This thesis describes: (1) the application of ring-closing metathesis (RCM) to the synthesis of constrained cyclic peptides, (2) the conformational analyses of these peptide architectures, and (3) the development of new selective cross-metathesis (CM) methodology employing alkylidene 1. (caltech.edu)
Cyclo1
Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain. (pharmacokinetica.ru)
Amino4
We also have developed a novel, cyclic dipeptide catalyst (1) for an asymmetric variant of the Strecker amino acid synthesis. (purdue.edu)
Introduction of olefin functionality into peptidic structures proved straightforward, and treatment with ruthenium alkylidene 1 generated cyclic amino acids and dipeptides in excellent yields. (caltech.edu)
This genome sequence provides a basis the condensation of two amino acids to a cyclic dipeptide, for elucidating the possible mechanism for the biosynthesis and then converted into the pyrazine molecule (Cheng et al. (sagepub.com)
Finally, free amino acids are taken up by enterocytes through specific Na-linked carrier systems (5 carriers with selective affinities for groups of amino acids are described), whereas dipeptides and tripeptides are translocated into the absorptive epithelial cells by the peptide transporter 1 (PEPT1), which is a carrier with a broad specificity linked to H entry. (medscape.com)
Epithelial Cells1
Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes. (mpg.de)
Synthesis2
We began with the synthesis of cyclic dipeptides 1 and 2 for our catalysis studies. (purdue.edu)
M.S Iyer, N. Namdev, K. Gigstad, and M.A.Lipton, "Asymmetric Catalysis of the Strecker Synthesis by a Cyclic Dipeptide," J. Am. Chem. (purdue.edu)
Biosurfactants1
Recent research attests the effect of lactic acid bacteria by producing antagonist compounds able to control pathogenic fungi (lactic, acetic, phenyl-lactic, cyclic dipeptides, reuterin, biosurfactants). (rjas.ro)
Peptide3
The agent activated T-cell differentiation, T-cell recognition of peptide-MHC complexes, induced changes in intracellular composition of cyclic nucleotides, and activated neutrophilic chemotaxis and phagocytosis. (nih.gov)
To test for specificity, an ELISA CEP dipeptide 1 using the control arginine cyclic peptide was performed as described previously[33]. (cancerrealitycheck.com)
In the hepatitis study CCP2 specific responses were observed in half of the hepatitis samples[38], whereas only 22% of the sera from pulmonary tuberculosis patients CEP dipeptide 1 was citrulline specific for CCP1 peptide compared to 94% of the sera from RA patients[39]. (cancerrealitycheck.com)
Tetrapeptide1
This is a cyclic tetrapeptide that induces chlorosis in hosts by binding a chloroplast-coupling factor involved in energy transfer. (plantsdiseases.com)
Analogs1
At the same time a more constrained collection cf dipeptide analogs was in fact served by Hruby ainsi que al. (gdidetection.com)
Compounds1
Nanoformulated calix[8]arenes functionalized with N -heterocyclic carbene (NHC)-palladium complexes were found to be efficient nano-reactors for Suzuki-Miyaura cross-coupling reactions of water soluble iodo- and bromoaryl compounds with cyclic triol arylborates at low temperature in water without any organic co-solvent. (mdpi.com)
Survival1
The effect of dipeptide on survival, life span and spontaneous tumor development was studied in female rats. (nih.gov)
Rats2
Seventy-six, five-month-old outbred female rats were randomly subdivided into two groups and were subcutaneously injected with 0.2 ml of normal saline (controls, 32 rats) or with 5 micrograms/rat of the dipeptide L-Glu-L-Trp, dissolved in 0.2 ml of saline (44 rats), 5 times per week for 12 months. (nih.gov)
0.02) in rats exposed to the dipeptide in comparison with controls. (nih.gov)
Found1
2.5-diketopiperazines are cyclic dipeptides found in a wide variety of food products. (italianfoodtech.com)
Basis1
On the basis of the synthesized dipeptide a pharmaceutical was designed containing this compound, which later receives the brand name Thymogen. (nih.gov)
Groups1
These cyclic dipeptides incorporate both donor and acceptor groups for hydrogen bonding. (wikipedia.org)
Amino-acids3
The greater facility of incorporation of the 7-membered lactam prompted us to prepare two 7-membered cyclic acylhydrazides (4 and 5) by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI)-mediated cyclization of amino acids having selectively protected hydrazine functional groups in their side chains. (elsevierpure.com)
With N-acetyl amino acids and dipeptides beta-scission of an alkoxyl radical at the C-terminal alpha-carbon results in C-terminal decarboxylation, with release of CO2. (ku.dk)
As shown below, a linear tripeptide with 3 different amino acids contains 2 different dipeptides, while a cyclic tripeptide contains 3 different dipeptides. (peplib.com)
Tripeptide1
12. Different behaviors of cyclic dipeptide prenyltransferases toward the tripeptide derivative ardeemin fumiquinazoline and its enantiomer. (nih.gov)
Analogues1
We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. (elsevierpure.com)
Ions1
In contrast to the b(2)(+) ions generated from tripeptides, synthetic cyclic dipeptides VP and HP were confirmed to have exclusive diketopiperazine structures. (pasteur.fr)
The effects of putative neurotransmitters or hormones on intracellular cyclic AMP or cyclic GMP levels, voltage-sensitive Ca2+ channel activity, and acetylcholine secretion were determined. (nih.gov)
Receptor-mediated increases in intracellular cyclic AMP or cyclic GMP levels had no immediate effect on K+-dependent 45Ca2+ uptake by cells or on acetylcholine secretion from cells. (nih.gov)
Mechanism1
17. Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity. (nih.gov)
Pmid2
PMID- 214392 TI - Regulation of lipogenesis by adenosine 3', 5'-cyclic monophosphate in chicken liver in vitro. (nih.gov)
PMID- 214393 TI - Regulation of growth & metabolism of ovariectomised rat uterus by adenosine 3', 5'-cyclic monophosphate. (nih.gov)
Derivatives3
These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lysine, having 5-, 6-, and 7-membered lactam rings, respectively. (elsevierpure.com)
10. Reinvestigation of a cyclic dipeptide N-prenyltransferase reveals rearrangement of N-1 prenylated indole derivatives. (nih.gov)
The team first synthesized a series of model dipeptides and their derivatives containing amide-to-ester substitutions. (titech.ac.jp)
Incorporate2
In common with the lactam dipeptides, acylhydrazide dipeptides 4 and 5 could be used to activate the same suppressor tRNA transcript and to incorporate the cyclic dipeptides into DHFR. (elsevierpure.com)
These cyclic dipeptides incorporate both donor and acceptor groups for hydrogen bonding. (wikipedia.org)
Ester1
The acetic ester, N-formyl-L-methionine, and the dipeptide examples above are each monoesters. (wikidoc.org)
Structures2
Part V. An Approach to the Computer Generation of Cyclic Structures. (nih.gov)
Crystal structures of nNOS-selective dipeptide inhibitors in complex with both nNOS and eNOS were solved and the inhibitors were found to adopt a curled conformation in nNOS but an extended conformation in eNOS. (rcsb.org)
Protein1
The suppression yields increased with increasing lactam ring size and were found to proceed in suppression yields ranging from 3.4 to 8.9% at two different protein sites for the 5-, 6- and 7-membered lactam dipeptides. (elsevierpure.com)
Molecular2
Keywords: electron capture, dipeptides, molecular ion fragmentation. (ioffe.ru)
Aggregation of Aβ40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations. (nih.gov)
Increases2
6. C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities. (nih.gov)
Exposure of hybrid cells for 3-7 days to PGE1, which results in activation of adenylate cyclase, or exposure to various cyclic nucleotide phosphodiesterase inhibitors markedly increases the number of synapses formed. (nih.gov)
Species1
Revision of the genus Aciculosporium (Clavicipitaceae) with a description of a new species on wavyleaf basketgrass, and proline-containing cyclic dipeptide production by A. take . (wikimedia.org)
Results2
4. Saturation mutagenesis on Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 results in mutants with strongly increased C3-prenylating activity. (nih.gov)
However, prolonged exposure of hybrid cells to PGE1 results both in an increase in cellular cyclic AMP and the gradual acquisition by cells of functional voltage-sensitive Ca2+ channels. (nih.gov)
Design1
CycPeptMPDB: A Database Aimed at Promoting Drug Design Using Cyclic Pe. (titech.ac.jp)