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  • gene
  • See 4 reference sequence protein isoforms for the CDKB1;2 gene. (nih.gov)
  • Our recent studies further suggested that transformation of L-G myeloid progenitor cells by TLS-ERG is likely to be associated with a repressive effect of the fusion protein on gene transcription ( 7 ). (aacrjournals.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. (uniprot.org)
  • Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. (uniprot.org)
  • KIP1
  • EBV latent membrane protein 2A orchestrates p27 kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice. (nih.gov)
  • Peptides
  • Cyclic peptides which represent the site of histone or vimentin were effectively phosphorylated by cdc2 kinase. (nii.ac.jp)
  • translocation
  • TLS-ERG fusion protein is derived from the t(16;21) translocation found in human myeloid leukemia. (aacrjournals.org)
  • Although TLS-ERG fusion is the primary genetic event leading to cellular transformation in acute myelogenous leukemia patients harboring t(16,21) translocation, how this fusion protein alters the differentiation, proliferation, and self-renewal of hematopoietic cells remains unclear. (aacrjournals.org)
  • Arabidopsis
  • In vivo, a phospho-null (APGR) variant of the Arabidopsis ( Arabidopsis thaliana ) eIF4A1 protein retains the ability to functionally complement a mutant ( eif4a1 ) plant line lacking eIF4A1, whereas a phosphomimetic (EPGR) variant fails to complement. (plantphysiol.org)
  • CKS2
  • The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. (nih.gov)
  • Patients with positive-CKS2 protein expression had a poorer five year survival frequency than patients who did not express CKS2 protein. (nih.gov)
  • binds
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • cell
  • We have previously shown that, in situ in the PSD fraction or in recombinant form in Sf9 cell membranes, synGAP is phosphorylated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), another prominent component of the PSD. (nih.gov)
  • In vitro, wild-type recombinant eIF4A1 and its phospho-null variant both support translation in cell-free wheat germ extracts dependent upon eIF4A, but the phosphomimetic variant does not support translation and also was deficient in ATP hydrolysis and helicase activity. (plantphysiol.org)
  • Cell and organ growth are profoundly dependent on protein production, a process that provides the building blocks for new cellular components. (plantphysiol.org)
  • Furthermore, this report also reviews key players involved in Cyclin Dependent Kinase 4 (Cell Division Protein Kinase 4 or PSK J3 or CDK4 or EC 2.7.11.22) targeted therapeutics development with respective active and dormant or discontinued projects. (reportsnreports.com)
  • The kinase activity is controlled by cyclin accumulation and destruction through the cell cycle. (researchmoz.us)
  • A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. (antibodies-online.com)
  • The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. (antibodies-online.com)
  • Nucleotide
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • sequence
  • View conserved domains detected in this protein sequence using CD-search. (nih.gov)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • mammalian
  • synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the mammalian forebrain. (nih.gov)
  • essential
  • We have examined structural features of proline which are essential for the substrate recognition by the kinase and found that the pyrrolidine ring of proline is primarily important. (nii.ac.jp)