Cyclin dependent kinase cdc2. Medical search. Frequent questions

The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. (wikipedia.org)
In addition, the levels of several key protein kinases involved in the phosphoinositide 3'-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, apoptosis, and cell cycle progression were analyzed in the presence and absence of the drugs. (nih.gov)
CDK - a family of cyclin-dependent protein kinases. (nih.gov)
During the eukaryotic cell cycle, reversible protein phosphorylation by protein kinases is a fundamental regulatory mechanism. (nih.gov)
It is now clear that, in addition to the much-studied cyclin-dependent protein kinases, the polo subfamily of serine/threonine protein kinases (collectively, polo-like kinases, or Plks) plays a pivotal role in regulating various mitotic events. (nih.gov)
But although cyclin-dependent protein * kinases (CDKs) are known to trigger the major events of the * cell cycle, the precise mechanisms of the checkpoint controls * are still uncertain. (nih.gov)
non-olfactory GPCRs, ion channels, and protein kinases. (nih.gov)
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs) . (medchemexpress.com)
ROCK-IN-5 (compound I- B -37) is a potent inhibitor of ROCK , ERK , GSK , and AGC protein kinases . (medchemexpress.com)

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. (wikipedia.org)
This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. (wikipedia.org)
Cdk2 is capable of binding to many different cyclins, including cyclins A, B, E, and possibly C. Recent studies suggest Cdk2 binds preferentially to cyclins A and E, while Cdk1 prefers cyclins A and B. Cdk2 becomes active when a cyclin protein (either A or E) binds at the active site located between the N and C lobes of the kinase. (wikipedia.org)
Due to the location of the active site, partner cyclins interact with both lobes of Cdk2. (wikipedia.org)
Cdk2 contains an important alpha helix located in the C lobe of the kinase, called the C-helix or the PSTAIRE-helix. (wikipedia.org)
It is important to note that throughout this activation process, cyclins binding to Cdk2 do not undergo any conformational change. (wikipedia.org)
Prior to G1 phase, levels of Cdk4 and Cdk6 increase along with cyclin D. This allows for the partial phosphorylation of Rb, and partial activation of E2F at the beginning of G1 phase, which promotes cyclin E synthesis and increased Cdk2 activity. (wikipedia.org)
Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. (nih.gov)
Immunohistochemistry was used to analyze samples of 40 newly diagnosed childhood acute lymphoblastic leukemias (ALL) for their expression of cyclins (D1, E, A), cyclin-dependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16INK4A), in order to discover whether or not the expression of these various proteins may be of prognostic relevance for the survival of children with ALL. (nih.gov)
A29: Cdk2 can bind either Cyclin A or Cyclin E. For details on activation of Cdk2 (PMID: 10436023). (nih.gov)
24. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein. (nih.gov)
29. Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma. (nih.gov)
35. Cyclin-dependent kinase (cdk) inhibitors/cdk4/cdk2 complexes in early stages of mouse mammary preneoplasia. (nih.gov)
They can bind and inhibit a broad range of cyclin/Cdk complexes, with a preference for those containing Cdk2 ( 17, 18 ). (aacrjournals.org)
Also dephosphorylates CDK2 in complex with cyclin E, in vitro. (nih.gov)
CDK2 is activated by cyclin E and is required for progression through the G 1/S checkpoint. (wikidot.com)
CCNE1 and CCNE2 (Cyclin E) are particularly involved in the G 1 / S checkpoint when bound with CDK2. (wikidot.com)
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner", Genes & Develop. (everypatent.com)
Formation and Activation of a Cyclin E-cdk2 Complex During the G.sub.1 Phase of the Human Cell Cycle", Science, 257:1689-1694 (1992). (everypatent.com)
Analysis of p27kip1 derived from Burkitt's lymphoma cell lines expressing high levels of p27kip1, BL40 and BL41, in a cyclin E/cdk2 kinase inhibition assay demonstrated that p27kip1 is not permanently inactivated since heat treatment can restore the inhibitory activity of p27kip1. (ox.ac.uk)
Furthermore, cyclinD3/cdk4 complex could sequester p27kip1 in a cyclin E/cdk2 kinase assay in vitro. (ox.ac.uk)

This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. (wikipedia.org)
Lymphoma samples from 38 cases of primary and recurrent DLBCL were analyzed using real-time quantitative PCR of the RPS6KB1 and CDC2 genes, and immunohistochemistry for their gene products p70S6K/p85S6K and cdc2/cdk1. (nih.gov)
Moreover, the vast majority of these lymphomas (approximately 94%) were strongly positive for phospho-p70S6K and cdc2/cdk1 proteins. (nih.gov)
a protein kinase that inhibits Cdk1. (nih.gov)
A30: Cdc2 (Cdk1), in association with either Cyclin B or Cyclin A, phosphorylates ORC2. (nih.gov)
Cdk1 is the same as Cdc2. (nih.gov)
It normally phosphorylates the Cdc2 cell cycle regulatory protein (cyclin-dependent kinase-1, CDK1 ) on a tyrosine residue. (wikidoc.org)
These genes include cell cycle regulatory cyclins and cyclin-dependent proteins CCNA2, CCNB1 and CDK1. (researchsquare.com)
Directly dephosphorylates CDK1 and stimulates its kinase activity. (nih.gov)
CDK1 , or CDC2, was the first described CDK. (wikidot.com)
ORC is phosphorylated by Cdk1/cyclin A during G2/M and released from chromatin. (nih.gov)
Xic1, a Cdk specific inhibitor, is present prior to S-phase, and presumably inhibits the ORC associated Cdk1/cyclin A activity, thereby allowing ORC to bind to chromatin. (nih.gov)
In mitotic cells, Orc1 is hyperphosphorylated by its association with Cdk1/cyclin A, then dephosphorylated and bound to chromatin during the M to G1-phase transition (10). (nih.gov)

This investigation demonstrated that cyclin D1 and cdk4 were the most important prognostic factors for children with ALL, and that the combination of them showed the strongest prognostic relevance. (nih.gov)
Although one molecule of p21 is sufficient to inhibit cyclin/Cdk complexes ( 22 ), Cip/Kip CKIs have been detected in active cyclin D/Cdk4 complexes ( 24 - 27 ). (aacrjournals.org)
p21 was shown to stabilize interactions between Cdk4 and cyclin D and promote the formation of active complexes in a concentration-dependent manner ( 27 ). (aacrjournals.org)

It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. (wikipedia.org)
Some of the key proteins are important for cell adhesion between myocytes and some are involved in adhesion-dependent cell-to-cell signal transduction that allows for a cascade of cell fusion events. (wikidoc.org)
Both the proteins of cdc2 and cdc28 are analogous in terms of their function and cdc2 − mutant of S. pombe is complemented to CDC28 of S. cerevisiae . (blogspot.com)
The transcribed proteins Clb5 and Clb6 get accumulated due to APC inactivation, which would then result in the degradation of these cyclins. (blogspot.com)
These proteins perform as mitotic cyclins, and bind with Cdc28 to form complexes that are necessary for nuclear division and chromosome segregation. (blogspot.com)
Intriguingly, PBIP1 interacted with cellular proteins whose deregulation is implicated for tumorigenesis, suggesting that the Plk1-dependent downregulation of PBIP1 may contribute to the development of cancers in humans. (nih.gov)
CCND1 , 2 and 3 (Cyclin D) are three similar proteins that are upregulated during G 1 . (wikidot.com)
Study cell division with antibodies for detecting cyclins and cyclin-dependent kinases that control cycle progression, bioactive and stable recombinant proteins that stimulate or suppress cell division, and specialized dyes that can track cell proliferation. (biolegend.com)
When extracellular signals are received, signal transduction pathways are initiated by proteins like kinases and phosphatases. (biolegend.com)
Altered expression of cyclins, such as overproduction of cyclins, particularly cyclin E, or production of alternative cyclin E proteins, as well as deranged appearance of mitotic cyclins during the cell cycle, are indicative of the presence of carcinoma. (everypatent.com)

In S. pombe, ORC2 is phosphorylated by Cdc2 (PMID: 10523506) and phosphorylation helps prevent reinitiation (PMID: 11486016). (nih.gov)
Assembly of Cdc2/cyclin B heterodimers promotes phosphorylation and inactivation of Cdc2 subunit ( left ). (comprehensivephysiology.com)
Additional DNA damage signal may influence aspect of Cdc2 activation other than Y15 phosphorylation (see text). (comprehensivephysiology.com)
DNA harm sets off Cdc25C phosphorylation at serine 216 offering the energetic binding site for 14-3-3 (8 17 33 38 44 52 Binding of T-705 14-3-3 towards the phosphorylated Cdc25C causes translocation from the complicated in to the cytoplasm separating the Cdc25C phosphatase from its nuclear substrates (28 41 52 such as for example Cdc2. (sciencepop.org)
The results from this study suggest that Aβ phosphorylation by cdc2 could play a role in the brain pathology of AD. (westminster.ac.uk)
Summary: Phosphorylation of importin-α1 by cyclin - dependent kinase 1 provides spatial and temporal control of mitotic spindle assembly through the release of spindle-assembly factors from inhibitory complexes during mitosis. (biologists.com)
Mark C. Hall ABSTRACT Inactivation of cyclin - dependent kinase (Cdk) and reversal of Cdk phosphorylation are universally required for mitotic exit. (biologists.com)
APC is activated by MPF phosphorylation, which in turn directs the polyubiquitination and proteasome degradation of yeast cyclin B, anaphase inhibitor, and spindle apparatus components. (blogspot.com)
Expression of the nondegradable PBIP1 lacking the Plk1-dependent phosphorylation sites induced a mitotic arrest, indicating that degradation of PBIP1 is required for proper mitotic progression. (nih.gov)
Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. (ox.ac.uk)
Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). (medchemexpress.com)

At the cellular level, the process is controlled by different levels of cyclin-dependent kinases (Cdks) and their partner cyclins. (wikipedia.org)
also called CCNB1) cyclin B, a cell cycle inducible protein, prominent in mitosis, which activates cdks. (nih.gov)
also called CCNA1) cyclin A, a cell cycle inducible protein, prominent in S-phase, which activates cdks. (nih.gov)
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. (elifesciences.org)
Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. (elifesciences.org)
Central components of these networks are the cyclin-dependent kinases (CDKs). (elifesciences.org)
Of these, five are divergent CDK-related kinases (CRK), i.e. they are clearly related to CDKs but have no clear orthologues in the yeast or human kinomes. (elifesciences.org)
Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin - dependent kinases (CDKs). (biologists.com)
Unlike CDKs, cyclins are only produced in the cell at specific points in the cell cycle. (wikidot.com)
Progression through checkpoints during interphase is regulated by cyclin-dependent kinases (CDKs), which are activated when bound by specific cyclins (see table below). (biolegend.com)
The roles of major cyclin-dependent kinases (CDKs) when they are activated by each cyclin. (biolegend.com)

The regulatory subunit of this kinase is Dbf4/Ddk. (nih.gov)
The primary regulator of CDK activity is the cyclin subunit. (elifesciences.org)
It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. (edu.au)

The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. (aacrjournals.org)
In NT-2 neurons the levels of pSAβ were increased in the presence of exogenous Aβ and this increase was prevented by a cdc2 protein kinase inhibitor, olomoucine, that also prevented Aβ cytotoxicity. (westminster.ac.uk)
Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H: KN-62, 1-[N, O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. (peptide-solubility.com)
Lack of detectable expression of p27kip1 cyclin dependent kinase inhibitor has previously been correlated with high degree of malignancy in human breast, colorectal, gastric and small cell lung carcinomas. (ox.ac.uk)
PknB-IN-2 (Compound 10) is a Mycobacterium tuberculosis protein kinase B ( PknB ) inhibitor with an IC 50 of 12.1 μM. (medchemexpress.com)
Cdc7-IN-5 (compound I- B ) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I- B . Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle. (medchemexpress.com)
B -Raf IN 5 (compound 3 b ) is a potent inhibitor of protein kinase B-Raf with an IC 50 of 2.0 nM. (medchemexpress.com)
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase ) inhibitor with an IC 50 of 28 nM. (medchemexpress.com)
OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11 , which binds to CDK11 B with a K d of 40 nM. (medchemexpress.com)

These results demonstrate that PTH-stimulated cdc2 expression was associated with TE-85 cell proliferation and that the mechanism of stimulating cdc2 gene expression involved increasing the levels of free E2F. (wustl.edu)
Active cyclin/Cdk complexes phosphorylate and inactivate members of the retinoblastoma protein (Rb) family that are negative regulators of G 1 and S-phase progression, leading to induction of E2F-regulated gene expression and cell proliferation. (aacrjournals.org)
CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. (nih.gov)
A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE. (ucdenver.edu)
The cdc28 gene of S. cerevisiae is highly homologous with cdc2 + gene of S. pombe . (blogspot.com)
A method of detecting carcinoma, particularly breast carcinoma, in a test sample of tissue, comprising assessing the expression cyclin E, or the amplification of cyclin genes, particularly the cyclin E gene, is disclosed. (everypatent.com)
Amplification of cyclin genes, particularly the cyclin E gene, is also indicative of the presence of carcinoma. (everypatent.com)
Gene Expression of PCNA/Cyclin in Adult Tissues and the R3230AC Mammary Tumor of Rat", Biochem. (everypatent.com)
Human Cyclin E, a New Cyclin That Interacts with Two Members of teh CDC2 Gene Family", Cell, 66:1217-1228, (1991). (everypatent.com)
Redundant cyclin overexpression and gene amplification in breast cancer cells", Proc. (everypatent.com)

Plks also regulate pathways leading to the inactivation of Cdc2 at mitotic exit. (nih.gov)
cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. (cshlpress.com)

CDC28 Protein Kinase, S cerevisiae" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
This graph shows the total number of publications written about "CDC28 Protein Kinase, S cerevisiae" by people in this website by year, and whether "CDC28 Protein Kinase, S cerevisiae" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "CDC28 Protein Kinase, S cerevisiae" by people in Profiles. (ucdenver.edu)
Studies involving cdc28 in S. cerevisiae and cdc2 in S. pombe continue to provide useful insights into mitosis. (blogspot.com)
The cdc28 of S. cerevisiae is cell cycle protein kinase that was identified as the first protein kinase. (blogspot.com)
A cyclin-dependent protein kinase in each yeast cell can replace each other between Cdc28 in S. cerevisiae and Cdc2 in S. pombe . (blogspot.com)
During the late S phase in S. cerevisiae , transcription of two additional genes Clb3 and Clb4 also occur, forming heterodimeric kinases along with Cdc28. (blogspot.com)
One of the critical events that budding yeast polo kinase Cdc5 mediates is mitotic entry, a process that requires activation of Cdc28 (homolog of mammalian Cdc2). (nih.gov)

CCNA1 and CCNA2 (Cyclin A) are active in S phase and G 2 . (wikidot.com)

[ 16 , 22 , 23 ] Metastases showed a significantly higher expression level of RHAMM than the primary tumor, and the expression is strongly correlated with overexpression of both ras and extracellular signal-regulated protein kinase. (medscape.com)
32. Overexpression of G1-S cyclins and cyclin-dependent kinases during multistage human pancreatic duct cell carcinogenesis. (nih.gov)
Interestingly, we observed that high level p27kip1 expression often correlated with cyclin D3 overexpression both in vivo and in BL cell lines. (ox.ac.uk)
They also suggest a novel role for the overexpression of D-type cyclins as one pathway allowing tumour cells to overcome the antiproliferative function of p27kip1. (ox.ac.uk)

39. Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. (nih.gov)
Virtual screening of selective multitarget kinase inhibitors by combinatorial support vector machines. (nih.gov)
We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge leucettamine B. Stepwise synthesis of analogues starting from the natural structure, guided by activity testing on eight purified kinases, led to highly potent inhibitors of CLKs and DYRKs, two families of kinases involved in alternative pre-mRNA splicing and Alzheimer's disease/Down syndrome. (ox.ac.uk)

CCNB1 and CCNB2 (Cyclin B) are active at the G 2 /M checkpoint. (wikidot.com)

calcium/calmodulin-dependent protein. (gsea-msigdb.org)

Amplification of the RPS6KB1 and CDC2 genes was found in both primary and recurrent DLBCL. (nih.gov)
Expression and amplification of cyclin genes in human breast cancer", Oncogene, 8(8):2127-2133 (1993). (everypatent.com)

Progression through the cell cycle critically relies upon post-translational mechanisms including changes in activity of cell cycle kinases and phosphatases, and ubiquitin-mediated degradation of specific components once their function is complete. (elifesciences.org)

These three CKIs contain a conserved region of sequence at the NH 2 terminus that is required and sufficient for the inhibition of cyclin/Cdk complexes, whereas the COOH terminal regions are variable in length and function ( 12, 14 - 16 ). (aacrjournals.org)

It can mediate both cell proliferation and p53-dependent/independent apoptosis. (thermofisher.com)

Analysis of the time course of PTH-stimulated cdc2 message levels demonstrated that cdc2 mRNA levels were increased 1.5- to 4-fold between 3-18 h following release from cell synchronization. (wustl.edu)
Induction of Cyclin mRNA and Cyclin-associated Histone H1 Kinase during Liver Regeneration", The Journal of Biological Chemistry, 267(5):2841-2844 (1992). (everypatent.com)

The Aβ 1-42, 1-40 and 25-35 peptides were shown to be substrates for the cdc2 kinase and phosphorylated on the Serine 26 residue. (westminster.ac.uk)

This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). (nih.gov)

Transfections of TE-85 cells with a series of cdc2 promoter-luciferase deletion constructs revealed PTH stimulation of the cdc2 promoter. (wustl.edu)
In Wee1 mutants, there is less Wee1 activity and Cdc2 becomes active in smaller cells, causing cell division before the yeast cells reach their normal size. (wikidoc.org)
Red No. 3, beta-estradiol, and DDT increase ER site-specific DNA binding to the estrogen response element in HTB 133 cells and increase cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells. (researchgate.net)
In glioma ( 28 ) and in vascular smooth muscle cells ( 29 ), p21 facilitates active cyclin-Cdk complex formation and induces cell proliferation. (aacrjournals.org)
In the lack of Cdc25C phosphatase activity Cdc2 is normally kept within an inactive phosphorylated condition as well as the cells no more get T-705 over the G2/M cell routine checkpoint (38). (sciencepop.org)
Furthermore, the two B type cyclins such as Clb1 and Clb2 are expressed when chromosome replication is completed by cells and entered into G 2. (blogspot.com)
Nuclear Patterns of Cyclin (PCNA) Antigen Distribution Subdivide S-Phase in Cultured Cells--Some Applications of PCNA Antibodies", Leukemia Res. (everypatent.com)
Cyclin: A Nuclear Protein Whose Level Correlates Directly with the Proliferative State of Normal As Well as Transformed Cells", Leukemia Res. (everypatent.com)
The majority of p27kip1 in BL40 cells was complexed with cyclin D3 indicating that overexpressed cyclin D3 may at least be part of the sequestering activity for the inhibitory function of p27kip1. (ox.ac.uk)
MS5033 is a potent PROTAC-based AKT ( protein kinase B) degrader, with a DC 50 of 430 nM in PC3 cells. (medchemexpress.com)
Finally we found that the double-stranded RNA-dependent protein kinase (PKR) is usually expressed at a constant level in persistently infected cells with or without warmth shock. (immune-source.com)
reported that persistent BDV illness constitutively triggered the mitogen-activated protein kinase pathway but efficiently clogged nuclear translocation of triggered extracellular signal-regulated kinase (ERK) in Personal computer12 cells (15). (immune-source.com)
Furthermore we have shown that BDV phosphoprotein (P) specifically interacts having a multifunctional protein HMGB1 (high-mobility group package 1 protein) and PSI-6130 interferes with its functions in persistently infected neural cells (19 54 More recently connection between BDV nucleoprotein (N) and the Cdc2-cyclin B1 complex has been reported to induce decelerated proliferation of infected rat fibroblast cells (36). (immune-source.com)

CKIs bind and inhibit the activity of cyclin/Cdk complexes and negatively regulate cell cycle progression (reviewed in Refs. (aacrjournals.org)
Identification and characterization of individual cyclin-dependent kinase complexes from Saccharomyces cerevisiae. (ucdenver.edu)

The success of the cell division process is dependent on the precise regulation of processes at both cellular and tissue levels. (wikipedia.org)
28. Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft. (nih.gov)
We expect that understanding Plk1-dependent PBIP1 regulation may provide new insights into how Plk1 deregulation promotes cancers in humans and how to approach the development of anti-Plk1 therapeutic agents. (nih.gov)
Cyclin-Dependent Regulation of G.sub.1 in Mammalian Fibroblasts", Science, 259:1908-1912 (1993). (everypatent.com)

There was also a significant correlation between expression of cyclin D1 and frequency of recurrence. (nih.gov)
21. Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma. (nih.gov)

The Wee1 protein is a tyrosine kinase . (wikidoc.org)
Signals relating to DNA damage and completeness of replication impact on balance of Wee1 (a Cdc2 inhibitory kinase) and Cdc25 activities to delay entry into M phase. (comprehensivephysiology.com)
peptide motifs (41 51 14 includes a nuclear export indication in the ninth helix (28 41 14 protein regulate cell routine development by changing the actions of Cdc25C Wee1 cyclin B1 and Chk1. (sciencepop.org)

Mitosis is directly linked to RHAMM by suppressing cell cycle-dependent kinase (Cdc2) and cyclin B1 expression. (medscape.com)
We show that Plasmodium berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. (elifesciences.org)
Activation of Cdc2 at onset of mitosis. (comprehensivephysiology.com)

This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. (thermofisher.com)

We have shown that the polo-box motif, which resides in the C-terminal noncata-lytic domain, is essential for the localization of both budding yeast polo kinase Cdc5 and mammalian Plk1 to specific subcellular structures. (nih.gov)

also called Cdc7) a kinase that is essential for initiation of DNA replication. (nih.gov)

Isolation of Three Novel Human Cyclins by Rescue of G1 Cyclin (Cln) Function in Yeast", Cell, 66:1197-1206 (1991). (everypatent.com)

Cyclin dependent kinases are a family of kinases which, when activated by binding with a cyclin, lead to progression through the cell cycle. (wikidot.com)

Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication. (elifesciences.org)

This covalent modification of the molecular structure of Cdc2 inhibits the enzymatic activity of Cdc2 and prevents cell division. (wikidoc.org)

cdc2 antisense oligonucleotides blocked PTH-induced DNA synthesis and cell cycle progression. (wustl.edu)

Identification of a nuclear polypeptide (cyclin) whose relative proportion is sensitive to changes in the rate of cell proliferation and to transformation", Prog. (everypatent.com)

The most well understood regulators are the cyclins, the cyclin dependent kinases, TP53 and RB1. (wikidot.com)

serine/threonine kinases that relay DNA damage signals to cell cycle checkpoints. (nih.gov)

Cyclin A:Cdc2 binds ORC and phosphorylates ORC2p in Xenopus (PMID: 10660590). (nih.gov)

When bound with cyclin B it promotes progression through the G2/M checkpoint. (wikidot.com)

Expression of Proliferating Cell Nuclear Antigen (PCNA)/Cyclin during the Cell Cycle", Exp. (everypatent.com)

The protein mTOR is a serine/threonine kinase that regulates translation and cell division [2] . (wikidoc.org)

In this study, we demonstrated that PTH stimulates proliferation of the osteoblast precursor cell line, TE-85, in association with increasing cdc2 protein levels and its kinase activity. (wustl.edu)
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. (edu.au)
Vanicoside B targets cyclin-dependent kinase 8 ( CDK8 ) and exhibits anti-tumor activity. (medchemexpress.com)

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. (cshlpress.com)

It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. (nih.gov)

Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)

Anatomy15

Organisms8

Diseases2

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Protein kinases9

Cdk221

Cdk113

Cdk43

Proteins10

Phosphorylation11

Cdks11

Subunit3

Inhibitor9

Gene10

Inactivation2

Cdc288

CCNA21

Overexpression4

Inhibitors3

CCNB11

Calmodulin-dependent protein1

Genes2

Phosphatases1

Inhibition1

Apoptosis1

MRNA2

Substrates1

Complex with cyclin1

Cells13

Complexes2

Regulation4

Expression of cyclin2

Wee13

Mitosis3

Retinoblastoma protein1

Mammalian1

Initiation of DNA replication1

Yeast1

Progression through the cell cycle1

Eukaryotic cell-cycle1

Molecular1

Cell cycle progression1

Polypeptide1

Regulators1

Checkpoints1

Phosphorylates1

Bound1

Antigen1

Regulates1

Activity3

Replication1

Activates1

Activation2