• Alzheimer's
  • Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. (semanticscholar.org)
  • activates
  • Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. (abcam.com)
  • determinant
  • Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes. (springer.com)
  • synaptic
  • Associative or Hebbian plasticity induces changes in synaptic transmission, which are use-dependent and lead to reinforcement of active and weakening of inactive circuits. (frontiersin.org)