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  • genes
  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. (abcam.com)
  • CDKs
  • Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. (yonsei.ac.kr)
  • An intricate network of cyclin-dependent kinases (CDKs) are organized in a pathway to ensure that each cell accurately replicates its DNA and segregate it equally between the two daughter cells. (wikipedia.org)
  • CDK7 is both a CDK-activating kinase (CAK), which phosphorylates cell-cycle CDKs within the activation segment (T-loop), and a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of the largest subunit of Pol II. (wikipedia.org)
  • Whether CDK7 really displays dual-substrate specificity remains to be further explored, but there is no question that the CDK7-cyclin H-MAT1 complex is able to phosphorylate both the T-loop of CDKs and the YSPTSPS (single-letter code for amino acids) repeats of the RNAPII CTD in vitro. (wikipedia.org)
  • activity
  • Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. (uniprot.org)
  • Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). (uniprot.org)
  • We show that MDA-MB-231 motility is affected by disturbing cyclin D1 levels or cyclin D1-cdk4/6 kinase activity. (aacrjournals.org)
  • It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential[citation needed] for the G1/S transition. (wikipedia.org)
  • The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. (wikipedia.org)
  • pathway
  • The frequency of these alterations alone clearly implies that abrogation of the G 1 checkpoint or acceleration of the Cdk4/cyclin D pathway provides a distinct advantage to cancer cells in terms of proliferation and perhaps survival. (aacrjournals.org)
  • P16/Rb pathway collaborates with the mitogenic signaling cascade for the induction of reactive oxygen species, which activates the protein kinase C delta, leading to an irreversible cell cycle arrest. (wikipedia.org)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (wikipedia.org)
  • In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (wikipedia.org)
  • transcription
  • In addition, P14ARF could down-regulate E2F-dependent transcription and plays a role in the control of the G1 to S phase transition as well. (wikipedia.org)
  • CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH. (wikipedia.org)
  • tyrosine
  • Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. (wikipedia.org)
  • This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. (wikipedia.org)
  • regulation
  • Taken together, our results suggest that up-regulation of cdk 4 is at least in part responsible for accelerated growth of prostate cancer cells selected during antiandrogen therapy. (aacrjournals.org)