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  • CDC2
  • To determine the effects of progesterone on the proliferation, cell cycle progression and apoptosis of hECs and to test if cyclin B1 is involved in these effects, progesterone and/or Alsterpaullone (Alp, a specific inhibitor of Cyclin B1/Cdc2) were added to primary hECs. (biomedsearch.com)
  • Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. (wikipedia.org)
  • For example, an increase in expression of cyclin B1/cdc2 is significantly higher in breast tumor tissue and shown to increase lymph node metastasis in breast cancer. (wikipedia.org)
  • Cyclins, when bound with the dependent kinases, such as the p34/cdc2/cdk1 protein, form the maturation-promoting factor. (wikipedia.org)
  • inhibitor
  • Thus, the in vitro cellular potency, together with in vivo antitumor activity, confirms the potential of P276-00, a cyclin-dependent kinase inhibitor as an anticancer molecule. (aacrjournals.org)
  • Interacts
  • Instead, cyclin F forms part of the ubiquitin-proteosome system (UPS) and ubiquitinates or directly interacts with the target substrates through the F-box domain. (wikipedia.org)
  • Cyclin F interacts with other enzymes that are important for DNA synthesis, stability and repair. (wikipedia.org)
  • Cyclin F interacts with RRM2 to control the production of dNTPs in the cell to avoid genomic instability and frequency of mutations. (wikipedia.org)
  • cell
  • Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 in human brain microvascular endothelial cells. (antibodies-online.com)
  • Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle. (mybiosource.com)
  • The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. (wikipedia.org)
  • Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. (wikipedia.org)
  • Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. (wikipedia.org)
  • NuSAP is a substrate of cyclin F that is involved in cell division. (wikipedia.org)
  • Cyclin F help to control NUSAP abundance and is therefore essential to proper cell division. (wikipedia.org)
  • Before mitosis almost all cyclin B1 in the cell is located in the cytoplasm, but in late prophase it relocates to the nucleus. (wikipedia.org)
  • Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins. (wikipedia.org)
  • R. Timothy Hunt: "By the way, the name cyclin, which I coined, was really a joke, it's because I liked cycling so much at the time, but they did come and go in the cell. (wikipedia.org)
  • Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle. (wikipedia.org)
  • Note that the cyclins are now classified according to their conserved cyclin box structure, and not all these cyclins alter in level through the cell cycle. (wikipedia.org)
  • Cyclins can be divided into four classes based on their behavior in the cell cycle of vertebrate somatic cells and yeast cells: G1 cyclins, G1/S cyclins, S cyclins, and M cyclins. (wikipedia.org)
  • This division is useful when talking about most cell cycles, but it is not universal as some cyclins have different functions or timing in different cell types. (wikipedia.org)
  • The cyclins also promote other activities to progress the cell cycle, such as centrosome duplication in vertebrates or spindle pole body in yeast. (wikipedia.org)
  • G1 cyclins do not behave like the other cyclins, in that the concentrations increase gradually (with no oscillation), throughout the cell cycle based on cell growth and the external growth-regulatory signals. (wikipedia.org)
  • The presence of G cyclins coordinate cell growth with the entry to a new cell cycle. (wikipedia.org)
  • M cyclin concentrations rise as the cell begins to enter mitosis and the concentrations peak at metaphase. (wikipedia.org)
  • Cell changes in the cell cycle like the assembly of mitotic spindles and alignment of sister-chromatids along the spindles are induced by M cyclin- Cdk complexes. (wikipedia.org)
  • There are several different cyclins that are active in different parts of the cell cycle and that cause the Cdk to phosphorylate different substrates. (wikipedia.org)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (wikipedia.org)