Mitotic-specificMouse Monoclonal AntibodyCdc2Subcellular localizationProteinP34cdc2Cdk9PCNABRCA1DetectionDependentCellTissueControlCellsShownTypeExpressionHumanBetaDomainCCNB2CdksKinasesCDK2MRNACDK1Mutations1998CCNA2PhosphorylateUpregulationCCND1ProliferationGene1995ProgressionSubunit1999OncogeneDrosophilaRegulatesGolgiProteinsCytoplasmicSymbolIsletsTranscriptionInteractActivationCriticalFamilySearchFound
Mitotic-specific1
- G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. (wikipedia.org)
Mouse Monoclonal Antibody3
- SDS-PAGE Analysis Purified Cyclin B2 Mouse Monoclonal Antibody (X29.2). (neobiotechnologies.com)
- Cite this (Santa Cruz Biotechnology Cat# sc-53239, RRID:AB_629356) cyclin B2 (X121.10) is a mouse monoclonal antibody raised against cyclin B2 of Xenopus origin. (xenbase.org)
- The following Anti- Cross Linked C-Telopeptide Of Type I Collagen (CTXI)-Mouse monoclonal Antibody, Anti- Crystallin Beta B2 (CRYbB2)-Mouse monoclonal Antibody, Anti- Crystallin Lambda 1 (CRYl1)-Mouse monoclonal Antibody, Anti- Cyclin D1 (CCND1)-Mouse monoclonal Antibody products are the most profitable elements of the Cloud Clone Corp offer. (mousanti.com)
Cdc24
- Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. (wikipedia.org)
- This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). (neobiotechnologies.com)
- Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. (neobiotechnologies.com)
- Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. (neobiotechnologies.com)
Subcellular localization1
- B1 and B2 differ in their subcellular localization. (wikipedia.org)
Protein2
- The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
- Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
P34cdc22
- The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. (wikipedia.org)
- Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. (wikipedia.org)
Cdk91
- PAT assay was performed with PAT primers for cdk9 , tbp and cyclin B1. (echinobase.org)
PCNA1
- Cyclin B1 and PCNA were used as loading controls for the left and right panels respectively. (insulin-receptor.info)
BRCA11
- F) ATR pathway signaling integrity after ATR, BRCA2 LP-533401 ic50 (B2) and BRCA1 (B1) depletion. (insulin-receptor.info)
Detection3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cyclin B (CCNB) in tissue homogenates, cell lysates and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cyclin B (CCNB) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (master-sistemisanitari-medicinenonconvenzionali.org)
- Description: A sandwich ELISA kit for detection of Cyclin B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
Dependent1
- Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
Cell1
- A one-cell embryo from a CYB-3 offers essential and unique buy SNS-032 functions from cyclin B1 and NOS3 B2 in the early embryo. (healthy-nutrition-plan.com)
Tissue1
- The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions. (neobiotechnologies.com)
Control1
- The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. (neobiotechnologies.com)
Cells2
- β3-LNCaP β6-LNCaP HT1080 HT2-19 cells cyclin B2-null and wt MEFs had been seeded on 5-μm (HT1080 HT2-19) 8 (β3-LNCaP β6-LNCaP) or 12-μm (cyclin B2-null MEFs wt MEFs) pore-sized transwell filtration system StemRegenin 1 (SR1) inserts covered with 5 or 10 μg/ml FN or 3 μg/ml VN. (colinsbraincancer.com)
- After 4 h (HT1080 HT2-19 cyclin B2-null MEFs wt MEFs) or 6 h (β3-LNCaP β6-LNCaP) cells had been set with 3% PFA/PBS stained with crystal violet and the amount of cells per square millimeter on underneath had been counted (standard StemRegenin 1 (SR1) and SEM of 10 arbitrary areas). (colinsbraincancer.com)
Shown1
- Cyclin B2 has been shown to interact with TGF beta receptor 2. (wikipedia.org)
Type2
- Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. (wikipedia.org)
- Supplementary MaterialsFigure S1: effectiveness and an positioning of B-type cyclins. (healthy-nutrition-plan.com)
Expression2
- Ki-67 expression both in the crypt-surface epithelium and cyclin D1, c-erb B2, bcl-2 over-expression may be a clue of dysplastic epithelium. (uwi.edu)
- RNA expression of γ-aminobutyric acid B2 receptor and that of STAT3 are significantly correlated in clinical CCA samples from Thai patients. (bioz.com)
Human1
- The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772-81. (wikipedia.org)
Beta1
- Functional association of TGF-beta receptor II with cyclin B". Oncogene. (wikipedia.org)
Domain1
- Localization to the chromocenters is mediated by an N-terminal domain, in addition we find that this domain may be involved in cyclin binding. (uni-bielefeld.de)
CCNB23
- G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. (wikipedia.org)
- At the time of transfer, encephalitogenic T cells in vitro are maximally activated, i.e. they exhibit a prominent upregulation of cell cycle genes such as cyclin A2 (CCNA2) and cyclin B2 (CCNB2) among others. (uni-muenchen.de)
- CCNB1 and CCNB2 (Cyclin B) are active at the G 2 /M checkpoint. (wikidot.com)
Cdks4
- In our body, the Cell Cycle (Cell Division Cycle) is an ordered sequence of events, culminating in cell growth and cell division into two daughter cells, regulated by temporal activation of cyclin-dependent kinases (CDKs) . (wellnessadvantage.com)
- Cyclin-dependent kinases (CDKs) and cyclins represent an ancient molecular module that drives and regulates cell cycle progression. (prolekarniky.cz)
- Unlike CDKs, cyclins are only produced in the cell at specific points in the cell cycle. (wikidot.com)
- The company is a developer of small molecule inhibitors of cyclin-dependent kinases (CDKs) intended to provide treatment for patients with advanced and resistant cancers. (silverwoodpartners.com)
Kinases2
- The most well understood regulators are the cyclins, the cyclin dependent kinases, TP53 and RB1. (wikidot.com)
- Cyclin dependent kinases are a family of kinases which, when activated by binding with a cyclin, lead to progression through the cell cycle. (wikidot.com)
CDK26
- Furthermore, this intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression. (ucl.ac.uk)
- 1997). Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2. (sdbonline.org)
- Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. (sdbonline.org)
- Knockdown of TPX2 inhibited malignancy cell growth and downregulation of cyclin A, cyclin E and CDK2 proteins. (thinkbeforeyouclickca.org)
- CDK2 is activated by cyclin E and is required for progression through the G 1/S checkpoint. (wikidot.com)
- CCNE1 and CCNE2 (Cyclin E) are particularly involved in the G 1 / S checkpoint when bound with CDK2. (wikidot.com)
MRNA3
- In particular, severe immunodeficiency is mostly associated with mutations that alter cyclin B2 mRNA cleavage and thus are likely to reflect disturbances in cell cycle control. (nih.gov)
- Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA. (sdbonline.org)
- 2000). CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division. (sdbonline.org)
CDK12
- 1999). Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. (sdbonline.org)
- A well-studied actor of cell cycle is cyclin dependent kinase 1 (cdk1) (Malumbres, 2014). (biologists.com)
Mutations2
- Various RMRP mutations may lead to abnormal ribosome assembly, telomere dysfunction, and altered cyclin B2 levels. (creative-biolabs.com)
- Chromosomal abnormalities and mutations involving cyclins are implicated in carcinogenesis. (wikidot.com)
19981
- 1998). Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. (sdbonline.org)
CCNA21
- CCNA1 and CCNA2 (Cyclin A) are active in S phase and G 2 . (wikidot.com)
Phosphorylate1
- They bind with cyclin D and phosphorylate RB1. (wikidot.com)
Upregulation2
- Alk5 kinase inhibition produced a similar loss of EMT marker expression but showed a contrasting upregulation of the proliferation and remodeling markers, Cyclin B2 and beta-catenin. (nih.gov)
- Senescence is a cell type-specific form of permanent growth arrest, which occurs during aging, tissue damage or stress and involves progressively acquired phenotypes including activation of a DNA damage response, upregulation of cyclin-dependent kinase inhibitors, an apoptosis resistance phenotype and a senescence-associated secretory phenotype (SASP). (npod.org)
CCND11
- CCND1 , 2 and 3 (Cyclin D) are three similar proteins that are upregulated during G 1 . (wikidot.com)
Proliferation3
- Cyclin A2 over expression in primary islets increased proliferation and reduced p27. (medscape.com)
- In Min6 cells, cyclin A2 knockdown prevented exendin-4-stimulated proliferation. (medscape.com)
- Cyclin A2 is required for β-cell proliferation, exendin-4 stimulates cyclin A2 expression via the cAMP pathway, and exendin-4 stimulation of cAMP requires PDX-1. (medscape.com)
Gene2
- The cyclin gene family has undergone a massive expansion in angiosperm plants, but only a few cyclins were thoroughly characterized. (prolekarniky.cz)
- The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. (sdbonline.org)
19951
- 1995). Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. (sdbonline.org)
Progression2
- Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet β-cells. (medscape.com)
- When bound with cyclin B it promotes progression through the G2/M checkpoint. (wikidot.com)
Subunit1
- ATPase H+ transporting V1 subunit B2 [So. (gsea-msigdb.org)
19991
- 1999). p53 regulates a G2 checkpoint through cyclin B1. (sdbonline.org)
Oncogene1
- Functional association of TGF-beta receptor II with cyclin B". Oncogene. (wikipedia.org)
Drosophila3
- Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. (sdbonline.org)
- The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. (sdbonline.org)
- Synergistic action of Drosophila cyclins A and B during the G2-M transition. (sdbonline.org)
Regulates1
- 2000). Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. (sdbonline.org)
Golgi3
- Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. (wikipedia.org)
- Ciclina de subtipo B que se colocaliza en el APARATO DE GOLGI durante la INTERFASE y es transportada al NÚCLEO CELULAR al final de la FASE G2. (bvsalud.org)
- B1 is found attached to microtubles and B2 with the Golgi apparatus. (wikidot.com)
Proteins1
- Members of the NAP/SET family of proteins interact specifically with B-type cyclins. (sdbonline.org)
Cytoplasmic1
- The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772-81. (wikipedia.org)
Symbol1
- cyclin B2 [Source:HGNC Symbol;Acc. (gsea-msigdb.org)
Islets2
- CBP-S436A islets exhibited elevated cyclin A2, reduced p27, and no changes in D-type cyclins, PDX-1, or Skp2. (medscape.com)
- In cultured islets, exendin-4 increased cyclin A2 and Skp2 and reduced p27. (medscape.com)
Transcription1
- PDX-1 knockdown reduced exendin-4-stimulated cAMP synthesis and cyclin A2 transcription. (medscape.com)
Interact1
- Cyclin B2 has been shown to interact with TGF beta receptor 2. (wikipedia.org)
Activation1
- 1997). Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. (sdbonline.org)
Critical1
- synthetic types in higher té: Critical and Many sergeant of cyclin something. (lolipop.jp)
Family1
- Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. (wikipedia.org)
Search1
- Your search for reliable Cyclin E1 antibodies ends here. (antibodies-online.com)
Found1
- We found six A-type cyclins and a single B-type cyclin (CYCB3;1) to be expressed in male meiosis. (prolekarniky.cz)