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  • genes
  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. (abcam.com)
  • tumor
  • These findings provide a mechanistic explanation for how Rb regulates cell division and apoptosis through different kinases, and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. (wustl.edu)
  • degradation
  • While both stress granules and processing bodies are associated with mRNAs, processing bodies have been long proposed to be sites of mRNA degradation because they contain enzymes like DCP1/2 and XRN1 that are known to degrade mRNAs. (wikipedia.org)
  • Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. (wikipedia.org)
  • stress granule
  • Many of these stressors result in the activation of particular stress-associated kinases (HRI, PERK, PKR, and GCN2), translational inhibition and stress granule formation. (wikipedia.org)
  • extracellular
  • Expression of phosphorylated (p-)tyrosine, p-Akt, phosphorylated extracellular signal-regulated kinase (p-ERK) 1/ERK2 (p42/p44), and p27 after treatment of erlotinib was not associated with erlotinib sensitivity. (pubmedcentralcanada.ca)
  • MAP kinases are also known as extracellular signal-regulated kinases (ERKs), and are involved in signaling cascades that regulate a number of cellular processes, including proliferation, differentiation, and transcriptional regulation. (wikipedia.org)
  • binds
  • This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. (wikipedia.org)
  • EGFR
  • To address this apparent paradox, we examined possible predictors of the sensitivity of 10 breast cancer cell lines to erlotinib in light of cyclin-dependent kinase 2 (CDK2), considered the farthest downstream kinase that controls cell cycling in the EGFR signaling pathway. (pubmedcentralcanada.ca)
  • This action blocks downstream signal transduction and inhibits the tumorigenic effects associated with ligand-dependent and ligand-independent EGFR activation ( 1 , 2 ). (pubmedcentralcanada.ca)
  • Reports that cell lines showing sensitivity to EGFR-TKIs showed G 1 arrest after treatment with EGFR-TKIs ( 11 - 13 ) led us to study the potential relationship between cyclin-dependent kinases (CDK), particularly CDK2 ( 12 , 13 ) and erlotinib sensitivity. (pubmedcentralcanada.ca)
  • mutations
  • Recent genetic studies indicate that mutations of Cdkl family kinases are associated with neurodevelopmental and neuropsychiatric disorders in humans. (frontiersin.org)
  • family
  • These findings suggest that Cdkl2 is involved in cognitive function and provide in vivo evidence for the function of Cdkl family kinases expressed in terminally differentiated neurons in mice. (frontiersin.org)
  • This evidence suggests that the Cdkl kinase family might be involved in behavioral modification, activity-dependent synaptic plasticity, and learning. (frontiersin.org)
  • activity
  • Understanding how kinase activity modulates TDP-43 accumulation may provide new pharmacological targets for disease intervention. (edu.au)
  • In vertebrate models, ERK8 is not constitutively active, and exhibits relatively low basal kinase activity. (wikipedia.org)
  • Regulation
  • The heterogeneity of kinases involved in phospho-regulation provides a fundamental basis for the sequential biochemical reactions that underlie the mechanisms of synaptic plasticity. (frontiersin.org)
  • shown
  • Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. (wikipedia.org)
  • expression
  • The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human. (naver.com)
  • Viral tropism for the decidua and placenta is then dependent on viral entry receptor expression in these tissues as well as on the maternal immune response to the virus. (jci.org)
  • novel
  • Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles. (naver.com)