern of those inductions revealed two groups of genes with distinct functions. (hal.science)
There are a number of cyclin D1 functions that are self-employed of an connected kinase. (healthyguide.info)

A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)

Anatomy19

Organisms9

Diseases5

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

CDK18

Kinases7

Cdc23

Spindle4

Including D-type cyclins1

Proteins5

Stably associate1

Expression35

CCNB11

Arrest3

Progression4

Mitosis4

Differentially expressed genes1

Transition3

Transcriptional3

Degradation2

Encodes4

Inhibitors1

Ontology4

Malignancy1

Localization1

Kinase partner2

CCNB21

Chromosome5

Regulation4

Upregulation3

Depletion1

Regulators2

Cytoplasm1

Oscillations2

Differentiation1

Tumor suppressor2

19941

Cycle7

Antibody6

CCNA21

Microtubules1

Inactivation1

Protein encoded by this gene1

Pathways2

Dependent3

Spindles2

Different genes2

Chromosomal1

Mutations2

Genomic1

PLK12

Functions2

Mutation1