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  • tumors
  • Expression of the ARF protein is extinguished in a variety of tumors through DNA methylation and silencing of the ARF promoter region ( 3 ). (aacrjournals.org)
  • essential
  • We have examined structural features of proline which are essential for the substrate recognition by the kinase and found that the pyrrolidine ring of proline is primarily important. (nii.ac.jp)
  • control
  • The level of p53 protein increased 2- to 3-fold within 1.5 h after H 2 O 2 exposure but returned to the control level by 48 h. (biochemj.org)