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  • high cyclin
  • One hundred and seventy-one patients (63%) had low cyclin E, 72 (27%) medium and 27 (10%) had high cyclin E content. (diva-portal.org)
  • In p53 mutated breast cancers high cyclin E content was associated with insertions, deletions and nonsense point mutations in the p53 tumor suppressor gene, whereas low cyclin E was linked to p53 missense point mutations. (diva-portal.org)
  • We also observed statistically significant associations between a high cyclin E content and aneuploidy, high S phase, larger tumor size, estrogen receptor negativity, presence of axillary node metastases and high tumor grade. (diva-portal.org)
  • High cyclin E content was associated with poor overall survival in univariate and multivariate analysis (hazard ratio 2.4, 95% confidence interval 1.3-4.5). (diva-portal.org)
  • Tumours displaying a pushing margin phenotype were strongly associated with high cyclin E levels, lymph node negative disease, a high histological grade, ER negativity, and exhibited a better prognosis compared to tumours with an infiltrative growth pattern. (bmj.com)
  • growth
  • However, when analysing the subgroup of tumours lacking a pushing growth pattern (N=141), cyclin E was significantly associated with RFS, independent of histological grade and node status. (bmj.com)
  • tumor
  • Immunity against cyclin B1 tumor antigen delays development of spontaneous cyclin B1-positive tumors in p53 (-/-) mice. (nih.gov)
  • Cyclin levels can easily be determined through immunohistological analysis of tumor biopsies. (wikipedia.org)
  • While the exact mechanism that explains how cyclin B1 becomes overexpressed is not very well understood, previous work has shown that down regulation of cyclin B1 can lead to tumor regression. (wikipedia.org)
  • Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the tumor. (wikipedia.org)
  • One of the best known substrates of cyclin D/Cdk4 and -6 is the retinoblastoma tumor suppressor protein (Rb). (wikipedia.org)
  • It is also possible that cyclin A2-CDK contributes to tumorigenesis by the phosphorylation of oncoproteins or tumor suppressors like p53. (wikipedia.org)
  • cytoplasmic
  • But, with Cyclin E antibodies, we get cytoplasmic staining rather than nuclear staining which is mentioned in all the literature I have read. (bio.net)
  • 2004). Cyclin A1 has an important role in the development of acute myeloid leukemia (AML): its localization in normal hematopoietic cells is nuclear, whereas in leukemic cells from AML patients and cell lines, it is predominantly cytoplasmic (Ekberg et al. (atlasgeneticsoncology.org)
  • The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772-81. (wikipedia.org)
  • homologues of cyclin
  • Since its initial discovery, homologues of cyclin A have been identified in numerous eukaryotes including Drosophila, Xenopus, mice, and in humans but has not been found in lower eukaryotes like yeast. (wikipedia.org)
  • The most studied homologues of cyclin D are found in yeast and viruses. (wikipedia.org)
  • regulation of cyclin
  • 1997). The cyclin A1 promoter does not possess a TATA box, whereas the region upstream of the transcriptional start site region contains four GC boxes, with multiple Sp1-binding sites important for the regulation of cyclin A1 expression (Müller et al. (atlasgeneticsoncology.org)
  • Cdc2
  • Results provide evidence that cdc2/cyclin B1 kinase activation was synchronous with the initial appearance of cytoskeletal lesions in mouse with Niemann-Pick disease type C. (nih.gov)
  • Title: Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C. (nih.gov)