• The genes IEGs are normally stimulated for transcription by cyclin C with an up regulation in CDK8 IEGs are expressed at a higher rate for a period of time. (wikipedia.org)
  • This mechanism blocks any kinase activity and prevents downstream hyper-phosphorylation of Rb that allows release of the E2F transcription factor and transcription of cell cycle-related genes. (wikipedia.org)
  • Protein kinases constitute a large family of structurally related enzymes that are responsible for the control of a wide variety of signal transduction processes within the cell (Hardie, G. and Hanks, S. (1995) The Protein Kinase Facts Book. (allindianpatents.com)
  • Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. (wikipedia.org)
  • Studies have shown other CDKCs, such as cyclin k-Cdk9 and cyclin T1-Cdk9, are involved in the replication stress response, and influence transcription. (wikipedia.org)
  • also known as Flavopiridol) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development for the treatment of acute myeloid leukemia, by Tolero Pharmaceuticals, Inc. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation The target of Flavopiridol is the positive transcription elongation factor P-TEFb. (wikipedia.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor Retinoblastoma protein making CDK6 an important protein in cancer development. (wikipedia.org)
  • The appropriate protein kinase functions in signalling pathways to activate or inactivate (either directly or indirectly), for example, a metabolic enzyme, regulatory protein, receptor, cytoskeletal protein, ion channel or pump, or transcription factor. (allindianpatents.com)
  • 5FP6: Structure of cyclin-dependent kinase 2 with small-molecule ligand 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (AT17833) in an alternate binding site. (rcsb.org)
  • Cyclins can directly bind the substrate or localize the CDK to a subcellular area where the substrate is found. (wikipedia.org)
  • Failure to satisfy the pre-requisite biochemical criteria at a given cell cycle checkpoint, i.e. failure to form a required CDK/cyclin complex, can lead to cell cycle arrest and/or cellular apoptosis. (allindianpatents.com)
  • 100 μg, ABP-PAB- (100 μg) Cyclin E1 (CCNE1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (allelebiotech.com)
  • Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase. (wikipedia.org)
  • CAK activity is not regulated by known cell-cycle pathways and cyclin binding is the limiting step for CDK activation. (wikipedia.org)
  • Depending on the cyclin, various portions of the cell cycle are affected. (wikipedia.org)
  • Even though the majority of the known CDKCs are involved in the cell cycle, not all kinase complexes function in this manner. (wikipedia.org)