AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Cyclin B1Cyclin BCyclin D1Cyclin ACyclin ECDC2 Protein KinaseCyclin D2Cyclin D3Cyclin A1Cyclin A2Cyclin DCyclinsMitosisCyclin G1Cyclin GCyclin-Dependent KinasesCell CycleG2 PhaseCyclin CCyclin B2Cell Cycle ProteinsCyclin-Dependent Kinase 2Maturation-Promoting FactorCyclin TCDC2-CDC28 Kinasescdc25 PhosphatasesCyclin G2Cyclin HG1 PhaseCyclin-Dependent Kinase 4S PhaseStarfishPhosphorylationOocytesProtamine KinaseProtein-Serine-Threonine KinasesUbiquitin-Protein Ligase ComplexesCyclin-Dependent Kinase Inhibitor p27MeiosisRetinoblastoma ProteinCell DivisionProto-Oncogene Proteins c-mosMetaphaseHeLa CellsCyclin-Dependent Kinase Inhibitor p21Cyclin IPrometaphaseXenopusXenopus ProteinsAnaphase-Promoting Complex-CyclosomeMolecular Sequence DataAnaphaseSecurinCell NucleusCell Line, TumorCell ProliferationNocodazoleSpindle ApparatusRNA, MessengerProtein KinasesCdh1 ProteinsOncogene ProteinsGenes, bcl-1Nuclear ProteinsCyclin-Dependent Kinase 6ApoptosisAmino Acid SequenceTumor Suppressor Protein p53Cdc20 ProteinsBlotting, WesternCell LineBase SequenceMicrotubule-Associated ProteinsXenopus laevisProtein BindingTumor Suppressor ProteinsProphaseRecombinant Fusion ProteinsTumor Cells, CulturedCentrosomeOvumCell ExtractsF-Box ProteinsEnzyme ActivationInterphaseGene Expression Regulation, NeoplasticProto-Oncogene ProteinsImmunohistochemistryTransfectionDown-RegulationGene Expression RegulationCytoplasmProliferating Cell Nuclear AntigenG2 Phase Cell Cycle CheckpointsPromoter Regions, GeneticE2F Transcription FactorsRNA, Small InterferingCDC28 Protein Kinase, S cerevisiaeMutationTranscription Factors
KinasesKinase InhibitorProteinsPhosphorylationCdksCDK4ComplexesGenesLevels of cyclinOverexpression of cyclinCDK2InhibitorsAntibodyRegulates cyclinGene expressionMRNAExpressionInactivationInteractsCellsRegulateProgressionEncodesInducesTriggersHumansMitosisPhosphorylateCdk1InhibitionDifferentiationReplicationSubsetsCell cycleTranscription factorDivergentAntibodiesProliferationComplexHomologPutativeMitoticMultivariateSaccharomycesSignaling pathwayCCND1TransitionPromoterCancers
Kinases12
Kinase Inhibitor5
  • The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. (aacrjournals.org)
  • The ubiquitin ligase SCF(Cdc4) (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sic1, in a multisite phosphorylation-dependent manner. (mshri.on.ca)
  • The expression of cyclin-dependent kinase inhibitor p27(kip1) in human tumors and normal tissues was investigated using a panel of novel anti-p27(kip1) mAbs. (ox.ac.uk)
  • We aimed to investigate whether there is an association between the cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) rs1333049 and zinc finger homeobox 3 (ZFHX3) rs2106261 single nucleotide polymorphisms (SNPs) and the degree of COVID-19 severity. (biomedcentral.com)
  • Cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) spans approximately 126.3 kb, overlaps with cyclin-dependent kinase inhibitor 2B (CDKN2B) (p15) at the 5´ end, comprises 20 exons that are prone to alternative splicing and is reported to be linked to CAD risk, hypertension (HTN) and stroke [ 13 ]. (biomedcentral.com)
Proteins15
  • Cyclin is a family of proteins that controls the progression of a cell through the cell cycle by activating cyclin-dependent kinase (CDK) enzymes or group of enzymes required for synthesis of cell cycle. (wikipedia.org)
  • For example, the amino-terminal regions of S and M cyclins contain short destruction-box motifs that target these proteins for proteolysis in mitosis. (wikipedia.org)
  • Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. (yeastgenome.org)
  • There are 61335 CYCLIN domains in 41443 proteins in SMART's nrdb database. (embl-heidelberg.de)
  • Taxonomic distribution of proteins containing CYCLIN domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with CYCLIN domain is also avaliable . (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing CYCLIN domain in the selected taxonomic class. (embl-heidelberg.de)
  • Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control. (embl-heidelberg.de)
  • Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity. (embl-heidelberg.de)
  • Cyclin D proteins promote proliferation in G1 and typically are down-regulated before differentiation. (ca.gov)
  • In chapter 3 of this work, I report my identification of all cyclin domain-containing proteins in A. nidulans and establish that this cyclin repertoire is well-conserved in closely and distantly related filamentous ascomycetes. (ku.edu)
  • Cyclin-dependent kinase 9 (CDK9) transcriptionally regulates several proteins and cellular pathways central to radiation induced tissue injury. (oncotarget.com)
  • Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. (ntu.edu.sg)
  • Cyclins are a family of proteins that control how cells proceed through the multi-step cycle of cell division. (medlineplus.gov)
  • Cells lacking cyclin B can enter mitosis and phosphorylate most mitotic proteins , because of parallel PP2AB55 phosphatase inactivation by Greatwall kinase . (bvsalud.org)
Phosphorylation12
  • A cyclin forms a complex with Cdk, which begins to activate but the complete activation requires phosphorylation, as well. (wikipedia.org)
  • In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. (thermofisher.com)
  • D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. (thermofisher.com)
  • Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. (thermofisher.com)
  • p21CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-Cdk2, cyclin D1-Cdk4, and cyclin D2-Cdk4 complexes. (nih.gov)
  • In many organisms, initial Cdh1 inactivation at G1/S occurs via phosphorylation by cyclin/CDK complexes which then triggers Cdh1 ubiquitination by the Skp1-Cullin1-F-box (SCF) complex. (ku.edu)
  • Beyond this point, cyclin B /Cdk1 is essential for phosphorylation of a distinct subset of mitotic Cdk1 substrates that are essential to complete cell division . (bvsalud.org)
  • Our results identify how cyclin A , cyclin B and Greatwall kinase coordinate mitotic progression by increasing levels of Cdk1-dependent substrate phosphorylation . (bvsalud.org)
  • Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. (nih.gov)
  • Vanadate also increased p21 and Chk1 levels and reduced Cdc25C expression, leading to phosphorylation of Cdc2 and a slight increase in cyclin B1 expression as analyzed by Western blot. (cdc.gov)
  • Catalase, a specific antioxidant for H2O2, decreased vanadate-induced expression of p21 and Chk1, reduced phosphorylation of Cdc2Tyr15, and decreased cyclin B1 levels. (cdc.gov)
  • Several regulatory pathways are involved: (1) activation of p21, (2) an increase of Chk1 expression and inhibition of Cdc25C, which results in phosphorylation of Cdc2 and possible inactivation of cyclin B1/Cdc2 complex. (cdc.gov)
Cdks3
  • Cyclins themselves have no enzymatic activity but have binding sites for some substrates and target the Cdks to specific subcellular locations. (wikipedia.org)
  • IMPORTANCE Giardia lamblia CDKs (GlCDKs) and their cognate cyclins have not yet been studied. (gene-tools.com)
  • Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. (elifesciences.org)
CDK47
  • Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. (thermofisher.com)
  • Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. (thermofisher.com)
  • Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (thermofisher.com)
  • Here, we show, in diploid human fibroblasts, that cyclosporin A arrested cells in G(1) before cyclin D/cdk4 complex activation and retinoblastoma hyperphosphorylation. (duke.edu)
  • Bioinformatics algorithm analysis predicted that cyclin-dependent kinase 4 (CDK4) was a direct target of miR-338-3p, and this was experimentally verified by a dual-luciferase reporter assay. (techscience.com)
  • Although one molecule of p21 is sufficient to inhibit cyclin/Cdk complexes ( 22 ), Cip/Kip CKIs have been detected in active cyclin D/Cdk4 complexes ( 24 - 27 ). (aacrjournals.org)
  • p21 was shown to stabilize interactions between Cdk4 and cyclin D and promote the formation of active complexes in a concentration-dependent manner ( 27 ). (aacrjournals.org)
Complexes5
  • Cell changes in the cell cycle like the assembly of mitotic spindles and alignment of sister-chromatids along the spindles are induced by M cyclin- Cdk complexes. (wikipedia.org)
  • Active cyclin/Cdk complexes phosphorylate and inactivate members of the retinoblastoma protein (Rb) family that are negative regulators of G 1 and S-phase progression, leading to induction of E2F-regulated gene expression and cell proliferation. (aacrjournals.org)
  • CKIs bind and inhibit the activity of cyclin/Cdk complexes and negatively regulate cell cycle progression (reviewed in Refs. (aacrjournals.org)
  • These three CKIs contain a conserved region of sequence at the NH 2 terminus that is required and sufficient for the inhibition of cyclin/Cdk complexes, whereas the COOH terminal regions are variable in length and function ( 12, 14 - 16 ). (aacrjournals.org)
  • They can bind and inhibit a broad range of cyclin/Cdk complexes, with a preference for those containing Cdk2 ( 17, 18 ). (aacrjournals.org)
Genes4
  • Recent studies have suggested that dysregulation of at least 1 of the cyclin D genes ( CCND1, CCND2, and/or CCND3 ) is a common, unifying pathogenic event in multiple myeloma. (medscape.com)
  • This inhibition is a key regulatory step, because it allows the transcription factor Pho4, a substrate for the cyclin-CDK complex, to be unphosphorylated and thereby turn on expression of phosphate-responsive genes. (harvard.edu)
  • The methylation status of Cyclin D2 was correlated with the methylation of nine other tumor suppressor genes published previously from our laboratory on the same set of samples (R. Maruyama et al. (nih.gov)
  • We also compared methylation of cyclin D2 with methylation of nine tumor suppressor genes [published previously from our laboratory (R. Maruyama et al. (nih.gov)
Levels of cyclin2
  • [ 8 ] Increased levels of cyclin D1 as detected by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), whether secondary to a translocation or due to other abnormalities, also have been reported to be associated with a favorable prognosis. (medscape.com)
  • This arrest occurred in early G(1) with low levels of cyclin D1 protein. (duke.edu)
Overexpression of cyclin1
  • In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. (portlandpress.com)
CDK24
  • The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. (rcsb.org)
  • The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB. (embl-heidelberg.de)
  • The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase transition in mammals. (nih.gov)
  • CIP1 encodes a novel 21 kd protein that is found in cyclin A, cyclin D1, cyclin E, and Cdk2 immunoprecipitates. (nih.gov)
Inhibitors2
  • The cyclin-dependent kinase (CDK) 4/6 inhibitors belong to a new class of drugs that interrupt proliferation of malignant cells by inhibiting progression through the cell cycle. (nih.gov)
  • Cyclin-dependent kinase (CDK) 4/6 inhibitors have become standard of care in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer. (nih.gov)
Antibody4
  • The significance of cyclin D1 expression in plasma cell myeloma was examined by immunohistochemical analysis using a newly available rabbit monoclonal antibody with superior staining properties. (medscape.com)
  • We used a newly available rabbit monoclonal cyclin D1 antibody with superior staining properties [ 12 ] to study cyclin D1 protein expression in plasma cell myeloma. (medscape.com)
  • The following product was used in this experiment: Cyclin D1 Monoclonal Antibody (3D8) from Thermo Fisher Scientific, catalog # MA5-15650, RRID AB_10978307. (thermofisher.com)
  • Specificity: This antibody recognizes a protein of 55-62kDa, identified as cyclin B1. (scytek.com)
Regulates cyclin4
  • Scholars@Duke publication: Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. (duke.edu)
  • Although these pharmacological experiments suggested that calcineurin regulates cyclin D1 synthesis, we evaluated the effects of overexpression of activated calcineurin on cyclin D1 synthesis. (duke.edu)
  • Therefore, calcineurin is a Ca(2+)/CaM-dependent target that regulates cyclin D1 accumulation in G(1). (duke.edu)
  • Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. (nih.gov)
Gene expression2
MRNA2
  • Because cyclin D1 mRNA was induced normally in the cyclosporin A-treated cells, we analyzed the half-life of cyclin D1 in the presence of cyclosporin A and found no difference from control cells. (duke.edu)
  • Cyclin A1 mRNA expression in EOC and healthy tissues was quantified by microarray analysis and quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
Expression16
  • Expression of cyclins detected immunocytochemically in individual cells in relation to cellular DNA content (cell cycle phase), or in relation to initiation and termination of DNA replication during S-phase, can be measured by flow cytometry. (wikipedia.org)
  • Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (thermofisher.com)
  • The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (thermofisher.com)
  • Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. (portlandpress.com)
  • In contrast to the reduction of cyclin D1 with cyclosporin A, ectopic expression of calcium/calmodulin-independent calcineurin promoted synthesis of cyclin D1 during G(1) progression. (duke.edu)
  • We observed that cyclin A1 (CCNA1) protein expression was relatively higher in PCa metastatic lesions in lymph node, lung, and bone/bone marrow. (lu.se)
  • In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. (lu.se)
  • Cyclin A1 expression has been reported in several epithelial malignancies, including testicular, endometrial, and epithelial ovarian cancer (EOC). (biomedcentral.com)
  • We analyzed Cyclin A1 expression in EOC and its correlation with clinical features to evaluate Cyclin A1 as a T-cell target in EOC. (biomedcentral.com)
  • The mechanism behind the prolonged TTP in patients with high Cyclin A1 expression warrants further investigation. (biomedcentral.com)
  • The frequent, selectively high expression of Cyclin A1 in EOC makes it a promising target for T-cell therapies. (biomedcentral.com)
  • Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. (laboratorynotes.com)
  • High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. (ox.ac.uk)
  • Detailed studies demonstrated a correlation between the high level expression of p27(kip1) and cyclin D1 in human breast cancer cells. (ox.ac.uk)
  • This study was conducted to assess patterns of expression and potential gene amplification of the G1 cyclins in 84 patients affected with extremity soft- tissue sarcomas. (mssm.edu)
  • Because estradiol represses expression of the cyclin G2 gene, which encodes a negative regulator of the cell cycle, our aim was to understand the mechanism by which cyclin G2 is repressed by estrogen. (nih.gov)
Inactivation2
  • My results also reveal that PucA is the essential cyclin required for CdhA inactivation at the G1/S transition and that there are no other redundant mechanisms for CdhA inactivation in A. nidulans. (ku.edu)
  • Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation. (nih.gov)
Interacts1
  • During a replicative cycle, CRK5 stably interacts with a single Plasmodium -specific cyclin (SOC2), although we obtained no evidence of SOC2 cycling by transcription, translation or degradation. (elifesciences.org)
Cells12
  • Cyclins can be divided into four classes based on their behaviour in the cell cycle of vertebrate somatic cells and yeast cells: G1 cyclins, G1/S cyclins, S cyclins, and M cyclins. (wikipedia.org)
  • This finding resolves a longstanding question about how cells communicate information about phosphate availability to a cyclin-CDK complex that is a central player in the phosphate-responsive signaling pathway. (harvard.edu)
  • In response to starvation for phosphate, cells increase IP7 levels and IP7 binds to the cyclin-CDK-CDK inhibitor complex and inactivates its kinase activity. (harvard.edu)
  • Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. (lu.se)
  • Cyclin A1 overexpression in the stem-like ALDHhigh subpopulation of PC3M cells, one model of PCa, enabled bone marrow integration and metastatic growth. (lu.se)
  • In the bone marrow, Cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted hte metastatic growth of PCa cells. (lu.se)
  • In glioma ( 28 ) and in vascular smooth muscle cells ( 29 ), p21 facilitates active cyclin-Cdk complex formation and induces cell proliferation. (aacrjournals.org)
  • As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. (ntu.edu.sg)
  • The resulting buildup of cyclin D2 in cells triggers them to continue dividing when they otherwise would not have, leading to abnormal cell proliferation. (medlineplus.gov)
  • Tsunekawa Y, Kikkawa T, Osumi N. Asymmetric inheritance of Cyclin D2 maintains proliferative neural stem/progenitor cells: a critical event in brain development and evolution. (medlineplus.gov)
  • We show that cyclin G2 is a primary ER target gene in MCF-7 breast cancer cells that is rapidly and robustly down-regulated by estrogen. (nih.gov)
  • Following estradiol treatment of cells, chromatin immunoprecipitation analyses reveal recruitment of ER to the cyclin G2 regulatory region, dismissal of RNA polymerase II, and recruitment of a complex containing N-CoR and histone deacetylases, leading to a hypoacetylated chromatin state. (nih.gov)
Regulate2
  • Here, we discuss the ability of the NF-κB (nuclear factor κB)/IKK [IκB (inhibitor of NF-κB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability. (portlandpress.com)
  • Cyclin D2 helps to regulate a step in the cycle called the G1-S transition, in which the cell moves from the G1 phase, when cell growth occurs, to the S phase, when the cell's DNA is copied (replicated) in preparation for cell division. (medlineplus.gov)
Progression1
  • In a second set of 44 cases of newly diagnosed plasma cell myeloma in which patients were enrolled in a phase 2 study of melphalan, prednisone, and rituximab, we examined the association of cyclin D1 immunohistochemical staining patterns with other clinicopathologic findings at diagnosis and with progression-free and overall survival. (medscape.com)
Encodes1
  • Kaposi sarcoma herpesvirus (KSHV) encodes a D-type cyclin (ORF72) that binds CDK6 and is likely to contribute to KSHV-related cancers. (wikipedia.org)
Induces1
Triggers1
  • Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B. (bvsalud.org)
Humans1
Mitosis4
Phosphorylate1
  • There are several different cyclins that are active in different parts of the cell cycle and that cause the Cdk to phosphorylate different substrates. (wikipedia.org)
Cdk11
  • The final barrier to mitotic establishment corresponds to nuclear envelope breakdown, which requires a decisive shift in the balance of cyclin-dependent kinase Cdk1 and PP2AB55 activity. (bvsalud.org)
Inhibition1
  • Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α. (laboratorynotes.com)
Differentiation2
  • Here we show that motoneuron progenitors in the embryonic spinal cord persistently express Cyclin D1 during the initial phase of differentiation, while down-regulating Cyclin D2. (ca.gov)
  • These data identify a cell cycle-independent function for Cyclin D1 in promoting neuronal differentiation, along with a potential genetic pathway through which this function is exerted. (ca.gov)
Replication1
  • The Cdk- G1/S cyclin complex begins to induce the initial processes of DNA replication, primarily by arresting systems that prevent S phase Cdk activity in G1. (wikipedia.org)
Subsets1
  • The findings showed that immunohistochemical analysis can identify 2 cyclin D1+ subsets of myeloma that display distinct clinicopathologic features but share a favorable prognosis. (medscape.com)
Cell cycle16
  • Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins. (wikipedia.org)
  • Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle. (wikipedia.org)
  • Note that the cyclins are now classified according to their conserved cyclin box structure, and not all these cyclins alter in level through the cell cycle. (wikipedia.org)
  • The cyclins also promote other activities to progress the cell cycle, such as centrosome duplication in vertebrates or spindle pole body in yeast. (wikipedia.org)
  • G1 cyclins do not behave like the other cyclins, in that the concentrations increase gradually (with no oscillation), throughout the cell cycle based on cell growth and the external growth-regulatory signals. (wikipedia.org)
  • The presence of G cyclins coordinate cell growth with the entry to a new cell cycle. (wikipedia.org)
  • The cyclin box fold: protein recognition in cell-cycle and transcription control. (embl-heidelberg.de)
  • The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (thermofisher.com)
  • Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. (thermofisher.com)
  • Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner. (ca.gov)
  • Interestingly, we found that Cyclin D1, a well-known key positive regulator of the cell cycle, unexpectedly regulates neuronal specification. (ca.gov)
  • Such role of Cyclin D1 in neuronal specification is not shared by other Cyclin Ds and is independent on its action on the cell cycle. (ca.gov)
  • Loss-of-function and gain-of-function experiments indicate that Cyclin D1 (but not D2) promotes neurogenesis in vivo, a role that can be dissociated from its cell cycle function. (ca.gov)
  • 2015)]. Experiments in our lab with the cold-sensitive γ-tubulin mutant mipAD159 in the filamentous fungus Aspergillus nidulans revealed that γ-tubulin has a role in inactivating the anaphase promoting complex/cyclosome (APC/C) resulting in continuous destruction of cyclin B and failure of nuclei to progress through the cell cycle (Nayak et al. (ku.edu)
  • Thus, A. nidulans is a much better model than these yeasts for studying cyclin function and cell cycle regulation in filamentous fungi. (ku.edu)
  • My phylogenetic analyses reveal there are three A. nidulans cyclins that likely carry out cell cycle-related functions (NimECyclin B, PucA, and ClbA). (ku.edu)
Transcription factor1
  • The neurogenic function of Cyclin D1 appears to be mediated, directly or indirectly, by Hes6, a proneurogenic basic helic-loop-helix transcription factor. (ca.gov)
Divergent1
  • The first of which is the conserved cyclin box, outside of which cyclins are divergent. (wikipedia.org)
Antibodies8
  • Your search for reliable Cyclin E1 antibodies ends here. (antibodies-online.com)
  • Utilize our Cyclin E1 antibodies in your research endeavors for dependable Cyclin E1 detection. (antibodies-online.com)
  • Find Cyclin E1 Antibodies for a variety of species such as anti-Human Cyclin E1, anti-Mouse Cyclin E1, anti-Rat Cyclin E1. (antibodies-online.com)
  • Find Cyclin E1 Antibodies validated for a specific application such as WB, IHC, FACS, ELISA. (antibodies-online.com)
  • Find Cyclin E1 Antibodies with a specific Host. (antibodies-online.com)
  • Find available monoclonal or polyclonal Cyclin E1 Antibodies. (antibodies-online.com)
  • Find Cyclin E1 Antibodies with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. (antibodies-online.com)
  • Immunohistochemical analyses were conducted using antibodies to cyclins D1, E, and A. Southern blot analysis was performed on DNA available from 53 of 84 patients with a cyclin D1-specific probe. (mssm.edu)
Proliferation2
  • Cyclin D2's role in the cell division cycle makes it a key controller of the rate of cell growth and division (proliferation) in the body. (medlineplus.gov)
  • It is less clear how a buildup of cyclin D2 contributes to polydactyly, although the extra digits are probably related to abnormal cell proliferation in the developing hands and feet. (medlineplus.gov)
Complex2
  • They demonstrated that IP7 regulates the activity of a cyclin-CDK-CDK inhibitor complex involved in relaying information about availability of the nutrient inorganic phosphate. (harvard.edu)
  • This work demonstrates a new mechanism for regulating cyclin-CDK activity, and also provides a glimpse of the complex metabolic network that underlies phosphate sensing and signaling. (harvard.edu)
Homolog1
  • 2010). Deletion of the APC/C co-activator CdhA (the A. nidulans Cdh1 homolog) restores cyclin B accumulation and these and other data demonstrate that γ-tubulin plays an important role in inactivating APC/C-CdhA at the G1/S boundary. (ku.edu)
Putative2
  • Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). (thermofisher.com)
  • Coimmunoprecipitation experiments with GlCDKs and the nine putative G. lamblia cyclins (Glcyclins) identified Glcyclins 3977/14488/17505 and 22394/6584 as cognate partners of GlCDK1 and GlCDK2, respectively. (gene-tools.com)
Mitotic1
Multivariate1
Saccharomyces1
  • This is significant as the complement of cyclins found in model yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida albicans) differs considerably from one another and from the great majority of filamentous ascomycetes. (ku.edu)
Signaling pathway1
CCND11
  • [ 3 , 4 ] The most common of these is t(11;14)(q13;q32) involving the cyclin D1 gene ( CCND1 ) and IGH, which is present in approximately 15% to 20% of cases. (medscape.com)
Transition1
  • For example, cyclin F is an orphan cyclin that is essential for G2/M transition. (wikipedia.org)
Promoter1
  • Cyclin D2 promoter methylation was analyzed in 101 prostate cancer samples by methylation-specific PCR. (nih.gov)
Cancers2
  • We investigated the epigenetic silencing of Cyclin D2 gene in prostate cancers and correlated the data with clinicopathological features. (nih.gov)
  • Our results indicate that methylation of Cyclin D2 in prostate cancers correlates with clinicopathological features of poor prognosis. (nih.gov)