• Mice with a global inactivation of the cyclic GMP kinase I (cGKI) gene (cGKI −/− ) and mice that express cGKIα or cGKIβ in all smooth muscles on a cGKI −/− background 1 (cGKI RM mice) have a bleeding duodenal ulcer 2 and anemia of unknown cause. (haematologica.org)
  • We designed duplex siRNA constructs to target GC-A, VASP, and cyclic GMP-dependent protein kinase (PKG). (ahajournals.org)
  • less thanbrgreater than less thanbrgreater thanIn the smooth muscle portion of the transition zone, immunosignals specific for the PDE5 were found co-localized with cyclic GMP, cGKI alpha, and cGKI, as well as with the cyclic cAMP-binding protein kinase A. Smooth muscle bundles were seen innervated by slender varicose nerves characterized by the expression of nNOS. (diva-portal.org)
  • E ) Different concentrations of the cGAS product, synthetic cGAMPs and c-di-GMP were delivered into digitonin-permeabilized L929 cells. (nih.gov)
  • For others, the ligands were titrated into c-di-GMP bound STING (3.55:1 in molar ratio). (nih.gov)
  • Cyclic GMP has been proposed to regulate axonal development, but the molecular and cellular mechanisms underlying the formation of axon branches are not well understood. (jneurosci.org)
  • Axelsson KL, Andersson RGG, Wikberg JES (1981) Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters. (springer.com)
  • Diamond J, Janis RA (1978) Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens. (springer.com)
  • Schultz KD, Schultz K, Schultz G (1977) Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. (springer.com)
  • Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. (booktopia.com.au)
  • Kukovetz WR, Holzmann S, Wurm A, Pöch G (1979) Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. (springer.com)
  • (A) The original titration traces (top) and integrated data (bottom) of ITC experiments, in which c-di-GMP was titrated into a solution of STING dimer. (nih.gov)
  • Mouse Direct Cyclic GMP (cGMP) Chemiluminescent Immunoassay kits will measure cGMP present in lysed cells, EDTA plasma, urine, saliva and culture media samples. (innov-research.com)