• Nitric oxide (NO) and cyclic GMP (cGMP) suppressed glutamatergic synaptic transmission to trigeminal motoneurons in brain stem slices of neonatal rats. (nih.gov)
  • Guanylate cyclase (GC) catalyzes the biosynthesis of cyclic guanosine 3',5'- monophosphate (cGMP) from GTP. (nih.gov)
  • The mutated form synthesizes cyclic adenosine 3',5'-monophosphate instead of cGMP, allowing the detection of enzymatic activity by a reporter gene approach. (nih.gov)
  • The relative functional importance of potassium channels and cGMP-dependent pathways in the relaxation of vascular smooth muscle to the novel nitric oxide donor, diethylamine NONOate (DEA NONOate), was investigated in a resistance artery. (ox.ac.uk)
  • Increasing evidence has suggested the possibility that the activation of N-methyl-D-aspartate (NMDA) receptors modulates spinal nociceptive transmission via a nitric oxide (NO)/cyclic guanosine 3',5'-monophosphate (cGMP) pathway. (silverchair.com)
  • 2,3 NO increases cyclic guanosine 3′,5′-monophosphate (cGMP) through the activation of soluble guanylate cyclase (sGC). (silverchair.com)
  • Most of the effects of the signaling molecule nitric oxide (NO) are mediated by cGMP, which is synthesized by soluble guanylyl cyclase and degraded by phosphodiesterases. (rupress.org)
  • This NO facilitates the secretion of an enzyme called cGMP (cyclic guanosine monophosphate). (lcarscom.net)
  • Nitric oxide diffuses into penile arterial smooth muscle cells, causing increased production of cyclic guanosine monophosphate (cGMP), which relaxes the arteries and allows more blood to flow through them and into the corpora cavernosa. (msdmanuals.com)
  • However, endothelium that has regenerated after percutaneous coronary intervention is incompetent in terms of its integrity and function, with poorly formed cell junctions, reduced expression of antithrombotic molecules, and decreased nitric oxide production. (nature.com)
  • This results in increased nitric oxide production and consequent vascular smooth muscle relaxation and an increase in vasodilation [ 1 ]. (karger.com)
  • Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing effects. (frontiersin.org)
  • There are three isoforms of the NO synthesizing enzyme nitric oxide synthase (NOS): neuronal (nNOS), endothelial (eNOS), and inducible nitric oxide synthase (iNOS), each one involved with specific events in the brain. (frontiersin.org)
  • Furthermore, superoxide anions can modify endothelial function by reducing nitric oxide (NO) biosynthesis and bioavailability [ 7 ]. (hindawi.com)
  • However, these previous studies did not determine the relative contributions of COX (COX‐1 and COX‐2) and nitric oxide synthase (NOS) isoforms (endothelial constitutive (ecNOS) and inducible NOS (iNOS)) to the abnormal acinar microvessel response to HA 4 , 7 . (ersjournals.com)
  • We previously reported the involvement of nitric oxide (NO) and cyclic nucleotide-gated ion channel 6 (CNGC6) in the responses of plants to heat shock (HS) exposure. (biomedcentral.com)
  • Mutations in the genes encoding the CNGA3 and CNGB3 subunits of the cyclic nucleotide-gated (CNG) channel of cone photoreceptors have been associated with autosomal recessive achromatopsia. (jneurosci.org)
  • The most important physiological activator of sGC is nitric oxide, which activates the enzyme upon binding to the heme moiety. (nih.gov)
  • Diagram showing the synthetic pathway responsible for nitric oxide (NO) production from arginine and O 2 and catalyzed by the enzyme nitric oxide synthase (NOS). (frontiersin.org)
  • 1 Nitric oxide synthase (NOS) is a Ca 2+ /calmodulin-dependent enzyme that is stimulated by the activation of NMDA receptors and synthesizes nitric oxide (NO) from L-arginine. (silverchair.com)
  • It acts by preventing the degradation of the second messenger cyclic guanosine 3′,5′-monophosphate by the enzyme PDE-5. (karger.com)
  • Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)
  • This project will exploit novel nitric oxide based therapies to improve the effectiveness of antibiotics against Pseudomonas aeruginosa biofilms. (southampton.ac.uk)
  • PO binding in mouse liver DNA was about one-twentieth that of ethylene oxide (EO). (who.int)
  • Supercapacitors were fabricated using these nanocomposites and cyclic voltammetry measurements were performed to infer specific capacitance. (techconnectworld.com)
  • The synthesized NPs were investigated through cyclic voltammetry, galvanostatic charge/discharge and electrostatic impedance spectroscopy studies. (ias.ac.in)
  • The specific capacitance, as determined through cyclic voltammetry and galvanostatic charge/discharge characteristics, respectively, was found tobe 523 and 55 F g$^{-1}$ for undoped samples. (ias.ac.in)
  • In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
  • Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)
  • Activated on the surface of nanometre-sized TiO 2 , NO gas can easily react with aliphatic cyclic amines and aryl free radicals at RT under atmospheric pressure to offer NONOates and cupferron sodiums, respectively. (utmb.edu)
  • N2 - Activated on the surface of nanometre-sized TiO2, NO gas can easily react with aliphatic cyclic amines and aryl free radicals at RT under atmospheric pressure to offer NONOates and cupferron sodiums, respectively. (utmb.edu)
  • The oxide continues to react with CO 2 to renew the supply of carbonate, creating a cyclic process. (materialstoday.com)
  • Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
  • Activates the nitric oxide-cyclic GMP-potassium channel pathway. (abcam.com)
  • On the partially oxidized Cu(111) investigated here, experiment and theory together suggest that Cu vacancies in the growing islands of cuprous oxide inhibit water adsorption in the centers of the islands (which have reached thermodynamic equilibrium). (princeton.edu)
  • Along with his mentor, he demonstrated that nitric oxide and cyclic GMP inhibit smooth muscle and mesangial cell growth and proliferation induced by serum and various growth factors, such as platelet-derived growth factor, epidermal growth factor, insulin-like growth factor, and fibroblast growth factor. (aacc.org)
  • DNA adducts of propylene oxide are formed in various organs of mice, rats and dogs. (who.int)
  • Terminating in the penile vasculature, these nonadrenergic, noncholinergic nerves liberate nitric oxide, a gas. (msdmanuals.com)
  • The new process is based on molten carbonate electrolysis in which CO 2 reacts directly with a solution phase oxide to form a carbonate. (materialstoday.com)
  • The infrastructure and costs would be similar to aluminum production via molten electrolysis of aluminum oxide, which is a widely used and inexpensive. (materialstoday.com)
  • Principles of Water Electrolysis and Recent Progress of Cobalt, Nickel, and Iron-based Oxides for Oxygen Evolution Reaction. (mpg.de)
  • In addition, this is the first time that cyclic nucleotides have been shown to play a role in the regulation of TLR2. (cdc.gov)
  • Nitric oxide-mediated regulation of biofilm dispersal. (southampton.ac.uk)
  • During his postdoctoral training Dr. Garg received an American Heart Association Fellowship to study the role of nitric oxide and atrial natriuretic factor in the regulation of smooth muscle cell growth. (aacc.org)
  • In situ total scattering experiments of nucleation and crystallisation of tantalum-based oxides: from highly dilute solutions via cluster formation to nanoparticles. (mpg.de)
  • This article reports enhancement in the specific capacitance of Mg-doped tin oxide nanoparticles (NPs) synthesized through a simple and low-cost solvothermal method. (ias.ac.in)
  • Occupational exposure occurs during the production of propylene oxide and its derivatives and during production of hydroxypropyl starch ethers. (who.int)
  • In a previous study, it was demonstrated that HA induces distinct venule dilatation closely associated with vasodilating prostaglandins generated by cyclo-oxygenase (COX), but not by nitric oxide (NO), in intact rat lung 4 . (ersjournals.com)
  • Some well characterized examples include sulfur monoxide (SO), its dimer S2O2, and a series of cyclic sulfur oxides, SnOx (x = 1, 2), based on cyclic Sn rings. (wikipedia.org)
  • Its low level of cyclic dimer can improve the stability and shelf life of dope solutions. (solvay.com)
  • MnTi-oxides were doped with cobalt to improve performance of a supercapacitor. (techconnectworld.com)
  • Synthesis and characterization of undoped and cobalt doped MnTi oxides and specific capacitance values will be presented. (techconnectworld.com)
  • Impact of Single-Pulse, Low-Intensity Laser Post-Processing on Structure and Activity of Mesostructured Cobalt Oxide for the Oxygen Evolution Reaction. (mpg.de)
  • Tailoring Morphology and Electronic Structure of Cobalt Iron Oxide Nanowires for Electrochemical Oxygen Evolution Reaction. (mpg.de)
  • Dual Role of Silver Moieties Coupled with Ordered Mesoporous Cobalt Oxide towards Electrocatalytic Oxygen Evolution Reaction. (mpg.de)
  • Coulometric Titration of Active Sites at Mesostructured Cobalt Oxide Spinel by Surface Interrogation Mode of Scanning Electrochemical Microscopy. (mpg.de)
  • Constitutive, but not inducible, isoforms of cyclo-oxygenase and nitric oxide synthase play an important role in abnormal microvessel responses to carbon dioxide and hydrogen ions in hyperoxia-injured lungs. (ersjournals.com)
  • The aim of the present study was to compare microvessel responses to hypercapnic and isocapnic acidosis in hyperoxia-injured lungs and to assess the role of constitutive and inducible forms of nitric oxide synthase (NOS) and cyclo-oxygenase (COX). (ersjournals.com)
  • Involvement of cyclic GMP and potassium channels in relaxation evoked by the nitric oxide donor, diethylamine NONOate, in the rat small isolated mesenteric artery. (ox.ac.uk)
  • For example, when white phosphorus burns in air it produces oxides of phosphorus including phosphorus pentoxide (P4O10, and phosphorus trioxide (P406). (cdc.gov)
  • Treatment of biofilms with nitric oxide also reduced their resistance to antimicrobial compounds. (southampton.ac.uk)
  • Propylene oxide is possibly carcinogenic to humans (Group 2B) . (who.int)
  • There is inadequate evidence in humans for the carcinogenicity of propylene oxide. (who.int)
  • Interest in the lower sulfur oxides has increased because of the need to understand terrestrial atmospheric sulfur pollution and the finding that the extraterrestrial atmospheres of Io, one of Jupiter's moons, and Venus contain significant amounts of sulfur oxides. (wikipedia.org)
  • Nanocomposites with varying amounts of Mn and Ti oxides were prepared using surfactant templating assisted sol-gel technique. (techconnectworld.com)
  • Intramural inhibitory nerves act by releasing nitric oxide ( NO ) and vasoactive intestinal peptide, whereas the excitatory nerves release acetylcholine and substance P. (nature.com)
  • The measurements are made on a new type of cyclic water cluster that is characterized by simultaneous and cooperative bonding interactions among molecules as well as with both metal and oxygen sites of an oxide surface. (princeton.edu)
  • Density functional theory + U + D calculations confirm the stability of these clusters and are used to discuss other potential water-oxide bonding scenarios. (princeton.edu)
  • Among various mechanisms, the uncoupling of nitric oxide synthase (NOS) in vascular cells has also widely been reported to be involved in ROS generation. (hindawi.com)
  • We report the observation and molecular-scale scanning probe electronic structure (dI/dV) mapping of hydrogen-bonded cyclic water clusters nucleated on an oxide surface. (princeton.edu)
  • Nanocast Mixed Ni-Co-Mn Oxides with Controlled Surface and Pore Structure for Electrochemical Oxygen Evolution Reaction. (mpg.de)
  • Although the high work function of the MoO x layer induced an interfacial inversion layer in the surface of the - Si substrate, forming the build-in-potential, it was not negligible that the 3.5 nm interfacial oxide layer also played a significant role in the transport of carriers. (hindawi.com)
  • The two dipole moment components are μa = 0.875 D and μb = 1.18 D. This species decomposes to give a polymeric sulfur oxides ("PSO's") with the approximate formula [S3O]n. (wikipedia.org)
  • instead the vasoprotective nitric oxide (NO ⋅ ), plays a critical role in vascular dysfunction under various pathophysiological conditions and in aging. (frontiersin.org)
  • In this study, based on the experimental results, we theoretically analyzed the role of the interfacial oxide layer in the charge carrier transport of the MSHJ device. (hindawi.com)
  • Monitoring the Structure Evolution of Titanium Oxide Photocatalysts: From the Molecular Form via the Amorphous State to the Crystalline Phase. (mpg.de)
  • Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. (hindawi.com)
  • Nitric oxide and biopterin: a study in Chiaroscuro. (jci.org)
  • The interfacial oxide layer is regarded as two layers: a quasi - type semiconductor interfacial oxide layer (SiO x (Mo))1 in which numerous negatively charged centers existed due to oxygen vacancies and molybdenum-ion-correlated ternary hybrids and a buffer layer (SiO x (Mo))2 in which the quantity of Si-O bonds was dominated by relatively good passivation. (hindawi.com)
  • This interfacial layer was regarded as two layers, including a quasi - type semiconductor interfacial oxide layer (SiO x (Mo))1 and a buffer layer (SiO x (Mo))2. (hindawi.com)
  • These results indicate that the antiplatelet activity of E. coli LPS may be involved in the activation of a nitric oxide/cyclic GMP pathway in platelets, resulting in inhibition of platelet aggregation. (tmu.edu.tw)
  • The nitric oxide produced by ecNOS attenuated COX‐1 activity in injured arterioles and venules, but carbon dioxide enhanced it, leading to paradoxical dilatation of these microvessels under hypercapnic conditions with ecNOS inhibition. (ersjournals.com)