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  • gene
  • This approach -- using cyclin A2 expression via gene transfer -- yielded improved myocardial function. (rxpgnews.com)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (genetex.com)
  • Together, these data identify the cyclin A2 gene as a cellular target for RASSF1A through p120 E4F and for the first time suggest a transcriptional mechanism for RASSF1A-dependent cell cycle regulation. (aacrjournals.org)
  • CDC6
  • X-ray studies with a 30-residue CDC6 peptide in complex with pCDK2/cyclin A showed binding of a dodecamer peptide at the recruitment site and a heptapeptide at the catalytic site, but no density for the linking 11 residues. (rcsb.org)
  • The CDC6 bispeptide was a potent inhibitor competitive with both ATP and peptide substrate of pCDK2/cyclin A activity against a heptapeptide substrate (Ki = 0.83 nm) but less effective against RXL-containing substrates. (rcsb.org)
  • complexes
  • These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. (biotium.com)
  • In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. (acris-antibodies.com)
  • Cyclin A has a second function in S phase, in addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes. (wikipedia.org)
  • Cyclin-CDK complexes phosphorylate substrates appropriate for the particular cell cycle phase. (wikipedia.org)
  • Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase. (wikipedia.org)
  • regulates cell
  • Contrary to full-length cyclin A2, which regulates cell proliferation, the A2V6 splice variant might play a role in regulating nondividing cell states such as terminal differentiation or senescence. (duhnnae.com)
  • cell cycle
  • It is unique in its control at two major transitions of the cell cycle and is the only cyclin that is completely silenced after birth in mice, rats and humans. (rxpgnews.com)
  • One such regulatory component is cyclin A which plays a role in the regulation of two different cell cycle stages. (wikipedia.org)
  • Cyclin A is the only cyclin that regulates multiple steps of the cell cycle. (wikipedia.org)
  • JDP2 induces cell cycle arrest through cyclin D, p53, and cyclin A transcription, by increasing JUNB, JUND, and Fra2, and by decreasing c-JUN through the loss of p27kip1. (wikipedia.org)
  • cyclin L CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. (wikipedia.org)
  • CAK activity is not regulated by known cell-cycle pathways and cyclin binding is the limiting step for CDK activation. (wikipedia.org)
  • Xenopus
  • Since its initial discovery, homologues of cyclin A have been identified in numerous eukaryotes including Drosophila, Xenopus, mice, and in humans but has not been found in lower eukaryotes like yeast. (wikipedia.org)
  • Residues
  • Without cyclin, a flexible loop called the activation loop or T-loop blocks the cleft, and the position of several key amino acid residues is not optimal for ATP-binding. (wikipedia.org)
  • cells
  • The nelipepimut-S sequence stimulates specific CD8+ cytotoxic T lymphocytes (CTLs) following binding to HLA-A2/A3 molecules on antigen presenting cells (APCs). (her2support.org)
  • Transfection with miR-663 also sees a resultant upregulation of cyclin B. Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells. (wikipedia.org)
  • It is thought that this hysteretic behavior ensures that cells commit to mitosis even if cyclin B1 levels falter. (wikipedia.org)
  • activation
  • Without cyclin, a flexible loop called the activation loop or T-loop blocks the cleft, and the position of several key amino acid residues is not optimal for ATP-binding. (wikipedia.org)