Loading...
  • gene
  • Cyclin H is implicated in the regulation of the transcriptional machinery during midblastula transition and is therefore an essential gene in early zebrafish larval development. (antibodies-online.com)
  • High
  • One hundred and seventy-one patients (63%) had low cyclin E, 72 (27%) medium and 27 (10%) had high cyclin E content. (diva-portal.org)
  • We also observed statistically significant associations between a high cyclin E content and aneuploidy, high S phase, larger tumor size, estrogen receptor negativity, presence of axillary node metastases and high tumor grade. (diva-portal.org)
  • High cyclin E content was associated with poor overall survival in univariate and multivariate analysis (hazard ratio 2.4, 95% confidence interval 1.3-4.5). (diva-portal.org)
  • patients
  • In the total cohort of non-treated patients (N=187), cyclin E was not associated with recurrence free survival (RFS). (bmj.com)
  • The prognostic value of cyclin E in premenopausal breast cancer is limited to patients with breast carcinomas exhibiting an exclusively infiltrative growth pattern. (bmj.com)
  • tumor
  • Cyclin levels can easily be determined through immunohistological analysis of tumor biopsies. (wikipedia.org)
  • While the exact mechanism that explains how cyclin B1 becomes overexpressed is not very well understood, previous work has shown that down regulation of cyclin B1 can lead to tumor regression. (wikipedia.org)
  • Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the tumor. (wikipedia.org)
  • One of the best known substrates of cyclin D/Cdk4 and -6 is the retinoblastoma tumor suppressor protein (Rb). (wikipedia.org)
  • It is also possible that cyclin A2-CDK contributes to tumorigenesis by the phosphorylation of oncoproteins or tumor suppressors like p53. (wikipedia.org)
  • Immunity against cyclin B1 tumor antigen delays development of spontaneous cyclin B1-positive tumors in p53 (-/-) mice. (nih.gov)
  • complexes
  • Cell changes in the cell cycle like the assembly of mitotic spindles and alignment of sister-chromatids along the spindles are induced by M cyclin- Cdk complexes. (wikipedia.org)
  • Cyclin A has a second function in S phase, in addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes. (wikipedia.org)
  • This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (wikipedia.org)
  • In general, all stages of the cell cycle are chronologically separated in humans and are triggered by cyclin-Cdk complexes which are periodically expressed and partially redundant in function. (wikipedia.org)
  • Even though cyclin D levels in proliferating cells are sustained as long as the growth factors are present, a key player for G1/S transition is active cyclin D-Cdk4/6 complexes. (wikipedia.org)
  • Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase. (wikipedia.org)
  • cytoplasmic
  • The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772-81. (wikipedia.org)
  • But, with Cyclin E antibodies, we get cytoplasmic staining rather than nuclear staining which is mentioned in all the literature I have read. (bio.net)
  • 2004). Cyclin A1 has an important role in the development of acute myeloid leukemia (AML): its localization in normal hematopoietic cells is nuclear, whereas in leukemic cells from AML patients and cell lines, it is predominantly cytoplasmic (Ekberg et al. (atlasgeneticsoncology.org)
  • homologues of cyclin
  • Since its initial discovery, homologues of cyclin A have been identified in numerous eukaryotes including Drosophila, Xenopus, mice, and in humans but has not been found in lower eukaryotes like yeast. (wikipedia.org)
  • The most studied homologues of cyclin D are found in yeast and viruses. (wikipedia.org)
  • regulation of cyclin
  • 1997). The cyclin A1 promoter does not possess a TATA box, whereas the region upstream of the transcriptional start site region contains four GC boxes, with multiple Sp1-binding sites important for the regulation of cyclin A1 expression (Müller et al. (atlasgeneticsoncology.org)
  • initiation
  • Their expression is also being measured by flow cytometry concurrently with the initiation and termination of DNA replication during S-phase Cyclins are generally very different from each other in primary structure, or amino acid sequence. (wikipedia.org)
  • Title: Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C. (nih.gov)
  • cdc2
  • Results provide evidence that cdc2/cyclin B1 kinase activation was synchronous with the initial appearance of cytoskeletal lesions in mouse with Niemann-Pick disease type C. (nih.gov)
  • human
  • Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). (wikipedia.org)
  • In viruses, like Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8/Kaposi's sarcoma-associated herpesvirus) cyclin D homologues have acquired new functions in order to manipulate the host cell's metabolism to the viruses' benefit. (wikipedia.org)
  • Schematic diagram of human cyclin A1. (atlasgeneticsoncology.org)
  • Mammalian cyclin A1 is primarily localized in the nuclei of spermatocytes in mouse and human (Liu et al. (atlasgeneticsoncology.org)
  • ab2098 (2µg/ml) staining Cyclin T1 in human lymph node using an automated system (DAKO Autostainer Plus). (abcam.com)
  • Full length protein corresponding to Human Cyclin A1 aa 1-464. (abcam.com)