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  • INK4a
  • p16(INK4a) (p16) is tight-binding and inhibitory protein for cyclin-dependent kinase 4. (bioinformatics.org)
  • Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. (bioinformatics.org)
  • Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours. (nih.gov)
  • In ulcerative colitis (UC)-associated tumours, p53 gene mutations and p53 protein overexpression are frequently found in early stages, but the two types of alteration do not always coincide.Regarding these mismatched crypts of the first type, significant increase in p16(INK4A) and Bax expression was found.No significant relation with p53-related gene products was detected with the p53 protein overexpression (-)/p53 mutation (+) mismatch. (nih.gov)
  • Regarding these mismatched crypts of the first type, significant increase in p16(INK4A) and Bax expression was found. (nih.gov)
  • p16(INK4A) was upregulated indirectly as part of the negative feedback, and increase in Bax, directly controlled by wild-type p53, indicates upregulation of apoptosis. (nih.gov)
  • molecular
  • Our findings suggest that the regulation of c-Myc in breast cancer cells is dependent on the molecular subtype, and that β-catenin-mediated regulation of c-Myc and p21 may control the balance of cell death and proliferation in breast cancer. (pubmedcentralcanada.ca)
  • Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A produced in E.coli is a single non-glycosylated polypeptide chain containing 156 amino acids and having a molecular mass of approximately 16.5 kDa. (creativebiomart.net)
  • Novel
  • Novel p16 allele with a G to T transversion at position 451, creating a missense amino acid change at codon 145 (Asp to Cys)and possibly disrupting the donor splice site of the exon 2/3 boundary. (bioinformatics.org)
  • Type
  • D-type cyclins are usually synthesized by mid-G1 phase and accumulate to a maximum as cells advance through the G1/S boundary. (biomedcentral.com)
  • specific
  • Based on the sequence data, primers specific for p16, p15 and p14 were designed. (ceek.jp)