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  • CDK2
  • This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. (wikipedia.org)
  • The cyclin E-Cdk2 CDKC formed in the G1 phase then aids in the initiation of DNA replication during S phase. (wikipedia.org)
  • At the end of S phase, cyclin A is associated with Cdk1 and Cdk2. (wikipedia.org)
  • CDC2
  • CDK5 was originally named NCLK (Neuronal CDC2-Like Kinase) due to its similar phosphorylation motif. (wikipedia.org)
  • S. pombe and S. cerevisiae are most known for their association with a single Cdk, Cdc2 and Cdc28 respectively, which complexes with several different cyclins. (wikipedia.org)
  • For instance, Cdk1 (also known as human Cdc2), the first human CDK to be identified, associates with cyclins A or B. CyclinA/B-Cdk1 complexes drive the transition between G2 phase and M phase, as well as early M phase. (wikipedia.org)
  • Cdk1
  • In mammalian cells, CDK1, with its partners cyclin A2 and B1, alone can drive the cell cycle. (wikipedia.org)
  • Cyclin B1 and B2 can localize Cdk1 to the nucleus and the Golgi, respectively, through a localization sequence outside the CDK-binding region. (wikipedia.org)
  • Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. (wikipedia.org)
  • Cdk1, like other kinases, contains a cleft in which ATP fits. (wikipedia.org)
  • Cdk1 also contains a PSTAIRE helix, which, upon cyclin binding, moves and rearranges the active site, facilitating Cdk1 kinase activities. (wikipedia.org)
  • however, when phosphorylated by Cln3-Cdk1, Whi5 is ejected from the nucleus, allowing for transcription of the G1/S regulon, which includes the G1/S cyclins Cln1,2. (wikipedia.org)
  • G1/S cyclin-Cdk1 activity leads to preparation for S phase entry (e.g., duplication of centromeres or the spindle pole body), and a rise in the S cyclins (Clb5,6 in S. cerevisiae). (wikipedia.org)
  • Cdk1 phosphorylation also leads to the activation of the ubiquitin-protein ligase APCCdc20, an activation which allows for chromatid segregation and, furthermore, degradation of M-phase cyclins. (wikipedia.org)
  • Most obviously, Cdk1 is regulated by its binding with its cyclin partners. (wikipedia.org)
  • furthermore, cyclins impart specificity to Cdk1 activity. (wikipedia.org)
  • Furthermore, cyclins can target Cdk1 to particular subcellular locations. (wikipedia.org)
  • During G2 phase, cyclin A is degraded, while cyclin B is synthesized and cyclin B-Cdk1 complexes form. (wikipedia.org)
  • Not only are cyclin B-Cdk1 complexes important for the transition into M phase, but these CDKCs play a role in the following regulatory and structural processes: Chromosomal condensation Fragmentation of Golgi network Breakdown of nuclear lamina Inactivation of the cyclin B-Cdk1 complex through the degradation of cyclin B is necessary for exit out of the M phase of the cell cycle. (wikipedia.org)
  • Cln1
  • In S. cerevisiae, the association of Cdc28 with cyclins, Cln1, Cln2, or Cln3, results in the transition from G1 phase to S phase. (wikipedia.org)