Ribociclib (RIB) is a cyclin- dependent kinases 4 and 6 (CDK4/6) inhibitor and has been rec- ommended as preferred regimens for the treatment of post- menopausal women with HR-positive, human epidermal growth factor receptor 2 (HER2)-negative ABC in 2017 based on the results from the MONALEESA-2 trial by The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology [4]. (pf-8380inhibitor.com)
IL-29 upregulated cyclin-dependent kinase inhibitor p21Waf1/Cip1 in cells sensitive, but not insensitive, to antiproliferative activity, and knockdown of p21 with small interfering RNA largely attenuated the antiproliferative effect. (elsevierpure.com)
Inhibitors4
The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
It has also been demonstrated that TGF-β induced cell cycle arrest can be partially attributed to the regulatory effects of TGF-β on both the expression and activity of cyclin-dependent kinase inhibitors [CDKI] such as p21 and p27. (biomedcentral.com)
The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. (sigmaaldrich.com)
CDK42
ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)
Inhibiting WEE1 abrogates G2 cell cycle arrest, resulting The tyrosine kinase WEE1 regulates cyclin-dependent kinase in premature entry into mitosis and leading to aberrantly 1 (CDK1), which drives cells from the G2 phase into mitosis, high CDK2 activity in S-phase cells, with the deregulated and CDK2, which drives cells into and through the S phaseDNA replication resulting in replication stress [1, 5]. (sagepub.com)
On the mechanistic level, we show that Cdk5 phosphorylates the forkhead transcription factor Foxc2 which regulates Foxc2-dependent transcription. (oncotarget.com)
Antigen1
Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
Apoptosis1
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Protein kinase1
Background: Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia mutated and rad3 related (ATR) and DNA-dependent protein kinase catalytic sub-unit (DNA-PKcs) play critical roles in DNA damage response (DDR) by linking DNA damage sensing to DDR effectors that regulate cell cycle progression and DNA repair. (ntu.ac.uk)
Gene4
The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. (wikipedia.org)
also known as CDK4I, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, MTS-1, p16-INK4, p16-INK4a, p16INK4A) is encoded by the CDKN2A (also known as CDKN2, MTS1) gene (Gene ID 1029) in human. (sigmaaldrich.com)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)
Association between cyclin-dependent kinase inhibitor 2B antisense RNA 1 and zinc finger homeobox 3 gene polymorphisms and COVID-19 severity. (cdc.gov)
This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. (wikipedia.org)
Diabetic1
In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
Proliferation marker1
In patients with prolonged clinical dormancy, the presence of dormant cells is often identified by their lack of the cellular proliferation marker Ki-67 as well as the lack of apoptotic markers [ 12 - 14 ]. (biomedcentral.com)
Progression1
Thus, WEE1 inhibition sensitizes cancers have loss-of-function TP53 mutations, meaning that tumor cells to DNA-damaging chemotherapy and can lead to they become more dependent on the G2/M- and S-phase unstable DNA replication, DNA damage and mitotic catas- checkpoints to halt progression of the cell cycle [3, 4]. (sagepub.com)
Markers2
We also aimed to evaluate the expression of TGF-β1 and p27 in the context of other cell cycle and proliferation markers such as cyclin D1 and Ki-67. (biomedcentral.com)
Modern molecular methods, including genetic markers, cytokines, proliferation indexes, and cyclins, are all undergoing study to help determine which atypical moles may progress to melanoma, although no single marker has been determined. (medscape.com)
Dose-dependent2
IL-29 significantly inhibited the in vitro growth of a wide range of NSCLC lines in a dose-dependent fashion. (elsevierpure.com)
In MDA-MB-231 cells, ST caused a significant dose-dependent cell growth inhibition by 31- 63% (p ≤ 0.0001) in 48 h and 40-50% (p ≤ 0.0001) in 72 h. (biomedcentral.com)
Methods1
Methods: We investigated ATM, ATR, and DNA-PKcs expressions in ovarian epithelial cancers [protein expression (n = 194 patients), mRNA expression (n = 156 patients)] and correlated to clinicopathological outcomes as well as expression of X-ray repair cross-complementing protein 1 (XRCC1), cell division cycle-45 (CDC45), cyclin-dependent kinase 1(CDK1) and Ki-67 in tumours. (ntu.ac.uk)
Expression2
Immunohistochemical analyses demonstrated marked upregulated p21 and downregulated Ki-67 expression in tumors treated with IL-29. (elsevierpure.com)
Also, the expression of Cyclin D should be decreased at the G2/M checkpoint (Figure 4). (ptgcn.com)
Cancer4
Objective: To access p16/Ki-67 double staining (DS) in cervical cells performance for detecting precursor lesions of cervical cancer, in comparison to immediate repetition of the liquid-based cervical cytology (LBCC) in women with screening cytology results of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). (edu.br)
The Ki-67 index is a measure of how many cells are making Ki-67, a protein made by cells in the process of reproducing, and is an indication of how fast the cancer is growing. (lbbc.org)
High Ki-67 scores have been associated with a high risk of breast cancer returning. (lbbc.org)
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 55004-1-AP (Cyclin B1 Antibody) at a dilution of 1:200 (under 10x lens). (ptgcn.com)
Cells2
Surprisingly, IL-12-dependent enhancement of CD8+ T-cell anti-tumor function did not occur through direct ligation of receptors on lymphocytes or NK cells. (gsea-msigdb.org)
Specific Aim 1: Elucidate The Roles Of Novel Age-Dependent TFs in Primary Human β-Cells. (einsteinmed.edu)
Study3
Looking specifically at people in the study who had Ki-67 scores of 20 percent or higher, the researchers found an even larger difference in 2 year invasive disease-free survival rates. (lbbc.org)
Our study elucidates cyclin dependent kinase 5 (Cdk5) as an essential player in the development of lymphatic vessels. (oncotarget.com)
Our recent study elucidates the serine-threonine kinase cyclin dependent kinase 5 (Cdk5) as the missing link in the regulation of Foxc2 in the lymphatic endothelium [ 12 ]. (oncotarget.com)
Domain1
Localization to the chromocenters is mediated by an N-terminal domain, in addition we find that this domain may be involved in cyclin binding. (uni-bielefeld.de)
Sensitive1
DS-p16/Ki-67 was2,5x more sensitive than the immediate repetition of the LBCC. (edu.br)