InhibitionGuanosine monophosphatePDEsInhibitorsCatalyze the hydrolysisAdenosineDegrades cyclicNucleosideInhibitory subunitsEnzymesIntracellularInhibitorSpecificityCGMP phosphodiesteraseEnzymeCalmodulin-dependentProteinMeSHLocalizationGeneMetabolismTypeCatalyticSynthesisModulationRolePDE10AActivityAlterationCellsCAMPAorticHumanReducesFamilyFunctionEssential
Inhibition3
- Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
- 7] Ghiadoni L, Versari D, Taddei S. Phosphodiesterase 5 inhibition in essential hypertension. (degruyter.com)
- Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. (taconic.com)
Guanosine monophosphate2
- Garg, U.C. and Hassid, A. (1989) Nitric Oxide-Generating Vasodilators and 8-Bromo-cyclic Guanosine Monophosphate Inhibit Mitogenesis and Proliferation of Cultured Rat Vascular Smooth Muscle Cells. (scirp.org)
- two of them play a dual role in cyclic guanosine monophosphate (cGMP) and cAMP signaling, whereas only Dunce (Dnc) is cAMP specific. (sdbonline.org)
PDEs4
- Our research interests are in the field of cyclic nucleotide signaling and cardiovascular biology, with a particular focus on cyclic nucleotide phosphodiesterases (PDEs) that catalyze the hydrolysis of cyclic nucleotide second messengers (cAMP and cGMP). (rochester.edu)
- Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. (thermofisher.com)
- cAMP-dependent phosphodiesterases (PDEs) are essential components of the cAMP signaling cascade and fine-tune cyclic nucleotide signaling. (sdbonline.org)
- The dnc gene encodes for at least eight isoforms with high homology to the human phosphodiesterase 4 class of PDEs. (sdbonline.org)
Inhibitors1
- Eli Lilly, Indianapolis, IN, USA), both of which are phosphodiesterase-5 (PDE5) inhibitors, are currently in Phase III clinical trials and could prove more potent, and produce fewer side effects, than sildenafil. (health.am)
Catalyze the hydrolysis1
- Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. (rush.edu)
Adenosine3
- In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
- Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)
- As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
Degrades cyclic1
- Phosphodiesterase 11A (PDE11A), an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the hippocampal formation. (frontiersin.org)
Nucleoside2
- Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate to a nucleoside 5′-phosphate: nucleoside 3′,5′-cyclic phosphate + H2O = nucleoside 5′-phosphate They thus control the cellular levels of the cyclic second messengers and the rates of their degradation. (wikipedia.org)
- Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. (rush.edu)
Inhibitory subunits1
- The proteins identified include transducin α (Gα t ), phosphodiesterase (PDE6) catalytic and inhibitory subunits, cyclic nucleotide-gated channel (CNGα) and arrestin. (bioone.org)
Enzymes4
- This study was designed to investigate the effects of Hunteria umbellata (HU) seeds and Cylicodiscus gabunensis (CG) stem barks aqueous extracts on key enzymes relevant to erectile dysfunction (phosphodiesterase-5 and arginase) and type-2 diabetes (α-amylase and α-glucosidase). (degruyter.com)
- In ascertaining the erectogenic and antidiabetic properties of the extracts, the effects of the extracts on activities of some enzymes relevant to erectile dysfunction (arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. (degruyter.com)
- Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain enigmatic. (crick.ac.uk)
- 1] Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. (axonmedchem.com)
Intracellular1
- Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
Inhibitor2
- 4. Chen X, Wang N, Liu Y, Liu Y, Zhang T, Zhu L, Wang Y, Wu C, Yang J. (2014) Yonkenafil: a novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke. (guidetopharmacology.org)
- The interaction with the non-selective PDE (cyclic nucleotide phosphodiesterase) inhibitor 3-isobutyl-1-methylxanthine (IBMX) was tested after three days. (scirp.org)
Specificity1
- The versatility and specificity of cyclic nucleotide signaling is achieved through specific compartmentalization of different cyclic nucleotide pools that are controlled by distinct PDE isoforms. (rochester.edu)
CGMP phosphodiesterase3
- Retinal 3′,5′-cGMP phosphodiesterase (PDE) is located in photoreceptor outer segments and is an important enzyme in phototransduction. (wikipedia.org)
- Mutations in the beta subunit of the cGMP phosphodiesterase gene (beta PDE) can cause a recessively inherited retinal degeneration in several species, including mice, dogs and humans. (nih.gov)
- Furthermore, we found that the levels of GTPase accelerating protein (GAP) activity and cyclic GMP (cGMP) phosphodiesterase activity were similar in gecko and mammalian rods. (bioone.org)
Enzyme2
- The systematic name for this enzyme is 3′,5′-cyclic-nucleotide 5'-nucleotidohydrolase. (wikipedia.org)
- Cyclic 3,5 nucleotide phosphodiesterase is a kind of enzyme with what effect? (viablife.com)
Calmodulin-dependent1
- Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia-reperfusion. (ouhsc.edu)
Protein6
- It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)
- We therefore immunized young female Cnp −/− mice lacking the structural myelin protein 2′-3′-cyclic nucleotide 3′-phosphodiesterase (Cnp) with a "cocktail" of NMDAR1 peptides. (nature.com)
- Chen, Z.S., Lee, K. and Kruh, G.D. (2001) Transport of Cyclic Nucleotides and Estradiol 17-Beta-d-glucuronide by Multidrug Resistance Protein 4. (scirp.org)
- Evidence is provided that Hangover acts as a nuclear RNA binding protein and the phosphodiesterase 4d ortholog dunce as a target RNA. (sdbonline.org)
- Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
- 2] Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. (axonmedchem.com)
MeSH1
- 2',3'-Cyclic-Nucleotide Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Localization1
- Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)
Gene1
- Pilz, R.B. and Broderick, K.E. (2005) Role of Cyclic GMP in Gene Regulation. (scirp.org)
Metabolism1
- Cyclic AMP (cAMP) and cGMP regulate a myriad of cellular functions, such as metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. (aspetjournals.org)
Type4
- Our previous studies have suggested that two phosphodiesterase type 10A (PDE10A) variants, PDE10A1 and PDE10A2 transcripts, are mainly expressed in humans and that PDE10A2 and PDE10A3 transcripts are major variants in rats. (johnshopkins.edu)
- However, when intact platelets were incubated with NO and then lysed, enhanced activity of phosphodiesterase type 5 was detected in the cytosol. (rupress.org)
- Furthermore, this increase in cGMP degradation is paralleled by the phosphorylation of phosphodiesterase type 5 at Ser-92. (rupress.org)
- Thus, our data suggest that NO-induced desensitization of the cGMP response is caused by the phosphorylation and subsequent activity increase of phosphodiesterase type 5. (rupress.org)
Catalytic1
- 3′,5′-cyclic-nucleotide phosphodiesterases in rod cells are oligomeric, made up of two heavy catalytic subunits, α (90 kDa) and β (85 kDa,) and two lighter inhibitory γ subunits (11 kDa each). (wikipedia.org)
Synthesis1
- Considerable effort over the last 20 years has allowed identification of the cellular components involved in the synthesis of cyclic nucleotides, as well as effectors of cyclic nucleotide-mediated signaling. (aspetjournals.org)
Modulation1
- We aim to reveal new molecular targets for pharmacologic modulation of specific cyclic nucleotide signaling in the treatment of cardiovascular diseases. (rochester.edu)
Role3
- More recently, a central role for cyclic nucleotide phosphodiesterase (PDE) has also been elaborated in many cell types, including those involved in regulating the activities of the cardiovascular system. (aspetjournals.org)
- Originally, cosmetic grade nicotinamide is a kind of substance that can activate the cyclic 3,5 nucleotide phosphodiesterase, so it can be seen that cosmetic grade nicotinamide plays a role in inhibiting melanin production by stimulating the cyclic 3,5 nucleotide phosphodiesterase. (viablife.com)
- A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction. (rochester.edu)
PDE10A1
- As a sub-objective, since PDE10A transcript variants were reported strictly through analyses of bovine genomic sequence, we also wanted to determine the nucleotide and amino acid sequences by experimental evidence. (plos.org)
Activity2
- Because cell behavior is a dynamic process influenced by numerous factors, we will attempt to emphasize how changes in the activity, expression, and targeting of PDE influence cyclic nucleotide-mediated regulation of the behavior of these cells. (aspetjournals.org)
- Using a mouse model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we found that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. (nih.gov)
Alteration1
- To understand the specific cyclic nucleotide signaling responsible for SMC phenotypic alteration, we have performed initial discovery screening for PDE isozymes that are differentially expressed in contractile versus synthetic SMCs. (rochester.edu)
Cells1
- Cyclic GMP was able to mimic the antiproliferative effect of SNP on HEK293 cells. (scirp.org)
CAMP4
- Here, we demonstrate that Plasmodium falciparum phosphodiesterase β (PDEβ) hydrolyses both cAMP and cGMP and is essential for blood stage viability. (crick.ac.uk)
- Within these neurons, two cyclic AMP (cAMP)-dependent mechanisms balance the degree of tolerance. (sdbonline.org)
- In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
- Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. (biolog.de)
Aortic1
- Here we show that in platelets and aortic tissue, NO led to a biphasic response characterized by a tremendous increase in cGMP (up to 100-fold) in less than 30 s and a rapid decline, reflecting the tightly controlled balance of guanylyl cyclase and phosphodiesterase activities. (rupress.org)
Human1
- Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (taconic.com)
Reduces1
- The cyclic 3, 5-nucleotide phosphodiesterase stimulates the breakdown of the melanocyte hormone cyclic adenylate into adenine-5-monophosphate, which reduces melanin production. (viablife.com)
Family1
- 3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. (wikipedia.org)
Function1
- Cyclic nucleotide phosphodiesterases: relating structure and function. (degruyter.com)
Essential1
- They are essential regulators of cyclic nucleotide signaling with diverse physiological functions. (axonmedchem.com)